Pathophysiology of Headaches: From Molecule to Man

277 Pages·2015·4.101 MB·English

by  Messoud Ashina, Pierangelo Geppetti (eds.)

Headache
Series Editors: Paolo Martelletti · Rigmor Jensen
Messoud Ashina
Pierangelo Geppetti Editors
Pathophysiology
of Headaches
From Molecule to Man
Headache
Series editors
Paolo Martelletti
Roma , Italy
Rigmor Jensen
Glostrup , Denmark
The huge importance of headache in public health arises from its causal association
with personal and societal burdens of pain, disability, damaged quality of life, and
fi nancial costs. Headache disorders are in fact common and ubiquitous. They have
a neurological basis, but rarely they are due to serious underlying illness. The
primary headache disorders – migraine, tension-type headache, and cluster
headache — are easily seen by family physicians or GPs; however, a relatively small
number of secondary headache disorders could also be encountered in primary care.
It is important that they are recognized and treated in the most appropriate way
because of their potentially dangerous underlying causes; moreover, mismanagement
and overuse of medications to treat acute headache are major risk factors for disease
aggravation. Purpose of this Series, endorsed by the European Headache Federation –
EHF, is to provide a detailed description of all aspects of headache disorders that are
common and relevant both in primary care and in hospital setting.
More information about this series at http://www.springer.com/series/11801
Messoud Ashina • Pierangelo Geppetti
Editors
Pathophysiology
of Headaches
From Molecule to Man
Editors
Messoud Ashina , MD, PhD, DMSc Pierangelo Geppetti , MD
Professor of Neurology Professor of Clinical Pharmacology
Department of Neurology Department of Health Sciences
Danish Headache Center University of Florence
Rigshospitalet and Glostrup Hospital Florence
Glostrup Italy
Denmark
Head, Headache Center
Faculty of Health and Medical Sciences University Hospital – Careggi
University of Copenhagen Florence
Copenhagen Italy
Denmark
ISSN 2197-652X ISSN 2197-6538 (electronic)
Headache
ISBN 978-3-319-15620-0 ISBN 978-3-319-15621-7 (eBook)
DOI 10.1007/978-3-319-15621-7
Library of Congress Control Number: 2015936082
Springer Cham Heidelberg New York Dordrecht London
© Springer International Publishing Switzerland 2015
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Foreword
The Headache Series is enhanced by this second volume, edited by Messoud Ashina
and Pierangelo Geppetti, both well-known scientists in the headache pathophysiol-
ogy area, to whom a delicate task has been assigned: to render the most updated
picture of pathophysiology of headache disorders involving all the many prestigious
actors who dominate the scenes of this shimmering theatre. Their different disci-
plinary b ackgrounds, primarily neurology but also pharmacology, guaranteed a
combined-vision, factual planning of this important chapter in Headache Medicine.
The operation has been brilliantly carried out and the completeness of the vol-
ume is now in front of the readers’ eyes and is available indiscriminately to every-
one with a clinical-scientifi c-educational interest towards Headache Medicine.
The European Headache Federation thanks the Editors for their essential contri-
bution to this complex and fi ne volume and every author of each chapter for playing
an important role in spreading headache culture through the medical world.
The education/dissemination path within the EHF project of the Headache Series
has concluded its second important step.

Paolo Martelletti
Sapienza University, Rome, Italy
Rigmor Høiland Jensen
University of Copenhagen, Copenhagen, Denmark
v

Pref ace
The purpose of the second H eadache Series book endorsed by the European
Headache Federation is to bring together in one book much of the diverse body of
work on the pathophysiology of headaches.
W e hoped to provide the reader with recent advances in the pathophysiology of
migraine, cluster headache, and tension-type headache. The topics we have chosen
for the book should be of interest to headache basic and clinical science researchers
as well as researchers in the pharmaceutical industry. We also believe that this book
will also be attractive to senior undergraduate and graduate students in the health
sciences, whose interests include headache.
T he book is organized into an introductory chapter on the anatomy of headache,
which is essential to understand the pathophysiology of headaches, followed by
topical chapters focusing on animal and human models, genetics, imaging, neuro-
physiology, and biochemistry. We also asked experts in the fi eld to provide the cur-
rent status and future perspectives on the pathophysiology of headaches.
W e hope that this book will not only provide interesting reading but also serve as
a useful reference in the fi eld of headache research.
Copenhagen, Denmark Messoud Ashina
Florence, Italy Pierangelo Geppetti
vii

Contents
1 Anatomy of Headache . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Hayrunnisa Bolay , Karl Messlinger , Mária Dux , and Didem Akcali
2 Animal Models of Migraine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31
Anna P. Andreou and Michael L. Oshinsky
3 Animal Models of Tension-Type Headache
and Trigeminal Autonomic Cephalalgias . . . . . . . . . . . . . . . . . . . . . . 67
Cristina Tassorelli , Rosaria Greco , and Simon Akerman
4 Genetics of Headache . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83
Cherubino Di Lorenzo , Filippo M. Santorelli ,
and Arn M. J. M. van den Maagdenberg
5 Human Models of Primary Headaches . . . . . . . . . . . . . . . . . . . . . . . . 101
Henrik Winther Schytz and Guus G. Schoonman
6 Imaging of Migraine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117
Michaela Andelova , David Borsook , and Till Sprenger
7 Imaging of Other Primary Headaches . . . . . . . . . . . . . . . . . . . . . . . . 137
Sarah Miller and Manjit S. Matharu
8 Neurophysiology of Migraine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155
Gianluca Coppola , Francesco Pierelli , Petter M. Omland ,
and Trond Sand
9 Neurophysiology of Other Primary Headaches . . . . . . . . . . . . . . . . . 175
Anna Ambrosini and Gianluca Coppola
10 Biochemistry of Primary Headaches . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Paola Sarchielli , Stefano Caproni , Cinzia Costa ,
Delia Szok , and Janos Tajti
ix