Pathophysiology

1222 Pages·2012·67.33 MB·English

by  Lee-Ellen C. Copstead

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FIFTH EDITION
PATHOPHYSIOLOGY
Lee-Ellen C. Copstead, PhD, RN Jacquelyn L. Banasik, PhD, ARNP
Professor Associate Professor
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Department of Nursing College of Nursing
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College of Nursing and Health Sciences Washington State University
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University of Wisconsin—Eau Claire Spokane, Washington

Eau Claire, Wisconsin -
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PATHOPHYSIOLOGY, ed 5 ISBN: 978-1-4557-2650-9
Copyright © 2013 by Saunders, an imprint of Elsevier Inc.
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Notices V

Knowledge and best practice in this ield are constantly changing. As new resea-rch and experience
broaden our understanding, changes in research methods, professional pra9ct ices, or medical treat- ir
ment may become necessary. .
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Practitioners and researchers must always rely on their own experience and knowledge in evalu-
ating and using any information, methods, compounds, or expeirimrents described h&erein. In using s
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such information or methods they should be mindful of their own safety and the safety of others,
including parties for whom they have a professional respoansibility. a
With respect to any drug or pharmaceutical productts identiied, readers are advised to cshieck the
most current information provided (i) on procedures featured or (ii) by the manufactrurer of each
product to be administered, to verify the recommended dose or formula, the methoed and duration
of administration, and contraindications. It is the responsibility of practitioneprs, relying on their
own experience and knowledge of their patients, to make diagnoses, to det.ermine dosages and the
best treatment for each individual patient, and to take all appropriate safpety precautions.
To the fullest extent of the law, neither the Publisher nor the auvthiors, contributors, or editors,
assume any liability for any injury and/or damage to persons or property as a matter of products
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tions, or ideas contained in the material herein.
Previous editions copyrighted 2010, 2005, 2000, 1995
Library of Congress Cataloging-in-Publication Data
Copstead, Lee Ellen.
Pathophysiology/Lee-Ellen C. Copstead, Jacquelyn L. Banasik. -- 5th ed.
p.; cm.
Includes bibliographical references and index.
ISBN 978-1-4557-2650-9 (pbk.: alk. paper)
I. Banasik, Jacquelyn L. II. Title.
[DNLM: 1. Disease. 2. Pathology. QZ 140]
616.07--dc23 2012037206
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Last digit is the print number: 9 8 7 6 5 4 3 2
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To:
My now teenaged daughter, Amelia Charlotte Kirkhorn,
who reminds me daily that there is always more to learn.
LECK
To:
Loved ones, past and present, who give meaning to the work.
JLB
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CONTRIBUTORS
Robin Y. Beeman, PhD, RN Rosemary A. Jadack, PhD, RN Faith Young Peterson, MSN, FNP
Professor Professor Family Nurse Practitioner
Department of Nursing Department of Nursing Marsing Clinic
University of Wisconsin—Eau Claire University of Wisconsin—Eau Claire Terry Reilly Health Services
Marshield, Wisconsin Eau Claire, Wisconsin Marsing, Idaho
Cheryl L. Brandt, PhD, ACNS-BC Debra A. Jansen, PhD, RN Dawn F. Rondeau, DNP, ACNP, FNP
Professor Associate Dean, Professor Clinical Assistant Professor
Department of Nursing Department of Nursing College of Nursing
University of Wisconsin—Eau Claire College of Nursing and Health Sciences Washington State University
Eau Claire, Wisconsin University of Wisconsin—Eau Claire Vancouver, Washington
Eau Claire, Wisconsin Assistant Professor
Ann Futterman Collier, PhD Oregon Health & Science University
Assistant Professor Shann Dyes Kim, PhD, RN Portland, Oregon
Department of Psychology Regional Scientiic Associate Director,
Northern Arizona University Specialty Medicines Jeffrey S. Sartin, MD
Flagstaff, Arizona Novartis Pharmaceuticals Infectious Diseases
Woodinville, Washington Infectious Disease and Epidemiology
Carol L. Danning, MD A ssociates
Rheumatologist Marie L. Kotter, PhD Omaha, Nebraska
Gundersen Lutheran Health Systems Department Chair Health Sciences
La Crosse, Wisconsin Weber State University Lorna L. Schumann, PhD, ACNP-BC,
Ogden, Utah ACNS-BC, CCRN, FAANP
Michael R. Diestelmeier, MD Associate Professor
Fellow American Academy of Dermatology Teresa G. Loftsgaarden, MSN, RN College of Nursing
Dermatologist Clinical Instructor Washington State University
Mayo Clinic Health System University of Wisconsin—Eau Claire Spokane, Washington
Eau Claire, Wisconsin Eau Claire, Wisconsin
Angela Stombaugh, PhD, FNP-BC
Ruth E. Diestelmeier, RN, MSN Joni D. Marsh, MN, ARNP Associate Professor
Clinical Instructor Family Nurse Practitioner Department of Nursing
Department of Nursing South Hill Family Medicine University of Wisconsin—Eau Claire
University of Wisconsin—Eau Claire Columbia Medical Associates Eau Claire, Wisconsin
Eau Claire, Wisconsin Spokane, Washington
Susan G. Trevithick, RN, MS, NE-BC
Roberta J. Emerson, PhD, RN Benjamin J. Miller, MN, ARNP, FNP, Compliance Oficer
Associate Professor, Retired ACNP, PhDc VA Salt Lake City Healthcare System
Washington State University President Salt Lake City, Utah
College of Nursing Practical Healthcare Solutions, Inc.
Spokane, Washington Lolo, Montana Marvin J. Van Every, MD
Staff Urologist
Linda Felver, PhD, RN Carrie W. Miller, MSN, RN, CNE, IBCLC Gundersen Clinic
Associate Professor Adjunct Faculty La Crosse, Wisconsin
School of Nursing Seattle University
Oregon Health Sciences University Seattle, Washington Linda D. Ward, PhD, ARNP
Portland, Oregon Assistant Professor
Nirav Y. Patel, MD, FACS College of Nursing
Daniel J. Guerra, PhD, MS Trauma, Acute Care Surgery, Critical Care Washington State University
Senior Scientiic Consultant Surgeon Spokane, Washington
Adjunct Professor, Department of Nutrition Banner Good Samaritan Medical Center
and Exercise Physiology Phoenix, Arizona
Washington State University
Spokane, Washington
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REVIEWERS
Deborah Allen, MSN, CNS, FNP-BC, Beth Forshee, DO, PhD Kristin Metcalf-Wilson,
AOCNP Internal Medicine Resident DNP, WHNP-BC
Advanced Practice Nurse Freeman Health Systems Instructor
Duke Cancer Institute Joplin, Missouri University of Missouri
Durham, North Carolina Sinclair School of Nursing
Charlene Beach Gagliardi, RN, MSN Columbia, Missouri
Nancy Burruss, PhD, RN, CNE Assistant Professor
Associate Professor Mount St. Mary’s College Katie Miller, BSN, MSN
BSN Program Director Los Angeles, California Assistant Professor
Bellin College, School of Nursing College of the Albemarle
Green Bay, Wisconsin Samantha Greed, RN, BSN Elizabeth City, North Carolina
Faculty Assistant
Joanna Cain, BSN, BA, RN Mt. Hood Community College Rebecca Ramirez, RN, BSN, MSN
President and Founder Gresham, Oregon Instructor, Nursing & Medical Assisting
Auctorial Pursuits, Inc. San Benito Consolidated Independent
Austin, Texas Sandra Kaminski, MS, PA-C School District
Assistant Professor San Benito, Texas
Deborah Cipale, RN, MSN School of Health & Medical Sciences
Coordinator, Nursing Resource Lab Physician Assistant Program Mona Sedrak, PhD, PA-C
Des Moines Area Community College Seton Hall University Associate Dean, Division of Health Sciences
Ankeny, Iowa South Orange, New Jersey Associate Professor
School of Health & Medical Sciences
David Derrico, RN, MS Lori Kelly, RN, MSN, MBA Physician Assistant Program
Assistant Clinical Professor Assistant Professor of Nursing Seton Hall University
University of Florida College of Nursing Aquinas College South Orange, New Jersey
Gainesville, Florida Nashville, Tennessee
Elise Webb, RN, MSN
Linda Felver, PhD, RN Claire Leonard, BS, MS, PhD Coordinator/Instructor
Associate Professor Professor CE Allied Health Program
School of Nursing William Paterson University Wilson Community College
Oregon Health Sciences University Wayne, New Jersey Wilson, North Carolina
Portland, Oregon
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