Table Of ContentRené P. Michel
Gerald J. Berry
Editors
Pathology of
Transplantation
A Practical Diagnostic
Approach
123
Pathology of Transplantation
René P. Michel (cid:129) G erald J. Berry
Editors
Pathology
of Transplantation
A Practical Diagnostic Approach
Editors
René P. Michel Gerald J. Berry
Department of Pathology Department of Pathology
McGill University and McGill Stanford University Medical Center
University Health Center Stanford , CA , USA
Montreal , QC , Canada
ISBN 978-3-319-29681-4 ISBN 978-3-319-29683-8 (eBook)
DOI 10.1007/978-3-319-29683-8
Library of Congress Control Number: 2016943076
© Springer International Publishing Switzerland 2016
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or
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The use of general descriptive names, registered names, trademarks, service marks, etc. in this
publication does not imply, even in the absence of a specifi c statement, that such names are
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The publisher, the authors and the editors are safe to assume that the advice and information in
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Printed on acid-free paper
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The registered company is Springer International Publishing AG Switzerland
René P. Michel: “Dedicated to my parents, to Manon and to my
three sons André, Adam and Cédrik for their love, support
and patience.”
Gerald J. Berry: “Dedicated to my parents for conveying
a lifelong love of learning and my family, Carol, Sarah,
Michael, Rachel and Nicole, for the many sacrifi ces,
love and support.”
Contents
Introduction ........................................................................................... 1
René P. Michel and Gerald J. Berry
Immunobiology of Transplantation ..................................................... 7
I. Esme Dijke
Immunosuppressive Drugs in Solid Organ Transplantation ............ 53
Gerald J. Berry and Randall E. Morris
Heart Transplantation .......................................................................... 81
René P. Michel and Gerald J. Berry
Lung Transplantation ........................................................................... 121
Gerald J. Berry
Liver Transplantation ........................................................................... 173
René P. Michel and Victoria A. Marcus
Pancreas Transplantation ..................................................................... 265
René P. Michel
Intestinal Transplantation .................................................................... 299
John P. Higgins and Neeraja Kambham
Kidney Transplantation ........................................................................ 315
Chantal Bernard and Megan Troxell
Hematopoietic Stem Cell Transplantation .......................................... 401
Chelsea Maedler-Kron , Victoria A. Marcus , and René P. Michel
Transplantation and Malignancy ........................................................ 451
Ramila Amre and René P. Michel
Future Directions in Transplantation .................................................. 477
Gerald J. Berry
Index ....................................................................................................... 479
vii
Contributors
Ramila Amre , M.D., F.R.C.P.(C.) Department of Pathology , McGill University
and McGill University Health Center , Montreal , QC , Canada
Chantal Bernard , M.D., F.R.C.P.(C.) Department of Pathology , McGill
University and McGill University Health Center , Montreal , QC , Canada
Gerald J. Berry , M.D. Department of Pathology , Stanford University
Medical Center , Stanford , CA , USA
I. Esme Dijke , Ph.D. Department of Pediatrics/Alberta Transplant Institute ,
University of Alberta , Edmonton , AB , Canada
John P. Higgins , M.D. Department of Pathology , Stanford University
Medical Center , Stanford , CA , USA
Neeraja Kambham , M.D. Department of Pathology , Stanford University
Medical Center , Stanford , CA , USA
Chelsea Maedler-Kron , M.D. Department of Pathology , McGill University
and McGill University Health Center , Montreal , QC , Canada
Victoria A. Marcus , M.D., C.M., F.R.C.P.(C.) Department of Pathology ,
McGill University and McGill University Health Center , Montreal , QC ,
Canada
René P. Michel , M.D., C.M., F.R.C.P.(C.) Department of Pathology , McGill
University and McGill University Health Center , Montreal , QC , Canada
Randall E. Morris , M.D., F.R.C.P. Department of Cardiothoracic Surgery ,
Stanford University Medical Center , Stanford , CA , USA
Megan Troxell , M.D., Ph.D. Department of Pathology , Stanford University
Medical Center , Stanford , CA , USA
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