Pathology and Genetics of Skin Tumours

357 Pages·2005·70.64 MB·English

by  The International Agency for Research on Cancer, P.E. LeBoit, G. Burg, D. Weedon, A. Sarasin

World Health Organization Classification of Tumours
Kleihues P., Cavenee W.K. (Eds.): Hamilton S.R., Aaltonen L.A. (Eds.): Jaffe E.S., Harris N.L., Stein H.,
World Health Organization World Health Organization Vardiman J.V. (Eds.): World Health
Classification of Tumours. Classification of Tumours. Organization Classification of Tumours.
Pathology and Genetics of Pathology and Genetics of Tumours Pathology and Genetics of Tumours of
Tumours of the Nervous System. of the Digestive System. Haematopoietic and Lymphoid Tissues.
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ISBN 92 832 2409 4 ISBN 92 832 2410 8 ISBN 92 832 2411 6
Fletcher C.D., Unni K.K., Tavassoli F.A., Devilee P. (Eds.): Eble J.N., Sauter G., Epstein J.E.,
Mertens F. (Eds.): World Health World Health Organization Sesterhenn I.A. (Eds.): World Health
Organization Classification of Classification of Tumours. Organization Classification of
Tumours. Pathology and Genetics of Pathology and Genetics of Tumours of Tumours. Pathology and Genetics of
Tumours of Soft Tissue and Bone. the Breast and Female Genital Organs Tumours of the Urinary System and
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Travis W.D., Brambilla E., Müller- DeLellis R.A., Lloyd R.V., Heitz, P.U., Barnes L., Eveson J.W., Reichart P.,
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World Health Organization Organization Classification of Organization Classification of
Classification of Tumours. Pathology Tumours. Pathology and Genetics of Tumours. Pathology and Genetics of
and Genetics of Tumours of Lung, Tumours of Endocrine Organs. Head and Neck Tumours.
Pleura, Thymus and Heart. IARC Press: Lyon 2004 IARC Press: Lyon 2005
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ISBN 92 832 2418 3
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World Health Organization Classification of Tumours
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Pathology and Genetics of
Skin Tumours
Edited by
Philip E. LeBoit
Günter Burg
David Weedon
Alain Sarasin
IARCPress
Lyon, 2006
World Health Organization Classification of Tumours
Series Editors Paul Kleihues, M.D.
Leslie H. Sobin, M.D.
Pathology and Genetics of Skin Tumours
Editors Philip E. LeBoit, M.D.
Günter Burg, M.D.
David Weedon, M.D.
Alain Sarasin, Ph.D.
Coordinating Editors Wojciech Biernat, M.D.
Hiroko Ohgaki, Ph.D.
Editorial assistants Asiedua Asante
Agnès Meneghel
Layout Marlen Grassinger
Stephan Rappo
Sibylle Söring
Illustrations Nobert Wey
Thomas Odin
Printed by Team Rush
69603 Villeurbanne, France
Publisher IARCPress
International Agency for
Research on Cancer (IARC)
69008 Lyon, France
This volume was produced in collaboration with the
International Academy of Pathology (IAP)
European Organization for Research and Treatment of Cancer (EORTC)
and the
Department of Pathology, University Hospital, Zurich, Switzerland
The WHO Classification of Skin Tumours
presented in this book reflects the views of a Working Group that convened for an
Editorial and Consensus Conference in Lyon, France,
September 22-25, 2003.
Members of the Working Group are indicated
in the List of Contributors on page 295.
Published by IARC Press, International Agency for Research on Cancer,
150 cours Albert Thomas, F-69008 Lyon, France
© International Agency for Research on Cancer, 2005
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Format for bibliographic citations:
LeBoit P.E., Burg G., Weedon D, Sarasain A. (Eds.): World Health Organization
Classification of Tumours. Pathology and Genetics of Skin Tumours. IARC Press:
Lyon 2006
IARC Library Cataloguing in Publication Data
Pathology and genetics of skin tumours/ edited by Philip E. LeBoit... [et. al.].
(World Health Organization classification of tumours ; 10)
1. Skin Neoplasms – genetics
2. Skin Neoplasms – pathology
I. LeBoit, P.E.
II. Series
ISBN 92 832 2414 0 (NLM Classification: WR 500)
Contents
1 Keratinocytic tumours 9 Persistent melanoma and local
WHO and TNM classification 10 metastasis of melanoma 90
Introduction 11 Congenital melanocytic naevus 93
Basal cell carcinoma 13 Superficial type 93
Superficial basal cell carcinoma 15 Proliferative nodules in congenital
Nodular basal cell carcinoma 16 melanocytic naevi 93
Micronodular basal cell carcinoma 16 Blue naevi 95
Infiltrating basal cell carcinoma 17 Common blue naevus 95
Fibroepithelial basal cell carcinoma 17 Mongolian spot 96
Basal cell carcinoma with adnexal differentiation 18 Naevus of Ito and naevus of Ota 96
Basosquamous carcinoma 18 Cellular blue naevus 96
Keratotic basal cell carcinoma 19 Deep penetrating naevus 98
Other variants 19 Combined naevus 100
Squamous cell carcinoma 20 Melanotic macules 103
Acantholytic squamous cell carcinoma 21 Simple lentigo – lentiginous melanocytic naevus 104
Spindle-cell squamous cell carcinoma 22 Dysplastic naevus 105
Verrucous squamous cell carcinoma 22 Site specific and Meyerson naevi 110
Pseudovascular squamous cell carcinoma 23 Acral naevus 110
Adenosquamous carcinoma 24 Genital naevus 110
Bowen disease 26 Meyerson naevus 111
Bowenoid papulosis 28 Persistent (recurrent) melanocytic naevus 113
Actinic keratosis 30 Spitz naevus 114
Arsenical keratosis 32 Pigmented spindle cell naevus (Reed) 117
PUVA keratosis 33 Halo naevus 118
Verrucas 34
Verruca vulgaris 36 3 Appendageal tumours 121
Verruca plantaris 37 WHO and TNM classification 122
Verruca plana 38 Introduction 123
Acanthomas 39 Malignant tumours with apocrine and
Epidermolytic acanthoma 39 eccrine differentiaton 125
Warty dyskeratoma 39 Tubular carcinoma 125
Acantholytic acanthoma 40 Microcystic adnexal carcinoma 125
Lentigo simplex 40 Malignant mixed tumour 127
Seborrhoeic keratosis 41 Porocarcinoma 128
Melanoacanthoma 43 Spiradenocarcinoma 130
Clear cell acanthoma 43 Hidradenocarcinoma 131
Large cell acanthoma 44 Mucinous carcinoma 131
Keratoacanthoma 44 Digital papillary carcinoma 133
Lichen planus-like keratosis 47 Adenoid cystic carcinoma 134
Apocrine carcinoma 135
2 Melanocytic tumours 49 Paget disease and extramammary
WHO classification 50 Paget disease 136
TNM classification 51 Benign tumours with apocrine and
Malignant melanoma: Introduction 52 eccrine differentiation 139
Superficial spreading melanoma 66 Hidrocystoma 139
Nodular melanoma 68 Syringoma 140
Lentigo maligna 70 Poroma 141
Acral-lentiginous melanoma 73 Syringofibroadenoma 142
Desmoplastic melanoma and desmoplastic Hidradenoma 143
neurotropic melanoma 76 Spiradenoma 143
Melanoma arising from blue naevus 79 Cylindroma 145
Melanoma arising in giant congenital naevi 83 Tubular and tubular papillary adenoma 145
Childhood melanoma 84 Syringocystadenoma papilliferum 146
Naevoid melanoma 86 Hidradenoma papilliferum 147
Mixed tumour (chondroid syringoma) 147 B-cell lymphoma 199
Malignant tumours with follicular differentiation 149 Intravascular large B-cell lymphoma 200
Pilomatrical carcinoma 149 Lymphomatoid granulomatosis 202
Proliferating tricholemmal tumour 150 Cutaneous involvement in primary extracutaneous
Benign tumours with follicular differentiation 152 B-cell lymphoma 204
Trichoblastoma 152 Mantle cell lymphoma 204
Pilomatricoma 153 Burkitt lymphoma 205
Tricholemmoma 155 Chronic lymphocytic leukaemia / small
Trichofolliculoma 156 lymphocytic lymphoma 205
Pilar sheath acanthoma 157 Hodgkin lymphoma 207
Tumour of the follicular infundibulum 158 Blastic NK-cell lymphoma 208
Fibrofolliculoma / trichodiscoma 158 Precursor T-lymphoblastic leukaemia / lymphoma
Tumours with sebaceous differentiation 160 and precursor B-lymphoblastic
Sebaceous carcinoma 160 leukaemia / lymphoma 210
Sebaceous adenoma 161 Cutaneous involvement by myeloid leukaemia 211
Sebaceoma 162 Lymphoid infiltrates of the skin mimicking
Cystic sebaceous tumour 163 lymphoma 212
Parapsoriasis 215
4 Haematolymphoid tumours 165 Small plaque parapsoriasis 215
WHO / EORTC classification 166 Parapsoriasis – Large patch type,
TNM classification 167 with or without poikiloderma 215
Introduction 168 Langerhans cell histiocytosis 217
Mycosis fungoides (MF) 169 Indeterminate cell histiocytosis 220
Pagetoid reticulosis 173 Sinus histiocytosis with massive lymphadenopathy
Syringotropic MF 173 (Rosai-Dorfman) 221
Folliculotropic MF 173 Juvenile xanthogranuloma 222
Granulomatous MF 174 Reticulohistiocytosis 224
Sézary syndrome 175 Mastocytosis 226
Granulomatous slack skin 178
CD30+ T-cell lymphoproliferative disorders 179 5 Soft tissue tumours 229
Lymphomatoid papulosis (LyP) 179 WHO and TNM classification 230
Primary cutaneous anaplastic large-cell Introduction 231
lymphoma 180 Vascular tumours 233
Subcutaneous panniculitis-like T-cell lymphoma 182 Haemangioma of infancy 233
Primary cutaneous peripheral T-cell lymphoma, Cherry haemangioma 233
unspecified 184 Sinusoidal haemangioma 234
Cutaneous γδ T-cell lymphoma 184 Hobnail haemangioma 234
Primary cutaneous aggressive epidermotropic Glomeruloid haemangioma 235
CD8+ cytotoxic T-cell lymphoma 185 Microvenular haemangioma 236
Primary cutaneous small-medium CD4+ T-cell Angiolymphoid hyperplasia with eosinophilia 237
lymphoma 186 Spindle cell haemangioma 239
Primary cutaneous PTL, unspecified 186 Tufted angioma 239
Cutaneous adult T-cell leukaemia / lymphoma 189 Bacillary angiomatosis 240
Extranodal NK/T-cell lymphoma, nasal-type 191 Reactive angioendotheliomatosis 241
Hydroa vacciniforme-like cutaneous T-cell Verrucous haemangioma 242
lymphoma 192 Pyogenic granuloma 243
Cutaneous involvement in primary extracutaneous Cavernous haemangioma 243
T-cell lymphoma 193 Angiokeratomas 244
Systemic anaplastic large cell lymphoma (ALCL) 193 Arteriovenous haemangioma 245
Angioimmunoblastic T-cell lymphoma (AITL) 193 Cutaneous angiosarcoma 246
Cutaneous marginal zone B-cell lymphoma 194 Lymphatic tumours 247
Cutaneous follicle centre lymphoma 196 Lymphangioma circumscriptum 247
Cutaneous diffuse large B-cell lymphoma 198 Progressive lymphangioma 248
Diffuse large B-cell lymphoma, leg-type 198 Lymphangiomatosis 249
Diffuse large B-cell lymphoma, other 198 Smooth and skeletal muscle tumours 250
T-cell / histiocyte-rich large B-cell lymphoma 199 Smooth muscle hamartoma 250
Plasmablastic lymphoma 199 Pilar leiomyoma 251
Secondary skin involvement by diffuse large Cutaneous leiomyosarcoma 251