Pasteurella multocida: Molecular Biology, Toxins and Infection

153 Pages·2012·2.5 MB·English

by  I. W. Wilkie

Current Topics in Microbiology and Immunology
Volume 361
SeriesEditors
KlausAktories
MedizinischeFakultät,InstitutfürExperimentelleundKlinischePharmakologieundToxikologie,Abt.IAlbert-
Ludwigs-UniversitätFreiburg,Albertstr.25,79104Freiburg,Germany
RichardW.Compans
DepartmentofMicrobiologyandImmunology,EmoryUniversity,1518CliftonRoad,CNR5005,Atlanta,
GA30322,USA
MaxD.Cooper
Department of Pathology and Laboratory Medicine, Georgia Research Alliance, Emory University, 1462
CliftonRoad,Atlanta,GA30322,USA
JorgeE.Galan
BoyerCtr.forMolecularMedicine,SchoolofMedicine,YaleUniversity,295CongressAvenue,room343,
NewHaven,CT,06536-0812,USA
YuriY.Gleba
ICONGeneticsAG,BiozentrumHalle,Weinbergweg22,06120Halle,Germany
TasukuHonjo
DepartmentofMedicalChemistry,FacultyofMedicine,KyotoUniversity,Sakyo-ku,Yoshida,Kyoto606-8501,
Japan
YoshihiroKawaoka
SchoolofVeterinaryMedicine,UniversityofWisconsin-Madison,2015LindenDrive,Madison,WI53706,
USA
HilaryKoprowski
BiotechnologyFoundation,Inc.,119SibleyAvenue,Ardmore,PA19003,USA
BernardMalissen
Centred’ImmunologiedeMarseille-Luminy,ParcScientifiquedeLuminy,Case906,13288MarseilleCedex9,
France
FritzMelchers
MaxPlanckInstituteforInfectionBiology,Charitéplatz1,10117Berlin,Germany
MichaelB.A.Oldstone
DepartmentofImmunologyandMicrobialScience,TheScrippsResearchInstitute,10550NorthTorreyPines
Road,LaJolla,CA92037,USA
RinoRappuoli
NovartisVaccines,ViaFiorentina1,Siena,53100,Italy
PeterK.Vogt
DepartmentofMolecularandExperimentalMedicine,TheScrippsResearchInstitute,10550NorthTorrey
PinesRoad,BCC-239,LaJolla,CA92037,USA
Current Topics in Microbiology and Immunology
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Klaus Aktories Joachim H. C. Orth
•
Ben Adler
Editors
Pasteurella multocida
Molecular Biology, Toxins and Infection
Responsible series editor: Klaus Aktories
123
Editors
Klaus Aktories BenAdler
Inst.für Experimentelle undKlinische Department of Microbiology
Pharmakologie undToxikologie Monash University
Universität Freiburg Melbourne,VIC
Freiburg Australia
Germany
JoachimH.C. Orth
Inst.für Experimentelle undKlinische
Pharmakologie undToxikologie
Universität Freiburg
Freiburg
Germany
ISSN 0070-217X
ISBN 978-3-642-31016-4 ISBN 978-3-642-31017-1 (eBook)
DOI 10.1007/978-3-642-31017-1
SpringerHeidelbergNewYorkDordrechtLondon
LibraryofCongressControlNumber:2012943375
(cid:2)Springer-VerlagBerlinHeidelberg2012
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Preface
It is more than 125 years since Louis Pasteur identified as the causative agent of
‘‘choléra des poules’’ the bacterium that now bears his name. Since that time,
Pasteurellamultocidahasbeenrecognizedasthecausativeagentofawide range
of infections in a wide range of animal species as well as in humans. Indeed, the
species name multocida could be literally translated as ‘‘multi-killer’’. The term
pasteurellosis is now widely applied to describe infections in mammals and birds
caused byP. multocida.It istherefore surprisingthat adetailed knowledge ofthe
cellular and molecular basis for pathogenesis in pasteurellosis lags behind what
has been elucidated for many other bacterial species. In particular, the molecular
basisforhostpredilectionremainscompletelyunknown.Forexample,whydoesa
B:2strainkill cattle, buffaloes (or mice)at avery lowdose, yet seems tohave no
effectwheninjectedintochickens,evenatveryhighdoses?Oneofthereasonsfor
this dearth of information may well be that the construction of defined targeted
mutants, the standard trade tool of molecular bacteriology, has only become
routinelyavailableinthelastdecadeorso.Nevertheless,thedevelopmentofsuch
tools and the availability of genome sequences in recent years have facilitated
significant advances in the understanding of the biology and pathogenesis of this
enigmaticpathogen.Asignificantexceptiontothislackofknowledgeisthemode
ofactionofPasteurellamultocidatoxin (PMT),akeyvirulencefactorspecifically
inatrophicrhinitis.ThemechanismsinvolvedintheinteractionofPMTwithhost
cells and target molecules are now understood in exquisite detail.
This volume brings together contributions from experts in the field of
Pasteurella research. It covers areas such as comparative genomics, pathogenic
mechanisms,bacterialproteomics,aswellasadetaileddescriptionandanalysisof
PMT and its interaction with host tissues, cells, immune system, and signaling
pathways. Each review article is intended to provide a stand-alone treatise. There
is, therefore, some unavoidable overlap between the various chapters.
19 March 2012 Klaus Aktories
Joachim H. C. Orth
Ben Adler
v
Contents
Pasteurella multocida: Diseases and Pathogenesis . . . . . . . . . . . . . . . . 1
I. W. Wilkie, M. Harper, J. D. Boyce and B. Adler
Pathogenomics of Pasteurella multocida . . . . . . . . . . . . . . . . . . . . . . . 23
J. D. Boyce, T. Seemann, B. Adler and M. Harper
The Key Surface Components of Pasteurella multocida: Capsule
and Lipopolysaccharide. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
Marina Harper, John D. Boyce and Ben Adler
Pasteurella multocida and Immune Cells. . . . . . . . . . . . . . . . . . . . . . . 53
Katharina F. Kubatzky
Molecular Biology of Pasteurella multocida Toxin. . . . . . . . . . . . . . . . 73
Joachim H. C. Orth and Klaus Aktories
Pasteurella multocida Toxin Interaction with Host Cells: Entry
and Cellular Effects. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93
Brenda A. Wilson and Mengfei Ho
Swine Atrophic Rhinitis Caused by Pasteurella multocida
Toxin and Bordetella Dermonecrotic Toxin. . . . . . . . . . . . . . . . . . . . . 113
Yasuhiko Horiguchi
The Pasteurella multocida Toxin: A New Paradigm for the Link
Between Bacterial Infection and Cancer. . . . . . . . . . . . . . . . . . . . . . . 131
Alistair Lax
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145
vii
Contributors
B. Adler Department of Microbiology, Australian Research Council Centre of
Excellence inStructuralandFunctional Microbial Genomics, MonashUniversity,
Clayton, VIC 3800, Australia, e-mail: [email protected]
Klaus Aktories Institut für Experimentelle und Klinische Pharmakologie und
Toxikologie, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg,
Germany, e-mail: [email protected]
J.D.Boyce DepartmentofMicrobiology,AustralianResearchCouncilCentreof
Excellence inStructuralandFunctional Microbial Genomics, MonashUniversity,
Clayton, VIC 3800, Australia
M.Harper Department ofMicrobiology,Australian ResearchCouncilCentre of
Excellence inStructuralandFunctional Microbial Genomics, MonashUniversity,
Clayton, VIC 3800, Australia
Marina Harper Department of Microbiology, Australian Research Council
Centre of Excellence in Structural and Functional Microbial Genomics, Monash
University, Clayton, VIC 3800, Australia
MengfeiHo DepartmentofMicrobiologyandtheHost-MicrobeSystemsTheme
oftheInstituteforGenomicBiology,UniversityofIllinoisatUrbana-Champaign,
Urbana, IL 61801, USA
Yasuhiko Horiguchi Department of Molecular Bacteriology, Research Institute
for Microbial Diseases, Osaka University, Yamada-oka 3-1, Suita, Osaka 565-
0871, Japan, e-mail: [email protected]
Katharina F. Kubatzky Department of Infectious Diseases, Medical Microbi-
ology and Hygiene, University Hospital Heidelberg, Im Neuenheimer Feld 324,
69120 Heidelberg, Germany, e-mail: [email protected]
Alistair Lax Department of Microbiology, King’s College London Dental
Institute, London, UK, e-mail: [email protected]
ix
x Contributors
Joachim H. C. Orth Institut für Experimentelle und Klinische Pharmakologie
und Toxikologie, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104
Freiburg, Germany, e-mail: [email protected]
T.Seemann DepartmentofMicrobiology,VictorianBioinformaticsConsortium,
Monash University, Clayton, VIC 3800, Australia
Brenda A. Wilson Department of Microbiology and the Host-Microbe Systems
Theme of the Institute for Genomic Biology, University of Illinois at Urbana-
Champaign, Urbana, IL 61801, USA, e-mail: [email protected]
I. W. Wilkie Department of Microbiology, Australian Research Council Centre
of Excellence in Structural and Functional Microbial Genomics, Monash Uni-
versity, Clayton, VIC 3800, Australia
Pasteurella multocida: Diseases
and Pathogenesis
I. W. Wilkie, M. Harper, J. D. Boyce and B. Adler
Abstract Pasteurellamultocidaisanenigmaticpathogen.Itisremarkablebothfor
thenumberandrangeofspecificdiseasesyndromeswithwhichitisassociated,and
the wide range of host species affected. The pathogenic mechanisms involved in
causing the different syndromesare, for the most part, poorly understood or com-
pletely unknown. The biochemical and serological properties of some organisms
responsibleforquitedifferentsyndromesappeartobesimilar.Thus,themolecular
basis for host predilection remains unknown. The recent development of genetic
manipulationsystemstogetherwiththeavailabilityofmultiplegenomesequences
should help to explain the association of particular pathological conditions with
particularhostsas well ashelpingtoelucidate pathogenic mechanisms.
Contents
1 Non-SpecificDiseaseSyndromesCausedbyPasteurellamultocida............................. 2
2 SpecificDiseaseSyndromes............................................................................................. 2
3 AvianCholera.................................................................................................................... 3
4 HaemorrhagicSepticaemia................................................................................................ 6
5 AtrophicRhinitis............................................................................................................... 7
6 SnufflesofRabbits............................................................................................................ 8
7 LowerRespiratoryTractInfectionsofUngulates............................................................ 9
8 SporadicSepticaemiasInvolvingDifferentCapsularTypes........................................... 11
9 MechanismsofPathogenesis:CellularandMolecularAspects...................................... 12
10 ResistancetoHostInnateImmunity................................................................................. 12
I.W.Wilkie(cid:2)M.Harper(cid:2)J.D.Boyce(cid:2)B.Adler(&)
DepartmentofMicrobiology,
AustralianResearchCouncilCentreofExcellenceinStructural
andFunctionalMicrobialGenomics,MonashUniversity,
Clayton,VIC3800,Australia
CurrentTopicsinMicrobiologyandImmunology(2012)361:1–22 1
DOI:10.1007/82_2012_216
(cid:2)Springer-VerlagBerlinHeidelberg2012
PublishedOnline:25May2012