Palate Development: Normal and Abnormal Cellular and Molecular Aspects

267 Pages·1984·13.96 MB·English

by  A.A. Moscona and Alberto Monroy (Eds.)

CURRENT TOPICS IN
DEVELOPMENTAL BIOLOGY
VOLUME 19
PALATE DEVELOPMENT:
NORMAL AND ABNORMAL CELLULAR
AND MOLECULAR ASPECTS
CONTRIBUTORS
FRED G. BIDDLE LAWRENCE S. HONIG
JOSEPH J. BONNER CHUNG S. KIM
LINDA L. BRINKLEY JOYCE MORRIS-WIMAN
MARK W. J. FERGUSON ROBERT M. PRATT
MICHELE P. GARBARINO RAVINDRA M. SHAH
ALLEN S. GOLDMAN HAROLD C. SLAVKIN
ROBERT M. GREENE MICHEL J. J. VEKEMANS
ROBERT I. GROVE ELIZABETH L. WEE
ERNEST F. ZIMMERMAN
CURRENT TOPICS IN
DEVELOPMENTAL BIOLOGY
EDITED BY
A. A. MOSCONA ALBERT0 MONROY
CUMMINGS LIFE SCIENCE CENTER STAZIONE ZOOLOGICA
THE UNIVERSITY OF CHICAGO NAPLES, ITALY
CHICAGO, ILLINOIS
VOLUME 19
PALATE DEVELOPMENT:
NORMAL AND ABNORMAL CELLULAR
AND MOLECULAR ASPECTS
VOLUME EDITOR
ERNEST F. ZIMMERMAN
CHILDREN'S HOSPITAL RESEARCH FOUNDATION
CINCINNATI, OHIO
1984
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CONTENTS
Contributors ............................................................ ix
Preface ................................................................. xi
CHAPTER 1. Morphogenesis of a Complex Organ: Vertebrate
Palate Development
HAROLDC . SLAVKIN
I . Introduction ..................................................... 1
I1. The Secondary Palate as a Morphogenetic Field .......... .. 2
111 . Determination of Polarity in the Palate ........................... 3
IV . Morphogenesis of the Secondary Palate: Cellular and
Tissue Interactions ...................... ................. 3
V. Epithelial-Mesenchymal Interactions ............................. 4
Vl . Hormonal Control of Developmental Processes .............. 7
VII . Prospectus ...................................................... 11
References ...................................................... 13
CHAPTER 2 . Role of Extracellular Matrices in Palatal Shelf Closure
LINDAL . BRINKLEAYN D JOYCEM ORRIS-WIMAN
I . Introduction ..................................................... 17
I1. The Mesenchymal Compartment .................................. 19
I11 . The Epithelial-Mesenchymal Interface ............................ 26
IV . Summary and Speculations ....................................... 34
References ...................................................... 35
CHAPTER 3 . Role of Neurotransmitters in Palate Development
ERNESTF . ZIMMERMANA ND ELIZABETLH . WEE
I . Introduction ..................................................... 37
I1. Neurotransmitters in Development ............................... 38
111 . Neuropharmacologic Action of Teratogens ......................... 41
V
vi CONTENTS
IV. Mechanisms of Palate Reorientation .............................. 42
V. Role of Neurotransmitters in Palate Reorientation ................. 45
VI. Serotoninergic Mechanisms in the Palate ............... 46
VII. Catecholamines in the Palate . ........................... 56
VIII. GABAergic System in the Pala
to Diazepam Teratogenesis ............. .................. 56
IX. Concluding Remarks ............................................. 59
References .................. 60
CHAPTER 4. Role of Cyclic AMP, Prostaglandins, and
Catecholamines during Normal Palate Development
ROBERTM . GREENEA ND MICHELEP . GARBARINO
I. Introduction ............................................... 65
ndary Palate Formation ......... 66
111. Cyclic AMP and Palate Differentiation ..................... 66
IV. Prostaglandins in Palatal Tissue ............................. 70
V. Catecholamines and Palate Developmen , . , , , . , , . , , , . , , , . , , , , 72
VI. Summary ............................................... 76
References ....................................... ... 77
CHAPTER 5. Role of Glucocorticoids and Epidermal Growth Factor
in Normal and Abnormal Palatal Development
ROBERTM . PRATTC, HUNGS . KIM,
AND ROBERTI . GROVE
I. Introduction .......................................... .. 81
11. Glucocorticoids ......... .... .......................... 82
111. Epidermal Growth Factor ........................................ 92
IV. Summary ....................................................... 98
References . . ..................................... 98
CHAPTER 6. Morphological, Cellular, and Biochemical Aspects of
Differentiation of Normal and Teratogen-Treated
Palate in Hamster and Chick Embryos
RAVINDRAM . SHAH
I. Introduction ..................................................... LO3
11. An Evolutionary Overview of Palate Morphogenesis in
Hamster and Chick .............................................. 105
111. Cellular and Biochemical Aspects of Palate Embryogenesis in
Hamster and Chick .............................................. 109
IV. Morphogenesis of Cleft Palate in Hamster ......................... 115
CONTENTS vii
V. Cellular Aspects of the Pathogenesis of Teratogen-Induced Cleft
Palate in Hamster ............................................... 116
References ...................................................... 132
CHAPTER 7 . Epithelial-Mesenchymal Interactions during
Vertebrate Pa latogenesi s
MARKW . J . FERGUSOANN D LAWRENCSE. HONIG
I . Introduction and Review ......................................... 138
I1. Experimental Strategy ............................... 140
I11. Palate Epithelium and Mesenchyme Cultured in Isolation .......... 141
IV . Intraspecies PalateiMandible Recombinations ..................... 143
V . Intraspecies PalateiPalate Recombinations ..... ..... 145
VI . Interspecies PalateiPalate Recombinations ........................ 150
VII . Experimental Production of Noncleft Palates in Chicken Embryos ... 156
VIII . Discussion ........................................... 157
References ........................... ............... 162
CHAPTER 8. Genetics of Palate Development
MICHELJ . J . VEKEMANSA ND FREDG . BIDDLE
I . Introduction .............................................. 166
I1 . Historical Perspectives of the Mouse Model for Palate Develop 167
I11. Palate Development: A Homeostatic Process ....................... 169
IV . Genetic Tools to Investigate the Homeostatic Process ............... 174
V . Methods of Genetic Analysis ................................. 177
VI . Results of Genetic Analysis ................................. 179
VII . Discussion . . .......................... 186
VIII . Summary ... ........................................... 189
References ................... ......................... 190
CHAPTER 9. The H-2 Genetic Complex. Dexamethasone-Induced
Cleft Palate. and Other Craniofacial Anomalies
JOSEPJH . B ONNER
I . Introduction ..................................................... 193
I1 . H-2 and Chromosome 17-Background ............................ 194
111. Linkage Analysis ................. .................. 198
IV . Gene Mapping Analyses ................................... 201
V . H-2 and Craniofacial Anomalies .................................. 208
VI . H-2 and Dorsoventral Vaginal Septa . .............. 213
VII . Concluding ...................................... 214
References ............................................. 214
...
Vlll CONTENTS
CHAPTER 10. Biochemical Mechanism of Glucocorticoid- and
Phenytoin-Induced Cleft Palate
ALLENS . GOLDMAN
I. Introduction ..................................................... 217
11. Androgens and Sexual Differentiation ............................. 218
111. Glucocorticoids and Cleft
IV. Phenytoin and Cleft Palate ....................................... 233
References ...................................................... 237
Index ................................................................... 241
Contents of Previous Volumes ............................................ 245
CONTRIBUTORS
Numbers in parentheses indicate the pages on which the authors’ contributions begin.
FREDG . BIDDLED, epartments of Pediatrics and Medical Biochemistry,
Alberta Children’s Hospital Reselctrch Centre, University of Calgary,
Calgary, Alberta T2T 5C7, Canada (165)
JOSEPJH. BONNERD, ental Research Institute, Center for the Health
Sciences, University of California, Los Angeles, California 90024
(193)
LINDAL . BRINKLEYD, epartment of Anatomy and Cell Biology, Univer-
sity of Michigan Medical School, Ann Arbor, Michigan 48109 (17)
MARK W. J. FERGUSON,D~e partm.ent of Anatomy, Medical Biology
Centre, The Queen’s University of Belfast, Belfast BT9 7BL, North-
ern Ireland (137)
MICHELEP . GARBARINOD, epartment of Anatomy, Daniel Baugh In-
stitute, Thomas Jefferson University, Philadelphia, Pennsylvania
19107 (65)
ALLENS . GOLDMANS, ection of Teratology, Division of Child Develop-
ment and Rehabilitation, The Children’s Hospital of Philadelphia,
and Department of Pediatrics, University of Pennsylvania School of
Medicine, Philadelphia, Pennsylvania 1910 4 (217)
ROBERTM . GREENE,D epartment of Anatomy, Daniel Baugh Institute,
Thomas Jefferson University, Philadelphia, Pennsylvania 191 07
(65)
ROBERTI . GROVEL, aboratory of Reproductive and Developmental Tox-
icology, National Institute of Environmental Health Sciences, Na-
tional Institutes of Health, Research Triangle Park, North Carolina
27709 (81)
“Present address: Department of Basic Dental Science, University of Manchester
Dental School, Manchester M15 6FH. England.