Table Of ContentOxidative Stress
Oxidative Stress
Eustress and Distress
Edited by
Helmut Sies
Academic Press is an imprint of Elsevier
125 London Wall, London EC2Y 5AS, United Kingdom
525 B Street, Suite 1650, San Diego, CA 92101, United States
50 Hampshire Street, 5th Floor, Cambridge, MA 02139, United States
The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, United Kingdom
© 2020 Elsevier Inc. All rights reserved.
No part of this publication may be reproduced or transmitted in any form or by any means, electronic
or mechanical, including photocopying, recording, or any information storage and retrieval system,
without permission in writing from the publisher. Details on how to seek permission, further
information about the Publisher’s permissions policies and our arrangements with organizations such
as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website:
www.elsevier.com/permissions.
This book and the individual contributions contained in it are protected under copyright by the
Publisher (other than as may be noted herein).
Notices
Knowledge and best practice in this field are constantly changing. As new research and experience
broaden our understanding, changes in research methods, professional practices, or medical treatment
may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating
and using any information, methods, compounds, or experiments described herein. In using such
information or methods they should be mindful of their own safety and the safety of others, including
parties for whom they have a professional responsibility.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume
any liability for any injury and/or damage to persons or property as a matter of products liability,
negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas
contained in the material herein.
Library of Congress Cataloging-in-Publication Data
A catalog record for this book is available from the Library of Congress
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library
ISBN: 978-0-12-818606-0
For information on all Academic Press publications
visit our website at https://www.elsevier.com/books-and-journals
Publisher: Andre Gerhard Wolff
Acquisition Editor: Peter B. Linsley
Editorial Project Manager: Samantha Allard
Production Project Manager: Swapna Srinivasan
Cover Designer: Greg Harris
Typeset by SPi Global, India
Contributors
Vikas Anathy
Department of Pathology and Laboratory Medicine, University of Vermont,
Larner College of Medicine, Burlington, VT, United States
Elias S.J. Arnér
Division of Biochemistry, Department of Medical Biochemistry and Biophysics,
Karolinska Institutet, Stockholm, Sweden
Kirstin Aschbacher
Department of Medicine, Division of Cardiology; Center for Health and
Community, Department of Psychiatry, UCSF, San Francisco, CA, United States
Liam Baird
Department of Medical Biochemistry, Tohoku University Graduate School of
Medicine, Sendai, Japan
Timothy E. Beach
Department of Surgery and Cambridge NIHR Biomedical Research Centre,
University of Cambridge, Cambridge, United Kingdom
Vsevolod V. Belousov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry; Pirogov Russian
National Research Medical University, Moscow, Russia; Institute for
Cardiovascular Physiology, Georg August University Göttingen, Göttingen,
Germany
Carsten Berndt
Department of Neurology, Medical Faculty, Heinrich-Heine Universität
Düsseldorf, Germany
Alfonso Blázquez-Castro
Department of Chemistry, Aarhus University, Aarhus, Denmark; Department of
Physics of Materials, Faculty of Sciences, Autonomous University of Madrid,
Madrid, Spain
Mikkel Bregnhøj
Department of Chemistry, Aarhus University, Aarhus, Denmark
Thomas Breitenbach
Department of Chemistry, Aarhus University, Aarhus, Denmark
Nils Burger
MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, United
Kingdom
Abigail Caron
Department of Organismal Biology and Anatomy, University of Chicago,
Chicago, IL; Department of Earth, Atmospheric and Planetary Sciences,
Massachusetts Institute of Technology, Boston, MA, United States
xxiii
xxiv Contributors
Navdeep S. Chandel
Department of Medicine, Division of Pulmonary and Critical Care; Department
of Biochemistry and Molecular Genetics, Northwestern University Feinberg
School of Medicine, Chicago, IL, United States
Danica Chen
Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of
California, Berkeley, CA, United States
James Nathan Cobley
Free Radical Research Group, Department of Biomedical Sciences, University
of the Highlands and Islands, Inverness, United Kingdom
Marcus Conrad
Helmholtz Zentrum München, Institute of Developmental Genetics,
Neuherberg, Germany
Miriam M. Cortese-Krott
Department of Cardiology, Pulmonology and Angiology, Medical Faculty,
Heinrich Heine University of Düsseldorf, Düsseldorf, Germany
Milene Costa da Silva
INL—International Iberian Nanotechnology Laboratory, Braga, Portugal
Andreas Daiber
University Medical Center at the Johannes Gutenberg University Mainz, Center
for Cardiology, Cardiology I, Mainz, Germany
Kevin Davies
Department of Clinical and Experimental Medicine, Brighton & Sussex Medical
School, Brighton, United Kingdom
Albert van der Vliet
Department of Pathology and Laboratory Medicine, University of Vermont,
Burlington, VT, United States
Charles Diamond
Department of Earth Sciences, University of California, Riverside, CA, United
States
Christopher M. Dustin
Department of Pathology and Laboratory Medicine, University of Vermont,
Burlington, VT, United States
Bernd Epe
Institute of Pharmacy and Biochemistry, University of Mainz, Mainz, Germany
Emrah Eroglu
Cardiovascular Medicine Division, Department of Medicine, Brigham and
Women’s Hospital, Harvard Medical School, Boston, MA, United States
Michael Etzerodt
Department of Molecular Biology and Genetics, Aarhus University, Aarhus,
Denmark
Contributors xxv
Martin Feelisch
Clinical & Experimental Sciences, Faculty of Medicine, University of
Southampton, Southampton, United Kingdom
Greg Fournier
Department of Earth, Atmospheric and Planetary Sciences, Massachusetts
Institute of Technology, Boston, MA, United States
Julia C Fussell
NIHR Health Impact of Environmental Hazards HPRU, MRC Centre for
Environment and Health, King’s College London, London, United Kingdom
Pietro Ghezzi
Department of Clinical and Experimental Medicine, Brighton & Sussex Medical
School, Brighton, United Kingdom
Virginia Ghiara
Department of Philosophy, University of Kent, Canterbury, United Kingdom
Robert Gill
Department of Biochemistry, Faculty of Science, Memorial University of
Newfoundland, St. John’s, NL, Canada
Young-Mi Go
Clinical Biomarkers Laboratory, Division of Pulmonary Medicine, Department of
Medicine, Emory University, Atlanta, GA, United States
Boris Görg
Clinic for Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-
Heine-University, Düsseldorf, Germany
Anja V. Gruszczyk
MRC Mitochondrial Biology Unit; Department of Surgery and Cambridge NIHR
Biomedical Research Centre, University of Cambridge, Cambridge, United
Kingdom
Dieter Häussinger
Clinic for Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-
Heine-University, Düsseldorf, Germany
David E. Heppner
Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical
School, Boston, MA, United States
Lili Hu
Department of Biomedicine, Aarhus University, Aarhus, Denmark
Alan A. Jackson
Human Nutrition, University of Southampton and University Hospital
Southampton, Southampton, United Kingdom
M.J. Jackson
Department of Musculoskeletal Biology, MRC-Arthritis Research UK Centre for
Integrated research into Musculoskeletal Ageing (CIMA), Institute of Ageing and
Chronic Disease, University of Liverpool, Liverpool, United Kingdom
xxvi Contributors
Yvonne Janssen-Heininger
Department of Pathology and Laboratory Medicine, University of Vermont,
Larner College of Medicine, Burlington, VT, United States
Dean P. Jones
Clinical Biomarkers Laboratory, Division of Pulmonary Medicine, Department of
Medicine, Emory University, Atlanta, GA, United States
Frank J Kelly
NIHR Health Impact of Environmental Hazards HPRU, MRC Centre
for Environment and Health, King’s College London, London, United
Kingdom
Lars-Oliver Klotz
Institute of Nutritional Sciences, Nutrigenomics Section, Friedrich Schiller
University Jena, Jena, Germany
Ulla G. Knaus
The UCD Conway Institute of Biomolecular and Biomedical Research, School of
Medicine, University College Dublin, Dublin, Ireland
Hyewon Kong
Department of Medicine, Division of Pulmonary and Critical Care; Department
of Biochemistry and Molecular Genetics, Northwestern University Feinberg
School of Medicine, Chicago, IL, United States
Swenja Kröller-Schön
University Medical Center at the Johannes Gutenberg University Mainz, Center
for Cardiology, Cardiology I, Mainz, Germany
Duvaraka Kula-Alwar
Department of Medicine, University of Cambridge, Cambridge, United
Kingdom
Santiago Lamas
Department of Cell Biology and Immunology, Centro de Biología Molecular
“Severo Ochoa,” (CSIC-UAM), Madrid, Spain
Laurel Y. Lee
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United
States
Jos Lelieveld
Atmospheric Chemistry Department, Max Planck Institute for Chemistry, Mainz,
Germany
Joseph Loscalzo
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United
States
Timothy W. Lyons
Department of Earth Sciences, University of California, Riverside, CA, United
States
Contributors xxvii
Ryan J. Mailloux
Department of Biochemistry, Faculty of Science, Memorial University of
Newfoundland, St. John’s, NL; School of Human Nutrition, Faculty of Agricultural
and Environmental Sciences, McGill University, Ste. Anne de Bellevue, QC, Canada
Ashley E. Mason
Center for Health and Community, Department of Psychiatry; Osher Center
for Integrative Medicine, University of California San Francisco (UCSF), San
Francisco, CA, United States
A. McArdle
Department of Musculoskeletal Biology, MRC-Arthritis Research UK Centre for
Integrated research into Musculoskeletal Ageing (CIMA), Institute of Ageing and
Chronic Disease, University of Liverpool, Liverpool, United Kingdom
Iria Medraño-Fernandez
Protein Transport and Secretion Unit, Division of Genetics and Cell
Biology, IRCCS Ospedale San Raffaele/Università Vita-Salute San Raffaele,
Milan, Italy
Thomas Michel
Cardiovascular Medicine Division, Department of Medicine, Brigham and
Women’s Hospital, Harvard Medical School, Boston, MA, United States
Verónica Miguel
Department of Cell Biology and Immunology, Centro de Biología Molecular
“Severo Ochoa,” (CSIC-UAM), Madrid, Spain
Ditte J. Mogensen
Department of Chemistry, Aarhus University, Aarhus, Denmark
Wei-Chieh Mu
Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of
California, Berkeley, CA, United States
Thomas Münzel
University Medical Center at the Johannes Gutenberg University Mainz, Center
for Cardiology, Cardiology I, Mainz, Germany
Michael P. Murphy
MRC Mitochondrial Biology Unit; Department of Medicine, University of
Cambridge, Cambridge, United Kingdom
Etsuo Niki
Research Center for Advanced Science and Technology, University of Tokyo,
Tokyo, Japan
Matthias Oelze
University Medical Center at the Johannes Gutenberg University Mainz, Center
for Cardiology, Cardiology I, Mainz, Germany
Peter R. Ogilby
Department of Chemistry, Aarhus University, Aarhus, Denmark
xxviii Contributors
Steen Vang Petersen
Department of Biomedicine, Aarhus University, Aarhus, Denmark
N. Pollock
Department of Musculoskeletal Biology, MRC-Arthritis Research UK Centre for
Integrated research into Musculoskeletal Ageing (CIMA), Institute of Ageing and
Chronic Disease, University of Liverpool, Liverpool, United Kingdom
Hiran A. Prag
MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, United
Kingdom
Naila Rabbani
Clinical Sciences Research Laboratories, Warwick Medical School, University of
Warwick, University Hospital, Coventry, United Kingdom
Jerome Santolini
Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris-Sud,
Université Paris-Saclay, Gif-sur-Yvette Cedex, France
Katrin Schröder
Institute for Cardiovascular Physiology, Medical Faculty of the
Goethe-University, Frankfurt am Main, Germany
Helmut Sies
Faculty of Medicine, Institute of Biochemistry and Molecular Biology I; Leibniz
Research Institute for Environmental Medicine, Heinrich-Heine-University
Düsseldorf, Düsseldorf, Germany
Hadley D. Sikes
Department of Chemical Engineering, Massachusetts Institute of Technology,
Cambridge, MA, United States
Roberto Sitia
Protein Transport and Secretion Unit, Division of Genetics and Cell Biology,
IRCCS Ospedale San Raffaele/Università Vita-Salute San Raffaele, Milan, Italy
Mette Sørensen
Danish Cancer Society Research Center, Copenhagen; Department of Natural
Science and Environment, Roskilde University, Roskilde, Denmark
Andrea Sorrentino
Cardiovascular Medicine Division, Department of Medicine, Brigham and
Women’s Hospital, Harvard Medical School, Boston, MA, United States
Corinne M. Spickett
Department of Biosciences, School of Life and Health Sciences, Aston
University, Birmingham, United Kingdom
Wilhelm Stahl
Faculty of Medicine, Institute of Biochemistry and Molecular Biology I,
Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
