Ovarian Follicular and Corpus Luteum Function

773 Pages·1979·19.511 MB·English

by  Gilbert S. Greenwald (auth.), Cornelia P. Channing, John M. Marsh, William A. Sadler (eds.)

OVARIAN FOLLICULAR
AND CORPUS
LUTEUM FUNCTION
OVARIAN FOLLICULAR
AND CORPUS
LUTEUM FUNCTION
Edited by
Cornelia P. Channing
Department of Physiology
University of Maryland School of Medicine
Baltimore, Maryland
John M. Marsh
Department of Biochemistry
University of Miami School of Medicine
Miami, Florida
and
William A. Sadler
Center for Population Research
National Institute of Child Health and Human Development
Bethesda, Maryland
PLENUM PRESS • NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data
Workshop on Ovarian Follicular and Corpus Luteum Function, 2d, Miami Beach,
Fla., 1978.
Ovarian follicular and corpus luteum function.
(Advances in experimental medicine and biology; v. 112)
"Proceedings of the second workshop ... sponsored by the Institute of Child
Health and Human Development, National Institutes of Health, Bethesda, Mary
land."
1. Ovulation - Congresses. 2. Graafian follicle - Congresses. 3. Corpus luteum
- Congresses. I. Channing, Cornelia P. II. Marsh, John M. III. United States. Na
tional Institute of Child Health and Human Development. IV. Title. V. Series.
[DNLM: 1. Corpus luteum - Physiology - Congresses. 2. Graafian follicle
Physiology - Congresses. WI AD559 v. 112/WP320 W9266 19780]
QP261.W66 1978 599'.01'66 79-48
ISBN 978-1-4684-3476-7 ISBN 978-1-4684-3474-3 (eBook)
DOI 10.1007/978-1-4684-3474-3
Proceedings of the Second Workshop on Ovarian Follicular and Corpus Luteum
Function held in Miami Beach, Florida, June 11-13, 1978. The workshop
was sponsored by the Institute of Child Health and Human Development,
National Institutes of Health, Bethesda, Maryland.
Published in 1979
Softcover reprint of the hardcover 1s t edition 1979
Plenum Press, New York
A Division of Plenum Publishing Corporation
227 West 17th Street, New York, N.Y. 10011
All right s reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted,
in any form or by any means, electronic, mechanical, photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
Preface
The purpose of this volume, the proceedings of the Second
Ovarian Workshop, is to review the state of the art in ,the field
of ovarian follicular and corpus luteum function. This workshop
was sponsored by the Center of Population Research, Institute of
Child Health and Human Development, National Institutes of Health,
Bethesda, Maryland. We also acknowledge the support of The
Channing-Weinberg Company, Mr. Henry Burckhardt, The Merck
Institute for Experimental Research, The Ortho Pharmaceutical
Company, The Expanded Program for Human Reproduction of the World
Health Organization, and The University of Miami.
We thank the organizing committee consisting of Drs.
Hans Lindner, Georgianna Jagiello, Neena Schwartz, Rees Midgley,
Gil Greenwald, Andrew Nalbandov, Sheldon Segal, Julia Labotsky,
and Griff Ross for their generous assistance in setting up the
program. We also thank the chairpersons of each session for their
skillful work and for using their expertise in keeping the
discussions to the point. We also are grateful to them for editing
the written discussions. Chairpersons included Drs. Robert J. Ryan,
Roy O. Greep, Allen W. Schuetz, Neena B. Schwartz, John M. Marsh,
John W. Wilks, Hans R. Lindner, and Scheldon J. Segal. Special
thanks go to all the invited speakers, discussants, participants
and particularly Dr. Irving Rothchild for his summing up remarks.
The above organization of Ms. Betty Howard and her staff is
gratefully acknowledged. The above secretarial assistance of
Ms. Gail Williams, Ms. Evelyn Wisowaty, Ms. Theda Smith and Ms.
Dorothy Tengood is acknowledged with thanks. The expert editorial
assistance of Ms. Alison Schwartz-Kripner is to be given special
recognition.
v
Contents
SECTION I
Introductory Remarks: Ruminations on Ovarian
Function • • • • • • • 3
Gilbert S. Greenwald
SECTION II
Follicular Growth in the Rat: A Reevaluation of
the Roles of FSH and LH. • • • • • • • • • • 11
J.S. Richards, J.Th.J. Uilenbroek, and
J.A. Jonassen
LH-Induced Desensitization of the Adenylyl Cyclase
System in Ovarian Follicles ••••••••• 27
Mary Hunzicker-Dunn, Richard Jungmann,
Dennis Derda, and Lutz Birnbaumer
Gonadal LH receptors: Resolution from Adenylate
Cyclase and Transfer to Heterologous Cells • • • 45
M.L. Dufau, K. Hayashi, G. Sala, A. Baukal,
and K.J. Catt
Prolactin Control of Receptor for Estradiol in
Corpora Lutea of Pregnant Rats •• • • • • 53
G. Gibori, J.S. Richards, and P.L. Keyes
Chairperson's Remarks. 59
Robert Ryan
Lateral Mobility and Internalization of Hormone
Receptors to Human Chorionic Gonadotropin in
Cultured Rat Granulosa Cells • • • •• 69
A. Amsterdam, F. Kohn, A. Nimrod, and
H.R. Lindner
vii
viii CONTENTS
FSH Stimulation of Mucopolysaccharide Synthesis in
Rat and Porcine Ovary • • •• • • • • • 77
R.L. Ax, A.R. LaBarbera, and R.J. Ryan
Immunologic Impairment of ~5_3B Hydroxysteroid
Dehydrogenase and Its Effect on Ovarian Function:
The Use of a Purified Enzyme •••••• 83
Shawky Badawy, William M. O'Leary, and
Kenneth A. Laurence
Receptors for Gonadotrophins in the Ovine Follicle
During Growth and Atresia • • • • • • • • • 89
R.S. Carson, J.K. Findlay, and H.G. Burger
Effect of Oestradiol-17B and Gonadotrophins on
Prostaglandin Production by Pre-Ovulatory Pig
Follicles Superfused in vitro • • • • • • • • • • • • • • 95
Kay S. Dodson and John Watson
LH-Stimulated cAMP Formation in Rat Granulosa
Cells During Follicular Maturation - a
Non-Refrac tory Response • • • • • • • • • • • 105
L. Hamberger, L. Nilsson, K. Nordenstrom,
and A. Sjogren
Effect of the Administration of an Ovulatory Dose
of HCG on the Subcellular Distribution of Follicular
Protein Kinase •••••••••••••••• 113
Mary Hunzicker-Dunn, Ming-ann Wang, and
Richard Jungmann
Structural Analysis of Granulosa Cells from Human
Ovaries in Correlation with Function. • • • • 123
W. Mestwerdt, O. MUller, and H. Brandau
Regulation of LH(hCG)-Receptor and Adenylate Cyclase
in Luteinizing Granulosa Cells ••••••••• 129
Hannu J. Rajaniemi and Kalle Jaaskelainen
Changes in Responsiveness of Porcine Granulosa
Cells to Prostaglandins and Luteinizing Hormone in
Terms of Cyclic-AMP Accumulation During Follicular
Maturation •••••••••••••.••••••• 137
Alison Schwartz-Kripner and Cornelia P. Channing
Some Morphological and Functional Characteristics
of Cells of the Porcine Theca Interna in Tissue
Culture 145
S. Stoklosowa, J. Bahr, and E. Gregoraszczuk
CONTENTS ix
The Control of Ovulation in the Cow by
Prostaglandin Inhibitor 149
M. Shemesh
SECTION III
Steroidal Modulation of Steroid Secretion in vitro:
An Experimental Approach to Intra-Follicular ----
Regula tory Mechanisms • • • • • • • • • • • • • • • 155
David W. Schomberg
On the Mechanism of Prolactin Stimulation of
Steroidogenesis • • • • • • • • • 169
Kunio Shiota and Walter G. Wiest
Steroid Secretion by Perifused Ovarian Follicles
of Immature, PMSG-Treated Immature, and Mature
Rabbits . . . . . . . . . . . . . . . 179
N. Shahabi, J. Bahr, O.K. Dial, and S. Glenn
Effects of Follicular Development on the Ability of
Cultured Porcine Granulosa Cells to Convert Androgens
to Estrogens. • • • • • • • • • • ••• • • . • • 187
L.D. Anderson, F.W. Schaerf, and C.P. Channing
Testosterone Synthesis by Chicken Follicular Cells. 197
E. Su-Rong Huang and A.V. Nalbandov
Modulation of Thecal Progesterone Secretion by
Estradiol-178 • • • •••••••••• 203
J.E. Fortune and W. Hansel
Chairperson's Remarks 209
Roy Greep
Steroid Secretion by Ovarian Follicles of Rabbits in
Different Reproductive States • • • • • • • • • • • • 219
J. Bahr, N. Shahabi, R. Gardner, and L. Critchlow
Hormone Requirements for Long-Term Maintenance of
Rat Granulosa Cell Cultures ••••••••••• 225
Grace M. Centola
Long-Term Perfusion of Rabbit Ovarian Follicles • • • 235
C. D'Amato, J. Bahr, G. Stockert, F. Calvo, and
D. Kesler
Estrogen Inhibits Porcine Thecal Androgen Production
in vit ro. . . . . . . . . . . . . . . 241
P.C.K. Leung, B.K. Tsang, and D.T. Armstrong
x CONTENTS
Antral Follicular and Interstitial Contributions to
Progesterone Secretion in the Proestrous Hamster • 245
Srinivas K. Saidapur and Gilbert S. Greenwald
SECTION IV
Meiotic Maturation of Mouse Oocytes in vitro • • • • 251
P.M. Wassarman, R.M. Schultz, G~. Letourneau,
M.J. LaMarca, W.J. Josefowicz, and J.D. Bleil
Mammalian Oocyte Maturation: Model Systems and
Their Physiological Relevance •••••••••• 269
A. Tsafriri
Action of Porcine Follicular Fluid Oocyte
Maturation Inhibitor -in- v-itr-o: Possible Role
of the Cumulus Cells • • • • • • • • • • • • 283
T. Hillensjo, A. Schwartz-Kripner, S.H. Pomerantz,
and C.P. Channing
Relationship Between Steroidogenesis and Oocyte
Maturation in Rat Graafian Follicles Cultured
-in- v-itr-o • • • • • • • • • • • • • • • • • • • • 293
C. Readhead, M.H. Kaufman, A.W. Scheutz, and
G.E. Abraham
Chairperson's Remarks. 301
Allen Schuetz
The Soma tic-Germ Cell Complex. • • • • • • • • • • • • • 307
A.W. Schuetz
Rapid Oocyte Death Prior to and at Puberty in
Neonatally Thymectomized Mice. • • • • • ••• 315
Teruyo Sakakura, Osamu Taguchi, Akinori Kojima,
and Uasuaki Nishizuka
Maturation and Atresia of Human Oocytes in vivo. 321
Mrinal K. Sanyal
SECTION V
Follicular Non-Steroidal Regulators. • • • • • • • • •• 327
C.P. Channing
The Influence of Follicular Fluid on Progesterone
Secretion by Porcine Granulosa Cells in vitro. 347
Florence Ledwitz-Rigby and Brian-W. Rigby
CONTENTS xi
Inhibition of in vivo and in vitro FSH Secretion
by Steroid-Fre~Hamster Ovarian Extracts • • 361
S.C. Chappel, T. Acott, and H.G. Spies
The Differential Ability of Porcine Follicular
Fluid to Suppress Serum FSH in Female Rats from
6 Days of Age to Adulthood • • • • • ••••• 375
Janice R. Lorenzen and Neena B. Schwartz
Evidence for the Presence of a Low Molecular Weight
Follitropin Binding Inhibitor in Bovine Follicular
Fluid. . . . . . . . . . . . . . . . . 383
Nina C. Darga and Leo E. Reichert, Jr.
Chairperson's Remarks
Neena B. Schwartz 389
Inhibition by Follicular Fluid of Luteinizing
Hormone-Sensitive Adenylate Cyclase in Ovarian
Plasma Membranes • • • • • •• .•••.• 401
A. Amsterdam, M. Shemesh, and Y. Salomon
Inhibitory Effect of Charcoal-Treated Porcine
Follicular Fluid upon Serum FSH Levels and Follicular
Development in the Rhesus Monkey • • • • • • • • • 407
Cornelia P. Channing, Larry D. Anderson, and
Gary D. Hodgen
Follicular Fluid Inhibition of Ovulation. • • • • • • • 417
Kurt F. Miller, John K. Critser, and O.J. Ginther
Modulation of Pituitary Responsiveness to LHRH by
Porcine Follicular Fluid: Time and Dose-Dependent
Effects. . • • • • • • • • . . . • • • • . • 423
Douglas Shander, Larry D. Anderson,
Charles A. Barraclough, and Cornelia P. Channing
Isolation and Preliminary Characterization of
Inhibin-f. . . . . . . . . . . . . 429
A. Trent Williams, Michael E. Rush, and H. Lipner
Evidence that the Pituitary Gland is the Site of
Inhibitory Action of Porcine Follicular Fluid upon
FSH Secretion in the Rat • • • • • • • • • • • • • 437
Phyllis M. Wise, Louis V. DePaolo, Larry D. Anderson,
Cornelia P. Channing, and Charles A. Barraclough
SECTION VI
Estrogen Action in the Corpus Luteum • • • • 447
P. Landis Keyes, Khe-Ching M. Yuh, and
Josephine B. Miller
xii CONTENTS
Follicular Determinants of Corpus Luteum Function
in the Human Ovary • • • • • • • • • • • • • • • • 465
Kenneth P. McNatty
LH Receptors in the Ovine Corpus Luteum During
the Estrous Cycle and Early Pregnancy ••••• 483
G.D. Niswender and M.A. Diekman
Gonadotropin Action in Isolated Ovarian Luteal Cells:
The Intermediate Role of Adenosine 3', 5' Cyclic
Monophosphate in Hormonal Stimulation of Progesterone
Synthesis. . . . . . . . . . . . . . . . . . . . . 489
G.B. Sala, M.L. Dufau, and K.J. Catt
Chairperson's Remarks. 497
John Marsh
Changes in Ovarian Mitochondria: Early Indicators
of Follicular Luteinization. • • • • • • 505
Michael J. Dimino, Edna A. Elfont, and
S. Kim Berman
Prostaglandin F2 and Progesterone Synthesis in vitro
by Bovine Corpor~ Lutea of Early Pregnancy •••••• 511
J. Lukaszewska and W. Hansel
Luteal Phase Deficiencies in Peripubertal Rhesus
Monkeys: Mechanistic Considerations •••••• 519
Thomas E. Nass, Donald J. Dierschke, James R. Clerk,
Patricia A. Meller, and Keith K. Schillo
Cellular Mechanisms Involved in Luteolysis • • 527
Laurie G. Paavola
Role of Pituitary LH and Placenta in Luteal
Progesterone Production and Maintenance of Pregnancy
in the Rat . . . . . . . . . . . . . . . . . . . . . 535
H.J. Madhwa Raj, L.M. Talbert, W.E. Easterling,
and Ruth Chen Dy
Relationships Between Cholesterol Supply and Luteal
Mitochondrial Steroid Synthesis ••••••••••• 541
M.E. Toaff, G.L. Flickinger, J.F. Strauss, III,
and S.J. Shattil
A Comparison of the LH Control of Progesterone
Synthesis in Small and Large Cells from Pregnant
Cow Corpus Luteum. • • • • • • • • • . • . . • • 545
Jocelyne Ursely and Pierre Leymarie