Organ Tissue Engineering

604 Pages·2021·11.549 MB·English

by  Andreas Traweger, Daniel Eberli, Sang Jin Lee

Reference Series in
Biomedical Engineering
Tissue Engineering and Regeneration
Series Editor: Heinz Redl
Daniel Eberli · Sang Jin Lee
Andreas Traweger
Editors
Organ
Tissue
Engineering
Reference Series in Biomedical
Engineering
Tissue Engineering and Regeneration
SeriesEditor
HeinzRedl
LudwigBoltzmannInstituteforExperimental
andClinicalTraumatology,AUVAResearch
CenterAustrianClusterforTissueRegeneration
Wien,Austria
This series Tissue Engineering and Regeneration consists of comprehensive refer-
encetextsencompassingthebiologicalbasisoftissueregeneration,basicprinciples
oftissueengineeringandthecurrentstate-of-the-artintissueengineeringofspecific
tissues and organs. Each volume combines established fundamentals and the latest
developments, thus forming an invaluable collection for both experienced
researchers as well as practitioners from other areas of expertise. The spectrum of
topics ranges from the use of cells for tissue regeneration and tissue engineering,
growth factors and biological molecules affecting tissue development and regener-
ation, to the specific roles of biophysical factors in tissue development and
regeneration.
Tissueengineeringliesatthecrossroadsofmedicine,lifesciencesandengineer-
ing. The field has developed extensively over the last two decades, addressing the
requirementsoftissueandorganreplacementaswellasregenerationinavarietyof
congenital, traumatic, disease and aging-related conditions, including some of the
mostcriticalunmetchallengesinmodernmedicine.Bothourincreasedunderstand-
ingofthebiologicalbasisoftissueengineeringaswellassignificanttechnological
advancesmeanthatengineeringdesignprinciplescannowbeusedforthedenovo
constructionoffunctionaltissuereplacementsthatmeettherequirementsofresearch
andclinicalapplications.
Moreinformationaboutthisseriesathttp://www.springer.com/series/13441
(cid:129)
Daniel Eberli Sang Jin Lee
Andreas Traweger
Editors
Organ Tissue Engineering
With61Figuresand28Tables
Editors
DanielEberli SangJinLee
UniversitätsSpitalZürich InstituteforRegenerativeMedicine
Zürich,Switzerland WakeForestUniversity
WinstonSalem,NC,USA
AndreasTraweger
InstituteofTendonandBoneRegeneration
ParacelsusMedicalUniversity
Salzburg,Austria
ISBN978-3-030-44210-1 ISBN978-3-030-44211-8(eBook)
ISBN978-3-030-44212-5(printandelectronicbundle)
https://doi.org/10.1007/978-3-030-44211-8
©SpringerNatureSwitzerlandAG2021
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Preface
Tissue engineering may offer new treatment alternatives for organ replacement or
repair of deteriorated organs. Among the many clinical applications of tissue engi-
neering are the production of artificial skin for burn patients, tissue-engineered
trachea, cartilage for knee-replacement procedures, urinary bladder replacement,
urethrasubstitutes, andcellular therapies for thetreatment ofurinary incontinence.
Thetissueengineeringapproachhasmajoradvantagesovertraditionalorgantrans-
plantation and circumvents the problem of organ shortage. Tissues reconstructed
from readily available biopsy material induce only minimal or no immunogenicity
whenreimplantedinthepatient.
ThisSpringerReference e-book onorgantissue engineering isaimed atanyone
interestedintheapplicationoftissueengineeringindifferentorgansystems.Itoffers
insights into a wide variety of state-of-the-art strategies applying the principles of
tissueengineeringtotissueandorganregenerationandisthusintendedtobebothan
introductory and deepening textbook for research and teaching. As this reference
bookiscontinuouslyupdated,itwillreflectthelatestdevelopmentsandfindingsof
bothbasicandclinicalresearchandwilldiscusscurrenttrends.
v
Contents
PartI CirculatoryandRespiratorySystems ................... 1
BioinspiredVascularGrafts .................................. 3
DavidMiranda-Nieves,AmnieAshour,andElliotL.Chaikof
HeartValveBioengineering .................................. 23
EmanuelaS.Fioretta,SarahE.Motta,EricK.N.Gähwiler,
NikolaosPoulis,MaximilianY.Emmert,andSimonP.Hoerstrup
CellSheetsforCardiacTissueEngineering ...................... 81
HidekazuSekine,JunHomma,andTatsuyaShimizu
BioengineeringofTracheaandEsophagus ...................... 101
SoichiShibuya,NatalieDurkin,MatíasGarrido,PaolaBonfanti,and
PaoloDeCoppi
PartII DigestiveandExocrineSystems ...................... 141
LiverTissueEngineering .................................... 143
IrisPla-Palacín,NataliaSánchez-Romero,SaraMorini,
DanielaRubio-Soto,andPedroM.Baptista
BioprintingStrategiestoEngineerFunctionalSalivary
GlandOrganoids .......................................... 173
ChristabellaAdineandJoãoFerreira
Tissue-EngineeredThymus .................................. 195
GauriKulkarniandJohnD.Jackson
PartIII ExcretoryandRespiratorySystems ................... 231
Tissue-EngineeredRenalTissue ............................... 233
DianaLim,AnthonyAtala,andJamesJ.Yoo
EngineeringoftheBladderandUrethra ........................ 259
XianLinYi,DianaLim,AnthonyAtala,andJamesJ.Yoo
vii
viii Contents
Tissue-EngineeredOvary .................................... 285
MonicaM.Laronda
Tissue-EngineeredApproachesforPenileReconstruction ........... 315
HeungJaePark
PartIV MusculoskeletalSystem ............................ 353
InjectableCalciumPhosphateCementsforthe
Reconstruction/RepairofOralandCranio-maxillofacial
BoneDefects:ClinicalOutcomeandPerspectives ................. 355
HongbingLiao,JanWillemHoekstra,JoopWolke,SanderLeeuwenburgh,
andJohnJansen
Tissue-EngineeredTeeth ..................................... 373
ZihanLi,WeiboZhang,andPamelaC.Yelick
GenerationofEarCartilageforAuricularReconstruction .......... 405
YuLiuandYilinCao
StemCell-BasedandTissueEngineeringApproachesforSkeletal
MuscleRepair ............................................. 429
SerainaA.Domenig,AndrewS.Palmer,andOriBar-Nur
LigamentTissueEngineering:TheAnteriorCruciateLigament ..... 489
ThomasNauandAndreasTeuschl
MultiscaleMultifactorialApproachesforEngineering
TendonSubstitutes ......................................... 507
AnaI.Gonçalves,MárciaT.Rodrigues,AnaM.Matos,HelenaAlmeida,
ManuelGómez-Florit,RuiM.A.Domingues,andManuelaE.Gomes
MeniscusRegenerationStrategies ............................. 531
JohannesZellnerandPeterAngele
PartV OcularSystem .................................... 555
BioengineeredCorneasEnteringtheClinicalRealm ............... 557
VictorH.Hu,PushpinderKanda,KamalMalhotra,EmilioI.Alarcon,
MiguelGonzalez-Andrades,MatthewBurton,andMayGriffith
Index .................................................... 589
About the Editors
DanielEberli
UniversitätsSpitalZürich
Zürich,Switzerland
M.D., Ph.D., is a scientific physician working in the
translational field of urologictissueengineering. He has
a medical degree from the Medical School in Zurich,
Switzerland, and a Ph.D. in molecular medicine from
Wake Forest University, Winston Salem, NC. He has a
faculty position in the Department of Urology at the
UniversityHospitalZurich,wherehedevoteshalfofhis
timetopatientcare.Togetherwithhisresearchteam,heis
workingonnovelbiomaterialsforbladderreconstruction,
improving autonomic innervation, cellular treatment of
incontinence,andtrackingofstemcells.
SangJinLee
InstituteforRegenerativeMedicine
WakeForestUniversity
WinstonSalem,NC,USA
SangJinLee,Ph.D.,iscurrentlyatenuredassociatepro-
fessoratWakeForestInstituteforRegenerativeMedicine
(WFIRM), Wake Forest School of Medicine. Dr. Lee
receivedhisPh.D.inchemicalengineeringfromHanyang
University,Seoul,Korea,in2003andtookapostdoctoral
fellowshipintheLaboratoriesforTissueEngineeringand
Cellular Therapeutics at Harvard Medical School and
Children’sHospitalBostonandtheWFIRM,whereheis
currentlyafacultymember.Heisalsocross-appointedto
theVirginiaTech–WFUBiomedicalEngineeringandSci-
ence.Dr.Leehasauthoredmorethan140scientificpub-
lications and reviews, has edited 2 textbooks, and has
written 34 chapters in several books. Dr. Lee has an
ix
x AbouttheEditors
extensiveknowledgeandexperienceinbiomaterialssci-
ence, especially, biodegradable polymers and tunable
hydrogels, with specific training and expertise in key
research areas for tissue engineering and regenerative
medicine. His research teamhas developed various bio-
material systems that improve cellular interactions by
providingappropriateenvironmentalcues.Thesebioma-
terial systems consist of drug/protein delivery system,
nano/micro-scaled topographical feature, and hybrid
materialsthatcanactivelyparticipateinfunctionaltissue
regeneration.Recently,histeamisutilizingautomated3D
bioprinting technology to manufacture complex, multi-
cellular living tissue constructs that mimic the structure
ofnativetissues.Thiscanbeaccomplishedbyoptimizing
theformulationofbiomaterialstoserveasbioinksfor3D
bioprinting, and by providing the biological microenvi-
ronment needed for the successful delivery of cells and
biomaterialstodiscretelocationswithinthe3Dstructure.
AndreasTraweger
InstituteofTendonandBoneRegeneration
ParacelsusMedicalUniversity
Salzburg,Austria
AndreasTrawegercurrentlyholdsaresearchprofessor-
ship for regenerative biology at the Paracelsus Medical
University in Salzburg, Austria. He received his Ph.D.
in genetics from the University of Salzburg and com-
pletedhispostdoctoraltrainingattheSamuelLunenfeld
Research Institute in Toronto, Canada. He was then
R&D manager at Baxter (Vienna, Austria) for 4 years
beforejoiningParacelsusMedicalUniversity.
His research is interdisciplinary in nature, focusing
on both high-quality fundamental science and transla-
tionforhumanhealth.Hisinterestslieinpromotingthe
understanding of tendon biology in general and to
devisenovelstrategiestoimprovetendonandligament
healing. He has a considerable track record in the
research area of tendinopathy, focusing on the role of
neoangiogenesis and inflammatory processes in tendon
health and disease. Further, he is co-founder of
CelericonTherapeuticsGmbH(2018),abiotechstartup
focusing on the use of MSC-derived extracellular vesi-
clestoimprovetissueregeneration.