Optimizing thrombolysis in acute ischaemic stroke Zinkstok, SM

208 Pages·2017·1.93 MB·English

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Optimizing thrombolysis in acute ischaemic stroke
Zinkstok, S.M.
Publication date
2014
Document Version
Final published version
Link to publication
Citation for published version (APA):
Zinkstok, S. M. (2014). Optimizing thrombolysis in acute ischaemic stroke. [Thesis, fully
internal, Universiteit van Amsterdam].
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Download date:15 Feb 2023

NATURA  
ARTIS  
MAGISTRA
De  natuur  is  de  leermeesteres  van  de  kunst
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TheresearchdescribedinthisthesiswassupportedbyagrantoftheDutchHeartFoundation(DHF-
2005B118).FinancialsupportbytheDutchHeartFoundationforthepublicationofthisthesisis
gratefullyacknowledged.
Printing of this thesis was financially supported by the department of Neurology of the Aca-
demicMedicalCenter,theUniversityofAmsterdam,FederatievanNederlandseTrombosedien-
sten,StichtingGillesHondiusFoundation,Chipsoft,RocheDiagnostics,Ipsen,ABNAMROand
Novymed.
Optimizingthrombolysisinacuteischaemicstroke
SanneZinkstok
ISBN:978-90-9028537-5
Coverdesign:ISOntwerp–IlseSchrauwers,DenBosch–www.isontwerp.nl
Typesetting:ZinkTypografie–www.zinktypografie.nl
Printing:IpskampDrukkersBV,Enschede
©SanneZinkstok,2014
Allrightsreserved.Nopartsofthispublicationmaybereportedortransmitted,inanyformorby
anymeans,withoutpermissionoftheauthor.
OPTIMIZINGTHROMBOLYSISINACUTEISCHAEMIC
STROKE
(cid:262)(cid:264)(cid:262)(cid:265)(cid:266)(cid:274)(cid:270)(cid:280)(cid:264)(cid:269)(cid:277)(cid:279)(cid:276)(cid:266)(cid:267)(cid:280)(cid:264)(cid:269)(cid:279)(cid:270)(cid:267)(cid:281)
terverkrijgingvandegraadvandoctor
aandeUniversiteitvanAmsterdam
opgezagvandeRectorMagnificus
prof.dr.D.C.vandenBoom
tenoverstaanvaneendoorhetcollegevoorpromoties
ingesteldecommissie,
inhetopenbaarteverdedigenindeAgnietenkapel
opvrijdag31oktober2014,te12.00uur
door
SanneMarinaZinkstok
geborenteUtrecht
Promotiecommissie:
Promotores: Prof.dr.Y.B.W.E.M.Roos
Prof.dr.R.J.deHaan
Co-promotor: Dr.P.J.Nederkoorn
Overigeleden: Prof.dr.R.J.vanOostenbrugge
Prof.dr.R.J.G.Peters
Prof.dr.J.Stam
Dr.M.Uyttenboogaart
Prof.dr.M.Vermeulen
FaculteitderGeneeskunde

CONTENTS
1 Generalintroduction 1
I ANTIPLATELETTHERAPYANDINTRAVENOUS
THROMBOLYSIS 11
2 Antiplatelettherapyincombinationwithrt-PAthrombolysisin
ischaemicstroke(ARTIS):rationaleanddesignofarandomised
controlledtrial(CerebrovascDis2010) 13
3 Earlyadministrationofaspirininpatientstreatedwith
thrombolysisforacuteischaemicstroke:arandomisedcontrolled
trial(Lancet2012) 21
4 Earlydeteriorationafterthrombolysisplusaspirininacutestroke:
aposthocanalysisoftheARTIStrial(AdaptedfromStroke2014) 41
II REDUCTIONOFTREATMENTDELAYSINACUTEISCHAEMIC
STROKE 57
5 Thrombolysisinstrokewithin30minutes:resultsoftheAcute
BrainCareinterventionstudy(submitted) 59
6 Safetyofthrombolysisinstrokemimics:resultsfromamulticenter
cohortstudy(Stroke2013) 79
7 Safetyandfunctionaloutcomeofthrombolysisin
dissection-relatedstroke:ameta-analysisofindividualpatient
data(Stroke2011) 95
8 Summaryandgeneraldiscussion 115
Contents | vii
APPENDICES
A Arandomisedcontrolledtrialofantiplatelettherapyin
combinationwithrt-PAthrombolysisinischaemicstroke:rationale
anddesignoftheARTIStrial(Trials2010) 135
B Datacollectionforms 153
Nederlandsesamenvatting 171
Abbreviations 177
Contributingauthorsandaffiliations 179
Listofpublications 183
Dankwoord 187
Abouttheauthor 195