Table Of ContentOpportunistic
Intracellular Bacteria
and Immunity
INFECTIOUS AGENTS AND PATHOGENESIS
SeriesEditors: Mauro Bendinelli, Universityof Pisa
Herman Friedman, University ofSouthFlorida
College ofMedicine
Recent volumes in the series:
DNATUMOR VIRUSES
Oncogenic Mechanisms
Edited by Giuseppe Barbanti-Brodano,Mauro Bendinelli, and
Herman Friedman
ENTERIC INFECTIONS AND IMMUNITY
Edited by Lois J. Paradise, Mauro Bendinelli, and Herman Friedman
FUNGAL INFECTIONS AND IMMUNE RESPONSES
Edited by Juneann W. Murphy, Herman Friedman, and
Mauro Bendinelli
HERPESVIRUSESAND IMMUNITY
Edited by Peter G. Medveczky, Herman Friedman, and
Mauro Bendinelli
MICROORGANISMSAND AUTOIMMUNE DISEASES
Edited by Herman Friedman, Noel R. Rose, and Mauro Bendinelli
NEUROPATHOGENIC VIRUSES AND IMMUNITY
Edited by Steven Specter, Mauro Bendinelli, and Herman Friedman
OPPORTUNISTIC INTRACELLULAR BACTERIA AND IMMUNITY
Edited by Lois J. Paradise, Herman Friedman, and Mauro Bendinelli
PSEUDOMONAS AERUGINOSA AS AN OPPORTUNISTIC
PATHOGEN
Edited by Mario Campa, Mauro Bendinelli, and Herman Friedman
PULMONARY INFECTIONS AND IMMUNITY
Edited by Herman Chmel, Mauro Bendinelli, and Herman Friedman
RAPID DETECTION OF INFECTIOUS AGENTS
Edited by Steven Specter, Mauro Bendinelli, and Herman Friedman
RICKETTSIAL INFECTION AND IMMUNITY
Edited by Burt Anderson, Herman Friedman, and Mauro Bendinelli
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upon actual shipment. For further information please contact the publisher.
Opportunistic
Intracellular Bacteria
and Immunity
Edited by
Lois J. Paradise
and
Herman Friedman
University of South Florida College of Medicine
Tampa, Florida
and
Mauro Bendinelli
University of Pisa
Pisa, Italy
Kluwer Academic Press
New York / Boston / Dordrecht / London / Moscow
eBook ISBN: 0-306-46809-3
Print ISBN: 0-306-45894-2
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Contributors
LINDA B. ADAMS • G. W. Long Hansen’s Research Center, Laboratory
Research Branch, Louisiana State University, Baton Rouge, Louisiana
70803
BURT E. ANDERSON • Department of Medical Microbiology and Immu-
nology, University of South Florida, College ofMedicine, Tampa, Florida
33612
CYNTHIA L. BALDWIN • Department of Veterinary and Animal Sciences,
Paige Laboratory, University of Massachusetts, Amherst, Massachusetts
01003
ANDREW W. O. BURGESS • Department of Medical Microbiology and
Immunology, University of South Florida, College of Medicine, Tampa,
Florida 33612
GERALD I. BYRNE • Department of Medical Microbiology and Immunol-
ogy, University of Wisconsin Medical School, Madison, Wisconsin 53706
FRANK M. COLLINS • Laboratory of Mycobacteria, CBER, FDA,
Bethesda, Maryland 20852
PATRICIA A. DARRAH • Department of Microbiology and Immunol-
ogy, Temple University School of Medicine, Philadelphia, Pennsylvania
19140
ROLIEN DE JONG • Department of Immunohematology and Blood Bank,
Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
v
vi CONTRIBUTORS
RENÉ R. P. DE VRIES • Department of Immunohematology and Blood
Bank,LeidenUniversityMedicalCenter,2333ZALeiden,TheNetherlands
JONS.FRIEDLAND • DepartmentofInfectiousDiseases,ImperialCollege,
Hammersmith Hospital, London, W12ONN, England
HERMANFRIEDMAN • DepartmentofMedicalMicrobiologyandImmu-
nology, University ofSouth Florida, College ofMedicine, Tampa, Florida
33612
RAFAEL GARDUNO • Department of Microbiology and Immunology,
Dalhousie University,Halifax,Nova Scotia B3H 3H7, Canada
DAVID L. HAHN • Arcand Park Clinic, Dean Medical Center, Madison,
Wisconsin 53705
ROGELIO HERNANDEZ-PANDO • Department of Pathology, Instituto
Nacional de la Nutricion, Salvador Zubrian, Delegacion Tlalpan, 1400
MexicoDF
M. B. HEVIN • Unité d’Immunophysiologie Cellulaire, Institut Pasteur,
75724 Paris-Cedex 15,France
HERBERT HOF • Institute ofMedical Microbiology and Hygiene, Faculty
of Clinical Medicine Mannheim, University of Heidelberg, Manheim
D-68165, Germany
PAUL S. HOFFMAN • Departments of Microbiology, Immunology, and
Medicine, Division ofInfectious Diseases, Dalhousie University, Halifax,
Nova Scotia B3H 3H7, Canada
MARYK. HONDALUS • Howard Hughes Medical Research Institute, Al-
bert EinsteinCollegeofMedicine, Bronx, New York 1046l
DAVIDJOHNSON • InfectiousDiseases Section,DepartmentofVeterinary
Affairs Medical Center,Bay Pines, Florida 33744
MURATV. KALAYOGLU • DepartmentofMedicalMicrobiologyandIm-
munology, University of Wisconsin Medical School, Madison, Wisconsin
53706
THOMAS W. KLEIN • Department ofMedical Microbiology and Immu-
nology, University ofSouth Florida, College ofMedicine, Tampa, Florida
33612
JAMESL.KRAHENBUHL • G.W.LongHansen’sResearchCenter,Labo-
ratory Research Branch, Louisiana State University, Baton Rouge,
Louisiana 70803
CONTRIBUTORS vii
M. LEBASTARD • Unité d’Immunophysiologie Cellulaire, InstitutPasteur,
75724 Paris-Cedex 15,France
DANIELLE MALO • Departments of Medicine and Human Genetics,
McGillUniversity,and Centre for the Study ofHost Resistance,Montreal
General Hospital, Montreal, Quebec H3G 1A4,Canada
G. MILON • United’Immunophysiologie Cellulaire, InstitutPasteur, 75724
Paris-Cedex 15,France
DAVID M. MOSSER • Department of Microbiology and Immunology,
Temple University School of Medicine, Philadelphia, Pennsylvania
19140
CHARLES NAUCIEL • Faculté de Médecine de Paris-Ouest, Université
Paris 5, 92380 Garches, France
CATHERINE NEWTON • Department ofMedical Microbiology and Im-
munology, University of South Florida, College of Medicine, Tampa,
Florida33612
PETER H. NIBBERING • Department ofInfectious Diseases, Leiden Uni-
versityMedical Center, 2333 ZA Leiden, The Netherlands
TOM H. M. OTTENHOFF • Department of Immunohematology and
Blood Bank, Leiden University Medical Center, 2333 ZA Leiden, The
Netherlands
LOISJ. PARADISE • Department ofMedical Microbiology and Immunol-
ogy, University of South Florida, College of Medicine, Tampa, Florida
33612
SALMAN T. QURESHI • Departments ofMedicine andHuman Genetics,
McGill University, andCentre forthe Study ofHost Resistance, Montreal
General Hospital, Montreal, Quebec H3G 1A4,Canada
GRAHAMA. W. ROOK • Department ofBacteriology, University College
LondonMedical School, London, W 1 P 6DB, England
R. MARTIN ROOP II • Department of Microbiology and Immunology,
Louisiana State University Medical Center, Shreveport, Louisiana 71130-
3939
JULIUSSCHACHTER • DepartmentofLaboratoryMedicine,Universityof
California, San Francisco, San Francisco,California 94110
EMILSKAMENE • DepartmentsofMedicineandHumanGenetics,McGill
University,and Centre forthe StudyofHost Resistance,Montreal General
Hospital, Montreal, Quebec H3G 1A4,Canada
viii CONTRIBUTORS
ERIC SPIERINGS • Department of Immunohematology and Blood Bank,
Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
YOSHIMASA YAMAMOTO • Department of Medical Microbiology and
Immunology, University of South Florida, College of Medicine, Tampa,
Florida 33612
Preface to the Series
Themechanismsofdiseaseproductionbyinfectious agents arepresentlythefocus
of an unprecedented flowering of studies. The field has undoubtedly received
impetus from the considerable advances recently made in the understanding of
the structure, biochemistry, and biology of viruses, bacteria, fungi, and other
parasites. Another contributing factor is our improved knowledge of immune
responsesand otheradaptiveor constitutive mechanisms bywhichhostsreact to
infection. Furthermore, recombinant DNA technology, monoclonal antibodies,
and othernewer methodologies have provided the technical tools for examining
questions previously considered too complex tobe successfullytackled.Themost
important incentiveof all isprobably the regenerated ideathatinfection might be
theinitiating event inmanyclinical entities presently classifiedasidiopathic orof
uncertain origin.
Infectious pathogenesis research holds greatpromise. As moreinformationis
uncovered,itis becoming increasingly apparent that our present knowledge ofthe
pathogenic potential of infectious agents is often limited to the most noticeable
effects,which sometimes represent only the tip ofthe iceberg. For example, it is
nowwell appreciated that pathologic processes caused by infectious agents may
emerge clinically after an incubation of decades and may result from genetic,
immunologic, and other indirect routes more than from the infecting agent in
itself.Thus,thereisageneral expectation that continued investigationwillleadto
the isolation ofnew agentsofinfection,theidentification of hitherto unsuspected
etiologic correlations, and, eventually, more effectiveapproaches to prevention
and therapy.
Studies on the mechanisms ofdiseasecausedby infectious agents demanda
breadthofunderstandingacrossmanyspecializedareas,aswellasmuch coopera-
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