Table Of ContentOphthalmic Oncology
M.D.ANDERSONSOLIDTUMORONCOLOGY SERIES
SeriesEditor:RaphaelE.Pollock,M.D.,Ph.D.
PUBLISHEDVOLUMES
LiverCancer
EditedbySTEVENA.CURLEY,M.D.
BreastCancer
EditedbyS.EVASINGLETARY,M.D.
PancreaticCancer
EditedbyDOUGLASB.EVANS,M.D.,PETERW.T.PISTERS,M.D.,
andJAMESL.ABBRUZZESE,M.D.
Bita Esmaeli
Editor
Ophthalmic Oncology
123
Editor
BitaEsmaeli
TheUniversityofTexas
M.D.AndersonCancerCenter
SectionofOphthalmology
DepartmentofHeadandNeckSurgery
Houston,TX77030,USA
[email protected]
SeriesEditor
RaphaelE.Pollock
TheUniversityofTexas
M.D.AndersonCancerCenter
Houston,TX,USA
ISBN978-1-4419-0373-0 e-ISBN978-1-4419-0374-7
DOI10.1007/978-1-4419-0374-7
SpringerNewYorkDordrechtHeidelbergLondon
LibraryofCongressControlNumber:2010934256
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Preface
A little over a decade ago, I had the privilege of helping to establish the first
full-time ophthalmic oncology service based at a Comprehensive Cancer Center
in the United States. Our Ophthalmic Oncology Service at The University of
Texas M.D. Anderson Cancer Center has grown to include 4 subspecialty areas
of ophthalmology: orbital oncology/oculoplastic surgery, ocular oncology, ocular
surface diseases, and neuro-ophthalmology. Ophthalmic Oncology grew from fac-
ulty’s unique experiences and observations in their ophthalmology subspecialty
areas at M.D. Anderson. The book highlights the unique aspects of ophthalmic
oncologyasasurgicalandmedicaldisciplinepracticedataComprehensiveCancer
Center. The multidisciplinary management of ocular, orbital, and ocular adnexal
(eyelid, conjunctival, and periocular soft tissues) cancers is emphasized, as well
as the current recommendations and practices at our institution. In addition, ocu-
lar conditions caused as a direct result of cancer treatment are reviewed using
illustrativephotographsandcasepresentations.Theauthorsincludeophthalmology
facultymembers,currentandformerM.D.Andersonfellows,andexpertsincom-
plementary disciplines such as radiation oncology, dermatopathology, ophthalmic
pathology,radiology,plasticsurgery,andothersurgicalsubspecialties.
With an abundance of clinical photographs, clinicians will be able to correctly
diagnosecancersoftheorbit,eye,andocularadnexalstructures.
I appreciate the contributions of each of the authors who took time out of their
busyschedulestomeetthedeadlinesforthisproject.Iparticularlythankmythree
ophthalmologycolleaguesatM.D.Anderson,Dr.DanGombos,Dr.StellaKim,and
Dr.JadeSchiffman,whonotonlyhavehelpedputtogethersomeofthesectionsin
this book as section editors and authors but also because of their unique contribu-
tionstothegrowthofourprograminOphthalmicOncologyatM.D.Anderson.My
specialgratitudegoestoStephanieDemingandSueMoreaufromtheDepartment
ofScientificPublicationsatM.D.Andersonfortheirtirelesslonghoursofediting
forthisbook.IalsowouldliketothankDr.RaphaelPollockfortheopportunityto
organizeandleadthiseffortandtheprivilegetoeditthisbookintheM.D.Anderson
SolidTumorOncologySeries.Finally,Iamgratefulforthesupportprovidedbythe
dedicatedstaffatSpringer—StacyLazar,MaureenTobin,andLauraWalsh.
BitaEsmaeli
Houston,Texas
v
Contents
PartI OrbitalandAdnexalOncology
SectionEditor:BitaEsmaeli
1 PrimaryOrbitalCancersinAdults . . . . . . . . . . . . . . . . . . 3
RomanShinderandBitaEsmaeli
2 NonmalignantTumorsoftheOrbit . . . . . . . . . . . . . . . . . . 13
EricM.HinkandVikramDurairaj
3 PediatricOrbitalTumors . . . . . . . . . . . . . . . . . . . . . . . 23
JonathanJ.DuttonandGeorgeK.Escaravage
4 MultidisciplinaryManagementofOrbitalRhabdomyosarcoma . . 61
WinstonW.HuhandAnitaMahajan
5 MetastaticOrbitalTumors. . . . . . . . . . . . . . . . . . . . . . . 69
SyedMehdiAhmadandBitaEsmaeli
6 Secondary Orbital Tumors Extending from Ocular
orPeriorbitalStructures . . . . . . . . . . . . . . . . . . . . . . . . 79
RomanShinderandBitaEsmaeli
7 LacrimalGlandTumors . . . . . . . . . . . . . . . . . . . . . . . . 89
BrentHayekandBitaEsmaeli
8 Optic Nerve Sheath Fenestration in Cancer Patients:
IndicationsandSurgicalTechnique . . . . . . . . . . . . . . . . . . 103
ThomasE.Johnson
9 ManagementofPrimaryEyelidCancers . . . . . . . . . . . . . . . 113
AaronSavarandBitaEsmaeli
10 ManagementofConjunctivalNeoplasms . . . . . . . . . . . . . . . 127
StellaK.Kim,DanS.Gombos,andBitaEsmaeli
11 SurgicalSpecimenHandlingforConjunctival
andEyelidTumors . . . . . . . . . . . . . . . . . . . . . . . . . . . 139
SheriL.DeMartelaere,FrankW.Scribbick,andDoinaIvan
vii
viii Contents
12 NeuroradiologyofOcularandOrbitalTumors . . . . . . . . . . . 149
J.MatthewDebnam
13 RadiationTherapyforOrbitalandAdnexalTumors . . . . . . . . 169
StevenJ.FrankandAnitaMahajan
PartII IntraocularTumors
SectionEditor:DanS.Gombos
14 Multidisciplinary Management of Retinoblastoma:
Diagnosis,Treatment,andFutureDirection . . . . . . . . . . . . . 179
MaurizioL.Ghisoli,PeterE.Zage,CindyHerzog,Patty
Chevez-Barrios,MuraliChintagumpala,RichardL.Hurwitz,
AnitaMahajan,andDanS.Gombos
15 ManagementofUvealMelanoma . . . . . . . . . . . . . . . . . . . 201
MichelleLudwig,AdamS.Garden,MichelleD.Williams,
andDanS.Gombos
16 UvealMetastasesfromSolidTumors . . . . . . . . . . . . . . . . . 215
GerardoD.CamorianoandDanS.Gombos
17 VascularTumorsofthePosteriorPole . . . . . . . . . . . . . . . . 223
DanS.Gombos
PartIII OculoplasticandPeriocularReconstructiveSurgery
inCancerPatients
SectionEditor:BitaEsmaeli
18 ReconstructiveSurgeryforEyelidDefects . . . . . . . . . . . . . . 231
RomanShinderandBitaEsmaeli
19 Nasolacrimal Duct Obstruction andLacrimal Surgery
inCancerPatients . . . . . . . . . . . . . . . . . . . . . . . . . . . 243
AaronSavarandBitaEsmaeli
20 EyelidMalposition:UniqueScenariosinCancerPatients . . . . . 251
AaronSavarandBitaEsmaeli
21 CraniofacialSurgeryintheOrbitandPeriorbitalRegion . . . . . 259
DominickGolio
22 Enucleation,Evisceration,OrbitalImplants,
andManagementoftheIrradiatedSocket . . . . . . . . . . . . . . 275
MiguelGonzalez-CandialandAaronSavar
23 Orbital Exenteration and Rehabilitation
oftheExenteratedSocket . . . . . . . . . . . . . . . . . . . . . . . 285
AdamHsuandMatthewM.Hanasono
Contents ix
24 Periorbital Surgical Rehabilitation After Facial
NerveParalysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 295
HeatherChang,MehryarTaban,andTanujNakra
25 Psychosocial Aspects of Orbitofacial Disfigurement
inCancerPatients . . . . . . . . . . . . . . . . . . . . . . . . . . . 311
AlessandroBonannoandJinYoungChoi
PartIV OcularSideEffectsofCancerTherapy
SectionEditor:BitaEsmaeli
26 LacrimalandCanalicularToxicity . . . . . . . . . . . . . . . . . . 321
M.AmirAhmadiandBitaEsmaeli
27 OrbitalandPeriorbitalSideEffectsofChemotherapy . . . . . . . 327
JohnD.Ng
28 OcularandOrbitalInfectionsintheImmunocompromised
CancerPatient . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 339
VietH.HoandHaoH.Ho
PartV Neuro-ophthalmicManifestationsofCancer
SectionEditor:JadeS.Schiffman
29 CranialNerveIII,IV,andVIPalsiesintheCancerPatient . . . . . 355
MeghanS.FlemmonsandJadeS.Schiffman
30 SkullBaseTumors . . . . . . . . . . . . . . . . . . . . . . . . . . . 363
AnithaRaghunathandJadeS.Schiffman
31 OpticNervePathwayGliomasandOpticNerveMeningiomas . . . 383
SonaliSinghandJadeS.Schiffman
32 LeptomeningealDisease . . . . . . . . . . . . . . . . . . . . . . . . 395
GerardoD.Camoriano,AnithaRaghunath,
andJadeS.Schiffman
33 ParaneoplasticVisualSyndromes . . . . . . . . . . . . . . . . . . . 407
AnithaRaghunathandJadeS.Schiffman
34 Neurofibromatosis:TumorsoftheOpticPathway . . . . . . . . . . 419
JohnM.SlopisandJadeS.Schiffman
35 OtherOpticNerveMaladiesinCancerPatients . . . . . . . . . . . 433
JadeS.Schiffman,AnithaRaghunath,andRosaAnaTang
PartVI Common Vitreoretinal Conditions
inCancerPatients
SectionEditor:BernardF.Godley
x Contents
36 ManagementofEndogenousEndophthalmitis . . . . . . . . . . . . 449
KapilG.Kapoor,GibranS.Khurshid,GarvinH.Davis,
andBernardF.Godley
37 ViralRetinitisintheCancerPatient . . . . . . . . . . . . . . . . . 459
GibranS.Khurshid,GarvinH.Davis,KapilG.Kapoor,
andBernardF.Godley
38 DiagnosticVitrectomyandtheCancerPatient:Special
Considerations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 471
GarvinH.Davis,GibranS.Khurshid,KapilG.Kapoor,
andBernardF.Godley
39 IntraocularLymphoma:CurrentTherapyandFutureTrends . . . 485
ChristopherJ.Calvano,StellaK.Kim,andDanS.Gombos
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 491
