Office Andrology

309 Pages·2005·3.07 MB·English

by  Sharon T. Mortimer PhD (auth.)

O A
FFICE NDROLOGY
Contributors
KAREN E. ADAMS, MD,FACOG, Department of Obstetrics and Gynecology,
Oregon Health and Science University, Portland, OR
DAVID E. BATTAGLIA,PhD, Department of Obstetrics and Gynecology, Oregon
Health and Science University, University Fertility Consultants, Portland, OR
KEITH L. BLAUER,MD, Reproductive Care Center, Salt Lake City, UT
EMMETT F. BRANIGAN,MD, Bellingham IVF and Infertility Center, Bellingham, WA
LISA V. BROCK, Attorney General’s Office, State of Washington, Olympia, WA
WILLIAM BYRD,PhD,HCLD, Department of Obstetrics and Gynecology, University
of Texas Southwestern Medical Center, Dallas, TX
GRACE M. CENTOLA,PhD,HCLD(ABB), Offices for Fertility and Reproductive
Medicine, New York, NY; Professional ReproLab Consulting, Macedon, NY
EUGENE F. FUCHS, MD, Department of Surgery, Division of Urology, Oregon
Health and Science University, Portland, OR
WAYNE J.G. HELLSTROM,MD,Department of Urology, Tulane University
School of Medicine, New Orleans, LA
ARON JOHNSON,Department of Obstetrics and Gynecology, Oregon Health
and Science University, University Fertility Consultants, Portland, OR
DAVID S. KARABINUS,PhD, Genetics and IVF Institute, Fairfax, VA
DOLORES J. LAMB,PhD,HCLD,Scott Department of Urology, Department
of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX
LARRY I. LIPSHULTZ,MD,Scott Department of Urology, Baylor College
of Medicine, Houston, TX
KIRK C. LO, MD, Scott Department of Urology, Baylor College of Medicine,
Houston, TX
ANNA C. MASTROIANNI, University of Washington School of Law and Institute
for Public Health Genetics, Seattle, WA.
R. DALE MCCLURE,MD,FRCS(C) Section of Urology, Virginia Mason Medical
Center, Seattle, WA
SHARON T. MORTIMER,PhD,Oozoa Biomedical Inc., West Vancouver, BC, Canada
KINLOCH NELSON, MD, Virginia Urology, Hanover Medical Park,
Mechanicsville, VA
ROBERT D. OATES,MD, Department of Urology, Boston University School of
Medicine, Boston, MA
DARIUS A. PADUCH,MD,Department of Urology, Weill Medical College
of Cornell University, New York, NY
ix
O A
FFICE NDROLOGY
Edited by
P E. P ,
HILLIP ATTON MD
and
D E. B ,
AVID ATTAGLIA PhD
Department of Obstetrics and Gynecology,
Oregon Health and Science University,
University Fertility Consultants, Portland, OR
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Cover Illustration: From Fig. 4, Chapter 4, “Specialized Sperm Testing: Pros and Cons,” by Kirk C. Lo, Aron
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Library of Congress Cataloging-in-Publication Data
Office andrology / edited by Phillip E. Patton, and David E.Battaglia.
p. ; cm. -- (Contemporary endocrinology)
Includes bibliographical references and index. ISBN 1-58829-318-1 (alk. paper)
1. Andrology. 2. Infertility, Male. I. Patton, Phillip E. II. Battaglia, David Edward.
III. Series: Contemporary endocrinology (Totowa, N.J.)
[DNLM: 1. Infertility, Male--diagnosis. 2. Genital Diseases, Male. 3. Infertility, Male--therapy.
4. Insemination, Artificial. WJ 709 O32 2005]
RC875.O35 2005
612.6'1--dc22
2004027128
Preface
The investigation and management of male infertility can be a formidable
diagnostic challenge to family physicians, urologists, and reproductive
specialists alike. For the first time, health care providers can access a
comprehensive resource that covers a broad spectrum of relevant clinical issues
related to male infertility disorders.
InOffice Andrology, a variety of topics including basic sperm biology, male
reproductive endocrinology, immunology, specialized sperm testing,
and genetic issues of male infertility are reviewed by recognized experts in the
field. In addition, this book features a pragmatic review of the investigation,
diagnostic testing, and management of the infertile male. Controversial medical
and surgical treatment options are focus areas that should assist the practicing
clinician. For the reproductive specialist, the text covers timely topics, including
gender selection, HIV discordance couples, and posthumous reproduction in a
thoughtful and comprehensive manner.
The goal of Office Andrology is to provide a practical guide for those requiring
concise answers to both the urbane and complex scenarios attendant on male
infertility. Practitioners wishing a greater understanding of the available diag-
nostic and treatment options will find Office Andrology especially useful in their
clinical practice.
Phillip E. Patton, MD
David E. Battaglia, PhD
v
Contents
Preface..........................................................................................v
Contributors.................................................................................ix
1 Essentials of Sperm Biology ..................................................1
Sharon T. Mortimer
2 Endocrinology of Male Infertility ........................................11
R. Dale McClure
3 Sperm Preparation for Insemination ....................................39
Grace M. Centola
4 Specialized Sperm Testing: Pros and Cons.........................53
Kirk C. Lo, Aron Johnson, Larry I. Lipshultz,
and Dolores J. Lamb
5 Genetic Testing for Male Infertility.....................................73
Robert D. Oates
6 Optimizing Success in a Donor Insemination Program.......91
Phillip E. Patton
7 Ethical and Legal Considerations of Donor Insemination
in the United States.........................................................109
Karen E. Adams
8 Laboratory Accreditation....................................................127
William Byrd
9 Office Evaluation of Male Infertility .................................141
Darius A. Paduch and Eugene F. Fuchs
10 Varicocele and Infertility....................................................155
Ulrike Zenke and Paul Turek
11 Strategic Therapies for Ejaculatory Disorders and Erectile
Dysfunction in the Infertile Man....................................169
Mustafa F. Usta and Wayne J. G. Hellstrom
12 Vasectomy Reversal ...........................................................183
Eugene F. Fuchs and Darius A. Paduch
vii
viii Contents
13 Infection and Male Infertility .............................................189
Emmett F. Branigan
14 Obstructive and Nonobstructive Azoospermia..................201
Kinloch Nelson and Peter Schlegel
15 Testis Biopsy and the Infertile Male..................................215
Sherman J. Silber
16 Intracytoplasmic Sperm Injection: The Process,
the Outcomes, and the Controversies ............................241
David E. Battaglia
17 Treatment of Human Immunodeficiency
Virus-Discordant Couples..............................................255
Joseph E. Peña and Mark V. Sauer
18 Sperm and Egg Retrieval for Posthumous Reproduction:
Practical, Ethical, and Legal Considerations...............267
Lisa V. Brock and Anna C. Mastroianni
19 Gender Selection: Separating Fact From Fiction. ............285
David S. Karabinus and Keith L. Blauer
Index.........................................................................................303
Contributors
KAREN E. ADAMS, MD,FACOG, Department of Obstetrics and Gynecology,
Oregon Health and Science University, Portland, OR
DAVID E. BATTAGLIA,PhD, Department of Obstetrics and Gynecology, Oregon
Health and Science University, University Fertility Consultants, Portland, OR
KEITH L. BLAUER,MD, Reproductive Care Center, Salt Lake City, UT
EMMETT F. BRANIGAN,MD, Bellingham IVF and Infertility Center, Bellingham, WA
LISA V. BROCK, Attorney GeneralÕs Office, State of Washington, Olympia, WA
WILLIAM BYRD,PhD,HCLD, Department of Obstetrics and Gynecology, University
of Texas Southwestern Medical Center, Dallas, TX
GRACE M. CENTOLA,PhD,HCLD(ABB), Offices for Fertility and Reproductive
Medicine, New York, NY; Professional ReproLab Consulting, Macedon, NY
EUGENE F. FUCHS,MD, Department of Surgery, Division of Urology, Oregon
Health and Science University, Portland, OR
WAYNE J.G. HELLSTROM,MD,Department of Urology, Tulane University
School of Medicine, New Orleans, LA
ARON JOHNSON, Department of Obstetrics and Gynecology, Oregon Health
and Science University, University Fertility Consultants, Portland, OR
DAVID S. KARABINUS,PhD, Genetics and IVF Institute, Fairfax, VA
DOLORES J. LAMB,PhD,HCLD,Scott Department of Urology, Department
of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX
LARRY I. LIPSHULTZ, MD,Scott Department of Urology, Baylor College
of Medicine, Houston, TX
KIRK C. LO,MD, Scott Department of Urology, Baylor College of Medicine,
Houston, TX
ANNA C. MASTROIANNI, Attorney General’s Office, State of Washington,
Olympia, WA.
R. DALE MCCLURE,MD,FRCS(C) Section of Urology, Virginia Mason Medical
Center, Seattle, WA
SHARON T. MORTIMER,PhD,Oozoa Biomedical Inc., West Vancouver, BC, Canada
KINLOCH NELSON, MD, Virginia Urology, Hanover Medical Park,
Mechanicsville, VA
ROBERT D. OATES,MD, Department of Urology, Boston University School of
Medicine, Boston, MA
DARIUS A. PADUCH, MD,Department of Urology, Weill Medical College
of Cornell University, New York, NY
ix
x Contributors
PHILLIP E. PATTON,MD, Department of Obstetrics and Gynecology, Oregon
Health and Science University, University Fertility Consultants, Portland, OR
JOSEPH E. PEÑA,MD, Department of Obstetrics and Gynecology, Columbia
Presbyterian Medical Center, New York, NY
MARK V. SAUER,MD, Department of Obstetrics and Gynecology, Columbia
Presbyterian Medical Center, New York, NY
PETER SCHLEGEL,MD,Department of Urology, Weill Medical College
of Cornell University, New York, NY
SHERMAN J. SILBER,MD, Infertility Center of St. Louis, St. Luke’s Hospital,
St. Louis, MO and Department of OB-GYN Infertility Center, New York, NY
PAUL TUREK,MD, Department of Urology, University of California San
Francisco, San Francisco, CA
MUSTAFA F. USTA,MD, Department of Urology, Tulane University School
of Medicine, New Orleans, LA
ULRIKE ZENKE,MD, Department of Urology, University of California San
Francisco, San Francisco, CA