Nucleic acid molecules encoding anti-P-selectin antibodies

58 Pages·2013·4.55 MB·English

USO0RE44359E
(19) United States
(12) Reissued Patent (10) Patent Number: US RE44,359 E
Graus et a]. (45) Date of Reissued Patent: Jul. 9, 2013
(54) NUCLEIC ACID MOLECULES ENCODING (56) References Cited
ANTI-P-SELECTIN ANTIBODIES
U.S. PATENT DOCUMENTS
(75) Inventors: Yvo Graus, Odijk (NL); Jacques 4,783,399 A 11/1988 Oldstone et a1.
Himber, GuebWiller (FR); Miranda 5,800,815 A 9/1998 Chestnut et al.
7,317,091 B2 1/2008 Lazar et a1.
J ansen-Molenaar, Maarssen (NL); 7,563,441 B2 7/2009 Graus et al.
Dorothee Kling, Kandern (DE); Erhard 7,754,867 B2 7/2010 Graus et al.
Kopetzki, PenZberg (DE); Paul Parren, 7,824,684 B2 * 11/2010 Graus et a1. .............. .. 424/1531
RE43,568 E * 8/2012 Graus et a1. .............. .. 424/1531
Odijk (NL); Frank Rebers, Utrecht
2006/0024298 A1 2/2006 LaZar et al.
(NL); Beat Steiner, Domach (CH);
FOREIGN PATENT DOCUMENTS
Anne Stern, PenZberg (DE); Pamela
Braemer, Weinheim (DE); Kay-Gunnar EP 0182634 5/1986
WO 88/07089 9/1988
Stubenrauch, PenZberg (DE); Jan van WO 93/06863 4/1993
de Winkel, Zeist (NL); Martine van W0 W0 03/074679 9/1993
Vugt, Houten (NL) WO 93/21956 11/1993
WO 94/25067 11/1994
WO 94/29351 12/1994
(73) Assignee: Hoffmann-La Roche Inc, Nutley, NJ WO 95/26403 10/1995
(Us) WO 97/20932 6/1997
WO 03/064606 8/2003
WO 03/074679 9/2003
(21) App1.No.: 13/471,s99
WO 03/075840 9/2003
WO 2004/029207 4/2004
(22) Filed: May 15, 2012 WO 2004/042072 5/2004
Related US. Patent Documents OTHER PUBLICATIONS
Reissue of: Kurome et al., J'. Biochem. 115:608-614 ( 1994).
Reddy et al., Journal oflmmunology 164: 1925-1933 ( 2000).
(64) Patent No.: 7,754,867
HeZareh, Journal ofI/lrology (XP002339184), 75(24): 12161-12168
Issued: Jul. 13, 2010 ( 2001).
Appl. No.: 12/481,623 Morgan et al., Immunology 86(2):319-324 ( 1995).
Idusogie, J'. oflmmunology (XP002965858), 164:4178-4184 (2000).
Filed: Jun. 10, 2009
Brekke, J'. of Immunology (XP000567079), 24(10.01):2542-2547
US. Applications: ( 1994).
Geng et al., 1. Bio. Chem. 266:22313-22318 ( 1991).
(62) Division of application No. 11/ 102,403, ?led on Apr. European Journal ofimmunology, vol. 24, No. 10.01. (Oct. 1994)pp.
8, 2005, noW Pat. No. 7,563,441. 2542-2547, XP000567079.
Journal of Immunology, vol. 164, (2000), pp. 4178-4184,
(30) Foreign Application Priority Data XP002965858.
Journal ofVirology, vol. 75, No. 24, (Dec. 2001), pp. 12161-12168,
XP002339184.
Apr. 13, 2004 (EP) ................................... .. 04008722
* cited by examiner
(51) Int. Cl.
C12N15/13 (2006.01) Primary Examiner * Phillip Gambel
C12N 15/12 (2006.01)
C12N15/63 (2006.01) (57) ABSTRACT
C12N 5/10 (2006.01) This invention relates to anti-P-selectin antibodies and, in
(52) US. Cl. particular, to anti-P-selectin antibodies and variants thereof
USPC 536/2353; 536/23.1; 536/235; 435/252.3; that contain an F0 part derived from human origin and do not
bind complement factor Clq. These antibodies have neW and
435/320.1; 435/326; 435/328; 435/332; 435/334;
inventive properties causing a bene?t for a patient suffering
435/343
from critical limb ischemia or peripheral arterial occlusive
(58) Field of Classi?cation Search
disease (CLI/PAOD).
None
See application ?le for complete search history. 169 Claims, 9 Drawing Sheets
US. Patent Jul. 9, 2013 Sheet 1 of9 US RE44,359 E
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US. Patent Jul. 9, 2013 Sheet 2 of9 US RE44,359 E

US. Patent Jul. 9, 2013 Sheet 5 of9 US RE44,359 E
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