Nomenclature, Methodology and Results of Clinical Trials in Acute Leukemias

179 Pages·1973·1.75 MB·English

by  G. Mathé (auth.)

Recent Results in Cancer Research
Fortschritte der Krebsforschung
Progres dans les recherches sur Ie cancer
43
Edited by
V.G. All/rey, New York • M.Allgower,Basel· K.H.Bauer,Heidelberg
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W. Braun, New Brunswick· P. Bucalossi, Milano· A. V. Chaklin, Moskva
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Editor in chief
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Nomenclature, Methodology and Results
of Clinical Trials in Acute Leukemias
Edited by
G. Mathe· P. Pouillart· L. Schwarzenberg
With 79 Figures
Springer-Verlag Berlin Heidelberg New York 1973
Workshop held June 19 and 20, 1972 at the Centre National de la Recherche Scientifique
(C.N.R.S.), 15, quai Anatole France, 75007 Paris, France
co-sponsored by
Institut de Cancerologie et d'Immunogenetique (LC.LG.)
Institut National de la Sante et de la Recherche Medicale (LN.S.E.R.M.)
European Organization for Research on Treatment of Cancer (E.O.R.T.C.)
National Cancer Institute (N.C.L)
Sponsored by the Swiss League against Cancer
ISBN-13:978-3 -642-80778-7 e-ISBN-13:978-3 -642-80776-3
DOl: 10.1007/978-3-642-80776-3
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is
concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by
photocopying mamine or similar means, and storage in data banks.
Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable
to the publisher, the amount of the fee to be determined by agreement with the publisher.
@ by Springer-Verlag Berlin· Heidelberg 1973. Library of Congress Catalog Card Number 73-9197.
Softcover reprint of the hardcover 1s t edition 1973
The use of registered names, trademarks, etc. in this publication does not imply, even in the absence
of a specific statement, that such names are exempt from the relevant protective laws and regulations and there
fore free for general use. Typesetting,
Nomenclature, Methodology and Results
of Clinical Trials in Acute Leukemias
Edited by
G. Mathe· P. Pouillan· L. Schwarzenberg
With 79 Figures
Springer-Verlag New York Heidelberg Berlin 1973
Workshop held June 19 and 20, 1972 at the Centre National de la Recherche Scientifique
(C.N.R.S.), 15, quai Anatole France, 75007 Paris, France
co-sponsored by
Institut de Cancerologie et d'Immunogenetique (LC.LG.)
Institut National de la Sante et de la Recherche Medicale (LN.S.E.R.M.)
European Organization for Research on Treatment of Cancer (E.O.R.T.C.)
National Cancer Institute (N.C.L)
Sponsored by the Swiss League against Cancer
ISBN-13:978-3 -642-80778-7 e-ISBN-13:978-3 -642-80776-3
DOl: 10.1007/978-3-642-80776-3
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is
concerned, specifically those of translation, reprinting, re~use of illustrations, broadcasting, reproduction by
photocopying machine or similar means, and storage in data banks.
Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable
to the publisher, the amount of the fee to be determined by agreement with the puhlisher.
@ by Springer-Verlag Berlin' Heidelberg 1973. Library of Congress Catalog Card Number 73-9197.
Sol'tcover reprint of the hardcover 1st edition 1973
The use of registered names, trademarks, etc. in this publication does not imply, even in the absence
of a specific statement, that such names are exempt from the relevant protective laws and regulations and there
fore free for general use. Typesetting,
Nomenclature, Methodology and Results
of Clinical Trials in Acute Leukemias
Edited by
G. Mathe· P. Pouillart· L. Schwarzenberg
With 79 Figures
1973
William Heinemann Medical Books Ltd., London
Springer-Verlag Berlin. Heidelberg. New York
Workshop held June 19 and 20, 1972 at the Centre National de la Recherche Scientifique
(C.N.R.S.), 15, quai Anatole France, 75007 Paris, France
co-sponsored by
Institut de Cancerologie et d'Immunogenetique (LC.LG.)
Institut National de la Sante et de la Recherche Medicale (LN.S.E.R.M.)
European Organization for Research on Treatment of Cancer (E.O.R.T.C.)
National Cancer Institute (N.C.L)
Sponsored by the Swiss League against Cancer
ISBN-13:978-3 -642-80778-7 e-ISBN-13:978-3 -642-80776-3
DOl: 10.1007/978-3-642-80776-3
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is
concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by
photocopying mamine or similar means, and storage in data banks.
Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable
to the publisher, the amount of the fee to be determined by agreement with the publisher.
@ by Springer-Verlag Berlin· Heidelberg 1973. Library of Congress Catalog Card Number 73-9197.
Softcover reprint of the hardcover 1st edition 1973
The use of registered names, trademarks, etc. in this publication does not imply, even in the absence
of a specific statement, that such names are exempt from the relevant protective laws and regulations and there
fore free for general use. Typesetting,
Contents
MATHE, G.: General Introduction. 1
First Session - Nomenclature and Classification
PERRY, S.: Introduction to Nomenclature and Classification of Acute Leukemias 3
MATHE, G., POUILLART, P., WEINER, R., HAYAT, M., STERESCO, M., LAFLEUR,
M.: Classification and Subclassification of Acute Leukemias Correlated with
Clinical Expression, Therapeutic Sensitivity and Prognosis 6
BEARD, M. E. J.: Classification of Acute Leukemias Using Romanowsky, Sudan
Bla&: and Periodic Acid Schiff Stains 21
BENNETT, J. M., KLEMPERER, M. R., SEGEL, G. B.: Survival Prediction Based on
Morphology of Lymphoblasts 23
LEE, S. L., GLIDEWELL, 0.: Cytology and Survival in Acute Lymphatic Leukemia
of Children . . . . . 28
RAPPAPORT, H.: Histologic Criteria for Diagnosis and Classification of Acute
Leukemias 35
FLANDRIN, G., DANIEL, M. T.: Practical Value of Cytochemical Studies for the
Classification in Acute Leukemias 43
LOFFLER, H.: Indications and Limits of Cytochemistry in Acute Leukemia 57
BESSIS, M.: Cytologic Diagnosis of Leukemias by Electron Microscopy . 63
PAINTRAND, M., DANTCHEV, D., MATHE, G.: Electron Microscopic Aspects of
Cells in the Four Subvarieties of Acute Lymphoid Leukemia 71
GAVOSTO, F.: Observations on the Kinetics of Acute Lymphoblastic Leukemia
in Relation to its Division into Subvarieties . 76
FREI, III, E., HART, J. S.: Cytokinetic Studies and Treatment Response in
Adult Acute Leukemia . . . . . 81
POUILLART, P.: Contribution of Cultures in Agar to the Classification of Acute
Leukemias: Preliminary Results . 88
COWAN, D. H., MESSNER, H. A., SENN, J. S., MCCULLOCH, E. A.: The Hetero-
geneity of Cell Culture Findings in Patients with Acute Myeloblastic Leukemia 92
c.,
HALL, T. KESSEL, D., NAHAS, A., HACKER, B.: Biochemical Techniques for
Classification of Leukemic Cell Types . 97
PERRY, S.: Conclusions of the Working Session on Nomenclature and Classifica-
tion 105
Second Session - Methodology of Clinical Trials
CARTER, S. K.: Introduction to Methodology of Clinical Trials in the Varieties
of Acute Leukemia; Defining the Numerator and Denominator in Leukemic
Trials. 107
VI Contents
MATHE, G., WEINER, R.: Criteria for Short-Term Results in the Treatment of
Acute Leukemia 110
KARON, M.: Problems in the Evaluation of Long-Term Results . 113
BERGSAGEL, D. E., COWAN, D. H.: Attempts at Standardization of Methods and
Expression of Results. 121
c.:
PIKE, M. The Analysis of Clinical Trials in Leukemia . 126
Third Session - Actuarial Results
c.,
DOWLING, JR., M. D., HAGHBIN, M., GEE, T. S., CUNNINGHAM, B., TAN, C. T.
CLARKSON, B. D., BURCHENAL, J. H.: Comparative Results Obtained in the
Treatment of Acute Leukemia 133
BORELLA, L., GREEN, A. A., AUR, R. J. A., SIMONE, J. V., PINKEL, D.: Clinical
and Immunological Recovery of Children with Acute Lymphocytic Leukemia
Admitted to "Total Therapy" Studies . 145
BERNARD, J., BOIRON, M., JACQUILLAT, CL., W"IL, M.: Recent Results in Acute
Leukemias at the Hospital Saint-Louis . 151
JACQUILLAT, CL., WElL, M., GEMON, M.-F., IZRAEL, V., BOIRON, M., BERNARD, J.:
A New Agent Active in the Treatment of Acute Myeloblastic Leukemia:
22050 R. P. . 155
SCHWARZENBERG, L., MATHE, G., POUILLART, P., WEINER, R., HAYAT, M., AMIEL,
J. L., JASMIN, c., ROSENFELD, c., DE VASSAL, F., SCHNEIDER, M., CATTAN, A.:
Comparative Results Obtained in the Treatment of Acute Lymphoid Leu-
kemia, Acute Myeloid Leukemia and Acute Monocytoid Leukemia. 160
Preliminary Results of a Trial on Acute Myeloid Leukemia Comparing the Effect
of Cytosine Arabinoside, the Combination of Cytosine Arabinoside and
Thioguanine and the Combination of Cytosine Arabinoside and Dauno
rubicine by "Leukemia and Hematosarcoma" Cooperative Group of the
EORTC . 165
List of Participants
AMIEL, J. L., Unite Fred-Siguier de Development Therapeutique, Institut de Cancero
logie et d'Immunogenetique, Hopital Paul-Brousse, 14-16, Avenue Paul-Vaillant
Couturier, 94800 Villejuif, France
AUR, R. J. A., St. Jude Children's Research Hospital, 332 North Lauderale, Memphis,
TN 38101, USA
BEARD, M. E. J., Department of Haematology, St. Bartholomew's Hospital, London,
E. C.l, UK
BENNETT, J. M., Departments of Medicine and Pediatrics, The University of Rochester,
School of Medicine and Dentistry, Division of Oncology and the Highland
Hospital of Rochester, Rochester, NY, USA
BERGSAGEL, D. E., Princess Margaret Hospital, 500 Sherbourne Street, Toronto 5,
Canada
BERNARD, J., Institut de Recherches sur les Leucemies, Hopital Saint-Louis, 2, place
du Docteur A. Fournier, 75010 Paris, France
BESSIS, M., Institut de Pathologie Cellulaire, Hopital de Bic&tre, Universite de Paris,
75 Paris, France
BOIRON, M., Institut de Recherches sur les Maladies du Sang, Hopital Saint-Louis, 2,
place de Docteur A. Fournier, 75010 Paris, France
BORELLA, L., St. Jude Children's Research Hospital, 332 North Lauderale, Memphis,
TN 38101, USA
BURCHENAL, J. H., Sloan-Kettering Institute for Cancer Research, Division of Chemo
therapy Research, Memorial Hospital for Cancer and Allied Diseases and Cornell
University Medical College, New York, NY, USA
CARTER, S. K., National Cancer Institute, N. I. H., Bethesda, MD 20014, USA
CATTAN, A., C.R.L.C., 45 rue Coqnacq Jay, 51100 Reims, France
CLARKSON, B. D., Sloan-Kettering Institute for Cancer Research, Division of Chemo
therapy Research, Memorial Hospital for Cancer and Allied Diseases and Cornell
University Medical College, New York, NY, USA
COWAN, D. H., Department of Medicine, Princess Margaret Hospital and the Ontario
Cancer Institute and Sunnybrook Hospital and the University of Toronto,
Toronto, Canada
CUNNINGHAM, B., Sloan-Kettering Institute for Cancer Research, Division of Chemo
therapy Research, Memorial Hospital for Cancer and Allied Diseases and Cornell
University Medical College, New York, NY, USA
DANIEL, M. T., Institut de Recherches sur les Leucemies et les Maladies du Sang, Hopi
tal Saint-Louis, 2, place de Docteur A. Fournier, 75010 Paris, France
DANTCHEV, D., Institut de Cancerologie et d'Immunogenetique, Hopital Paul-Brousse,
14-16, Avenue Paul-Vaillant-Courturier, 94800 Villejuif, France