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About NIH Public Access: Author Manuscript
This document discusses malignancies in children with Down syndrome. Children with Down syndrome have a 10 to 20-fold increased risk of developing acute leukemias, especially acute megakaryoblastic leukemia and acute lymphoblastic leukemia. They are also at higher risk for a transient myeloproliferative disorder that can sometimes lead to acute myeloid leukemia. In contrast, children with Down syndrome have a markedly decreased risk of developing solid tumors. The document reviews the underlying biology and clinical features of the leukemias common in Down syndrome, as well as epidemiological risk factors and pharmacogenetic considerations for this population.
Detailed Information
Author: | ['pelangi'] |
---|---|
Publication Year: | 2019 |
Pages: | 16 |
Language: | English |
Format: | |
Price: | FREE |
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