Next Generation Tools Enabling Personalized Medicine

100 Pages·2011·5.78 MB·English

by  Erika Reymolds

Next Generation Tools Enabling Personalized Medicine
Caliper Owners Group, May 17, 2011
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Disruptive Technologies Enabling Personalized Medicine
More From Less, Faster and Better™
Diagnostics Therapeutics
Genome Sequencing: Biologics & Vaccines:
Imaging & Pathology Targeted Small Molecules
Biomarkers Stem Cells
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Triple Crown Focus
Innovation
• Patient Centric
• Therapeutics
• Diagnostics
Revolutionizing
Medicine
Collaboration Culture
• Clinical Data • Integration
• Technology • Inspiration
• Business • Boldness
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Dennis Ausiello, MD
 Chief of Medicine at Massachusetts General Hospital
 Chief Scientific Officer, Partners Healthcare System
 Jackson Professor of Clinical Medicine at Harvard Medical School
 Member of Board of Directors of Pfizer, Broad Institute and TARIS
 SAB member: Entra, Promedior, Pulmatrix, BIND Biosciences, Proventys
 Undergraduate degree from Harvard College and medical degree from
the University of Pennsylvania.
 Dr. Ausiello was elected to the Institute of Medicine of the National
Academy of Science in 1999 and the American Academy of Arts and
Sciences in 2003.
 He has made a substantial contribution to knowledge of epithelial biology
in the areas of membrane protein trafficking, ion channel regulation and
signal transduction. He has published numerous articles, book chapters,
and textbooks and currently serves as the co-editor of Cecil's Textbook
of Medicine, now in its 23rd edition.
 “The Practice of Medicine in the 21st Century”
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Next Generation Tools Enabling Personalized Medicine
Kevin Hrusovsky
President & CEO
Caliper Owners Group, May 17, 2011
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Next Generation Tools Enabling Personalized Medicine
 State of Healthcare
 Triple Crown Focus
Innovation
Revolutionizing
Medicine
Collaboration Culture
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State of Healthcare
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Life Expectancy is Slowing
Lyman & Hirsch (2010), Personalized Medicine, pp223
 Extending life has become more difficult
 Heart / Cancer account for 50% of deaths
 First time in two centuries, children‟s life
expectancy is shorter than parents – obesity
 Five year decline is projected
 50% decrease in infectious disease
 30% decrease in infant mortality
 40% decrease in smoking
 30% decrease in premature cardiovascular deaths
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Obesity Reduces Life Spans & Natural Resources
 37% increase in obesity since 2000; 2/3 now overweight
 Costs doubled to $150B since 2000 (10% of costs)
 Costs projected to be $400B by 2020
 Linked diseases: Diabetes, heart, kidney, cancer
 Reverse correlation w/ per capita energy consumption
+
=
+
(NEJM, 2005; AHRQ, 2006; CBO, 2008; CDC, 2009)
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Historical Increase in Healthcare Costs
 Increasing for most every nation
 15% of GDP and increasing
 Quadrupled since 1980, but life spans have only
increased by 3-4 years
 Extending life significantly increases costs
 65+ year olds spend 4x more per year
than under 65
 5% consume 50% of medical care
Lyman & Hirsch (2010), Personalized Medicine, pp223
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