New Trends in Allergy III

576 Pages·1991·11.45 MB·English

by  B. Kunz

1. Ring B. Przybilla (Eds.)
New Trends
.
In
Allergy III
Foreword by O. Braun-Falco
With 168 Figures and 152 Tables
Springer-Verlag
Berlin Heidelberg New York
London Paris Tokyo
Hong Kong Barcelona
Budapest
Prof. Dr. med. Dr. phil. JOHANNES RING
Hautklinik und Allergie-Abteilung
UniversiHits-Krankenhaus Eppendorf
Martinistrasse 52, 2000 Hamburg 20
Federal Republic of Germany
Priv.-Doz. Dr. med. BERNHARD PRZYBlLLA
Dermatologische Klinik und Poliklinik
Ludwig-Maximilians-Universitat
Frauenlobstrasse 9-11, 8000 Miinchen 2
Federal Republic of Germany
ISBN-13 978-3-642-46719-6 e-ISBN-13: 978-3-642-46717-2
DOl: 10.1007/978-3-642-46717-2
Library of Congress Cataloging-in-Publication Data
New trends in allergy III / Johannes Ring, Bernhard Przybilla (eds.); foreword by O. Braun-Falco.
p. cm. Contains papers presented at a symposium, held July 13-15, 1990 in Munich. Includes
bibliographical references and indexes.
(alk. paper) 1. Allergy - Congresses. [1. Hypersensitivity - congresses.] I. Ring, Johannes, 1945-.
II. Przybilla, Bernhard, 1949-. III. Title: New trends in allergy three. [DNLM: WD 300 N5321
1990] RC583.2.N483 1991 616.97-dc20 DNLMIDLC
This work is subject to copyright. All rights are reserved, whether the whole or part of the material
is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation,
broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplica
tion of this publication or parts thereof is permitted only under the provisions of the German
Copyright Law of September 9, 1965, in its current version, and permission for use must always
be obtained from Springer Verlag. Violations are liable for prosecution under the German
Copyright Law.
© Springer-Verlag Berlin Heidelberg 1991
Softcover reprint of the hardcover 1s t edition 1991
The use of general descriptive names, registered names, trademarks, etc. in this publication does
not imply, even in the absence of a specific statement, that such names are exempt from the relevant
protective laws and regulations and therefore free for general use.
Product liability: The publishers cannot guarantee the accuracy of any information about dosage
and application contained in this book. In every individual case the user must check such informa
tion by consulting the relevant literature.
Production Editor: Isolde Scherich
Reproduction of the figures: Gustav Dreher GmbH, Stuttgart
Typesetting: K + V Fotosatz GmbH, Beerfelden
27/3145-543210 - Printed on acid-free paper
Foreword
The international symposium "New Trends in Allergy", held in
Munich from July 13 to 15, 1990, brought together for the third time
since 1980 some of the most experienced researchers working in the
field of allergy. This volume comprises the papers presented at this
meeting.
All over the world, and not merely in the industrialized countries,
allergy is becoming a cause of evermore serious diseases. In recent
years, research in the field of allergy has provided numerous impor
tant and fascinating results extending our knowledge considerably.
Despite the new insights into basic mechanisms of allergic reactions,
improved diagnostic methods, and new therapeutic approaches, how
ever, many questions remain to be answered, including:
Are allergies really increasing in frequency?
If so, what are the reasons? Especially, does environmental pollution
playa role?
Which factors influence IgE synthesis? Can the IgE immune response
be switched off?
Does the nervous system interact with allergic reactions? If so, what
are the mechanisms?
Are new approaches in allergy prophylaxis and allergy therapy effi
cient? What measures have proven useful and deserve to be employed
in daily practice?
In this volume, these questions and other current topics are dealt
with. As each issue is covered by authors competent in the respective
fields, the result is an extensive and critical review of the state of the
art. Going through these papers, one comes to the conviction that
allergy research is a multifacetted, explosively expanding, most
stimulating field of work.
I would like to express my gratitude to all those at the Department
of Dermatology of the University of Munich who worked hard to in
sure the success of the symposium. Furthermore, I am very grateful
to Springer-Verlag for publishing this volume so splendidly. May it
VI Foreword
find a wide distribution and thus improve the understanding of
allergic diseases to the benefit of our patients.
Munich, March 1991 o. BRAUN-FALCO
Contents
Foreword ........................................... V
0. BRAUN-FALCO
List of Senior Authors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XV
List of Chairmen .................................... XXIII
Epidemiology
Are Allergies Increasing? 3
B. KUNZ and J. RING
Epidemiology of Various Allergic Reactions 14
D. VERVLOET and D. CHARPIN
Epidemiology of Contact Allergy 23
P. 1. FROSCH and 1. ZIMMERMANN
Allergens
Epitopes on Allergens ................................ 33
L. JAGER, C. DIENER, W.-D. MULLER, and G. SCHLENVOIGT
Cloning of Birch Pollen Allergens ...................... 48
H. BREITENEDER, O. SCHEINER, K. PETTENBURGER,
R. VALENTA, M. TEJKL, K. HOFFMANN-SOMMERGRUBER,
M. DUCHENE, H. RUMP OLD , M. BREITENBACH,
and D. KRAFT
Molecular Structure of Allergens .. . . . . . . . . . . . . . . . . . . . . . 57
X. BAUR, G. MAZUR, and V. LIEBERS
VIII Contents
Characterization of Antigens and Allergens of Bird Feathers
and Bird Sera ......................................... 63
1. TAUER, G. FRUHMANN, and X. BAUR
Hop Allergy: Cross-Reactivity to Birch Pollen ............. 65
C. M. KALVERAM, C. CRONEMEYER, and K. J. KALVERAM
Immunoglobulin E Response
Possible Approaches to Controlling
the IgE Antibody Response ............................. 73
K. ISHIZAKA
Human FceRII/CD23 in the Regulation
of the Allergic Immune Response ....................... 82
E. P. RIEBER, U. PIRRON, N. ENDRES, and 1. C. PRINZ
Inbred Strains of Guinea Pigs in Studies of Allergy . . . . . . . . 92
L.K. POULSEN, L. LUNDBERG, D. SOMPOLINSKY,
J. V. SPARCK, M. PLOUG, C. BINDSLEV-JENSEN,
and P. S. SKOV
Multispecific Allergic Reactions ......................... 100
J. M. VARGA, G. F. KLEIN, and P. FRITSCH
Loss of FceR2/CD23 Expression on T and B Lymphocytes
During Rush Hyposensitization ......................... 105
J. C. PRINZ, E. P. RIEBER, and 1. RING
Construction of Human Suppressor T Cell Hybridomas
That Produce Glycosylation Inhibiting Factors
from Peripheral Blood Mononuclear Cells
of Bee Venom Sensitive Patients ......................... 109
P. THOMAS, C. CARINI, M. IWATA, and K. ISHIZAKA
Anti-IgE Autoantibodies Hide Specific IgE
and Are Mistaken for Specific IgG ...................... 112
E. JENSEN-JAROLIM and B. M. STADLER
Mast Cells and Mediator Release
In Vitro Growth of Human Mast Cells and Their Functions 117
T. ISHIZAKA, T. FURITSU, N. INAGAKI, and A.M. DVORAK
Mast Cells and Fibroblasts: Partners or Neighbors? 126
F. LEVI-SCHAFFER and M. SHALIT
Contents IX
Factors Promoting Histamine and Leukotriene Release ..... 138
C.A. DAHINDEN, M. KRIEGER, T. BRUNNER, S. TAKAFUJI,
and S. C. BISCHOFF
Cyclosporin A Inhibits IgE Receptor Mediated Exocytosis
from Rat Basophilic Leukemia Cells Without Inhibiting
Phosphatidylinositol Hydrolysis, Ca2+ Uptake,
the Rise in Cytosolic Ca2+ Actin Polymerization
or Arachidonic Acid Release ............................ 143
T. HULTSCH, M. KALINER, and R.1. HOHMAN
Prostaglandin D Synthetase is Localized
in Antigen Presenting Cells and Mast Cells ............... 149
K. lKAI, M. UJIHARA, Y. HORIGUCHI, and Y. URADE
Influence of Histamine Hj, H2, and H3 Agonists
and Antagonists on IgE Mediated Histamine Release
from Human Basophils ................................ 152
J. KLEINE-TEBBE, J. SCHRAMM, M. BOLZ, H. GAGNE,
C. JOSTIES, R. LIpp, A. FRIESE, H. STARK, V. ZINGEL,
A. BUSCHAUER, W. SCHUNACK, and G. KUNKEL
Impact of Biophysical Plasma Membrane Properties
on Leukocyte/Endothelium Interaction ................... 158
H.-A. LEHR, C. HUBNER, J. P. ZIMMER, A. KOHLSCHUTTER,
and K. MESSMER
Interleukin-3 and Granulocyte/Macrophage Colony
Stimulating Factor Change the Anaphylatoxin-Induced
Basophil Mediator Release Pattern. . . . . . . . . . . . . . . . . . . . . .. 161
S. C. BISCHOFF, Y. KURIMOTO, and C. A. DAHINDEN
Neuropeptides and Human Mast Cells 166
M.K. CHURCH and S. EL-LATI
Neuronal Interaction with Mast Cells .................... 175
1. BIENENSTOCK, M. H. PERDUE, and R. H. STEAD
Atopic Eczema
T Cells in Atopic Dermatitis ............................ 187
C.A.EM. BRUIJNZEEL-KoOMEN, EC. VAN REIJSEN,
and G. C. MUDDE
IgE Receptor Expression on Langerhans Cells 191
T. BIEBER
X Contents
Contact Sensitivity to Pityrosporum ovale in Patients
with Atopic Dermatitis ................................. 200
H. TAGAMI, M. ROKUGO, Y. USUBA, and Y. TOMITA
Irritable Skin in Atopic Eczema 207
R. GOLLHAUSEN
Stigmata and Signs of Atopic Eczema 222
T. L. DIEPGEN and M. F ARTASCH
Patch Test with Immediate Type Allergens in Patients
with Atopic Dermatitis ................................. 230
E. VOCKS, H.-V. SEIFERT, B. SEIFERT, and M. DROSNER
Chronobiological Aspects of Atopic Disease .............. 234
E. HAEN, T. LEDERER, S. BODENSTEINER, K. WOITE,
R. HAUCK, and H. P. EMSLANDER
Food Allergy
On the Diagnosis of Food Allergy in Adults -
A Comparison Between DBPCFC
and Intragastric Provocations ........................... 243
C. BINDSLEv-JENSEN, A. NORGAARD, K. LADEFOGED,
E. HYLLANDER, and L. K. POULSEN
Gastric Reactivity to Flour Extracts
and Helicobacter pylori Associated Gastritis
in Patients with Flour Allergy. . . . . . . . . . . . . . . . . . . . . . . . . .. 247
M. KUREK, R. BABIC, and J. RING
Immediate Contact Allergy to Foods: Skin Test Based
on Contact Urticaria and IgE Tests in Children
with Atopic Dermatitis ................................. 255
A. P. ORANJE, R. S. R. AARSEN, G. LIEFAARD,
P. G. H. MULDER, and A. W. VAN TOORENENBERGEN
The Prevalence of Food Allergy in Children
with Atopic Dermatitis ................................. 259
A. TAIEB, M. DEBONS, M.H. CAVERT, M.H. MAUPOME,
N. ALLOS, D. MONTAUDON, and J. MALEVILLE
Computer System of Medical Information (KSIMPA)
Useful for an Allergological Outpatient Clinic ............ 265
P. Z. BREWCZYNSKI, L. TOMICA, and Z. KALINA
Contents XI
Drug Reactions
Drug Metabolism and Drug Allergy ..................... 269
H. F. MERK, D. NIEDERAU, M. HERTL, and F. JUGERT
Adverse Reactions to Quinolones ........................ 281
D. VIELUF, R. RUSSWURM, B. PRZYBILLA, and J. RING
Drug Induced Photosensitivity 291
E. HbLZLE
Angiotensin Peptides and Anaphylaxis ................... 302
K. HERMANN, R. RITTWEGER, and 1. RING
Granulocyte Mediator Release in Pseudo-allergic Reactions 311
W. CZECH, E. SCHOPF, and A. KAPP
Photocontact Dermatitis and Persistent Light Reaction
from Olaquindox in Piglet Feed ......................... 318
S. SCHAUDER
Hyposensitization
Allergoids for Hyposensitization ........................ 329
J. BOUSQUET, A. HEJJAOUI, and F.-B. MICHEL
Hymenoptera Venom Allergy 335
B. PRZYBILLA and J. RING
Safety of Hyposensitization ............................. 350
1. RAKOSKI, B. JESSBERGER, C. SZLISKA, and E. VOCKS
Trends in the Use of Specific Immunotherapy ............. 354
A. ROSENDAHL LASSEN, L. JACOBSEN, and UG. SVENDSEN
Autoimmune Diseases
Autoantibodies Provide Insights into Antigens
Driving Autoimmunity ................................. 363
E.M. TAN
The Diagnostic Significance of Antinuclear Antibodies 372
M. MEURER
The Anticardiolipin Syndrome - A Clinical Study ........ 382
P. A. REYES-LoPEZ, 1. M. CASANOVA, and M. C. AMIGO