Table Of ContentRecent Results 142
in Cancer Research
Managing Editors
Ch. Herfarth, Heidelberg· H.-I. Senn, St. Gallen
Associate Editors
M. Baum, London· V. Diehl, Koln
P. Gutzwiller, Zurich· M.P. Rajewsky, Essen
M. Wannenmacher, Heidelberg
Founding Editor
P. Rentchnik, Geneva
E. D. Kreuser P. M. Schlag (Eds.)
New Perspectives
in Molecular
and Clinical Management
of Gastrointestinal Tumors
With 61 Figures and 101 Tables
Springer
Prof. Dr. med. Ernst-D. Kreuser
Freie Universitat Berlin
Fachbereich Humanmedizin
Univ.-Klinikum Benjamin Franklin
Medizinische Klinik und Poliklinik
Schwerpunkt Hamatologie und Onkologie
Hindenburgdamm 30
12200 Berlin, Germany
Prof. Dr. med. P.M. Schlag
Robert-RossIe Klinik am
Max-Delbruck- Centrum
Humboldt- Universitat
Lindenberger Weg 80
13122 Berlin, Germany
ISBN-13: 978-3-642-80037-5
Library of Congress Cataloging-in-Publication Data. New perspectives in molecular and
clinical management of gastrointestinal tumors/E.D. Kreuser. P.M. Schlag (eds.).
p. cm. - (Recent results in cancer research; 142) Includes bibliographical references
and index. ISBN-13 :978-3-642-80037-5 e·ISBN·13: 978·3·642·80035·1
DOl: 10.1007/978·3·642·80035·1 1. Gastrointestinal system -
Cancer - Molecular aspects. 2. Gastrointestinal system - Cancer Treatment. 1.
Kreuser, E.D. (Ernst Dietrich), 1945- . II. Schlag, P. (Peter), 1948- . III. Series.
[DNLM: 1. Gastrointestinal Neoplasms - diagnosis. 2. Gastrointestinal Neoplasms -
therapy. WI RE106Pv. 1421995/WI 149N5321995] RC261.R35 vol. 142 [RC280.D5]
616.99'4 s - dc20 [616.99'433] DNLMIDLC for Library of Congress 95·39447
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Preface
Over the past few years, a wealth of new insights have been
gained and put to use in basic gastrointestinal tumor research,
including tumor suppressor genes, oncogenes, cell-cycle con
trol, apoptosis, adhesion receptors, signal transduction, and
gene therapy. Similarly, progress has been made in preven
tion, molecular diagnosis, laparoscopic staging, and antibody
based immunotherapy, and new drugs such as thyrnidylate
and topoisomerase I inhibitors have been developed espe
cially for the treatment of colorectal carcinoma. Despite this
burgeoning of knowledge in both basic and clinical research,
however, we have just begun to put these results into clinical
practice. Therefore, the key goal of this volume is to bring
together basic and clinical research findings so as to facilitate
the translation of these advances into the clinical manage
ment of gastrointestinal tumors.
We hope that this volume, which covers a broad spectrum
of research and clinical medicine, will impart new insights and
greater understanding to all those interested in the therapy of
gastrointestinal tumors and will stimulate further scientific
research.
Berlin, January 1996 E.D. Kreuser
P.M. Schlag
Contents
I. Basic Research 1
S.J. Meltzer
The Molecular Biology of Esophageal Carcinoma 1
E.R. Greenberg
Preventing Colorectal Cancer. . . . . . . . . . . . . . . . . . . . . . 9
M. Streit, R. Schmidt, R. U. Hi/genfeld, E. Thiel,
and E.-D. Kreuser
Adhesion Receptors in Malignant Transformation
and Dissemination of Gastrointestinal Tumors. . . . . . . 19
R. Kaiser, E. Thiel, and E.-D. Kreuser
Human Gene Therapy in Gastrointestinal Diseases:
In Vivo and In Vitro Approaches .................. 51
K. Moelling, B. Strack, and G. Radziwill
Signal Transduction as Target of Gene Therapy 63
n. Diagnostic Tools. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
1. Ruschoff, T. Boeker, P. Vogel, and 1. Schlegel
Prognostic Significance of Molecular Biological
and Immunohistological Parameters
in Gastrointestinal Carcinomas. . . . . . . . . . . . . . . . . . . . . 73
M. Dietel
Molecular Mechanisms and Possibilities
of Overcoming Drug Resistance
in Gastrointestinal Tumors ........................ 89
Vln Contents
T.I. V ogl, W. Pegios, M. G. Mack, M. Rausch,
H. Hintze, M. Hunerbein, R. Hammerstingl,
H. Lobbeck, and R. Felix
Radiological Modalities in the Staging
of Colorectal Tumors: New Perspectives
for Increasing Accuracy ......................... " 103
A. Schmitt-Graff
Immunological and Molecular Classification
of Mucosa-Associated Lymphoid Tissue Lymphoma.. 121
M. Bader and K. Koppenhagen
Somatostatin Receptor Scintigraphy in the Diagnosis
of Neuroendocrine Gastroenteropancreatic Tumors. .. 137
m. Therapeutic Approaches. . . . . . . . . . . . . . . . . . . . . .. 163
P. Goldin-Lang, E.-D. Kreuser, and H.I.F. ZunJt
Basis and Consequences of Primary
and Secondary Prevention of Gastrointestinal Tumors 163
S. Faiss, H. Scherubl, E. O. Riecken,
and B. Wiedenmann
Drug Therapy in Metastatic Neuroendocrine Tumors
of the Gastroenteropancreatic System. . . . . . . . . . . . . .. 193
B. Rau, M. Hunerbein, B. Reingruber, P. Hohenberger,
and P.M. Schlag
Laparoscopic Lymph Node Assessment
in Pretherapeutic Staging
of Gastric and Esophageal Cancer ................ " 209
B.D. Minsky
Radiation Therapy Alone or Combined
with Chemotherapy in the Treatment
of Esophageal Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . .. 217
H. Wilke, H.I. Meyer, and U. Fink
Preoperative Chemotherapy in Gastric Cancer ....... 237
P.M. Schlag
Current Aspects of Sphincter Preservation
in the Surgical Therapy of Rectal Cancer. . . . . . . . . . .. 249
Contents IX
V. Budach, L. Schlenger, and P. Feyer
Preoperative and Postoperative Radiotherapy
in Rectal Carcinoma ............................. 257
P. Wust, J. Gellermann, B. Rau, J. Lottel,
A. Speidel, H. Stahl, H. Riess, T.J. Vogl, R. Felix,
and P.M. Schlag
Hyperthermia in the Multimodal Therapy
of Advanced Rectal Carcinomas. . . . . . . . . . . . . . . . . . .. 281
K.H. Link, L. Staib, E.-D. Kreuser, and H.G. Beger
Adjuvant Treatment of Colon and Rectal Cancer:
Impact of Chemotherapy, Radiotherapy,
and Immunotherapy
on Routine Postsurgical Patient Management. . . . . . .. 311
R. U. Hilgenfeld, M. Streit, E. Thiel, and E.-D. Kreuser
Current Treatment Modalities
in Advanced Colorectal Carcinoma. . . . . . . . . . . . . . . .. 353
E. Holz, R. Raab, and G. Riethmiiller
Antibody-Based Immunotherapeutic Strategies
in Colorectal Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . .. 381
H. Keck, J.M. Langrehr, V. Henneken, M. Knoop,
and P. Neuhaus
Surgical Concepts for Therapy
of Pancreatic Neoplasms. . . . . . . . . . . . . . . . . . . . . . . . .. 401
H. Riess, J. Loffel, P. Htun, and D. Huhn
Chemotherapy for Patients with Adenocarcinoma
of the Pancreas ................................... 415
M.S. Aapro
Phase II Data on Paclitaxel and Docetaxel
in Gastrointestinal Malignancies. . . . . . . . . . . . . . . . . .. 425
Subject Index .................................... 431
List of Contributors*
Aapro, M.S. 4251 Kreuser, E.-D. 19, 51, 163,
Bader, M. 137 311, 353
Beger, H.G. 311 Langrehr,l.M. 401
Bocker, T. 73 Link, K.H. 311
Budach, V. 257 Lobbeck, H. 103
Dietel, M. 89 Loffel,l. 281,415
Faiss, S. 193 Mack, M.G. 103
Felix, R 103,281 Meltzer, S.l. 1
Feyer, P. 257 Meyer, H.l. 237
Fink, U. 237 Minsky, B.D. 217
Goldin-Lang, P. 163 Moelling, K. 63
Greenberg, E.R 9 Neuhaus, P. 401
Gellermann,l. 281 Pegios, W. 103
Hammerstingl, R 103 Raab, R 381
Henneken, V. 401 Radziwill, G. 63
Hilgenfeld, RU. 19,353 Rau, B. 209, 281
Hintze, H. 103 Rausch, M. 103
Hohenberger, P. 209 Reingruber, B. 209
Holz, E. 381 Riecken, E.O. 193
Htun, P. 415 Riess, H. 281, 415
Huhn, D. 415 Riethmiiller, G. 381
Hiinerbein, M. 103,209 Riischoff, 1. 73
Kaiser, R 51 Scheriibl, H. 193
Keck, H. 401 Schlag, P.M. 209, 249, 281
Knoop, M. 401 Schlegel,l. 73
Koppenhagen, K. 137 Schlenger, L. 257
* The addresses of the authors are given on the first page of each
contribution.
Page on which contribution begins.
1
XII Contents
Schmidt, R. 19 Thiel, E. 19,51,353
Schmitt-Graff, A. 121 Vogel, P. 73
Speidel, A. 281 Vogl, T.J. 103, 281
Stahl, H. 281 Wiedenmann, B. 193
Staib, L. 311 Wilke, H. 237
Strack, B. 63 Wust, P. 281
Streit, M. 19,353 Zunft, H.J.F. 163
