Table Of ContentNew Frontiers
in the Study of
Gene Functions
NEW HORIZONS IN THERAPEUTICS
Smith Kline & French Laboratories Research Symposia Series
Series Editors: George Poste and Stanley T. Crooke
Smith Kline & French Laboratories, Philadelphia, Pennsylvania
DOPAMINE RECEPTOR AGONISTS
Edited by George Poste and Stanley T. Crooke
MECHANISMS OF RECEPTOR REGULATION
Edited by George Poste and Stanley T. Crooke
NEW FRONTIERS IN THE STUDY OF GENE FUNCTIONS
Edited by George Poste and Stanley T. Crooke
NEW INSIGHTS INTO CELL AND MEMBRANE TRANSPORT
PROCESSES
Edited by George Poste and Stanley T. Crooke
New Frontiers
in tbe Study of
Gene Functions
Edited by
GEORGE POSTE
and
STANLEY T. CROOKE
Smith Kline & French Laboratories
Philadelphia, Pennsylvania
PLENUM PRESS • NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data
New frontiers in the study of gene functions.
(New horizons in therapeutics)
Includes bibliographies and index.
I. Gene expression. 2. Genetic regulation. 3. Microbial genetics. 4. Genetic
engineering. I. Poste, George. II. Crooke, Stanley T. III. Series. [DNLM: 1. Genetic
Intervention. II. Genetics, Biochemical. QH 450 N532]
QH450.N5 1987 575.1 86-30313
ISBN-13: 978-1-4612-9030-8 e-ISBN-13: 978-1-4613-1845-3
DOl: 10.1007/978-1-4613-1845-3
© 1987 Plenum Press, New York
Softcover reprint of the hardcover 1st edition 1987
A Division of Plenum Publishing Corporation
233 Spring Street, New York, N.Y. 10013
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted
in any form or by any means, electronic, mechanical, photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
Contributors
Richard Axel, Howard Hughes Medical Institute, College of Physicians
and Surgeons, Columbia University, New York, New York 10032
John Brady, Laboratory of Molecular Virology, National Cancer Insti
tute, National Institutes of Health, Bethesda, Maryland 20892
Michael R. Briggs, Department of Biochemistry, University of Califor
nia, Berkeley, California 94720
Ana B. Chepelinsky, Laboratory of Molecular and Developmental Biol
ogy, National Eye Institute, National Institutes of Health, Bethesda, Mary
land 20892
Leonard Chess, Department of Medicine, College of Physicians and Sur
geons, Columbia University, New York, New York 10032
Paul R. Clapham, Institute of Cancer Research, Chester Beatty Labora
tories, London SW3 6JB, England
Deborah Cowing, Department of Bacteriology, University of Wisconsin,
Madison, Wisconsin 53706
Angus G. Dalgleish, Institute of Cancer Research, Chester Beatty Labora
tories, London SW3 6JB, England
Benoit de Crombrugghe, Laboratory of Molecular Biology, Division of
Cancer Biology and Diagnosis, National Cancer Institute, National Insti
tutes of Health, Bethesda, Maryland 20892
v
VI Contributors
Janet Duvall, Laboratory of Molecular Virology, National Cancer Insti
tute, National Institutes of Health, Bethesda, Maryland 20892
Beverly M. Emerson, Laboratory of Molecular Biology, National Insti
tute of Diabetes, and Digestive and Kidney Diseases, National Institutes
of Health, Bethesda, Maryland 20892
James Erickson, Department of Bacteriology, University of Wisconsin,
Madison, Wisconsin 53706
Gary Felsenfeld, Laboratory of Molecular Biology, National Institute of
Diabetes, and Digestive and Kidney Diseases, National Institutes of
Health, Bethesda, Maryland 20892
Anne Ferguson-Smith, Department of Biology, Yale University, New Ha
ven, Connecticut 06511
Gerald R. Fink, Whitehead Institute for Biomedical Research, Mas
sachusetts Institute of Technology, Cambridge, Massachusetts 02142
Martin Gellert, Laboratory of Molecular Biology, National Institute of
Diabetes, and Digestive and Kidney Diseases, National Institutes of Health,
Bethesda, Maryland 20892
Maurice Godfrey, Department of Medicine, College of Physicians and Sur
geons, Columbia University, New York, New York 10032
Carol Gross, Department of Bacteriology, University of Wisconsin, Madi
son, Wisconsin 53706
Alan Grossman, Department of Bacteriology, University of Wisconsin,
Madison, Wisconsin 53706
Charles P. Hart, Department of Biology, Yale University, New Haven,
Connecticut 06511
Michael H. Hecht, Department of Biology, Massachusetts Institute of
Technology, Cambridge, Massachusetts 02139
Contributors
Vll
Joanne E. Hesse, Laboratory of Molecular Biology, National Institute of
Diabetes, and Digestive and Kidney Diseases, National Institutes of
Health, Bethesda, Maryland 20892
P. David Jackson, Laboratory of Molecular Biology, National Institute
of Diabetes, and Digestive and Kidney Diseases, National Institutes of
Health, Bethesda, Maryland 20892
Rudolf Jaenisch, Whitehead Institute for Biomedical Research, Mas
sachusetts Institute of Technology, Cambridge, Massachusetts 02142
James T. Kadonaga, Department of Biochemistry, University of Califor
nia, Berkeley, California 94720
Kamel Khalili, Laboratory of Molecular Virology, National Cancer In
stitute, National Institutes of Health, Bethesda, Maryland 20892
Jaspal S. Khillan, Laboratory of Molecular Genetics, National Institute
of Child Health and Human Development, National Institutes of Health,
Bethesda, Maryland 20892
George Khoury, Laboratory of Molecular Virology, National Cancer In
stitute, National Institutes of Health, Bethesda, Maryland 20892
Frank A. Laski, Department of Biochemistry, University of California,
Berkeley, California 94720
Catherine D. Lewis, Laboratory of Molecular Biology, National Institute
of Diabetes, and Digestive and Kidney Diseases, National Institutes of
Health, Bethesda, Maryland 20892
Michael R. Lieber, Laboratory of Molecular Biology, National Institute
of Diabetes, and Digestive and Kidney Diseases, National Institutes of
Health, Bethesda, Maryland 20892
Dan R. Littman, Howard Hughes Medical Institute, College of Physicians
and Surgeons, Columbia University, New York, New York 10032
VllI Contributors
Paul J. Maddon, Department of Biochemistry and Molecular Biophysics,
College of Physicians and Surgeons, Columbia University, New York,
New York 10032
Kathleen A. Mahon, Laboratory of Molecular Genetics, National Insti
tute of Child Health and Human Development, National Institutes of
Health, Bethesda, Maryland 20892
J. Steven McDougal, Immunology Branch, Centers for Disease Control,
Atlanta, Georgia 30333
Rolf Menzel, Laboratory of Molecular Biology, National Institute of Di
abetes, and Digestive and Kidney Diseases, National Institutes of Health,
Bethesda, Maryland 20892. Present address: Department of Research
and Development, DuPont de Nemours, Wilmington, Delaware 19898.
Hillary C. M. Nelson, Department of Biology, Massachusetts Institute of
Technology, Cambridge, Massachusetts 02139
Joanne M. Nickol, Laboratory of Molecular Biology, National Institute
of Diabetes, and Digestive and Kidney Diseases, National Institutes of
Health, Bethesda, Maryland 20892
Paul A. Overbeek, Laboratory of Molecular Genetics, National Institute
of Child Health and Human Development, National Institutes of Health,
Bethesda, Maryland 20892
Andrew Pakula, Department of Biology, Massachusetts Institute of Tech
nology, Cambridge, Massachusetts 02139
Joram Piatigorsky, Laboratory of Molecular and Developmental Biology,
National Eye Institute, National Institutes of Health, Bethesda, Maryland
20892
Dimitrina Pravtcheva, Department of Biology, Yale University, New Ha
ven, Connecticut 06511
Mark Rabin, Department of Biology, Yale University, New Haven, Con
necticut 06511
Contributors IX
Donald C. Rio, Department of Biochemistry, University of California,
Berkeley, California 94720
James M. Roberts, Department of Genetics, Fred Hutchinson Cancer Re
search Center, Seattle, Washington 98104
Gerald M. Rubin, Department of Biochemistry, University of California,
Berkeley, California 94720
Frank H. Ruddle, Department of Biology, Yale University, New Haven,
Connecticut 06511
Robert T. Sauer, Department of Biology, Massachusetts Institute of Tech
nology, Cambridge, Massachusetts 02139
Azriel Schmidt, Laboratory of Molecular Biology, Division of Cancer Bi
ology and Diagnosis, National Cancer Institute, National Institutes of
Health, Bethesda, Maryland 20892
Marc J. Schulman, Department of Immunology, University of Toronto,
Toronto, Ontario, Canada M5S 1A8
Philippe Soriano, Whitehead Institute for Biomedical Research, Mas
sachusetts Institute of Technology, Cambridge, Massachusetts 02142
David Straus, Department of Bacteriology, University of Wisconsin,
Madison, Wisconsin 53706
Robert Tjian, Department of Biochemistry, University of California, Ber
keley, California 94720
William Walter, Department of Bacteriology, University of Wisconsin,
Madison, Wisconsin 53706
Harold Weintraub, Department of Genetics, Fred Hutchinson Cancer Re
search Center, Seattle, Washington 98104
Robin A. Weiss, Institute of Cancer Research, Chester Beatty Laborato
ries, London SW3 6JB, England
