New Arrhythmia Technologies

307 Pages·2005·4.9 MB·English

by  Paul J. Wang MD

New Arrhythmia
Technologies
EDITED BY
Paul J. Wang,
MD
Director,Cardiac Arrhythmia Service and Cardiac Electrophysiology Laboratory
Professor ofMedicine
Stanford University Medical Center
AND CO-EDITORS
Gerald V. Naccarelli, MD
Chief,Division ofCardiology
Professor ofMedicine
Penn State University College ofMedicine
Michael R. Rosen, MD
Gustavus A.Pfeiffer Professor ofPharmacology
Professor ofPediatrics
Director,Center for Molecular Therapeutics
Columbia University
N.A. Mark Estes III, MD
Director,Cardiac Arrhythmia Service
Professor ofMedicine
Tufts New England Medical Center
David L. Hayes, MD
Chair,Division ofCardiovascular Diseases
Professor ofMedicine
Mayo Clinic
David E. Haines, MD
Director,Heart Rhythm Center
William Beaumont Hospital

New Arrhythmia Technologies
To our families and the memories ofall those
who have inspired us to look toward the future.
New Arrhythmia
Technologies
EDITED BY
Paul J. Wang,
MD
Director,Cardiac Arrhythmia Service and Cardiac Electrophysiology Laboratory
Professor ofMedicine
Stanford University Medical Center
AND CO-EDITORS
Gerald V. Naccarelli, MD
Chief,Division ofCardiology
Professor ofMedicine
Penn State University College ofMedicine
Michael R. Rosen, MD
Gustavus A.Pfeiffer Professor ofPharmacology
Professor ofPediatrics
Director,Center for Molecular Therapeutics
Columbia University
N.A. Mark Estes III, MD
Director,Cardiac Arrhythmia Service
Professor ofMedicine
Tufts New England Medical Center
David L. Hayes, MD
Chair,Division ofCardiovascular Diseases
Professor ofMedicine
Mayo Clinic
David E. Haines, MD
Director,Heart Rhythm Center
William Beaumont Hospital
© 2005 by Blackwell Publishing
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First published 2005
ISBN-13:978-1-4051-3293-0
ISBN-10:1-4051-3293-0
Library ofCongress Cataloging-in-Publication Data
New arrhythmia technologies/edited by Paul J.Wang … [et al.].
p.;cm.
Includes bibliographical references and index.
ISBN-13:978-1-4051-3293-0 (alk.paper)
ISBN-10:1-4051-3293-0 (alk.paper)
1.Arrhythmia–Treatment–Technological innovations.
[DNLM:1. Arrhythmia–therapy.2. Anti–Arrhythmia Agents–therapeutic use.
3. Defibrillators.4. Electric Countershock–methods. WG 330 N532 2005] I.Wang,Paul J.
RC685.A65N49 2005
616.1(cid:2)28–dc22 2005004581
A catalogue record for this title is available from the British Library
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Contents
List ofContributors,vii 6 Gene and cell therapy for sinus and AV nodal
Preface,xiii dysfunction,54
Peter Danilo,Jr.,Steven Girouard,Peter
R Brink,Ira S.Cohen,Richard B.Robinson,
Part I Advances in antiarrhythmic Michael R.Rosen
pharmacologic therapy
7 Gene therapy for cardiac tachyarrhythmias,65
Gerald V.Naccarelli (Section Editor)
J.Kevin Donahue,Amy D.McDonald,
1 New antiarrhythmic pharmacologic therapies Alexander Bauer,Kan Kikuchi,Tetsuo Sasano
and regulatory issues in antiarrhythmic drug
development,3
Heather M.Ross,Peter R.Kowey,Gerald Part III Monitoring, noninvasive
V.Naccarelli mapping, risk assessment, and
external defibrillation
2 New frontiers in antithrombotic therapy for N.A.Mark Estes III (Section Editor)
atrial fibrillation,14
8 New developments in noninvasive rhythm
James A.Reiffel
monitoring,implantable hemodynamic
monitoring,functional status monitoring,
and noninvasive mapping,75
Part II Future of antiarrhythmic
Jonathan Weinstock,Munther K.Homoud,
therapy
Mark S.Link,N.A.Mark Estes III
Michael R.Rosen (Section Editor)
9 Techniques ofprediction ofarrhythmia
3 Principles ofpharmacogenomics:Focus on
occurrence and stratification for sudden
arrhythmias,31
cardiac death,84
Dan M.Roden
Aseem D.Desai,Bradley P.Knight
4 The cardiac sodium-channel carboxy terminus:
10 Beta-blocker efficacy in long-QT syndrome
predicted and detected structure provide a
patients with mutations in the pore and
novel target for antiarrhythmic drugs
nonpore regions ofthe hERG potassium-
development,36
channel gene,91
Robert S.Kass,Joseph W.Cormier,
Arthur J.Moss,Derick R.Peterson,Wojciech
Ian W.Glaaser
Zareba,Rahul Seth,Scott A.McNitt,Mark
5 Embryonic stem-cell-derived cardiomyocytes L.Andrews,Ming Qi,Michael J.Ackerman,
as a model for arrhythmia,48 Jesaia Benhorin,Elizabeth S.Kaufman,Jennifer
J.Hescheler,M.Halbach,Z.J.Lu,H.Bohlen, L.Robinson,Jeffrey A.Towbin,G.Michael
B.K.Fleischmann,M.Reppel Vincent,Li Zhang
v
vi Contents
11 New developments in out-of-hospital cardiac 19 Arrhythmia prevention and termination
defibrillation:evaluation ofAED strategies,95 algorithms,178
Robert J.Myerburg,Shaurtelle Elliot,Donald Gregory Engel,Paul J.Wang,Amin Al-Ahmad
G.Rosemberg,Alberto Interian Jr.,Agustin
20 New lead designs and lead-less systems,187
Castellanos
Kenneth A.Ellenbogen,Bruce D.Gunderson,
Mark A.Wood
Part IV Advances in pacing 21 Optimization ofdefibrillation function,197
David L.Hayes (Section Editor) Michael R.Gold,Paul J.DeGroot
12 Sensor and sensor integration,111 22 Remote web-based device monitoring,206
Robert F.Rea Edmund Keung,Yang Xue
23 New ICD indications,219
13 New electrode and lead designs for
Erik Sirulnick,Amin Al-Ahmad,Paul J.Wang
pacemakers,119
Charles J.Love
Part VI Advances in catheter
14 Current concepts in intravascular pacemaker
surgical ablation
and defibrillator lead extraction,124
David E.Haines (Section Editor)
Dhanunjaya R.Lakkireddy,Atul Verma,Bruce
L.Wilkoff 24 Advances in surgical ablation devices for atrial
fibrillation,233
15 Left ventricular epicardial lead implantation: Spencer J.Melby,Anson M.Lee,Ralph J.
Anatomy,techniques,and tools,134 Damiano,Jr.
Jennifer Cummings,William Belden,Bruce L.
25 Epicardial access:present and future
Wilkoff
applications for interventional
16 New resynchronization lead systems and electrophysiologists,242
devices,145 Robert A.Schweikert,Andre Natale
Robert F.Rea
26 Advances in catheter control devices,257
17 New indications for pacing,154 Girish Narayan,Paul J.Wang,
David L.Hayes Amin Al-Ahmad
27 Advances in energy sources in catheter
ablation,262
Part V Advances in implantable
David E.Haines
defibrillators
Paul J.Wang (Section Editor) 28 New ablation paradigms:Anatomic ablation of
complex arrhythmia substrates,274
18 Implantable defibrillator sensing and
David J.Callans
discrimination algorithms,163
Kelly Richardson,Amin Al-Ahmad,
Paul J.Wang Index, 283
Contributors
Michael J. Ackerman, MD, PhD David J. Callans, MD
Director,LQTS Clinic and Sudden Death Professor ofMedicine,University ofPennsylvania
Genomics Laboratory, Hospital ofthe University ofPhiladelphia,PA,
Mayo Clinic,Rochester,MN,USA USA
Amin Al-Ahmad, MD Agustin Castellanos, MD
Associate Director ofCardiac Arrhythmia Service Professor ofMedicine,Division ofCardiology
Cardiac Arrhythmia Service, Miller School ofMedicine,
Standford University Medical Center University ofMiami
Stanford,CA,USA Miami,FL,USA
Mark L. Andrews, BBS Ira S. Cohen, PhD
Analyst/Programmer
Leading Professor ofPhysiology and Biophysics;
University ofRochester Medical Center
Director ofthe Institute ofMolecular Cardiology
Rochester,NY,USA
Health Sciences Center,Stony Brook University
Stony Brook,NY,USA
Alexander Bauer, MD
Johns Hopkins Unviersity School ofMedicine Joseph W. Cormier, PhD
Baltimore,MD,USA
Graduate Research Assistant
William Belden, MD Department ofPharmacology,
Columbia University
Fellow in Electrophysiology,
New York,NY,USA
Cleveland Clinic Foundation,Cleveland Clinic
Cleveland,OH,USA
Jennifer Cummings, MD
Jesaia Benhorin, MD Associate Staff
Cleveland Clinic Foundation
Professor ofMedicine
Cleveland,OH,USA
The Heiden Department ofCardiology,
Bikur Cholim Hospital
Jerusalem,Israel Ralph J. Damiano, Jr, MD
John M.Shoenberg Professor ofSurgery,
Heribert Bohlen, PhD ChiefofCardiac Surgery,
Director ofAxiogenesis AG Washington University School of
Axiogenesis AG Medicine at Barnes Jewish Hospital
Cologne,Germany St Louis,MO,USA
Peter R. Brink, PhD Peter Danilo, Jr, PhD
Professor and Chairman, Senior Research Scientist
Department ofPhysiology and Biophysics Department ofPharmacology,
Health Sciences Center, Center for Molecular Therapeutics,
Stony Brook University Columbia University
Stony Brook,NY,USA New York,NY,USA
vii