Neurodevelopment and Schizophrenia

507 Pages·2004·9.502 MB·English

by  Matcheri S. Keshavan, James L. Kennedy, Robin M. Murray

Neurodevelopment and Schizophrenia
Sincetheearly1990s,developmentalneurobiologyhasmadeimportantstridestowardseluci-
datingthepathophysiologyofpsychiatricdisorders.Nowherehasthislinkbetweenbasicscience
andclinicalinsightsbecomemoreevidentthaninthefieldofschizophreniaresearch.Inthis
volume,theeditorsbringtogethersomeofthemostactiveinvestigatorsinthisfield.Eachcon-
tributorprovidesanup-to-dateoverviewoftherelevantresearch,includingdirectionsforfurther
investigation.
Thebookbeginswithasectiononadvancesindevelopmentalneurobiology.Thisisfollowed
bysectionsonetiologicalandpathophysiologicaldevelopments,andmodelsthatintegratethis
knowledge.Thefinalsectionaddressestheclinicalinsightsthatemergefromthedevelopmental
modelsandsetsthesceneforfutureeffortsatearlydetectionandpreventionofschizophrenia.
Thisbookwillbevaluabletoresearchersinpsychiatryandneurobiology,studentsinmedicine
andpsychology,andallmentalhealthpractitioners.
http://avaxhome.ws/blogs/ChrisRedfield

Neurodevelopment and
Schizophrenia
Editedby
Matcheri S. Keshavan
UniversityofPittsburghandWesternPsychiatricInstituteandClinic,
Pittsburgh,PAandWayneStateUniversity,Detroit,MI,USA
James L. Kennedy
UniversityofTorontoCentreforMentalHealthandAddiction,
Toronto,Canada
and
Robin M. Murray
King’sCollegeLondonandInstituteofPsychiatry,London,UK
published by the press syndicate of the university of cambridge
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Firstpublished2004
PrintedintheUnitedKingdomattheUniversityPress,Cambridge
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LibraryofCongressCataloginginPublicationdata
Neurodevelopmentandschizophrenia/[editedby]MatcheriS.Keshavan,
JamesL.Kennedy,RobinM.Murray.
p. cm.
Includesbibliographicalreferencesandindex.
ISBN0521823315(hardback)
1.Schizophrenia–Etiology. 2.Schizophrenia–Pathophysiology. 3.Developmentalneurobiology.
4.Brain–Growth. I.Keshavan,MatcheriS.,1953– II.Kennedy,JamesL. III.Murray,Robin,M.
[DNLM:1.Brain–growth&development. 2.Schizophrenia–etiology. 3.Brain–abnormalities.
4.Models,neurological. 5.Neurobiology–methods. WM203N49318 2004]
RC514.N4433 2004
616.89(cid:2)8071–dc22 2004045710
ISBN0521823315hardback
ThepublisherhasuseditsbestendeavorstoensurethattheURLsforexternalwebsitesreferredtointhis
bookarecorrectandactiveatthetimeofgoingtopress.However,thepublisherhasnoresponsibilityfor
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inaccordwithacceptedstandardsandpracticeatthetimeofpublication.Nevertheless,theauthors,editors,
andpublishercanmakenowarrantiesthattheinformationcontainedhereinistotallyfreefromerror,not
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Contents
Listofcontributors page viii
Foreword xiii
Preface xvii
Part I Basic aspects
1 Genesandbraindevelopment 3
TimothyA.Klempan,PierandreaMuglia,andJamesL.Kennedy
2 Braindevelopmentinhealthychildrenandadolescents:magnetic
resonanceimagingstudies 35
JayN.Giedd,MichaelA.Rosenthal,A.BlytheRose,JonathanD.Blumenthal,
ElizabethMolloy,RichardR.Dopp,LivS.Clasen,DanielJ.Fridberg,andNitinGogtay
3 Cognitivedevelopment:functionalmagneticresonanceimagingstudies 45
BeatrizLunaandJohnA.Sweeney
4 Cognitivedevelopmentinadolescence:cerebralunderpinnings,neural
trajectories,andtheimpactofaberrations 69
StephenJ.Wood,CinziaR.DeLuca,VickiAnderson,andChristosPantelis
5 Brainplasticityandlong-termfunctionafterearlycerebralinsult:the
exampleofverypretermbirth 89
MatthewAllin,ChiaraNosarti,LarryRifkin,andRobinM.Murray
Part II Etiological factors
6 Dodegenerativechangesoperateacrossdiagnosticboundaries?The
caseforglucocorticoidinvolvementinmajorpsychiatricdisorders 111
CarmineM.ParianteandDavidCotter
7 Velo-cardio-facialsyndrome(deletion22q11.2):ahomogeneous
neurodevelopmentalmodelforschizophrenia 121
StephanEliezandCarlFeinstein
v
vi Contents
8 Canstructuralmagneticresonanceimagingprovideanalternative
phenotypeforgeneticstudiesofschizophrenia? 138
ColmMcDonaldandRobinM.Murray
9 Nutritionalfactorsandschizophrenia 156
SahebaraoP.Mahadik
10 Schizophrenia,neurodevelopment,andepigenetics 174
ArturasPetronis
11 Earlyenvironmentalriskfactorsforschizophrenia 191
MaryCannon,KimberlieDean,andPeterB.Jones
12 Transcriptomesinschizophrenia:assessingalteredgeneexpressionwith
microarrays 210
DavidA.Lewis,KarolyMirnics,andPatLevitt
13 Istherearoleforsocialfactorsinacomprehensivedevelopmentmodel
forschizophrenia? 224
JaneBoydell,JimvanOs,andRobinM.Murray
14 Howdoesdrugabuseinteractwithfamilialanddevelopmentalfactors
intheetiologyofschizophrenia? 248
Chih-KenChenandRobinM.Murray
Part III Pathophysiology
15 Developmentaldysregulationofthedopaminesystemandthe
pathophysiologyofschizophrenia 273
AnthonyA.Grace
16 Thedevelopmentof“mis-wired”limbiclobecircuitryinschizophrenia
andbipolardisorder 295
FrancineM.Benes
17 Developmentofthalamocorticalcircuitryandthepathophysiologyof
schizophrenia 310
DarleneS.MelchitzkyandDavidA.Lewis
18 Xchromosome,estrogen,andbraindevelopment:implicationsfor
schizophrenia 330
MichaelCraig,WilliamCutter,RayNorbury,andDeclanMurphy
19 Premorbidstructuralabnormalitiesinschizophrenia 347
StephenM.Lawrie
vii Contents
20 Neurodegenerativemodelsofschizophrenia 373
L.FredrikJarskog,JohnH.Gilmore,andJeffreyA.Lieberman
21 Doesdisorderedbraindevelopmentoccuracrossdiagnostic
boundaries? 390
ChristianW.Kreipke,DavidR.Rosenberg,andMatcheriS.Keshavan
Part IV Clinical implications
22 Canoneidentifypreschizophreniachildren? 415
EugeniaKravariti,PaolaDazzan,PaulFearon,andRobinM.Murray
23 High-riskstudies,braindevelopment,andschizophrenia 432
MatcheriS.Keshavan
24 Developmentalmodelsandhypothesis-drivenearlyinterventionsin
schizophrenia 455
MatcheriS.KeshavanandBarbaraA.Cornblatt
Index 473
Theplatesaresituatedbetweenpages190and191.
Contributors
MatthewAllin MaryCannon
InstituteofPsychiatryatTheMaudsleyand DivisionofPsychologicalMedicine,
DepartmentofPsychiatry,King’sCollege InstituteofPsychiatry,DeCrespigny
London,DeCrespignyPark,London Park,DenmarkHill,London
SE58AF,UK SE58AF,UK
VickiAnderson Chih-KenChen
DepartmentofPsychology,University DepartmentofPsychiatry,ChangGung
ofMelbourneandtheMurdoch MemorialHospital,222Mai-ChinRoad,
Children’sResearchInstitute,Royal Keelung,Taiwan
Children’sHospital,Melbourne,
Australia LivS.Clasen
ChildPsychiatryBranch,NationalInstitute
FrancineM.Benes ofMentalHealth,NationalInstitutesof
PrograminStructuralandMolecular Health,Bethesda,MD20892,
Neuroscience,McLeanHospital,Belmont USA
andPrograminNeuroscienceand
DepartmentofPsychiatry,Harvard BarbaraA.Cornblatt
MedicalSchool,Boston,MA, RecognitionandPrevention(RAP)
USA Program,444LakevilleRoad,LakeSuccess,
NY11042,USA
JonathanD.Blumenthal
ChildPsychiatryBranch,NationalInstitute DavidCotter
ofMentalHealth,National DivisionofPsychologicalMedicine,
InstitutesofHealth,Bethesda, InstituteofPsychiatry,DeCrespignyPark,
MD20892,USA DenmarkHill,LondonSE58AF,UK
JaneBoydell MichaelCraig
InstituteofPsychiatryatTheMaudsleyand DivisionofPsychologicalMedicine,
DepartmentofPsychiatry,King’sCollege InstituteofPsychiatry,DeCrespignyPark,
London,DeCrespignyPark,London DenmarkHill,London
SE58AF,UK SE58AF,UK
viii
ix Listofcontributors
WilliamCutter CarlFeinstein
DivisionofPsychologicalMedicine, StanfordUniversitySchoolofMedicine,
InstituteofPsychiatry,DeCrespignyPark, 401QuarryRoad,Stanford,CA
DenmarkHill,London 94305–5719,USA
SE58AF,UK
DanielJ.Fridberg
PaolaDazzan ChildPsychiatryBranch,National
DivisionofPsychologicalMedicine, InstituteofMentalHealth,National
InstituteofPsychiatry,DeCrespigny InstitutesofHealth,Bethesda,MD20892,
Park,DenmarkHill,London USA
SE58AF,UK
JayN.Giedd
KimberlieDean ChildPsychiatryBranch,National
DivisionofPsychologicalMedicine, InstituteofMentalHealth,National
InstituteofPsychiatry,DeCrespignyPark, InstitutesofHealth,Bethesda,MD20892,
DenmarkHill,LondonSE58AF,UK USA
CinziaR.DeLuca JohnH.Gilmore
DepartmentsofPsychologyandPsychiatry, DepartmentofPsychiatry,UNCConte
UniversityofMelbourneandMelbourne CenterforNeuroscienceofMental
NeuropsychiatryCentre,Sunshine Disorders,UniversityofNorthCarolina
Hospital,Melbourne, SchoolofMedicine,ChapelHill,NC27599,
Australia USA
RichardR.Dopp NitinGogtay
ChildPsychiatryBranch,National ChildPsychiatryBranch,NationalInstitute
InstituteofMentalHealth,National ofMentalHealth,NationalInstitutesof
InstitutesofHealth,Bethesda,MD20892, Health,Bethesda,MD20892,
USA USA
StephanEliez AnthonyA.Grace
DivisionofChildandAdolescent DepartmentofNeuroscience,
Psychiatry,UniversityofGenevaSchoolof 458CrawfordHall,Universityof
Medicine,41CheminCrts-de-Champel, Pittsburgh,Pittsburgh,PA15206,
1206Geneva,Switzerland USA
PaulFearon L.FredrikJarskog
DivisionofPsychologicalMedicine, DepartmentofPsychiatry,UNCConte
InstituteofPsychiatryatthe CenterforNeuroscienceofMental
MaudsleyNHSTrust,DeCrespignyPark, Disorders,UniversityofNorthCarolina
DenmarkHill,LondonSE58AF, SchoolofMedicine,ChapelHill,NC27599,
UK USA