Neurobiology of Aggression: Understanding and Preventing Violence

336 Pages·2003·5.55 MB·English

by  Mark P Mattson

NNeeuurroobbiioollooggyy ooff
AAggggrreessssiioonn
UUnnddeerrssttaannddiinngg
aanndd PPrreevveennttiinngg VViioolleennccee
EEddiitteedd bbyy
MMaarrkk PP.. MMaattttssoonn
Neurobiology of Aggression
Contemporary Neuroscience
Neurobiology of Aggression: Understanding Highly Selective Neurotoxins: Basic and
and Preventing Violence, edited by Mark Clinical Applications, edited by Richard
P. Mattson, 2003 M. Kostrzewa, 1998
Neuroinflammation: Mechanisms and Neuroinflammation: Mechanisms and
Management, Second Edition, edited by Management, edited by Paul L. Wood,
Paul L. Wood, 2003 1998
Neural Stem Cells for Brain and Spinal Cord Neuroprotective Signal Transduction, edited
Repair, edited by Tanja Zigova, Evan Y. by Mark P. Mattson, 1998
Snyder, and Paul R. Sanberg, 2002
Clinical Pharmacology of Cerebral
Neurotransmitter Transporters: Structure,
Ischemia, edited by Gert J. Ter Horst and
Function, and Regulation, 2/e, edited by
Jakob Korf, 1997
Maarten E. A. Reith, 2002
Molecular Mechanisms of Dementia, edited
The Neuronal Environment: Brain Homeostasis
by Wilma Wasco and Rudolph E. Tanzi,
in Health and Disease, edited by Wolfgang
1997
Walz, 2002
Neurotransmitter Transporters: Structure,
Pathogenesis of Neurodegenerative Disorders,
Function, and Regulation, edited by
edited by Mark P. Mattson, 2001
Maarten E. A. Reith, 1997
Stem Cells and CNS Development, edited by
Motor Activity and Movement Disorders:
Mahendra S. Rao, 2001
Research Issues and Applications,
Neurobiology of Spinal Cord Injury, edited
edited by Paul R. Sanberg, Klaus-Peter
by Robert G. Kalb and Stephen M.
Ossenkopp, and Martin Kavaliers, 1996
Strittmatter, 2000
Neurotherapeutics: Emerging Strategies,
Cerebral Signal Transduction: From First to
edited by Linda M. Pullan and Jitendra
Fourth Messengers, edited by Maarten E.
Patel, 1996
A. Reith, 2000
Neuron–Glia Interrelations During Phylog-
Central Nervous System Diseases: Innovative
eny: II. Plasticity and Regeneration,
Animal Models from Lab to Clinic, edited
edited by Antonia Vernadakis and
by Dwaine F. Emerich, Reginald L.
Betty I. Roots, 1995
Dean, III,
and Paul R. Sanberg, 2000 Neuron–Glia Interrelations During
Mitochondrial Inhibitors and Neurodegen- Phylogeny: I. Phylogeny
erative Disorders, edited by Paul R. and Ontogeny of Glial Cells, edited by
Sanberg, Hitoo Nishino, and Cesario V. Antonia Vernadakis
Borlongan, 2000 and Betty I. Roots, 1995
Cerebral Ischemia: Molecular and Cellular The Biology of Neuropeptide Y and Related
Pathophysiology, edited by Wolfgang Peptides, edited by William F. Colmers
Walz, 1999 and Claes Wahlestedt, 1993
Cell Transplantation for Neurological Psychoactive Drugs: Tolerance and Sensitiza-
Disorders, edited by Thomas B. Freeman tion, edited by A. J. Goudie and M. W.
and Håkan Widner,1998 Emmett-Oglesby, 1989
Gene Therapy for Neurological Disorders and Experimental Psychopharmacology, edited
Brain Tumors, edited by E. Antonio by Andrew J. Greenshaw and Colin T.
Chiocca and Xandra O. Breakefield, 1998 Dourish, 1987
Neurobiology of
Aggression
Understanding and Preventing Violence
Edited by
Mark P. Mattson,
PhD
National Institute on Aging, Baltimore, MD
Humana Press Totowa, New Jersey
© 2003 Humana Press Inc.
999 Riverview Drive, Suite 208
Totowa, New Jersey 07512
www.humanapress.com
All rights reserved.
No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means,
electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the
Publisher.
All papers, comments, opinions, conclusions, or recommendations are those of the author(s), and do not necessarily
reflect the views of the publisher.
For additional copies, pricing for bulk purchases, and/or information about other Humana titles, contact Humana at
the above address or at any of the following numbers: Tel.: [phone]; Fax: [phone]; E-mail:
[email protected], or visit our Website: www.humanapress.com
This publication is printed on acid-free paper. ∞
ANSI Z39.48-1984 (American Standards Institute) Permanence of Paper for Printed Library Materials.
Brain illustration provided by Mark P. Mattson.
Cover design by Patricia F. Cleary.
Photocopy Authorization Policy:
Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted
by Humana Press Inc., provided that the base fee of US $20 is paid directly to the Copyright Clearance Center at 222
Rosewood Drive, Danvers, MA 01923. For those organizations that have been granted a photocopy license from the
CCC, a separate system of payment has been arranged and is acceptable to Humana Press Inc. The fee code for users
of the Transactional Reporting Service is: [1-58829-188-X/03 $20].
Printed in the United States of America. 10 9 8 7 6 5 4 3 2 1
Library of Congress Cataloging-in-Publication Data
Neurobiology of aggression: understanding and preventing violence / edited by Mark P. Mattson.
p. cm.
Includes bibliographical references and index.
ISBN 1-58829-188-X (hb); 1-59259-382-8 (e-book)
1. Aggressiveness—Physiological aspects. 2. Aggressiveness—Social aspects. 3. Aggressiveness—
Treatment. 4. Violence—Prevention. 5. Violence—Physiological aspects.
I. Mattson, Mark Paul.
RC569.5.A342 N486 2003
616.85'–dc21 2002032942
Preface
Aggression is a highly conserved behavioral adaptation that evolved to help organ-
isms compete for limited resources and thereby ensure their survival. However, in
modern societies where resources such as food, shelter, etc. are not limiting, aggres-
sion has become a major cultural problem worldwide presumably because of its deep
seeded roots in the neuronal circuits and neurochemical pathways of the human brain.
In Neurobiology of Aggression: Understanding and Preventing Violence, leading
experts in the fields of the neurobiology, neurochemistry, genetics, and behavioral
and cultural aspects of aggression and violence provide a comprehensive collection of
review articles on one of the most important cross-disciplinary issues of our time.
Rather than summarize the topics covered by each author in each chapter, I present a
schematic diagram to guide the reader in thinking about different aspects of aggres-
sive and violent behavior from its neurobiological roots to environmental factors that
can either promote or prevent aggression to visions of some of the most horrific acts
of violence of our times, and then towards the development of strategies to reduce
aggressive behavior and prevent violence.
It is hoped that Neurobiology of Aggression: Understanding and Preventing Vio-
lence will foster further research aimed at understanding the environmental genetic and
neurochemical roots of aggression and how such information can be used to move
forward towards the goal of eliminating violence.
Mark P. Mattson, PhD
v

Contents
Preface...................................................................................................................v
Contributors....................................................................................................... ix
1 Cortical and Limbic Neural Circuits Mediating Aggressive Behavior
Thomas R. Gregg .................................................................................................1
2 Emotion Regulation: An Affective Neuroscience Approach
R. James R. Blair and Dennis S. Charney ...................................................21
3 The Serotonergic Dimension of Aggression and Violence
Klaus Peter Lesch ............................................................................................33
4 The Neurochemical Genetics of Serotonin in Aggression,
Impulsivity, and Suicide
Mark D. Underwood and J. John Mann .......................................................65
5 Behavioral and Neuropharmacological Differentiation
of Offensive and Defensive Aggression in Experimental
and Seminaturalistic Models
Philip M. Wall, D. Caroline Blanchard, and Robert J. Blanchard..........73
6 Neuroendocrine Stress Responses and Aggression
Jozsef Haller and Menno R. Kruk ..................................................................93
7 Y Chromosome and Antisocial Behavior
Pierre L. Roubertoux and Michèle Carlier ...............................................119
8 Aggression in Psychiatric Disorders
Shari R. Kohn and Gregory M. Asnis .........................................................135
9 Aggression in Brain Injury, Aging, and Neurodegenerative
Disorders
Mark P. Mattson ...........................................................................................151
10 Environmental Factors and Aggression in Nonhuman Primates
Michael Lawrence Wilson ............................................................................167
11 Aggression, Biology, and Context: Dejá-Vù All Over Again?
Rebecca M. Young and Evan Balaban .......................................................191
12 The Family Environment in Early Life and Aggressive Behavior
in Adolescents and Young Adults
Sven Barnow and Harald-J. Freyberger ....................................................213
vii
viii Contents
13 Television and Movies, Rock Music and Music Videos,
and Computer and Video Games: Understanding and
Preventing Learned Violence in the Information Age
Susan Villani and Nandita Joshi.................................................................231
14 Social Drinking and Aggression
Kathryn Graham .............................................................................................253
15 Cognitive-Behavioral Intervention for Childhood Aggressions
Cynthia Hudley ...............................................................................................275
16 Pharmacological Intervention in Aggression
Debra V. McQuade, R. Joffree Barrnett, and Bryan H. King ..................289
Index ...............................................................................................................315
Contributors
GREGORY M. ASNIS, MD • Department of Psychiatry, Albert Einstein College
of Medicine, Montefiore Medical Center, Bronx, NY
EVAN BALABAN • Neurosciences Program, CUNY CSI, Staten Island, NY
R. JOFFREE BARRNETT • Dartmouth Medical School, Hanover, NH
SVEN BARNOW, PhD • Department of Psychiatry and Psychotherapy of the Ernst-
Moritz-Arndt University Greifswald, Medical Centre of Stralsund, Germany
R. JAMES R. BLAIR • Mood and Anxiety Disorders Program, National Institute
of Mental Health, Bethesda, MD
D. CAROLINE BLANCHARD, PhD • Pacific Biomedical Research Center, and Division
of Neuroscience, John A. Burns School of Medicine, University of Hawaii,
Honolulu, HI
ROBERT J. BLANCHARD, PhD • Department of Psychology and Pacific Biomedical
Research Center, University of Hawaii, Honolulu, HI
MICHÈLE CARLIER • Centre de recherche PsyCLÉ (Connaissance, Langage, Émotion),
Université de Provence, France
DENNIS S. CHARNEY • Mood and Anxiety Disorders Program, National Institute
of Mental Health, Bethesda, MD
HARALD-J. FREYBERGER • Department of Psychiatry and Psychotherapy of the Ernst-
Moritz-Arndt University Greifswald, Medical Centre of Stralsund, Germany
KATHRYN GRAHAM, PhD • Senior Scientist and Head, Social Factors and Prevention
Initiatives, Social, Prevention and Health Policy Research Department,
Centre for Addiction and Mental Health, London, Ontario, Canada
THOMAS R. GREGG, MA • Department of Neurosciences, University of Medicine
and Dentistry, Newark, NJ
JOZSEF HALLER, PhD • Institute of Experimental Medicine, Budapest, Hungary
CYNTHIA HUDLEY • Rossier School of Education, University of Southern California,
Los Angeles, CA
NANDITA JOSHI, MBBS • Department of Child Psychiatry, Johns Hopkins University,
Baltimore, MD
BRYAN H. KING • Dartmouth Medical School, Hanover, NH
SHARI R. KOHN, PhD • Department of Psychiatry, Albert Einstein College of Medicine,
Montefiore Medical Center, Bronx, NY
MENNO R. KRUK • Department of Medical Pharmacology, Leiden University,
The Netherlands
KLAUS PETER LESCH, MD • Department of Psychiatry and Psychotherapy, University
of Würzburg, Würzberg, Germany
J. JOHN MANN, MD • Department of Neuroscience, New York State Psychiatric Institute,
and Department of Psychiatry, Columbia University College of Physicians and
Surgeons, New York, NY
ix