Neurobiological Mechanisms of Acupuncture

209 Pages·2013·35.54 MB·English

Evidence-Based Complementary and Alternative Medicine
Neurobiological Mechanisms
of Acupuncture
Guest Editors: Lijun Bai, Richard E. Harris, Jian Kong, Lixing Lao, Vitaly Napadow,
and Baixiao Zhao
Neurobiological Mechanisms of Acupuncture
Evidence-Based Complementary and Alternative Medicine
Neurobiological Mechanisms of Acupuncture
Guest Editors: Lijun Bai, Richard E. Harris, Jian Kong,
Lixing Lao, Vitaly Napadow, and Baixiao Zhao
Copyright©2013HindawiPublishingCorporation.Allrightsreserved.
Thisisaspecialissuepublishedin“Evidence-BasedComplementaryandAlternativeMedicine.”Allarticlesareopenaccessarticles
distributedundertheCreativeCommonsAttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninany
medium,providedtheoriginalworkisproperlycited.
Editorial Board
M.AmeenAbdulla,Malaysia Jen-HweyChiu,Taiwan JingHu,China
JonAdams,Australia C.S.Cho,HongKong GanSiewHua,Malaysia
ZurainiAhmad,Malaysia JaeYoulCho,Korea Sheng-TengHuang,Taiwan
U.P.deAlbuquerque,Brazil Seung-HunCho,RepublicofKorea BennyTanKwongHuat,Singapore
GianniAllais,Italy CheeYanChoo,Malaysia RomanHuber,Germany
TerjeAlraek,Norway Li-FangChou,Taiwan AngeloAntonioIzzo,Italy
SoulimanAmrani,Morocco RyowonChoue,RepublicofKorea SureshJadhav,India
AkshayAnand,India Shuang-EnChuang,Taiwan KanokwanJarukamjorn,Thailand
ShrikantAnant,USA Joo-HoChung,RepublicofKorea ZhengL.Jiang,China
ManuelArroyo-Morales,Spain EdwinL.Cooper,USA YongJiang,China
S.M.B.Asdaq,SaudiArabia GregoryD.Cramer,USA StefanieJoos,Germany
SeddighehAsgary,Iran MengCui,China SirajudeenK.N.S.,Malaysia
HyunsuBae,RepublicofKorea R.K.NakamuraCuman,Brazil Z.Kain,USA
LijunBai,China VincenzoDeFeo,Italy OsamuKanauchi,Japan
SandipK.Bandyopadhyay,India R.DelaPuertaVa´zquez,Spain WenyiKang,China
SarangBani,India MartinDescarreaux,USA DaeGillKang,RepublicofKorea
VassyaBankova,Bulgaria AlexandraDeters,Germany Shao-HsuanKao,Taiwan
WinfriedBanzer,Germany S.S.K.Durairajan,HongKong KrishnaKaphle,Nepal
VernonA.Barnes,USA MohamedEddouks,Morocco KenjiKawakita,Japan
SamraBashir,Pakistan ThomasEfferth,Germany JongYeolKim,RepublicofKorea
JairoKenuppBastos,Brazil TobiasEsch,Germany YounChulKim,RepublicofKorea
SujitBasu,USA SaeedEsmaeili-Mahani,Iran Cheorl-HoKim,RepublicofKorea
DavidBaxter,NewZealand NianpingFeng,China YoshiyukiKimura,Japan
Andre-MichaelBeer,Germany YibinFeng,HongKong JoshuaK.Ko,China
AlvinJ.Beitz,USA JosueFernandez-Carnero,Spain ToshiakiKogure,Japan
Y.ChoolBoo,RepublicofKorea JulianoFerreira,Brazil JianKong,USA
FrancescaBorrelli,Italy FabioFirenzuoli,Italy NandakumarKrishnadas,India
GloriaBrusotti,Italy PeterFisher,UK YiuWaKwan,HongKong
IshfaqA.Bukhari,Pakistan W.F.Fong,HongKong KuangChiLai,Taiwan
ArndtBu¨ssing,Germany JoelJ.Gagnier,Canada ChingLan,Taiwan
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RaffaeleCapasso,Italy GabinoGarrido,Chile LixingLao,HongKong
OpherCaspi,Israel M.NabeelGhayur,Pakistan ClaraBik-SanLau,HongKong
HanChae,Korea AnwarulHassanGilani,Pakistan Jang-HernLee,RepublicofKorea
Shun-WanChan,HongKong MichaelGoldstein,USA MyeongSooLee,RepublicofKorea
Il-MooChang,RepublicofKorea MahabirP.Gupta,Panama TatleangLee,Singapore
RajnishChaturvedi,India SveinHaavik,Norway ChristianLehmann,Canada
ChunTaoChe,USA AbidHamid,India MarcoLeonti,Italy
HubiaoChen,HongKong N.Hanazaki,Brazil Ping-ChungLeung,HongKong
Jian-GuoChen,China K.B.Harikumar,India LawrenceLeung,Canada
KevinChen,USA CoryS.Harris,Canada KwokNamLeung,HongKong
Tzeng-JiChen,Taiwan ThierryHennebelle,France PingLi,China
YunfeiChen,China Seung-HeonHong,Korea MinLi,China
Juei-TangCheng,Taiwan MarkusHorneber,Germany ManLi,China
EvanPaulCherniack,USA Ching-LiangHsieh,Taiwan ChunGuangLi,Australia
Xiu-MinLi,USA AndreaPieroni,Italy MeiTian,China
ShaoLi,China RichardPietras,USA EvelinTiralongo,Australia
YongHongLiao,China WarisQidwai,Pakistan StephanieTjen-A-Looi,USA
SabinaLim,Korea XianqinQu,Australia MichaThlTomczyk,Poland
WenChuanLin,China CassandraL.Quave,USA YaoTong,HongKong
Bi-FongLin,Taiwan RojaRahimi,Iran K.V.Trinh,Canada
ChristopherG.Lis,USA KhalidRahman,UK KarlWah-KeungTsim,HongKong
GerhardLitscher,Austria CheppailRamachandran,USA VolkanTugcu,Turkey
I-MinLiu,Taiwan GamalRamadan,Egypt Yew-MinTzeng,Taiwan
KeLiu,China KeRen,USA DawnM.Upchurch,USA
GaofengLiu,China ManHeeRhee,RepublicofKorea MarynaVandeVenter,SouthAfrica
YijunLiu,USA Mee-RaRhyu,RepublicofKorea SandyvanVuuren,SouthAfrica
Cun-ZhiLiu,China Jose´LuisR´ıos,Spain AlfredoVannacci,Italy
GailB.Mahady,USA PaoloRobertidiSarsina,Italy ManiVasudevan,Malaysia
JurajMajtan,Slovakia BasharSaad,PalestinianAuthority CarloVentura,Italy
SubhashC.Mandal,India SumairaSahreen,Pakistan WagnerVilegas,Brazil
JeanineL.Marnewick,SouthAfrica OmarSaid,Israel PradeepVisen,Canada
VirginiaS.Martino,Argentina LuisA.Salazar-Olivo,Mexico AristoVojdani,USA
JamesH.McAuley,Australia Mohd.ZakiSalleh,Malaysia Y.Wang,USA
KarinMeissner,Germany AndreasSandner-Kiesling,Austria Shu-MingWang,USA
AndreasMichalsen,Germany AdairSantos,Brazil ChenchenWang,USA
DavidMischoulon,USA G.Schmeda-Hirschmann,Chile Chong-ZhiWang,USA
SyamMohan,Malaysia AndrewScholey,Australia KenjiWatanabe,Japan
J.Molnar,Hungary VeroniqueSeidel,UK JintanapornWattanathorn,Thailand
Vale´rioMonteiro-Neto,Brazil SenthamilR.Selvan,USA WolfgangWeidenhammer,Germany
Hyung-InMoon,RepublicofKorea TuhinadriSen,India JennyM.Wilkinson,Australia
AlbertMoraska,USA HongcaiShang,China DarrenR.Williams,RepublicofKorea
MarkMoss,UK KarenJ.Sherman,USA HarukiYamada,Japan
YoshiharuMotoo,Japan RonaldSherman,USA NobuoYamaguchi,Japan
FraukeMusial,Germany KuniyoshiShimizu,Japan Yong-QingYang,China
MinKyunNa,RepublicofKorea KanShimpo,Japan JunqingYang,China
RichardL.Nahin,USA Byung-CheulShin,Korea LingYang,China
VitalyNapadow,USA YukihiroShoyama,Japan EunJinYang,RepublicofKorea
F.R.F.Nascimento,Brazil ChangGueSon,Korea XiufenYang,China
ShivanandaNayak,TrinidadAndTobRaagcohidSoulimani,France KenYasukawa,Japan
RolandNdipNdip,SouthAfrica DidierStien,France MinYe,China
IsabellaNeri,Italy Shan-YuSu,Taiwan M.Yoon,RepublicofKorea
T.BenoˆıtNguelefack,Cameroon MohdRoslanSulaiman,Malaysia JieYu,China
MartinOffenbaecher,Germany VenilN.Sumantran,India ZunjianZhang,China
Ki-WanOh,RepublicofKorea JohnR.S.Tabuti,Uganda Jin-LanZhang,China
Y.Ohta,Japan TokuTakahashi,USA WeiboZhang,China
OlumayokunA.Olajide,UK RabihTalhouk,Lebanon HongQ.Zhang,HongKong
ThomasOstermann,Germany YupingTang,China BoliZhang,China
StaceyA.Page,Canada Wen-FuTang,China RuixinZhang,USA
Tai-LongPan,Taiwan LayKekTeh,Malaysia HongZhang,Sweden
BhushanPatwardhan,India MayankThakur,Germany HaiboZhu,China
BeritSmestadPaulsen,Norway MenakaC.Thounaojam,India
Contents
NeurobiologicalMechanismsofAcupuncture,LijunBai,RichardE.Harris,JianKong,LixingLao,
VitalyNapadow,andBaixiaoZhao
Volume2013,ArticleID652457,2pages
EffectsofPretreatmentwithaCombinationofMelatoninandElectroacupunctureinaRatModelof
TransientFocalCerebralIschemia,LingguangLiuandR.T.F.Cheung
Volume2013,ArticleID953162,12pages
ElectroacupunctureStimulationatCV12InhibitsGastricMotilityviaTRPV1Receptor,ZhiYu,XinCao,
YoubingXia,BinbinRen,HongFeng,YaliWang,JingfengJiang,andBinXu
Volume2013,ArticleID294789,6pages
NeuralEncodingofAcupunctureNeedlingSensations:EvidencefromafMRIStudy,XiaolingWang,
Suk-TakChan,JiliangFang,ErikaE.Nixon,JingLiu,KennethK.Kwong,BruceR.Rosen,
andKathleenK.S.Hui
Volume2013,ArticleID483105,15pages
EffectofBeeVenomAcupunctureonOxaliplatin-InducedColdAllodyniainRats,Bong-SooLim,
HakJinMoon,DongXingLi,MunsooGil,JoonKiMin,GiseogLee,HyunsuBae,SunKwangKim,
andByung-IlMin
Volume2013,ArticleID369324,8pages
MultivariateGrangerCausalityAnalysisofAcupunctureEffectsinMildCognitiveImpairment
Patients:AnfMRIStudy,ShangjieChen,LijunBai,MaoshengXu,FangWang,LiangYin,XumingPeng,
XinghuaChen,andXueminShi
Volume2013,ArticleID127271,12pages
MechanismsofElectroacupuncture-InducedAnalgesiaonNeuropathicPaininAnimalModel,
WoojinKim,SunKwangKim,andByung-IlMin
Volume2013,ArticleID436913,11pages
ElectroacupunctureCouldRegulatetheNF-𝜅BSignalingPathwaytoAmelioratetheInflammatory
InjuryinFocalCerebralIschemia/ReperfusionModelRats,Wen-yiQin,YongLuo,LingChen,TaoTao,
YangLi,Yan-liCai,andYa-huiLi
Volume2013,ArticleID924541,15pages
Acupuncture-EvokedResponseinSomatosensoryandPrefrontalCorticesPredictsImmediatePain
ReductioninCarpalTunnelSyndrome,YumiMaeda,NormanKettner,JeungchanLee,JieunKim,
StephenCina,CristinaMalatesta,JessicaGerber,ClaireMcManus,JaehyunIm,AlexandraLibby,
PiaMezzacappa,LeslieR.Morse,KyungmoPark,JosephAudette,andVitalyNapadow
Volume2013,ArticleID795906,13pages
PlaceboAcupunctureDevices:ConsiderationsforAcupunctureResearch,DanZhu,YingGao,
JinglingChang,andJianKong
Volume2013,ArticleID628907,9pages
Hypothalamus-RelatedRestingBrainNetworkUnderlyingShort-TermAcupunctureTreatmentin
PrimaryHypertension,HongyanChen,JianpingDai,XiaozheZhang,KaiWang,ShuhuaHuang,
QingtianCao,HongWang,YuhongLiang,ChuanyingShi,MengyuanLi,TingtingHa,LinAi,ShaowuLi,
JunMa,WenjuanWei,YouboYou,ZhenyuLiu,JieTian,andLijunBai
Volume2013,ArticleID808971,9pages
AcupunctureEffectandCentralAutonomicRegulation,Qian-QianLi,Guang-XiaShi,QianXu,
JingWang,Cun-ZhiLiu,andLin-PengWang
Volume2013,ArticleID267959,6pages
fMRIEvidenceofAcupointsSpecificityinTwoAdjacentAcupoints,HuaLiu,Jian-YangXu,LinLi,
Bao-CiShan,Bin-BinNie,andJing-quanXue
Volume2013,ArticleID932581,5pages
VisceralNociceptiveAfferentFacilitatesReactionofSubnucleusReticularisDorsalistoAcupoint
StimulationinRats,LiangLi,LinglingYu,PeijingRong,HuiBen,XiaLi,BingZhu,andRixinChen
Volume2013,ArticleID931283,7pages
NeurobiologicalFoundationsofAcupuncture:TheRelevanceandFutureProspectBasedon
NeuroimagingEvidence,LijunBaiandLixingLao
Volume2013,ArticleID812568,9pages
EffectsofMoxaSmokeonMonoamineNeurotransmittersinSAMP8Mice,HuanfangXu,BaixiaoZhao,
YingxueCui,MinYeeLim,PingLiu,LiHan,HongzhuGuo,andLixingLao
Volume2013,ArticleID178067,6pages
EnhancedAntidepressant-LikeEffectsofElectroacupunctureCombinedwithCitalopraminaRat
ModelofDepression,JianYang,YuPei,Yan-LiPan,JunJia,ChenShi,YanYu,Jia-HuiDeng,BoLi,
Xiao-LiGong,XuanWang,Xiao-MinWang,andXinMa
Volume2013,ArticleID107380,12pages
ModulationofBrainElectroencephalographyOscillationsbyElectroacupunctureinaRatModelof
PostincisionalPain,JingWang,JingWang,XuezhuLi,DuanLi,Xiao-LiLi,Ji-ShengHan,andYouWan
Volume2013,ArticleID160357,11pages
Long-TermStimulationwithElectroacupunctureatDU20andST36RescuesHippocampalNeuron
throughAttenuatingCerebralBloodFlowinSpontaneouslyHypertensiveRats,Gui-HuaTian,KaiSun,
PingHuang,Chang-ManZhou,Hai-JiangYao,Ze-JunHuo,Hui-FengHao,LeiYang,Chun-ShuiPan,
KeHe,Jing-YuFan,Zhi-GangLi,andJing-YanHan
Volume2013,ArticleID482947,10pages
SpinalSerotonergicandOpioidReceptorsAreInvolvedinElectroacupuncture-Induced
AntinociceptionatDifferentFrequenciesonZuSanLi(ST36)Acupoint,Chi-ChungKuo,
Huei-YannTsai,Jaung-GengLin,Hong-LinSu,andYuh-FungChen
Volume2013,ArticleID291972,10pages
ThePossibleNeuronalMechanismofAcupuncture:MorphologicalEvidenceoftheNeuronal
ConnectionbetweenGroinA-ShiPointandUterus,Chun-YenChen,Rey-ShyongChern,
Ming-HueiLiao,Yung-HsienChang,Jung-YuC.Hsu,andChi-HsienChien
Volume2013,ArticleID429186,13pages
HindawiPublishingCorporation
Evidence-BasedComplementaryandAlternativeMedicine
Volume2013,ArticleID652457,2pages
http://dx.doi.org/10.1155/2013/652457
Editorial
Neurobiological Mechanisms of Acupuncture
LijunBai,1RichardE.Harris,2JianKong,3LixingLao,4
VitalyNapadow,5andBaixiaoZhao6
1TheKeyLaboratoryofBiomedicalInformationEngineering,MinistryofEducation,DepartmentofBiomedicalEngineering,
SchoolofLifeScienceandTechnology,Xi’anJiaotongUniversity,Xi’an710049,China
2DepartmentofAnesthesiology,UniversityofMichigan,AnnArbor,MI48109,USA
3DepartmentofPsychiatry,MassachusettsGeneralHospital(MGH),HarvardMedicalSchool,Boston,MA02129,USA
4SchoolofChineseMedicine,TheUniversityofHongKong,10SassoonRoad,Pokfulam,HongKong
5MGH/HMS/MITMartinosCenterforBiomedicalImaging,MassachusettsGeneralHospital,HarvardMedicalSchool,
Boston,MA02129,USA
6SchoolofAcupuncture-MoxibustionandTuina,BeijingUniversityofChineseMedicine,Beijing100029,China
CorrespondenceshouldbeaddressedtoLijunBai;[email protected]
Received24November2013;Accepted24November2013
Copyright©2013LijunBaietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,which
permitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.
Acupuncture, an age-old healing art, has been accepted to andtreatmentevaluations,D.Zhuetal.outlinedtheadvan-
effectively treat various diseases, particularly chronic pain tages and disadvantages of kinds of acupuncture controls
and neurodegenerative diseases. Since its public acceptance andhighlightedhowthedifferencesamongplacebodevices
and good efficacy, increasing attention has been now paid can be used to isolate distinct components of acupuncture
toexploringthephysiologicalandbiochemicalmechanisms treatment.
underlyingacupuncture,particularlythebrainmechanisms. Fivepapersdealwithpotentialneuralmechanismunder-
Basic and clinical acupuncture studies on neurobiological lying acupuncture treatments on the stroke, hypertension,
mechanismsofacupuncturearecrucialforthedevelopment andmildcognitiveimpairments.ThepaperbyL.LiuandR.
ofacupuncture.Thisissuecompiles32excitingpapers,most T. F. Cheungaimedto investigatewhetherthecombination
of which are very novel and excellent investigations in this of melatonin and electroacupuncture therapies could be
field. beneficial against transient focal cerebral ischemia in a rat
The neural mechanism underlying acupuncture anal- modeloftransientmiddlecerebralarteryocclusion.W.Qin
gesia was addressed in four articles. J. Wang et al. estab- et al. accompanied by L. Liu and R. T. F. Cheung’s paper
lished a postincisional pain model of rats and investigated explored the importance of anti-inflammatory acupuncture
electroacupuncture effect on the brain oscillations involv- treatment for the focal cerebral ischemia/reperfusion by
ing postoperative pain. B.-S. Lim et al., using interesting inhibitingtheNF-𝜅Bsignalingpathway.Anothertwopapers
bee venom acupuncture, explored whether it can relieve mainly focused on the acupuncture modulation of neural
oxaliplatin-induced cold allodynia and which endogenous mechanism for hypertension regulation with long-term as
analgesic system is implicated. The paper by Y. Maeda et well as short-term treatments. The paper by G.-H. Tian et
al. aimed to evaluate this linkage between brain response al. addressed the long-term electroacupuncture on cerebral
to acupuncture and subsequent analgesia in chronic pain microvessels and neurons in CA1 region of hippocampus
patients with carpal tunnel syndrome. Since many articles in spontaneously hypertensive rats. H. Chen et al. aimed
aimedtoassesstheeffectofelectroacupunctureinducedanal- to explore the hypothalamus-anchored resting brain net-
gesia,W.Kimetal.systemicallyconductedareviewtoassess workunderlyingprimaryhypertensionpatientsaftershort-
theefficacyandclarifyitsmechanismonneuropathicpain. term acupuncture treatments. Moreover, for mild cognitive
In addition, as a great challenge in acupuncture analgesia impairments,S.Chenetal.havepointedoutthatacupuncture
2 Evidence-BasedComplementaryandAlternativeMedicine
atKI3atdifferentcognitivestatesandwithvaryingneedling
depthsmayinducedistinctreorganizationsofeffectivecon-
nectivityofbrainnetworks.
The neuroendocrine system involving acupuncture has
been addressed by the following three papers. Z. Yu et al.
hassuggestedthatTRPV1receptorispartiallyinvolvedinthe
electroacupuncture-mediatedmodulationofgastricmotility.
The paper by C.-C. Kuo et al. explored the mechanism of
electroacupuncture(EAc)inducedantinociceptioninvolved
opioidreceptorsandtheserotonergicsystem.Q.-Q.Lietal.
conducted a systemic review about the central mechanism
ofacupunctureinmodulatingvariousautonomicresponses.
Moreover, other papers focused on the relatively acupoint
specificity fromwide aspects. Oneofthestudies by L. Liet
al.suggestedthatboththesizeandfunctionoftheacupoints
comply with the functionality of the internal organs; thus
the sensitive degree of acupoints changed according to
malfunctionofinternalorgans.C.-Y.Chenetal.impliedthat
somatoparasympathetic neuronal connection (groin-spinal
dorsal horn-NTS/DMX-uterus) and a somatosympathetic
neuronal connection (groin-spinal dorsal horn-NTS-PVN-
uterus) could be the prerequisites to the neuronal basis of
the somatovisceral reflex and also the neuronal mechanism
ofacupuncture.Z.Wangetal.advancedthatthemodulatory
effectsofdifferentneedlingsensationsinducedbyrelatively
different acupoints contribute to acupuncture modulations
oflimbic-paralimbic-neocorticalnetwork.Althoughtheacu-
pointswerespatiallyadjacent,therewasalsorelativelyfunc-
tionalspecificityinflectedbybrainnetworks.
Bygatheringthesepapers,wehopetoenrichourreaders
andresearcherswithrespecttotheunderlyingneurological
mechanism of acupuncture, and we look forward to an
increasing number of both clinical trials and experimental
studiestofurtherpromotethedevelopmentofunderstanding
theneurologicalmechanisminvolvingacupuncture.
Lijun Bai
Richard E. Harris
Jian Kong
Lixing Lao
Vitaly Napadow
Baixiao Zhao