Neonatal management and outcome in red cell alloimmunization

174 Pages·2012·0.77 MB·English

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Neonatal management and outcome
in red cell alloimmunization
ISBN/EAN: 978-90-9026589-6
Cover-photos: Mika van Zon, participant in the LOTUS study.
Mika’s photos (a few days after birth and at the age of 5) are published with kind permission of his parents.
Layout and printing: Pasmans Offsetdrukkerij BV, Den Haag.
The printing of this thesis was financially supported by Willem-Alexander Kinderziekenhuis, Leiden.
© 2012 V.E.H.J. Smits-Wintjens, Leiden, The Netherlands.
All rights reserved. No part of this publication may be reproduced, stored or transmitted in any way or by
any means, without the prior permission of the author or the copyright-owning journals for previously
published chapters.
Neonatal management and outcome
in red cell alloimmunization
Proefschrift
ter verkrijging van
de graad van doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties
te verdedigen op woensdag 15 februari 2012
klokke 13:45 uur
door
Vivianne Elise Huberta Johanna Smits - Wintjens
geboren te Maastricht
in 1972
Promotiecommissie
Promotor : Prof. dr. F.J. Walther
Copromotor : dr. E. Lopriore
Overige leden : Prof. dr. A. Brand
Prof. dr. R. Devlieger, Katholieke Universiteit Leuven, België
dr. P.H. Dijk, Universitair Medisch Centrum Groningen
dr. D. Oepkes
Aan mijn ouders,
Robert, Koen, Tijn en Lieke
Table of contents
Chapter 1 General introduction and outline of the thesis ......................................... 9
Chapter 2 Rhesus hemolytic disease of the newborn: postnatal management,
associated morbidity and long-term outcome
Semin Fetal Neonatal Med 2008; 13:265-271 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19

Chapter 3 Intravenous immunoglobulin in neonates with Rhesus hemolytic
disease: a randomized controlled trial
Pediatrics 2011; 127:680-686 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
Chapter 4 Bacillus cereus cerebral abscesses in a term neonate with Rhesus
hemolytic disease treated with exchange transfusion
J Pediatr Inf Dis 2010; 5(3):277-280 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
Chapter 5 Neonatal morbidity after exchange transfusion for red cell alloimmune
hemolytic disease
Submitted . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57
Chapter 6 Cholestasis in neonates with red cell alloimmune hemolytic disease:
incidence, risk factors and outcome
Neonatology; In press . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71

Chapter 7 Thrombocytopenia at birth in neonates with red cell alloimmune
hemolytic disease
Vox Sang 2011; Epub ahead of print . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83
Chapter 8 Top-up transfusions in neonates with Rhesus hemolytic disease in
relation to exchange transfusions
Vox Sang 2010; 99(1):65-70 ........................................................................ 95
Chapter 9 Exchange transfusions and top-up transfusions in neonates with Kell
hemolytic disease
Vox Sang 2010; 100(3):312-316 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107
Chapter 10 Long-term neurodevelopmental outcome after intrauterine transfusion
for fetal alloimmune anemia: the LOTUS study
Am J Obstet Gynecol 2011; Epub ahead of print . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117
Chapter 11 General discussion and future perspectives ............................................. 133
Chapter 12 Summary ................................................................................................. 147
Chapter 13 Samenvatting .......................................................................................... 153
List of abbreviations ..................................................................................................... 163
Authors and affiliations ................................................................................................ 165
Curriculum Vitae ........................................................................................................... 167
Publications ................................................................................................................. 169
Dankwoord .................................................................................................................. 171

1
General introduction
and outline of the thesis