Table Of ContentNATURAL PRODUCTS
INTERACTIONS
GENOMES
ON
Clinical Pharmacognosy Series
Series Editors
Navindra P. Seeram
Maria Tiziana Corasaniti
Aromatherapy: Basic Mechanisms and Evidence Based Clinical Use
Giacinto Bagetta, Marco Cosentino,
and Tsukasa Sakurada
Herbal Medicines: Development and Validation of Plant-Derived
Medicines for Human Health
Giacinto Bagetta, Marco Cosentino, Marie Tiziana Corasaniti,
and Shinobu Sakurada
Natural Products Interactions on Genomes
Siva G. Somasundaram
Clinical Pharmacognosy Series
NATURAL PRODUCTS
INTERACTIONS
GENOMES
ON
Edited by
Siva G. Somasundaram, PhD
University of Houston - Victoria
Sugar Land, Texas, USA
Boca Raton London New York
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Version Date: 20150813
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Dedication
I dedicate to my beloved sons, Dr. Aswin, MD,
and Mr. Alwin for their support.
Contents
Series Preface ............................................................................................................ix
Preface.......................................................................................................................xi
Acknowledgments ..................................................................................................xiii
Editor .......................................................................................................................xv
Contributors ...........................................................................................................xvii
Chapter 1 Genomics Is an Evolving Science due to the Interactions
of Natural Products ..............................................................................1
Siva G. Somasundaram
Chapter 2 Interactions of Natural Products with Selected Genes
of Mammalian Chromosomes ............................................................11
Siva G. Somasundaram
Chapter 3 Interaction of Citrus Natural Products with Genomes .......................89
Siva G. Somasundaram, Janet Price, G. K. Jayaprakasha,
and Bhimanagouda S. Patil
Chapter 4 Combinatorial Effect of Natural Products and Chemotherapy
Interactions in Cancer ......................................................................113
Siva G. Somasundaram, Janet Price, G. K. Jayaprakasha,
Richard S. Gunasekera, and Bhimanagouda S. Patil
Chapter 5 Interactions of Natural Products with Microbial Genomes .............131
Chandra Somasundaram
Chapter 6 Interactions of Natural Products with Genomes:
Future Challenges ...........................................................................183
Siva G. Somasundaram
Appendix I ............................................................................................................199
Index ......................................................................................................................205
vii
Series Preface
Botanical medicines are rapidly increasing in global recognition with significant
public health and economic implications. For instance, in developing countries, a vast
majority of indigenous populations use medicinal plants as a major form of health
care. Also, in industrialized nations, including those in Europe and North America,
consumers are increasingly using herbs and botanical dietary supplements as part
of integrative health and complementary and alternative therapies. Moreover, the
paradigm shifts occurring in modern medicine, from mono-drug to multi-drug and
poly-pharmaceutical therapies, have led to renewed interest in botanical medicines
and botanical drugs. This is due, in part, to the basic underpinnings of botanical
medicines, according to which a complex matrix of multiple compounds within an
extract elicits multiple biological actions and the activity of a major compound may
be potentiated by multiple minor constituents. In short, the whole is greater than the
sum of its parts. However, the widespread use and resurgence in the popularity of
herbal medicines raises concerns about clinical efficacy, quality, safety, dosing, and
the potential for herb–herb, herb–food, and herb–drug interactions. Pharmacognosy,
the study of drugs from natural sources, plays a critical role in the process of ensur-
ing the authenticity, purity, and consistency of botanicals and also for developing
tools and models for determining their mechanisms and modes of action, doses,
toxicity, and safety. The cross-fertilization of classical pharmacognosy with mod-
ern chemical and biological approaches, and their applications in a clinical setting,
has led to the Clinical Pharmacognosy series, which seeks to disseminate emerging
research and discuss challenges and opportunities on the aforementioned issues.
Navindra P. Seeram
University of Rhode Island
ix
