Table Of ContentCHALLENGES FOR THE CHEMICAL SCIENCES
IN THE 21ST CENTURY
NATIONAL
SECURITY &
HOMELAND
DEFENSE
COMMITTEE ON CHALLENGES FOR THE CHEMICAL SCIENCES
IN THE 21ST CENTURY
BOARD ON CHEMICAL SCIENCES AND TECHNOLOGY
DIVISION ON EARTH AND LIFE STUDIES
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appropriate balance.
Support for this study was provided by the American Chemical Society; the American Institute
of Chemical Engineers; the Defense Advanced Research Projects Agency under Contract No.
MDA972-01-M-0001; the Camille and Henry Dreyfus Foundation, Inc. under Contract No. SG00-093;
the National Institute of Standards and Technology under Contract No. NA1341-01-W-1070; the
National Institutes of Health/National Cancer Institute under Contract No. N0-OD-4-2139; the
National Science Foundation under Contract No. CTS-9908440; the U.S. Department of Energy/
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mental Protection Agency under Contract No. CR828233-01-0.
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for this project.
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ORGANIZING COMMITTEE FOR THE WORKSHOP ON
NATIONAL SECURITY AND HOMELAND DEFENSE
JOHN L. ANDERSON, Carnegie Mellon University, Co-Chair
JOHN I. BRAUMAN, Stanford University, Co-Chair
JACQUELINE K. BARTON, California Institute of Technology, Steering Committee
Liaison
MARVIN H. CARUTHERS, University of Colorado
LIANG-SHIH FAN, Ohio State University
LARRY E. OVERMAN, University of California, Irvine
MICHAEL J. SAILOR, University of California, San Diego
JEFFREY J. SIIROLA, Eastman Chemical Company, Steering Committee and
BCST Liaison
Staff
JENNIFER J. JACKIW, Program Officer
CHRISTOPHER K. MURPHY, Program Officer
SYBIL A. PAIGE, Administrative Associate
DOUGLAS J. RABER, Senior Scholar
DAVID C. RASMUSSEN, Program Assistant
iv
COMMITTEE ON CHALLENGES FOR THE CHEMICAL SCIENCES
IN THE 21ST CENTURY
RONALD BRESLOW, Columbia University, Co-Chair
MATTHEW V. TIRRELL, University of California, Santa Barbara, Co-Chair
JACQUELINE K. BARTON, California Institute of Technology
MARK A. BARTEAU, University of Delaware
CAROLYN R. BERTOZZI, University of California, Berkeley
ROBERT A. BROWN, Massachusetts Institute of Technology
1
ALICE P. GAST, Stanford University
IGNACIO E. GROSSMANN, Carnegie Mellon University
2
JAMES M. MEYER, E. I. du Pont de Nemours and Company
ROYCE W. MURRAY, University of North Carolina, Chapel Hill
PAUL J. REIDER, Amgen, Inc.
WILLIAM R. ROUSH, University of Michigan
MICHAEL L. SHULER, Cornell University
JEFFREY J. SIIROLA, Eastman Chemical Company
GEORGE M. WHITESIDES, Harvard University
PETER G. WOLYNES, University of California, San Diego
RICHARD N. ZARE, Stanford University
Staff
JENNIFER J. JACKIW, Program Officer
CHRISTOPHER K. MURPHY, Program Officer
SYBIL A. PAIGE, Administrative Associate
DOUGLAS J. RABER, Senior Scholar
DAVID C. RASMUSSEN, Project Assistant
1
Committee member until July 2001; subsequently the Board on Chemical Sciences and Tech-
nology (BCST) liaison to the committee in her role as co-chair of the BCST.
2
Meyer’s committee membership ended March 2002, following his retirement from DuPont.
v
BOARD ON CHEMICAL SCIENCES AND TECHNOLOGY
ALICE P. GAST, Massachusetts Institute of Technology, Co-Chair
WILLIAM KLEMPERER, Harvard University, Co-Chair
ARTHUR I. BIENENSTOCK, Stanford University
A. WELFORD CASTLEMAN, JR., The Pennsylvania State University
ANDREA W. CHOW, Caliper Technologies Corp.
THOMAS M. CONNELLY, JR., E. I. du Pont de Nemours and Company
JEAN DE GRAEVE, Institut de Pathologie, Liège, Belgium
JOSEPH M. DESIMONE, University of North Carolina, Chapel Hill, and North
Carolina State University
CATHERINE FENSELAU, University of Maryland
JON FRANKLIN, University of Maryland
MARY L. GOOD, University of Arkansas, Little Rock
RICHARD M. GROSS, Dow Chemical Company
NANCY B. JACKSON, Sandia National Laboratories
SANGTAE KIM, Eli Lilly and Company
WILLIAM KLEMPERER, Harvard University
THOMAS J. MEYER, Los Alamos National Laboratory
PAUL J. REIDER, Amgen, Inc.
ARNOLD F. STANCELL, Georgia Institute of Technology
ROBERT M. SUSSMAN, Latham & Watkins
JOHN C. TULLY, Yale University
CHI-HUEY WONG, Scripps Research Institute
Staff
JENNIFER J. JACKIW, Program Officer
CHRISTOPHER K. MURPHY, Program Officer
SYBIL A. PAIGE, Administrative Associate
DOUGLAS J. RABER, Senior Scholar
DAVID C. RASMUSSEN, Program Assistant
DOROTHY ZOLANDZ, Director
vi
Preface
Initially, the Challenges for the Chemical Sciences in the 21st Century project
was designed to be a series of five workshops encompassing the main tech-
nological areas to which the chemical sciences contribute. After the events of
September 11, 2001, it was recognized that chemists and chemical engineers have
always contributed significantly to our nation’s defense capabilities and that now
they will play an increasingly important part in homeland security. Thus, the
National Security and Homeland Defense Workshop was arranged on an emer-
gency basis. It is hoped that the presentations and discussions at the workshop
found in this report will help chemical scientists understand how their research
can be applied to national security problems and will guide them in new directions
to ultimately enhance the safety of U.S. civilians and military personnel.
In some cases, modified or improved existing technologies were identified as
likely contributors to national security solutions, and in others, completely new
technologies were called for. However, the workshop was not designed to pro-
vide specific recommended solutions to national security and homeland defense
problems (see Appendix A for the Statement of Task). The workshop report is
just that—a report of the proceedings of and discussions at the workshop that
focused on research in chemistry and chemical engineering clearly related to
national security. Topics in other areas of the chemical sciences are addressed in
the other reports in the “Challenges” series including Beyond the Molecular
Frontier: Challenges for Chemists and Chemical Engineers as well as in Making
the Nation Safer: The Role of Science and Technology in Countering Terrorism.
Following the workshop, the organizing committee met to reach preliminary
consensus on the workshop findings and to create an outline for its report. The
vii
viii PREFACE
report was fully developed through iterations among the committee members. In
addition to summaries of the speaker presentations (Appendix D), the committee
has attempted to capture participants’ input from both the plenary and breakout
sessions in the report chapters. Illustrative comments from presentations and
subsequent discussions are highlighted in boxes interspersed throughout the
chapters.
This study was conducted under the auspices of the NRC’s Board on Chemi-
cal Sciences and Technology with assistance provided by its staff. The committee
acknowledges this support.
John L. Anderson and John I. Brauman
Co-Chairs
Organizing Committee for the Workshop on
National Security and Homeland Defense
Acknowledgment of Reviewers
This report has been reviewed in draft form by individuals chosen for their
diverse perspectives and technical expertise, in accordance with procedures
approved by the NRC’s Report Review Committee. The purpose of this indepen-
dent review is to provide candid and critical comments that will assist the
institution in making the published report as sound as possible and to ensure that
the report meets institutional standards for objectivity, evidence, and responsive-
ness to the study charge. The review comments and draft manuscript remain
confidential to protect the integrity of the deliberative process. We wish to thank
the following individuals for their review of this report:
Peter K. Dorhout, Colorado State University
Catherine C. Fenselau, University of Maryland
Nancy B. Jackson, Sandia National Laboratories
C. Bradley Moore, Ohio State University
George Parshall, E. I. duPont de Nemours and Company (retired)
K. John Pournoor, 3M
Steven J. Sibener, University of Chicago
George M. Whitesides, Harvard University
Charles Zukoski, University of Illinois
Although the reviewers listed above have provided many constructive com-
ments and suggestions, they were not asked to endorse the conclusions or recom-
mendations nor did they see the final draft of the report before its release. The
review of this report was overseen by R. Stephen Berry, University of Chicago.
Appointed by the National Research Council, he was responsible for making
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