Table Of ContentNANOTECHNOLOGY
FOR ORAL DRUG
DELIVERY
NANOTECHNOLOGY
FOR ORAL DRUG
DELIVERY
From Concept to Applications
Edited by
JOÃO PEDRO MARTINS
Drug Research Program, Division of PharmaceuticalChemistry and
Technology,FacultyofPharmacy,UniversityofHelsinki,Helsinki,Finland
HE(cid:1)LDER A. SANTOS
FullProfessor,Drug Research Program, Division of Pharmaceutical
Chemistry and Technology, Facultyof Pharmacy, University of Helsinki,
Helsinki, Finland
FullProfessor,Helsinki Institute of Life Science (HiLIFE), University of
Helsinki, Helsinki, Finland
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Contributors
Beatrice Albertini
Departmentof Pharmacy and BioTechnology, University of Bologna, Bologna, Italy
Andreia Almeida
i3S—Instituto deInvestigac¸a˜oe Inovac¸a˜oem Sau´de; Instituto de Ci^encias Biom(cid:2)edicasAbel
Salazar, Universidade do Porto, Porto, Portugal
Mar´ıaJos(cid:2)eAlonso
CenterforResearchinMolecularandChronicDiseases(CIMUS);DepartmentofPharmaceutics
andPharmaceuticalTechnology,SchoolofPharmacy,CampusVida,UniversityofSantiagode
Compostela,Santiago de Compostela, Spain
Manuel Arruebo
Departmentof Chemical Engineering, Aragon Institute of Nanoscience (INA), Universityof
Zaragozaand Instituto de Ciencia de Materiales deArago´n (ICMA),Universidad de
Zaragoza-CSIC, Zaragoza; NetworkingResearch Center on Bioengineering, Biomaterials
and Nanomedicine, CIBER-BBN, Madrid, Spain
Cla´udia Azevedo
i3S—Instituto deInvestigac¸a˜oe Inovac¸a˜oem Sau´de; Instituto de Ci^encias Biom(cid:2)edicasAbel
Salazar, Universidade do Porto, Porto, Portugal
Abdul W. Basit
UCLSchool of Pharmacy,University College London,London, United Kingdom
Serena Bertoni
Departmentof Pharmacy and BioTechnology, University of Bologna, Bologna, Italy
Johan Peter Boetker
Departmentof Pharmacy,Facultyof Healthand Medical Sciences, Universityof Copenhagen,
Copenhagen, Denmark
Maria Cristina Bonferoni
Departmentof Drug Sciences, University of Pavia, Pavia,Italy
Marcos Luciano Bruschi
LaboratoryofResearchandDevelopmentofDrugDeliverySystems,DepartmentofPharmacy,
State University of Maringa,Maringa,Parana, Brazil
J(cid:2)essica Bassi daSilva
LaboratoryofResearchandDevelopmentofDrugDeliverySystems,DepartmentofPharmacy,
State University of Maringa,Maringa,Parana, Brazil
Henry P.Diehl
Departmentof Pharmaceutical Chemistry,TheUniversity of Kansas, Lawrence,KS,
United States
Franca Ferrari
Departmentof Drug Sciences, University of Pavia, Pavia,Italy
xi
xii Contributors
Mo´nica P.A.Ferreira
DrugResearchProgram, Division of Pharmaceutical Chemistry and Technology,Faculty of
Pharmacy, University of Helsinki, Helsinki, Finland
Natalja Genina
Departmentof Pharmacy,Faculty of HealthandMedical Sciences, Universityof Copenhagen,
Copenhagen, Denmark
Nazende Gu€nday Tu€reli
€
MyBiotech GmbH, Uberherrn, Germany
Jouni Hirvonen
DrugResearchProgram, Division of Pharmaceutical Chemistry and Technology,Faculty of
Pharmacy, University of Helsinki, Helsinki, Finland
Tushar Kumeria
School of Pharmacy,TheUniversity of Queensland; Translational Research Institute,Mater
Research Institute-The University of Queensland, Brisbane, QLD, Australia
Robert Langer
DepartmentofChemicalEngineering,MassachusettsInstituteofTechnology,Cambridge,MA,
UnitedStates
Mar´ıaVictoriaLozano
CellularNeurobiologyandMolecularChemistryoftheCentralNervousSystemGroup,Faculty
of Pharmacy; Regional Centre of Biomedical Research (CRIB), Universityof Castilla-La
Mancha (UCLM), Albacete,Spain
Maria Helena Macedo
i3S—Instituto de Investigac¸a˜o e Inovac¸a˜oem Sau´de;Instituto de Ci^enciasBiom(cid:2)edicas Abel
Salazar, Universidade do Porto, Porto, Portugal
Joa˜o Pedro Martins
DrugResearchProgram, Division of Pharmaceutical Chemistry and Technology,Faculty of
Pharmacy, University of Helsinki, Helsinki, Finland
Chiara Mazzoni
Departmentof HealthTechnology, Technical University of Denmark, Lyngby, Denmark
Line HagnerNielsen
Departmentof HealthTechnology, Technical University of Denmark, Lyngby, Denmark
Nadia Passerini
Departmentof Pharmacy and BioTechnology, Universityof Bologna, Bologna, Italy
Amirali Popat
School of Pharmacy,TheUniversity of Queensland; Translational Research Institute,Mater
Research Institute-The University of Queensland, Brisbane, QLD, Australia
Vivitri D. Prasasty
Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta,Indonesia
Veronique Pr(cid:2)eat
Advanced DrugDelivery and Biomaterials,Louvain DrugResearchInstitute, Universit(cid:2)e
catholique deLouvain, Brussels, Belgium
Contributors xiii
Jukka Rantanen
Departmentof Pharmacy,Facultyof Healthand Medical Sciences, Universityof Copenhagen,
Copenhagen, Denmark
PrarthanaRewatkar
School of Pharmacy, TheUniversity of Queensland, Brisbane,QLD,Australia
Silvia Rossi
Departmentof Drug Sciences, University of Pavia, Pavia,Italy
Marco Ruggeri
Departmentof Drug Sciences, University of Pavia, Pavia,Italy
Giuseppina Sandri
Departmentof Drug Sciences, University of Pavia, Pavia,Italy
Manuel J.Santander-Ortega
CellularNeurobiologyandMolecularChemistryoftheCentralNervousSystemGroup,Faculty
of Pharmacy;Regional Centre of Biomedical Research (CRIB), University of Castilla-La
Mancha (UCLM), Albacete,Spain
H(cid:2)elderA. Santos
FullProfessor,DrugResearchProgram,DivisionofPharmaceuticalChemistryandTechnology,
Faculty of Pharmacy;FullProfessor, Helsinki Institute of Life Science (HiLIFE), University of
Helsinki, Helsinki, Finland
Bruno Sarmento
i3S—Instituto deInvestigac¸a˜oe Inovac¸a˜oem Sau´de, Universidade do Porto, Porto; CESPU,
Instituto de Investigac¸a˜o eFormac¸a˜o Avanc¸ada em Ci^encias e Tecnologiasda Sau´de, Gandra,
Portugal
Victor Sebastian
Departmentof Chemical Engineering, Aragon Institute of Nanoscience (INA), Universityof
Zaragozaand Instituto de Ciencia de Materiales deArago´n (ICMA),Universidad de
Zaragoza-CSIC, Zaragoza;Networking ResearchCenter onBioengineering, Biomaterials and
Nanomedicine, CIBER-BBN,Madrid,Spain
Katia P. Seremeta
Departmentof Basic and AppliedSciences, National University of the Chaco Austral;
National Scientific and Technical ResearchCouncil (CONICET), Pcia. Roque Sa´enzPen˜a,
Chaco, Argentina
Neha Shrestha
Advanced Drug Delivery and Biomaterials, Louvain Drug Research Institute, Universit(cid:2)e
catholique de Louvain, Brussels, Belgium
Teruna J.Siahaan
Departmentof Pharmaceutical Chemistry,TheUniversity of Kansas, Lawrence,KS,
United States
Alejandro Sosnik
Laboratory of Pharmaceutical Nanomaterials Science, Departmentof Materials Science and
Engineering, Technion-Israel Institute of Technology,Haifa,Israel
xiv Contributors
Sabrina Barbosa de SouzaFerreira
LaboratoryofResearchandDevelopmentofDrugDeliverySystems,DepartmentofPharmacy,
State Universityof Maringa, Maringa,Parana, Brazil
Sarah J.Trenfield
UCL School of Pharmacy,University College London,London, United Kingdom
Akif EmreTu€reli
€
MyBiotech GmbH, Uberherrn, Germany
Barbara Vigani
Departmentof DrugSciences, University of Pavia, Pavia,Italy
Aldyn Wildey
Departmentof Pharmaceutical Chemistry,The University of Kansas, Lawrence, KS,
UnitedStates
Foreword
Thisbookaddressestwoofthemostsignificantareasofdrugdeliverytoday—oraldrug
deliveryandnanotechnology.Thebookboastsanumberofexcellentscientistsasauthors
from around the world. It covers chemical, biological, and engineering aspects of oral
drug delivery using micro and nano-particles.
In particular,thebookcontainsanumberofchapterson thebiology andbarriersto
oraldrugdelivery,aswellaswaystostudythem.Thesechaptersincludeanexamination
oftheintestinalmucosaasabarriertodrugdeliveryaswellasthedevelopmentofthree-
dimensionalintestinalmodelsandhowtousethesemodelstorealisticallyscreenfordrug
permeability.
A number of chapters focus on biomaterials. There are chapters on nanomaterials
for oral drug administration, and on microadhesive and mucus penetrating particles.
Other chapters discuss manufacturing considerations. For example, three-dimensional
printing and spray drying are examined in detail, as are the use of different reactions
in the synthesis of enteric drug carriers. Microdevices for oral drug delivery are also
discussed. In addition, an industrial perspective is provided.
Thebookhaschaptersexamininganumberofotherimportanttopics.Theseinclude
chaptersonthesizeandshapeofparticulatecarriers,ontargetingsuchsystemstoincrease
transport of orally administered drugs, and on other approaches for modifying drug
release. Buccal drug delivery is also discussed. Finally, both in vitro and in vivo
approaches for examining oral delivery of nanoparticles are provided.
This book should be a useful reference to scientists in universities and companies
alikewhoareworkingonoraldrugdeliveryandnanoparticulatesystems.Thisisanarea
that is also expected to increase in importance in the future.
Robert Langer
MITDepartmentofChemicalEngineering,MassachusettsInstituteofTechnology,
Cambridge, MA, United States
xv
