Table Of ContentChalla S.S.R. Kumar Editor
Nanotechnology
Characterization Tools
for Environment,
Health, and Safety
MATERIALS.SPRINGER.COM
Nanotechnology Characterization Tools for
Environment, Health, and Safety
Challa S. S. R. Kumar
Editor
Nanotechnology
Characterization Tools for
Environment, Health, and
Safety
With113Figuresand16Tables
Editor
ChallaS.S.R.Kumar
IntegratedMesoscaleArchitecturesforSustainableCatalysis(IMASC)
RowlandInstituteofScience
HarvardUniversity
Cambridge,MA,USA
ISBN978-3-662-59599-2 ISBN978-3-662-59600-5(eBook)
https://doi.org/10.1007/978-3-662-59600-5
©Springer-VerlagGmbHGermany,partofSpringerNature2019
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Contents
1 AssessingtheAdverseEffectsofTwo-DimensionalMaterials
UsingCellCulture-BasedModels .......................... 1
LidianeSilvaFranqui,LuisAugustoVisanideLuna,ThomasLoret,
DiegoStefaniTeodoroMartinez,andCyrillBussy
2 BiotransformationandPotentialAdverseEffectsofRare
EarthOxideNanoparticles ............................... 47
RuthHwang,ChongHyunChang,YifangZhu,andTianXia
3 EvaluationofBiodistribution,Toxicology,andToxicologic
PathologyofNanomaterialsUsedtoDeliverNucleicAcids ...... 65
H.DennyLiggitt
4 EvaluatingCarcinogenicPotentialofCarbonNanomaterials .... 103
RajibGhoshandYonRojanasakul
5 Nanotechnology-BasedRemediationofGroundwater .......... 145
TannazPak,NathalyLopesArchilha,andLuizFernandodeLima
LuzJr.
6 NanoscaleGraphene-BasedEnvironmentalGasSensing ........ 167
ManoharanMuruganathanandHiroshiMizuta
7 Nanotechnology-EnabledPoint-of-Use(POU)Filtersfor
DrinkingWaterDisinfection .............................. 187
LokR.Pokhrel,RebeccaL.Dean,ZacharyL.Jacobs,and
WilliamB.Burrows
8 CeriumOxideNanoparticles:PotentialforRevolutionizing
TreatmentofDiseases ................................... 217
BeverlyA.RzigalinskiandCharlesS.CarfagnaJr.
9 Nanoparticles-BasedFlexibleWearableSensorsforHealth
MonitoringApplications ................................. 245
AnindyaNagandSubhasChandraMukhopadhyay
v
vi Contents
10 ToolsandTechniquesforPurificationofWaterUsing
NanoMaterials ........................................ 285
BarışŞimşek,İnciSevgili,ÖzgeBildiCeran,andHalukKorucu
11 CaenorhabditiselegansNematode:AVersatileModelto
EvaluatetheToxicityofNanomaterialsInVivo ............... 323
SvetlanaBatasheva,GölnurFakhrullina,FaridaAkhatova,and
RawilFakhrullin
Index .................................................... 347
Contributors
FaridaAkhatova BionanotechnologyLab,InstituteofFundamentalMedicineand
Biology, Kazan Federal University, Kazan, Republic of Tatarstan, Russian
Federation
Nathaly Lopes Archilha Brazilian Synchrotron Light Laboratory (LNLS) - Bra-
zilianCentreforResearchinEnergyandMaterials(CNPEM),Campinas,Brazil
Svetlana Batasheva Bionanotechnology Lab, Institute of Fundamental Medicine
and Biology, Kazan Federal University, Kazan, Republic of Tatarstan, Russian
Federation
WilliamB.Burrows DepartmentofPublicHealth,TheBrodySchoolofMedicine,
EastCarolinaUniversity,Greenville,NC,USA
Cyrill Bussy Nanomedicine Lab, Nano-Inflammation Team, School of Health
Sciences,FacultyofBiology,MedicineandHealth,TheUniversityofManchester,
Manchester,UK
NationalGrapheneInstitute,TheUniversityofManchester,Manchester,UK
School of Technology, University of Campinas (UNICAMP), Limeira, São Paulo,
Brazil
Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology,
MedicineandHealth,TheUniversityofManchester,Manchester,UK
Thomas Ashton Institute for Risk and Regulatory Research, The University of
Manchester,Manchester,UK
Charles S. Carfagna Jr. Advanced Materials, Luna Innovations Inc, Roanoke,
VA,USA
Özge Bildi Ceran Department of Chemical Engineering, Çankırı Karatekin Uni-
versity,Çankırı,Turkey
Chong Hyun Chang Center for Environmental Implications of Nanotechnology,
California NanoSystems Institute, University of California Los Angeles, Los
Angeles,CA,USA
LuizFernandodeLimaLuzJr. FederalUniversityofParana,Curitiba,Brazil
vii
viii Contributors
Luis Augusto Visani de Luna Nanomedicine Lab, Nano-Inflammation Team,
SchoolofHealthSciences,FacultyofBiology,MedicineandHealth,TheUniversity
ofManchester,Manchester,UK
NationalGrapheneInstitute,TheUniversityofManchester,Manchester,UK
Rebecca L. Dean Department of Public Health, The Brody School of Medicine,
EastCarolinaUniversity,Greenville,NC,USA
RawilFakhrullin BionanotechnologyLab,InstituteofFundamentalMedicineand
Biology, Kazan Federal University, Kazan, Republic of Tatarstan, Russian
Federation
Gölnur Fakhrullina Bionanotechnology Lab, Institute of Fundamental Medicine
and Biology, Kazan Federal University, Kazan, Republic of Tatarstan, Russian
Federation
Lidiane Silva Franqui Nanomedicine Lab, Nano-Inflammation Team, School of
Health Sciences, Faculty of Biology, Medicine and Health, The University of
Manchester,Manchester,UK
NationalGrapheneInstitute,TheUniversityofManchester,Manchester,UK
Brazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for
ResearchinEnergyandMaterials(CNPEM),Campinas,SãoPaulo,Brazil
School of Technology, University of Campinas (UNICAMP), Limeira, São Paulo,
Brazil
RajibGhosh DepartmentofPharmaceuticalSciencesandWestVirginiaUniversity
CancerInstitute,WestVirginiaUniversity,Morgantown,VA,USA
Ruth Hwang Fielding School of Public Health, Department of Environmental
Health Science, Center for Health Sciences, University of California Los Angeles,
LosAngeles,CA,USA
Zachary L. Jacobs School of Law, University of California-Berkeley, Berkeley,
CA,USA
Haluk Korucu Department of Chemical Engineering, Çankırı Karatekin Univer-
sity,Çankırı,Turkey
H. Denny Liggitt Department of Comparative Medicine, School of Medicine,
UniversityofWashington,Seattle,WA,USA
Thomas Loret Nanomedicine Lab, Nano-Inflammation Team, School of Health
Sciences,FacultyofBiology,MedicineandHealth,TheUniversityofManchester,
Manchester,UK
NationalGrapheneInstitute,TheUniversityofManchester,Manchester,UK
Diego Stefani Teodoro Martinez Brazilian Nanotechnology National Laboratory
(LNNano), Brazilian Center for Research in Energy and Materials (CNPEM),
Campinas,SãoPaulo,Brazil
Contributors ix
School of Technology, University of Campinas (UNICAMP), Limeira, São Paulo,
Brazil
Hiroshi Mizuta School of Material Science, Japan Advanced Institute of Science
andTechnology,Ishikawa,Japan
HitachiCambridgeLaboratory,Cambridge,UK
SubhasChandraMukhopadhyay SchoolofEngineering,MacquarieUniversity,
Sydney,NSW,Australia
Manoharan Muruganathan School of Material Science, Japan Advanced Insti-
tuteofScienceandTechnology,Ishikawa,Japan
Anindya Nag School of Engineering, Macquarie University, Sydney, NSW,
Australia
TannazPak TeessideUniversity,Middlesbrough,UK
LokR.Pokhrel DepartmentofPublicHealth,TheBrodySchoolofMedicine,East
CarolinaUniversity,Greenville,NC,USA
Department of Health Education and Promotion, Environmental Health Program,
College of Health and Human Performance, East Carolina University, Greenville,
NC,USA
YonRojanasakul DepartmentofPharmaceuticalSciencesandWestVirginiaUni-
versityCancerInstitute,WestVirginiaUniversity,Morgantown,VA,USA
BeverlyA.Rzigalinski NanoNeurolab, EdwardViaCollegeofOsteopathicMed-
icine,VirginiaCampus,Blacksburg,VA,USA
İnci Sevgili Department of Chemical Engineering, Çankırı Karatekin University,
Çankırı,Turkey
ÇankırıMunicipalities,WaterandServiceAssociation,Çankırı,Turkey
BarışŞimşek DepartmentofChemicalEngineering,ÇankırıKaratekinUniversity,
Çankırı,Turkey
Tian Xia Center for Environmental Implications of Nanotechnology, California
NanoSystems Institute, University of California Los Angeles, Los Angeles, CA,
USA
Division of NanoMedicine, Department of Medicine, University of California Los
Angeles,LosAngeles,CA,USA
Yifang Zhu Fielding School of Public Health, Department of Environmental
Health Science, Center for Health Sciences, University of California Los Angeles,
LosAngeles,CA,USA
1
Assessing the Adverse Effects of
Two-Dimensional Materials Using Cell
Culture-Based Models
Lidiane Silva Franqui, Luis Augusto Visani de Luna, Thomas Loret,
Diego Stefani Teodoro Martinez, and Cyrill Bussy
Contents
1 DefinitionoftheTopic....................................................................... 2
2 Overview...................................................................................... 2
3 Introduction................................................................................... 3
4 ExperimentalandInstrumentalMethodology............................................... 12
4.1 AssessingtheCytotoxicityof2DMaterials........................................... 12
4.2 AssessingtheImmunotoxicityof2DMaterials....................................... 15
4.3 AssessingtheGenotoxicityof2DMaterials........................................... 16
4.4 AssessingtheMechanismsLeadingto2DMaterialToxicities....................... 19
4.5 AssessingtheImportanceofBiomolecularCorona,ItsComposition,and
Presencefor2DMaterialToxicity..................................................... 21
5 KeyResearchFindingsfromtheReview.................................................... 23
5.1 Cytotoxicityof2DMaterials........................................................... 23
5.2 Immunotoxicityof2DMaterials....................................................... 26
5.3 Genotoxicityof2DMaterials.......................................................... 28
5.4 BiomolecularCoronasand2DMaterials.............................................. 32
6 ConclusionsandFuturePerspective......................................................... 38
References........................................................................................ 40
L.S.Franqui
NanomedicineLab,Nano-InflammationTeam,SchoolofHealthSciences,FacultyofBiology,
MedicineandHealth,TheUniversityofManchester,Manchester,UK
NationalGrapheneInstitute,TheUniversityofManchester,Manchester,UK
BrazilianNanotechnologyNationalLaboratory(LNNano),BrazilianCenterforResearchinEnergy
andMaterials(CNPEM),Campinas,SãoPaulo,Brazil
SchoolofTechnology,UniversityofCampinas(UNICAMP),Limeira,SãoPaulo,Brazil
L.A.V.deLuna·T.Loret
NanomedicineLab,Nano-InflammationTeam,SchoolofHealthSciences,FacultyofBiology,
MedicineandHealth,TheUniversityofManchester,Manchester,UK
NationalGrapheneInstitute,TheUniversityofManchester,Manchester,UK
©Springer-VerlagGmbHGermany,partofSpringerNature2019 1
C.S.S.R.Kumar(ed.),NanotechnologyCharacterizationToolsforEnvironment,
Health,andSafety,https://doi.org/10.1007/978-3-662-59600-5_1
