Table Of ContentMahendra Rai · Alka Yadav Editors
Nanobiotechnology
in
Neurodegenerative
Diseases
Nanobiotechnology in Neurodegenerative Diseases
Mahendra Rai • Alka Yadav
Editors
Nanobiotechnology
in Neurodegenerative
Diseases
Editors
Mahendra Rai Alka Yadav
Nanobiotechnology Laboratory Nanobiotechnology Laboratory
Department of Biotechnology Department of Biotechnology
SGB Amravati University SGB Amravati University
Amravati, Maharashtra, India Amravati, Maharashtra, India
Department of Chemistry
Federal University of Piauí
Teresina, Piauí, Brazil
ISBN 978-3-030-30929-9 ISBN 978-3-030-30930-5 (eBook)
https://doi.org/10.1007/978-3-030-30930-5
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Preface
Neurodegenerative (ND) diseases comprise a range of conditions that primarily
affect the neurons in the human brain. Neurons are the building blocks of our brain,
which normally don’t reproduce or replace themselves if they get damaged. ND
diseases include Parkinson’s disease, Alzheimer’s disease, and Huntington’s dis-
ease. The most problematic feature of ND diseases is that they are incurable and
result in the progressive degeneration of neuron cells. The major cause of ND dis-
eases is related to genetic mutation; apart from this, protein misfolding, DNA dam-
age, apoptosis, mitochondrial dysfunction, and programmed cell death are the other
causes of ND diseases. A number of ND disorders have been thoroughly examined,
but successful, early diagnoses and treatment have been limited. The key reason for
this is the blood–brain barrier that prevents the penetration of the majority of drugs
and agents to effectively treat the disorders.
Nanobiotechnology as an emerging tool has the potential to play a pivotal role to
improve the understanding and treatment of neurodegenerative diseases. Different
types of nanomaterials can be implemented for diagnosis, drug delivery, and treat-
ment of neurodegenerative diseases. Engineered nanoparticles are materials with
dimension 1–100 nm. Metal nanoparticles showcase an innovative and promising
approach to potentially solve problems related to ND diseases. Due to their smaller
size, nanoparticles are able to interact with biological systems at a molecular level.
The smaller sized nanoparticles can also cross the blood–brain barrier. Hence, the
physical, chemical, and biological properties of nanoparticles can be utilized for
diagnosis, therapy, tissue engineering, regeneration, and drug delivery. Similarly,
exosomes are also evolving as therapeutic nanobiomaterials for drug delivery in
neurodegenerative diseases as they have the ability to cross the blood–brain barrier.
Moreover, in recent years, the field of nanobiosensors is growing quickly, and with
the help of nanotechnology, it is possible to develop higher sensitivity for nanobio-
sensors. This area of research is attracting scientists in general and medical experts
in particular. In this book, a brief overview of the different ND diseases and
advancements in nanobiotechnology for the treatment of ND is discussed by
eminent contributors.
v
vi Preface
This book is beneficial for a wide range of readers including nanotechnologists,
biotechnologists, pharmacists, medical professionals, bioengineers, biochemists,
and researchers who are involved in the field of research on neurodegenerative
diseases.
Amravati, Maharashtra, India Mahendra Rai
Alka Yadav
Contents
1 Neurodegenerative Diseases: The Real Problem
and Nanobiotechnological Solutions . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Mahendra Rai, Alka Yadav, Avinsh P. Ingle, Anatoly Reshetilov,
María José Blanco-Prieto, and Chistiane M. Feitosa
2 Nanotechnology at the Rescue of Neurodegenerative Diseases:
Tools for Early Diagnostic . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
Jean-Michel Rabanel, Morgane Perrotte, and Charles Ramassamy
3 The Role of Nanomedicine in the Treatment
of Neurodegenerative Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
Syed Tazib Rahaman
4 Nanobiotechnology in Neurodegenerative Diseases . . . . . . . . . . . . . . . 65
Josef Jampílek, Katarína Kráľová, Petr Novák, and Michal Novák
5 Application of Mycogenic Nanoparticles Against
Neurodegenerative Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139
Jhonatas Rodrigues Barbosa, Maurício Madson dos Santos Freitas,
Luiza Helena da Silva Martins, Andrea Komesu,
Alessandra Santos Lopes, Raul Nunes de Carvalho Junior,
and Mahendra Rai
6 Nanotechnology-Mediated Nose-to-Brain Drug Delivery
for Neurodegenerative Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163
Chandrakantsing V. Pardeshi, Veena S. Belgamwar,
and Sanjay J. Surana
7 Nanobiotechnology in Parkinson’s Disease . . . . . . . . . . . . . . . . . . . . . 177
Pablo Vicente Torres-Ortega, Iván Martínez-Valbuena,
Gloria Martí-Andrés, Amira Sayed Hanafy, María Rosario Luquin,
Elisa Garbayo, and María José Blanco-Prieto
vii
viii Contents
8 Selenium Nanoparticles as Therapeutic Agents
in Neurodegenerative Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 209
Shanmugam Rajeshkumar, Lakshmanan Ganesh,
and Jayakodi Santhoshkumar
9 Role of Supermagnetic Nanoparticles in Alzheimer Disease . . . . . . . 225
Shanmugam Rajeshkumar, Devaraj Ezhilarasan,
Napaphol Puyathron, and Thangavelu Lakshmi
10 Nanomedicines for Improved Antiretroviral Therapy
in Neuro-AIDS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 241
Aarti Belgamwar, Shagufta Khan, and Pramod Yeole
11 Nanocarrier-Mediated Drug Delivery Systems
for Neurodegenerative Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 267
Sathika G. G. Arachchige, Ryan Rienzie,
and Nadeesh M. Adassooriya
12 Gold Nanoparticles in Diagnosis and Treatment
of Alzheimer’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289
Senthilkumar Sivanesan and Shanmugam Rajeshkumar
13 Nanolipidic Carriers as Potential Drug Delivery Vehicles
in Alzheimer’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 307
Sushama Talegaonkar, Namrata Gautam, Venu Varshney,
Sandeep Kumar Sharma, and Arundhati Bhattacharyya
14 Curcumin and Its Nanoformulations as Therapeutic
for Alzheimer’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 343
Vandita Kakkar, Parina Kumari, Suneera Adlakha,
and Indu Pal Kaur
15 Nanopharmaceuticals for the Improved Treatment
of Cerebral Stroke . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 369
Shagufta Khan, Aarti Belgamwar, and Pramod Yeole
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 387
Contributors
Nadeesh M. Adassooriya Department of Food Science and Technology, Wayamba
University of Sri Lanka, Makandura, Gonawila, Sri Lanka
Suneera Adlakha Department of Pharmaceutics, University Institute of
Pharmaceutical Sciences, Panjab University, Chandigarh, India
Sathika G. G. Arachchige Postgraduate Institute of Science, University of
Peradeniya, Peradeniya, Sri Lanka
Jhonatas Rodrigues Barbosa LABEX/FEA (Faculty of Food Engineering),
Graduate Program in Food Science and Technology, Federal University of Para,
Belém, Pará, Brazil
Aarti Belgamwar SVKM’s Institute of Pharmacy, Dhule, Maharashtra, India
Veena S. Belgamwar R.T.M. Nagpur University, Nagpur, India
Arundhati Bhattacharyya Dr. K. N. Modi Institute of Pharmaceutical Education
and Research, Ghaziabad, Uttar Pradesh, India
María José Blanco-Prieto Department of Pharmaceutical Technology and
Chemistry, Faculty of Pharmacy and Nutrition, Universidad de Navarra, Pamplona,
Spain
Instituto de Investigación Sanitaria de Navarra, IdiSNA, Universidad de Navarra,
Pamplona, Spain
Luiza Helena da Silva Martins LABIOTEC/FEA (Faculty of Food Engineering),
Graduate Program in Food Science and Technology, Federal University of Pará,
Belém, Pará, Brazil
Raul Nunes de Carvalho Junior LABEX/FEA (Faculty of Food Engineering),
Graduate Program in Food Science and Technology, Federal University of Para,
Belém, Pará, Brazil
ix
x Contributors
Maurício Madson dos Santos Freitas LAPOA/FEA (Faculty of Food
Engineering), Graduate Program in Food Science and Technology, Federal
University of Para, Belém, Pará, Brazil
Devaraj Ezhilarasan Department of Pharmacology, Saveetha Dental College,
Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil
Nadu, India
Chistiane M. Feitosa Department of Chemistry, Federal University of Piaui,
Teresina, Brazil
Lakshmanan Ganesh Department of Anatomy, Saveetha Dental College, Saveetha
Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu, India
Elisa Garbayo Department of Pharmaceutical Technology and Chemistry, Faculty
of Pharmacy and Nutrition, Universidad de Navarra, Pamplona, Spain
Instituto de Investigación Sanitaria de Navarra, IdiSNA, Pamplona, Spain
Namrata Gautam Delhi Pharmaceutical Sciences and Research University
(DPSRU), New Delhi, Delhi, India
Amira Sayed Hanafy Department of Pharmaceutics and Pharmaceutical
Technology, Faculty of Pharmacy and Drug Manufacturing, Pharos University in
Alexandria (PUA), Alexandria, Egypt
Department of Pharmacy, Ludwig-Maximilians-Universität München, Munich,
Germany
Avinsh P. Ingle Department of Biotechnology, Engineering School of Lorena,
University of Sao Paulo, Lorena, SP, Brazil
Josef Jampílek Institute of Neuroimmunology, Slovak Academy of Sciences,
Bratislava, Slovakia
Division of Biologically Active Complexes and Molecular Magnets, Faculty of
Science, Regional Centre of Advanced Technologies and Materials, Palacký
University, Olomouc, Czech Republic
Vandita Kakkar Department of Pharmaceutics, University Institute of
Pharmaceutical Sciences, Panjab University, Chandigarh, India
Indu Pal Kaur Department of Pharmaceutics, University Institute of
Pharmaceutical Sciences, Panjab University, Chandigarh, India
Shagufta Khan Institute of Pharmaceutical Education and Research, Borgaon
(Meghe), Wardha, Maharashtra, India
Andrea Komesu Department of Marine Sciences (DCMar), Federal University of
São Paulo (UNIFESP), Santos, SP, Brazil
Katarína Kráľová Faculty of Natural Sciences, Institute of Chemistry, Comenius
University, Bratislava, Slovakia
