Table Of ContentNanobiomaterials in
Cancer Therapy
Applications of
Nanobiomaterials
Nanobiomaterials in
Cancer Therapy
Applications of
Nanobiomaterials
Edited by
Alexandru Mihai Grumezescu
Department of Science and Engineering of Oxide Materials and
Nanomaterials, Faculty of Applied Chemistry and Materials Science,
University Politehnica of Bucharest, Bucharest, Romania
Department of Biomaterials and Medical Devices, Faculty of
Medical Engineering, University Politehnica of Bucharest,
Bucharest, Romania
AMSTERDAM(cid:129)BOSTON(cid:129)HEIDELBERG(cid:129)LONDON
NEWYORK(cid:129)OXFORD(cid:129)PARIS(cid:129)SANDIEGO
SANFRANCISCO(cid:129)SINGAPORE(cid:129)SYDNEY(cid:129)TOKYO
WilliamAndrewisanimprintofElsevier
WilliamAndrewisanimprintofElsevier
TheBoulevard,LangfordLane,Kidlington,Oxford,OX51GB,UK
50HampshireStreet,5thFloor,Cambridge,MA02139,USA
Copyright©2016ElsevierInc.Allrightsreserved.
Nopartofthispublicationmaybereproducedortransmittedinanyformorbyanymeans,
electronicormechanical,includingphotocopying,recording,oranyinformationstorageand
retrievalsystem,withoutpermissioninwritingfromthepublisher.Detailsonhowtoseek
permission,furtherinformationaboutthePublisher’spermissionspoliciesandourarrangements
withorganizationssuchastheCopyrightClearanceCenterandtheCopyrightLicensing
Agency,canbefoundatourwebsite:www.elsevier.com/permissions.
Thisbookandtheindividualcontributionscontainedinitareprotectedundercopyright
bythePublisher(otherthanasmaybenotedherein).
Notices
Knowledgeandbestpracticeinthisfieldareconstantlychanging.Asnewresearchand
experiencebroadenourunderstanding,changesinresearchmethods,professionalpractices,
ormedicaltreatmentmaybecomenecessary.
Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgein
evaluatingandusinganyinformation,methods,compounds,orexperimentsdescribedherein.
Inusingsuchinformationormethodstheyshouldbemindfuloftheirownsafetyandthe
safetyofothers,includingpartiesforwhomtheyhaveaprofessionalresponsibility.
Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,oreditors,
assumeanyliabilityforanyinjuryand/ordamagetopersonsorpropertyasamatterofproducts
liability,negligenceorotherwise,orfromanyuseoroperationofanymethods,products,
instructions,orideascontainedinthematerialherein.
ISBN:978-0-323-42863-7
BritishLibraryCataloguing-in-PublicationData
AcataloguerecordforthisbookisavailablefromtheBritishLibrary.
LibraryofCongressCataloging-in-PublicationData
AcatalogrecordforthisbookisavailablefromtheLibraryofCongress.
ForInformationonallWilliamAndrewpublications
visitourwebsiteathttp://www.elsevier.com/
TypesetbyMPSLimited,Chennai,India
List of contributors
Udita Agrawal
Drug Delivery Research Laboratory,Department of Pharmaceutical Sciences,
Dr. Hari Singh Gour CentralUniversity,Sagar,MadhyaPradesh, India
Ecaterina Andronescu
Department ofScience and Engineering ofOxide Materialsand Nanomaterials,
FacultyofAppliedChemistry and MaterialsScience, University Politehnicaof
Bucharest, Bucharest, Romania
BhawaniAryasomayajula
Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern
University,Boston, MA, USA
Maria Vito´ria Lopes BadraBentley
School ofPharmaceutical Sciencesof Ribeira˜o Preto, University ofSa˜o Paulo,
Ribeira˜oPreto,Sa˜o Paulo, Brazil
Archana Bhaw-Luximon
ANDI Centre ofExcellence for Biomedical and Biomaterials Research,
University ofMauritius,Re´duit,Mauritius
Ioana Raluca Bucur
Department ofBiomaterials and Medical Devices, Faculty ofMedical
Engineering, University Politehnica ofBucharest, Bucharest, Romania
Patrı´ciaMazureki Campos
School ofPharmaceutical Sciencesof Ribeira˜o Preto, University ofSa˜o Paulo,
Ribeira˜oPreto,Sa˜o Paulo, Brazil
Yu Cao
Key Laboratory ofPesticide and Chemical Biology (Ministry of Education),
College ofChemistry, Central ChinaNormal University, Wuhan,PR, China
SamratChakraborty
Department ofPharmaceutical Technology,Jadavpur University, Kolkata, India
Ankan Choudhury
Department ofPharmaceutical Technology,Jadavpur University, Kolkata, India
LucianaM. De Hollanda
Department ofInternal Medicine,Hemocentro, School of Medical Science,
Universidade Estadualde Campinas, Campinas, Sa˜o Paulo, Brazil
xvii
xviii List of contributors
Surbhi Dubey
DrugDelivery Research Laboratory, Department ofPharmaceutical Sciences,
Dr.Hari Singh Gour CentralUniversity,Sagar, Madhya Pradesh, India
LopamudraDutta
Department ofPharmaceutical Technology,JadavpurUniversity,Kolkata, India
Elena Mikhailivna Egorova
Institute ofGeneral Pathologyand Pathophysiology,Russian Academy of
Medical Sciences, Moscow, Russia
Norhaizan Mohd. Esa
Universiti Putra Malaysia (UPM),Selangor,Malaysia
Yoshiya Furusawa
ResearchCenter for Charged Particle Therapy,NationalInstitute of
Radiological Sciences, Chiba, Japan
SharonE.Gao
Department ofPharmaceutical Sciences, University ofPittsburgh School of
Pharmacy, Pittsburgh,PA,USA
Nowsheen Goonoo
ANDICentre ofExcellence for Biomedicaland Biomaterials Research,
University ofMauritius, Re´duit, Mauritius
Alexandru Mihai Grumezescu
Department ofBiomaterials and Medical Devices, Facultyof Medical
Engineering, University Politehnica ofBucharest, Bucharest, Romania;
Department ofScience and EngineeringofOxideMaterials and Nanomaterials,
Faculty ofApplied Chemistry and Materials Science,University Politehnica of
Bucharest, Bucharest,Romania
Nidhi Gupta
Department ofBiotechnology, The IIS University, Jaipur, Rajasthan, India
Dhanjay Jhurry
ANDICentre ofExcellence for Biomedicaland Biomaterials Research,
University ofMauritius, Re´duit, Mauritius
SaidIbragimovitch Kaba
Institute ofGeneral Pathologyand Pathophysiology,Russian Academy of
Medical Sciences, Moscow, Russia
Samikannu Kanagesan
Materials Synthesis and CharacterizationLaboratory, Instituteof Advanced
Technology (ITMA), Universiti Putra Malaysia (UPM), Selangor,Malaysia
List of contributors xix
Katsumi Kobayashi
PhotonFactory,Instituteof MaterialsStructure Science,High Energy
Accelerator Research Organization, Ibaraki, Japan
Aslan Amirkhanovitch Kubatiev
Institute ofGeneral Pathology and Pathophysiology, Russian Academy of
Medical Sciences, Moscow,Russia
Claude LeSech
Institut des SciencesMole´lculaires d’Orsay—ISMO Baˆt351, Universite´ Paris,
Orsay Cedex, France
Ma˘da˘lina Lemnaru
Department ofBiomaterials and Medical Devices, Faculty ofMedical
Engineering, University Politehnica ofBucharest, Bucharest, Romania
Song Li
Department ofPharmaceutical Sciences, University ofPittsburghSchool of
Pharmacy,Pittsburgh, PA, USA
Min Liu
Key Laboratory ofPesticide and Chemical Biology (Ministry of Education),
College ofChemistry, Central ChinaNormal University, Wuhan,PR, China
Shiying Luo
Key Laboratory ofPesticide and Chemical Biology (Ministry of Education),
College ofChemistry, Central ChinaNormal University, Wuhan,PR, China
Dipika Mandal
Department ofPharmaceutical Technology,Jadavpur University, Kolkata, India
Maria MinodoraMarin
Department ofBiomaterials and Medical Devices, Faculty ofMedical
Engineering, University Politehnica ofBucharest, Bucharest, Romania
S¸tefania Marin
Department ofBiomaterials and Medical Devices, Faculty ofMedical
Engineering, University Politehnica ofBucharest, Bucharest, Romania
Nishi Mody
Drug Delivery Research Laboratory,Department of Pharmaceutical Sciences,
Dr. Hari Singh Gour CentralUniversity,Sagar,MadhyaPradesh, India
Laboni Mondal
Department ofPharmaceutical Technology,Jadavpur University, Kolkata, India
Shaker A.Mousa
The Pharmaceutical Research Institute,Albany College ofPharmacy and
Health Sciences, Rensselaer,NY,USA
xx List of contributors
Jean Felix Mukerabigwi
KeyLaboratory ofPesticide and Chemical Biology(Ministry ofEducation),
College ofChemistry,CentralChina Normal University,Wuhan,PR, China
Biswajit Mukherjee
Department ofPharmaceutical Technology,JadavpurUniversity,Kolkata, India
Radhakrishnan Narayanaswamy
Universiti Putra Malaysia (UPM),Selangor,Malaysia; Laboratory ofNatural
Products,Institute ofBioscience (IBS), Universiti Putra Malaysia (UPM),
Selangor, Malaysia
Surendra Nimesh
Department ofBiotechnology, School of LifeSciences, Central University of
Rajasthan,Ajmer,Rajasthan,India
AshokKumar Pandurangan
Department ofPharmacology, University ofMalaya, Kuala Lumpur,Malaysia
Padmanabhan Parasuraman
LeeKongChian School ofMedicine, Nanyang Technological University (NTU),
Singapore
Kalyani C. Patil
Institute ofCancerSciences, University ofGlasgow,Glasgow, Lanarkshire, UK
MehdiRajabi
The Pharmaceutical Research Institute,Albany College ofPharmacy and
HealthSciences, Rensselaer,NY, USA
Lucinda V.Reis
Department ofChemistry and CQ-VR,UTAD, Vila Real,Portugal
Antonello Santini
Department ofPharmacy,Universita` degliStudidiNapoliFedericoII, Napoli,
Italy
Bhabani Sankar Satapathy
Department ofPharmaceutical Technology,JadavpurUniversity,Kolkata, India
Soma Sengupta
Department ofPharmaceutical Technology,JadavpurUniversity,Kolkata, India
Patrı´cia Severino
Laboratory of nanotechnology and nanomedicine (LNMED),University of
Tiradentes and Institute ofTechnology and Research, Aracaju, Brazil
List of contributors xxi
Rajeev Sharma
Drug Delivery Research Laboratory,Department of Pharmaceutical Sciences,
Dr. Hari Singh Gour CentralUniversity,Sagar,MadhyaPradesh, India
Ame´lia M. Silva
Department ofBiology and Environment, University ofTra´s-os Montese Alto
Douro, Vila Real, Portugal;Centre for Research and Technology ofAgro-
Environmental and BiologicalSciences (CITAB,UTAD),Vila Real, Portugal
Eliana B.Souto
Department ofPharmaceutical Technology,Faculty ofPharmacy,University of
Coimbra(FFUC), Coimbra, Portugal; Center for Neuroscience and Cell Biology
(CNC), University ofCoimbra, Coimbra, Portugal
Selma B. Souto
Department ofEndocrinology and Metabolism, Hospital of Braga, Braga,
Portugal
Mathangi Srinivasan
The Pharmaceutical Research Institute,Albany College ofPharmacy and
Health Sciences, Rensselaer,NY,USA
Roxana Elena T¸iplea
Department ofBiomaterials and Medical Devices, Faculty ofMedical
Engineering, University Politehnica ofBucharest, Bucharest, Romania
Vladimir P.Torchilin
Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern
University,Boston, MA, USA; Department ofBiochemistry,Faculty ofScience,
King AbdulazizUniversity,Jeddah,SaudiArabia
NorikoUsami
PhotonFactory,Instituteof MaterialsStructure Science,High Energy
Accelerator Research Organization, Ibaraki, Japan
George MihailVla˘sceanu
Department ofBiomaterials and Medical Devices, Faculty ofMedical
Engineering, University Politehnica ofBucharest, Bucharest, Romania
Ruchi Vyas
Department ofBiotechnology,The IIS University,Jaipur,Rajasthan,India
Suresh P.Vyas
Drug Delivery Research Laboratory,Department of Pharmaceutical Sciences,
Dr. Hari Singh Gour CentralUniversity,Sagar,MadhyaPradesh, India
xxii List of contributors
JieniXu
Department ofPharmaceutical Sciences, University ofPittsburgh School of
Pharmacy, Pittsburgh,PA,USA
Jatinder Vir Yakhmi
Department ofAtomic Energy,Homi BhabhaNationalInstitute, Mumbai,
Maharashtra, India
PengZhang
Department ofPharmaceutical Sciences, University ofPittsburgh School of
Pharmacy, Pittsburgh,PA,USA
Yuannian Zhang
KeyLaboratory ofPesticide and Chemical Biology(Ministry ofEducation),
College ofChemistry,CentralChina Normal University,Wuhan,PR, China
Preface of the series
The era of nanosized materials is now considered the center of the evolution
of future tools and emerging technologies with wide applications in industry,
research, health, and beyond. Despite recent scientific progress, biological appli-
cations of nanomaterials are far from being depleted and current knowledge is
limited by the poor access to significant data, but also by widespread and usually
unfounded speculation. Although exhaustive, the current literature is difficult to
reach and understand because of the specificity and strict focuses of researchers
investigating different applicationsof nanomaterials.
Inthiscontext,thescientificseriesentitled“ApplicationsofNanobiomaterials”
was motivated by the desire of the Editor, Alexandru Mihai Grumezescu, and
others to bring together comprehensive, up-to-date, and relevant findings on the
field of biological applications of nanostructured materials, to promote the knowl-
edge and expand our vision regarding future perspectives. Even though the
approached domain is quite specific and research-oriented, this multivolume set is
easilyintelligiblefor awide audienceincluding:under-graduate andpost-graduate
students, engineers, researchers, academic staff, pharmaceutical companies,
biomedicalsector andindustrialbiotechnologies.However,somebasicknowledge
of the field of materials science (nanobiomaterials, pharmaceutical industry,
products for medicinal treatments, nanoarchitectonics for delivery of biological
active molecules and release, bone implants and stomatology) and engineering is
arequisiteforunderstandingtechnicalaspects.
The selected authors of each chapter are outstanding specialists in the field of
nanobiomaterials, who have made impressive contributions in a specific area of
research orapplied area within the scope ofthisbook.
Each of the 11 volumes of the series contains 15 chapters, addressing the most
relevantand recent matters on the field of the volume.
The first volume, Fabrication and Self-Assembly of Nanobiomaterials, intro-
duces the reader to the amazing field of nanostructured materials and offers inter-
esting information regarding the fabrication and assembly of these nanosized
structures. In Volume II, entitled Engineering of Nanobiomaterials, readers can
easily findthemostcommonlyinvestigatedmethods andapproachesforobtaining
tailored nanomaterials for a particular application, especially those with a
great deal of significance in the biomedical field. In the following step, readers
will discover the importance and the ways of modifying the surface of nanostruc-
tured materials to obtain bioactive materials, by reading Volume III, Surface
Chemistry of Nanobiomaterials. Starting with Volume IV Nanobiomaterials in
Hard Tissue Engineering and Volume V Nanobiomaterials in Soft Tissue
Engineering,thebiomedicalapplicationsofengineerednanomaterialsarerevealed
and discussed, focusing on one of the most impacted fields, tissue engineering.
Volume VI, Nanobiomaterials in Antimicrobial Therapy, highlights the potential
xxiii
