Table Of ContentNANOBIOANALYTICAL
APPROACHES TO
MEDICAL DIAGNOSTICS
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Woodhead Publishing
Series in Biomaterials
NANOBIOANALYTICAL
APPROACHES TO
MEDICAL
DIAGNOSTICS
Edited by
PAWAN KUMAR MAURYA
DepartmentofBiochemistry,CentralUniversityofHaryana,
Mahendergarh, Haryana, India
PRANJAL CHANDRA
LaboratoryofBio-PhysioSensorsandNanobioengineering,
SchoolofBiochemicalEngineering,IndianInstituteof
Technology(BHU),Varanasi
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Contents
Contributors xi
Preface xv
1. Prospects of fluidic forcemicroscopy and related biosensors
for medical applications 1
TamásGerecsei,BeatrixP(cid:1)eter,RitaUngai-Salánki,SándorKurunczi,
InnaSz(cid:1)ekács,BálintSzabó,andRobertHorvath
1.1 Atomicforcemicroscopy 1
1.2 CellbiologywithAFM 2
1.3 Fluidicforcemicroscopy 4
1.4 Single-cellforcespectroscopybyFluidFM 5
1.5 BacterialadhesionmeasuredbyFluidFM 6
1.6 Eukaryoticcelladhesion 8
1.7 Additionalfluidicforcemicroscopyfunctions 12
1.8 Measurementsbycomputer-controlled
micropipette 15
1.9 Label-freebiosensorsforcelladhesionanalysis 18
1.10 Summary 22
Acknowledgments 23
References 23
2. Point ofcarediagnostics for cancer:Recent trendsand
challenges 29
HemaniDara,MukundMali,HrushikeshAher,PrafullaKumarPatil,
BichismitaSahu,andNehaArya
2.1 Introduction 29
2.2 Roleofbiomarkersinthedetectionofcancer 30
2.3 Point-of-carediagnosticsforcancer 40
2.4 Conclusionandfutureperspectives 57
Acknowledgments 57
References 58
v
vi Contents
3. Bioelectrochemical methodsin biomolecular analysis 65
RituparnaAddy,AnkitYadav,ManojKumar,UbhatAli,AnkenapallyAnjali,
VijayKumarGarlapati,SudipaBhadra,andSurajbhanSevda
3.1 Introduction 65
3.2 Typesofbioelectrochemicalmethodsforbimolecularanalysis:
Workingmechanism 67
3.3 Applicationofbioelectrochemicalsystembased
biosensor 71
3.4 Bioelectrochemicalmethodsforcellanalysis 85
3.5 Bioelectrochemicalmethodsforcellanalysis 91
3.6 Bioelectrochemicalmethodsforcellculturefabricationandcell
stimulation 93
3.7 Prospectiveandfuturetrends 93
References 94
4. Electrochemical nano-aptasensor as potential diagnostic
device for thrombin 105
WeiJuenLiew,ChitraPadmakumariKurup,MohammadRizwan,
andMinhazUddinAhmed
4.1 Introduction 105
4.2 Aptasensor 106
4.3 Thrombin 116
4.4 Applicationofelectrochemicalaptasensorsin
thrombindetection 122
4.5 Conclusionsandfutureoutlook 134
Conflictofinterest 134
Acknowledgments 134
References 135
5. Antibiotics and analytical methods used for their
determination 143
O.I.Guliy,B.D.Zaitsev,andI.A.Borodina
5.1 Introduction 143
5.2 Antibacterialdrugsandtheextentoftheiruse 144
5.3 Conclusion 168
Acknowledgments 170
Conflictofinterest 170
References 170
Contents vii
6. Integration of microfluidics with biosensing technology
for noncommunicable disease diagnosis 179
SyazanaAbdullahLim,AfiqahNabihahAhmad,RoslynnaRosli,
andSitiNoorfatimahSafar
6.1 Introduction 179
6.2 Biosensortechnology 183
6.3 Microfluidicstechnology 184
6.4 Microfluidics-basedbiosensors 189
6.5 Communicationtechnology 197
6.6 Conclusion 202
References 202
7. Role andimplication of nanomaterials in clinical
diagnostics 209
JuhiShah,StutiBhagat,andSanjaySingh
7.1 Introduction 209
7.2 Nanomaterialsinbioimagingbaseddiagnostics 210
7.3 Nanodevices 219
7.4 Nano-biosensors 227
7.5 Lateralflowassay 239
7.6 Safetyconcernsandlimitationsofusingnanoparticle 243
7.7 Conclusionandfutureprospects 244
Acknowledgments 244
References 245
8. Nano-materials in biochemical analysis 255
SomuYadavandPawanKumarMaurya
8.1 Introduction 255
8.2 Classificationofnanoparticles 256
8.3 Synthesisofnanoparticles 258
8.4 Functionalizationofnanomaterialsforbiochemicalapplications 260
8.5 Biochemicalapplicationsofnanoparticles 261
8.6 Conclusionandfutureprospects 278
References 279
9. Lignocellulose-based nanomaterials for diagnostic and
therapeutic applications 285
HemansiandJitendraKumarSaini
9.1 Introduction 285
viii Contents
9.2 Lignocelluloseanditscomposition 287
9.3 Nanoparticlesfromlignocellulose 287
9.4 BiomedicalapplicationsofLCBnanomaterials 294
9.5 Conclusionandfutureprospects 296
References 298
10. Bioanalytical approaches in detection of free radicals
andRONS 303
AdityaArya
10.1 Introduction 303
10.2 OverviewofROSdetectionmethods 305
10.3 Conventionalexvivobioanalyticalmethods 306
10.4 Conventionalinvivomethods 311
10.5 Advancemethodsforradical/RNOSdetection 314
10.6 Conclusion 316
References 316
11. Nano-biosensors for biochemical analysis 319
NimitShah,AshishBadiye,NeetiKapoor,andRiteshK.Shukla
11.1 Introduction 319
11.2 Biosensors 322
11.3 AuNP-basedbiosensors 325
11.4 Carbonnanotubebasedbiosensors 327
11.5 Quantumdotsbasedbiosensors 328
11.6 Nanoparticlesinanalyticalbiochemistry 328
11.7 Nanoparticlesinbioassays 336
11.8 Applications 337
11.9 Conclusionandfutureperspectives 338
Acknowledgments 339
References 339
12. Nanobiomaterials inbiomedicine: Designing approaches
andcritical concepts 345
PallabiBanerjeeandImteyazQamar
12.1 Introduction 345
12.2 Nanomaterialsandit’sapplicationsinnanomedicine 346
12.3 Nanoparticlesusedindrugdeliverysystem 351
12.4 Conclusion 357
References 358
Contents ix
13. Erythrocytes modelfor oxidative stress analysis 363
VikramDalalandSagarikaBiswas
5.1 Oxidativestress 363
5.2 Oxidativestressanddiseases 367
5.3 Oxidativestressandautoimmunediseases 371
5.4 Oxidativestressandrheumatoidarthritis 374
5.5 Oxidativestressanderythrocytes 377
5.6 Conclusion 379
Acknowledgment 381
Authorscontributions 381
References 381
14. Lipid film based biosensors:A protectiontool for
the public health 391
Georgia-ParaskeviNikoleli
14.1 Introduction 391
14.2 Constructionoflipidfilmbasednanosensors 392
14.3 Applicationsoflipidfilmbasedbiosensorsinclinicalanalysisforthe
protectionofpublichealth 396
14.4 Conclusion 400
References 401
Index 405
