Nano-Tera.ch: Engineering the Future of Systems for Health, Environment and Energy

232 Pages·2019·21.067 MB·English

by  Anil Leblebici, Patrick Mayor, Martin Rajman, Giovanni De Micheli

Anil Leblebici
Patrick Mayor
Martin Rajman
Giovanni De Micheli
Nano-Tera.ch
Engineering the Future of Systems
for Health, Environment and Energy
Nano-Tera.ch
Anil Leblebici • Patrick Mayor
Martin Rajman • Giovanni De Micheli
Nano-Tera.ch
Engineering the Future of Systems
for Health, Environment and Energy
Anil Leblebici Patrick Mayor
École Polytechnique Fédérale de École Polytechnique Fédérale de
Lausanne Lausanne
Lausanne, Switzerland Lausanne, Switzerland
Martin Rajman Giovanni De Micheli
École Polytechnique Fédérale de École Polytechnique Fédérale de
Lausanne Lausanne
Lausanne, Switzerland Lausanne, Switzerland
ISBN 978-3-319-99108-5 ISBN 978-3-319-99109-2 (eBook)
https://doi.org/10.1007/978-3-319-99109-2
Library of Congress Control Number: 2018959437
© Springer Nature Switzerland AG 2019
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To the Nano-Tera Community, who has brought the laboratory
experience to our daily lives
Foreword
The scientific and industrial challenges studied in the Nano-Tera.ch program
are related to exploiting established and emerging micro- and nanocompo-
nents within complex systems whose added value is much larger than the
sum of their parts. A notable example is networked sensors for medical and
environmental applications. Networking boosts the intrinsic power of local
measurements and allows us to reach new standards in health and environ-
ment management, with positive fallout on security of individuals and
communities.
Smart and diversified energy generation and distribution, such as smart
grids, as well as harvesting and low-power system design are of the utmost
importance to society and the economy. Truly innovative approaches are
needed that can only be found by massively investing in engineering research.
The upcoming scientific and engineering challenges are too heterogeneous
and complex to be solved within a single scientific domain. They require a
truly collaborative and cross-disciplinary approach. The Nano-Tera.ch pro-
gram has brought together excellent researchers in various fields from many
Swiss institutions with outstanding reputation.
The program has not only been of high scientific value but also of eminent
economic importance for the industrial sector of Switzerland. The program
will serve as the seed for truly innovative products and industries. It also fos-
tered the education of highly qualified engineers and researchers who are the
most valuable and indispensable resource for this country.
The Nano-Tera initiative has fully achieved its goal to bring Switzerland
to the forefront of a new technological revolution: using engineering and
information technology to improve health and security and to broaden our
management of energy and the environment.
For a program such as Nano-Tera, brilliant researchers are only a neces-
sary condition for its success. Experience in numerous programs has shown
that true scientific leadership is of utmost importance. The Scientific Advisory
Board congratulates Prof. Giovanni De Micheli for having done an outstand-
ing job. The board also acknowledges the excellent job done by Dr. Martin
Rajman as executive director.
RWTH Aachen, Aachen, Germany Heinrich Meyr
Nano-Tera.ch, Lausanne, Switzerland
vii
Acknowledgments
The Nano-Tera program is due to the concerted effort and dedication of sev-
eral persons. First of all, we are indebted to the former Swiss Secretary of
State Charles Kleber for receiving the original idea and supporting it through
the parliamentary approval process. EPFL’s President Emeritus Patrick
Aebischer and former Vice-President Giorgio Margaritondo were instrumen-
tal in shaping the program and in infusing enthusiasm and cohesion through-
out the country. We are grateful to State Secretary Mauro Dell’Ambrogio and
to Gregor Haefliger (SERI) for the sustained procedural and financial
support.
We would also like to thank the past and current presidents (and their
deputies) of the Swiss Federal Institute of Technology (Lausanne and Zurich)
and of the universities that are part of the Nano-Tera consortium: Patrick
Aebischer, Philippe Gillet, Ralph Eichler, Detlef Günther, Jean-Pierre
Derendinger, Yves Flückiger, Felix Kessler, Benedetto Lepori, Antonio
Loprieno, Piero Martinoli, Martine Rahier, Andrea Schenker-Wiki, Jean-
Dominique Vassalli, Martin Vetterli, as well as Mario El Khoury and Thomas
Hinderling, current and past CEO of CSEM, for their advisory work in the
steering committee. We want to extend thanks to the Scientific Advisory
Board for their time and effort to advise: Andrea Cuomo, Satoshi Goto,
Enrico Macii, Teresa Meng, Heinrich Meyr, Khalil Najafi, Calton Pu, Lina
Sarro, Göran Stemme, and Nick Jennings. Nano-Tera operations were coor-
dinated through the members of the executive committee (led by Giovanni De
Micheli), including Nico de Rooij, Michel Despont, Alex Dommann, Boi
Faltings, Christofer Hierold, Qiuting Huang, Miroslaw Malek, and Hugo
Zbinden (and previously Christian Schönenberger and Lothar Thiele) whose
wisdom and dedication has been widely appreciated. We thank the panel of
the Swiss National Science Foundation (led by Paul Leiderer) and the NTF
panel for their thankless job in evaluating the proposals. Last but not least, we
would like to thank the Nano-Tera Management Office for running the pro-
gram’s tasks.
The authors acknowledge the outstanding work of the Nano-Tera.ch proj-
ects, whose outcome is outlined in this book. The authors would like to thank
John Maxwell for his help in preparing the images for this work.
ix
Contents
1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
1.1 M otivation and Essential Features of the Program . . . . . . . . . 1
1.1.1 The Research Space . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
1.1.2 Collaboration in Nano-Tera . . . . . . . . . . . . . . . . . . . . . 4
1.1.3 Nano-Tera Organization . . . . . . . . . . . . . . . . . . . . . . . . 4
1.2 A chievements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
1.3 P rogram Organization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
1.3.1 Call Mechanisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
1.3.2 Project Partners, Third Parties and Staff
Members . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
1.3.3 Financial Data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
2 Health Monitoring . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
2.1 S mart Prosthetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
2.1.1 HearRestore: Image-Guided Micro Surgery
for Hearing Aid Implantation . . . . . . . . . . . . . . . . . . . . 15
2.1.2 SpineRepair: Hybrid CMOS- Polymer Neural
Interfaces for Restoration of Sensorimotor
Functions After Spinal Cord Injury . . . . . . . . . . . . . . . 21
2.2 Advanced Diagnosis Tools . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
2.2.1 UltraSoundToGo: High Performance Portable 3D
Ultrasound Platform . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
2.2.2 Wearable MRI: Wearable MRI Detector
and Sensor Arrays . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29
2.2.3 PATLiSci: Probe Array Technology for Life
Science Applications . . . . . . . . . . . . . . . . . . . . . . . . . . 32
2.2.4 PATLiSci II: Rapid Sensing of Cancer . . . . . . . . . . . . 37
2.2.5 NutriChip: A Technological Platform
for Nutrition Analysis to Promote Healthy Food . . . . . 41
2.3 Medical Care Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
2.3.1 ObeSense: Monitoring the Consequences
of Obesity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
2.3.2 TecInTex: Technology Integration into Textiles:
Empowering Health . . . . . . . . . . . . . . . . . . . . . . . . . . . 50
2.3.3 FlusiTex: Fabrication of Fluorescence Sensors
Integrated into a Textile Dressing
for Non-invasive Wound Monitoring . . . . . . . . . . . . . . 55
xi
xii Contents
2.3.4 ISyPeM: Intelligent Integrated Systems
for Personalized Medicine . . . . . . . . . . . . . . . . . . . . . . 59
2.3.5 ISyPeM II: Therapeutic Drug Monitoring
for Personalized Medicine . . . . . . . . . . . . . . . . . . . . . . 64
2.4 Biosensing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66
2.4.1 IrSens: Integrated Sensing Platform for Gases
and Liquids in the Near and Mid-infrared Range . . . . 66
2.4.2 i-IronIC: Implantable/Wearable System
for On-Line Monitoring of Human Metabolic
Conditions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70
3 Environmental Monitoring . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
3.1 Monitoring Water Pollution . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
3.1.1 LiveSense: Cell-Based Sensing Microsystem . . . . . . . 77
3.1.2 Envirobot: Automated Surveying of Surface
Water Quality by a Physical, Chemical
and Biological Sensor Equipped Anguilliform
Robot . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 82
3.2 Monitoring Air Pollution . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
3.2.1 IrSens II: A Multi-component Sensor for Air
Pollutants and Greenhouse Gases . . . . . . . . . . . . . . . . 86
3.2.2 OpenSense: Open Sensor Networks for Air
Quality Monitoring . . . . . . . . . . . . . . . . . . . . . . . . . . . 90
3.2.3 OpenSense II: Crowdsourcing High-Resolution
Air Quality Sensing . . . . . . . . . . . . . . . . . . . . . . . . . . . 93
3.3 Monitoring Rock and Glacier Movements . . . . . . . . . . . . . . . . 98
3.3.1 X-Sense: Monitoring Alpine Mass Movements
at Multiple Scales . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
3.3.2 X-Sense II: MEMS Acoustic Detectors
for Natural Hazard Warning Systems . . . . . . . . . . . . . 103
4 Smart Energy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109
4.1 Low Power Electronics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109
4.1.1 CMOSAIC: 3D Stacked Architectures
with Interlayer Cooling . . . . . . . . . . . . . . . . . . . . . . . . 109
4.1.2 YINS: Energy and Thermal- Aware Design
of Many-Core Heterogenous Datacenters . . . . . . . . . . 117
4.2 Energy Production and Distribution . . . . . . . . . . . . . . . . . . . . 122
4.2.1 SHINE: Solar Hydrogen Integrated Nano
Electrolysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 122
4.2.2 Synergy: Systems for Ultra- High Performance
Photovoltaic Energy Harvesting . . . . . . . . . . . . . . . . . 127
4.2.3 SmartGrid: Smart Grids, Smart Buildings
and Smart Sensors for Optimized and Secure
Management of Electricity Distribution Using
Dedicated Microelectronic ICS and Real
Time ICT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133
Contents xiii
5 Impact Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139
5.1 S cientific Impact . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
5.1.1 Funded Projects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143
5.2 E ducational Impact . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143
5.2.1 NextStep Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145
5.2.2 Education and Dissemination Activities . . . . . . . . . . . 148
5.3 E conomic Impact . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151
5.3.1 Involvement of Industrial Partners
and End-Users . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151
5.3.2 Education of PhD Graduates for the Industry . . . . . . . 152
5.3.3 Economic Potential Resulting
from the Production of Exploitable
Demonstrators and Platforms . . . . . . . . . . . . . . . . . . . . 152
5.3.4 The Nano-Tera Gateway Program . . . . . . . . . . . . . . . . 155
5.4 S ocietal Impact . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 158
5.5 I nstitutional Impact . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163
5.6 B eyond Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163
5.6.1 Symposia Within the Nano- Tera International
Exchange Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163
5.6.2 Switzerland-Korea Joint Workshops . . . . . . . . . . . . . . 164
5.6.3 Medi-Labo-Tech 2017 Conference . . . . . . . . . . . . . . . 166
5.6.4 N ano-Tera: SSSTC Pilot Grants . . . . . . . . . . . . . . . . . 166
5.6.5 I nfo Days for Industrial Players . . . . . . . . . . . . . . . . . . 167
5.6.6 THE Nano-Tera Annual Meeting . . . . . . . . . . . . . . . . . 169
6 Projects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171
6.1 R TD Projects: Phase 1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 72
6.2 R TD Projects: Phase 2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 91
6.3 N TF Projects: Phase 1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 216
6.4 N TF Projects: Phase 2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 217
6.5 G ateway Projects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 218
6.6 T imeline of Projects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 220
6.6.1 Phase 1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 20
6.6.2 Phase 2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 21
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223