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About Myeloid Leukemia: Methods and Protocols
A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia, classification of AML by DNA-oligonucleotide microarrays, and detection of the V617F JAK2 mutation in myeloproliferative disorders. In addition to gene rearrangments, other prognostically relevant molecular lesions such as FLT3 mutations and WT-1 overexpression are covered.
Detailed Information
| Author: | Harry Iland, Mark Hertzberg, Paula Marlton |
|---|---|
| Publication Year: | 2005 |
| ISBN: | 1597450170 |
| Pages: | 319 |
| Language: | English |
| File Size: | 9.032 |
| Format: | |
| Price: | FREE |
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