Multiple Origins of Sex Differences in Brain: Neuroendocrine Functions and their Pathologies

187 Pages·2013·2.537 MB·English

by  Khatuna Gagnidze, Donald W. Pfaff (auth.), Donald W. Pfaff, Yves Christen (eds.)

Research and Perspectives in Endocrine Interactions
For furthervolumes:
http://www.springer.com/series/5241
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Donald W. Pfaff (cid:129) Yves Christen
Editors
Multiple Origins of Sex
Differences in Brain
Neuroendocrine Functions and their
Pathologies
Editors
DonaldW.Pfaff YvesChristen
LaboratoryofNeurobiologyandBehavior FondationIpsenpourla
TheRockefellerUniversity RechercheTherapeutique,
NewYork France
USA
ISSN1861-2253
ISBN978-3-642-33720-8 ISBN978-3-642-33721-5(eBook)
DOI10.1007/978-3-642-33721-5
SpringerHeidelbergNewYorkDordrechtLondon
LibraryofCongressControlNumber:2012955940
#Springer-VerlagBerlinHeidelberg2013
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Foreword
Multiple Origins of Sex Differences in Brain. Neuroendocrine
Functions and their Pathologies
Intheoreticalterms,sexdifferencesinbrainsandbehaviorsoflaboratoryanimals
offer the possibility of fascinating scientific studies on a range of molecular
phenomena such as genomic imprinting, DNA methylation, chromatin protein
modification,non-codingDNA,potentiallyresultinginimportantneuroanatomical
and neurochemical sex differences in the brain. Such sex differences could arise
consequent to exposures to testosterone early in development, or to other effects
deriving from the Y chromosome. However, this general subject has been treated
with much hyperbole. Historically, sex differences were assumed to be present
wheretheydidnotreallyexist,e.g.withrespecttomathematics,executiveleader-
ship,etc.etc.Underwhatcircumstancesdowereallycareaboutsexdifferencesin
brain and behavior? These circumstances concern human maladies whose
diagnoses are much different between boys and girls, or between women and
men.Prominentexamplesdiscussedinthisvolumeincludeautism,attentiondeficit
hyperactivitydisordersandcongenitaladrenalhyperplasia.Infact,infantboysare
more susceptible than infant girls to a variety of disorders that arise early in
development. This volume then ends with a consideration of effects of estrogenic
hormonesontheinjuredbrain,andtheirrolesasprotectiveagents.
This volume contains the proceedings of the XIth Colloque Me´decine et
Recherche of Fondation Ipsen held in Paris, on December 3, 2011 which bring
togethercliniciansandbasicscientistsworkinginendocrinologyandneuroscience.
DonaldPfaff(TheRockefellerUniversity,NewYork,USA)
YvesChristen(FondationIPSEN,Paris,France)
v
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Acknowledgments
TheeditorswishtoexpresstheirgratitudetoMrsMaryLynnGageforhereditorial
assistance,MrsSoniaLeCornec,AstriddeGe´rard,Ce´lineMaffre,andJacqueline
Mervailliefortheorganizationofthemeeting.
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Contents
Hormone-DependentChromatinModificationsRelated
toSexuallyDifferentiatedBehaviors. . . . . . . . . . . . . . . . . . . . . . . . . . . 1
KhatunaGagnidzeandDonaldW.Pfaff
ImportanceofGenomicImprintingintheEvolution
andDevelopmentoftheMaternalBrain. . . . . . . . . . . . . . . . . . . . . . . . 21
BarryE.Keverne
GenomicImprintingintheAdultandDevelopingBrain. . . . . . . . . . . . 35
CatherineDulacandGreggChristopher
TheSynapse:DifferencesBetweenMenandWomen. . . . . . . . . . . . . . . 43
JavierDeFelipeandLidiaAlonso-Nanclares
GonadalHormoneInfluencesonHumanNeurobehavioral
Development:OutcomesandMechanisms. . . . . . . . . . . . . . . . . . . . . . . 59
MelissaHines
CongenitalAdrenalHyperplasia:Neuroendocrine,Behavioral
andCognitiveImplications. . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . .. 71
PhyllisW.Speiser
GeneticVariationWithinSerotoninGenes,Hormones,
andAggression. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81
FrancescaDucci,LauraBevilacqua,PaolaLandi,andDavidGoldman
MultipleOriginsofSexDifferencesinAttentionDeficit
HyperactivityDisorder. . . . . .. . . . . . . . . .. . . . . . . . . .. . . . . . . . . .. . 103
JamesM.Swanson,KimberlyD.Lakes,TimL.Wigal,
andNoraD.Volkow
FetalTestosteroneinMind:ImplicationsforAutism. . . . . . . . . . . . . . . 123
BonnieAuyeungandSimonBaron-Cohen
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