Multi-Targeted Approach to Treatment of Cancer

407 Pages·2015·8.3 MB·English

by  Varsha Gandhi

Varsha Gandhi · Kapil Mehta
Rajesh Grover · Sen Pathak
Bharat B. Aggarwal Editors
Multi-Targeted
Approach to
Treatment
of Cancer
Multi-Targeted Approach to Treatment of Cancer
ThiSisaFMBlankPage
Varsha Gandhi (cid:129) Kapil Mehta (cid:129) Rajesh Grover (cid:129)
Sen Pathak (cid:129) Bharat B. Aggarwal
Editors
Multi-Targeted Approach to
Treatment of Cancer
Editors
VarshaGandhi KapilMehta
DepartmentofExperimentalTherapeutics DepartmentofExperimentalTherapeutics
UniversityofTexas UniversityofTexas
M.D.AndersonCancerCenter M.D.AndersonCancerCenter
Houston,Texas,USA Houston,Texas,USA
RajeshGrover SenPathak
DelhiStateCancerInstitute(East) DepartmentofExperimentalTherapeutics
Delhi UniversityofTexas
India M.D.AndersonCancerCenter
Houston,Texas,USA
BharatB.Aggarwal
DepartmentofBioimmunotherapy
SectionofCytokineResearch
UniversityofTexas
M.D.AndersonCancerCenter
Houston,Texas,USA
ISBN978-3-319-12252-6 ISBN978-3-319-12253-3(eBook)
DOI10.1007/978-3-319-12253-3
SpringerChamHeidelbergNewYorkDordrechtLondon
LibraryofCongressControlNumber:2015930738
©SpringerInternationalPublishingSwitzerland2015
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Contents
PartI Genetics/Genome/Microenvironment
1 DiversityofChromosomalCharacteristicsAmongMammals:With
SpecialReferencetoLaboratoryMouseinCancerResearch. . . . . 3
SenPathak
2 Genome-BasedMulti-targetingofCancer:HypeorHope?. . . . . . 19
ShinjiniSingh,AmitKumarTyagi,SashaRaman,JiaminHuang,
LokeshDeb,QaisarManzoor,ArfaaSajid,LiXinYang,
JagnyeswarRatha,SahdeoPrasad,andBharatB.Aggarwal
3 ChronicLymphocyticLeukemiaattheGenomicLevel. . . . . . . . . 57
HimaV.VangapanduandVarshaGandhi
4 ApoptosisPathwaysinChronicLymphocyticLeukemia:Roleofthe
MicroenvironmentandTherapeuticStrategies. . . . . . . . . . . . . . . . 73
ViralkumarPatel,KumudhaBalakrishnan,andVarshaGandhi
5 Tumor-AssociatedMacrophagesinTumorProgression:From
BenchtoBedside. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
MariaRosariaGaldieroandAlbertoMantovani
6 RoleofOsteopontininTumorMicroenvironment:ANewParadigm
inCancerTherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113
RameshButti,PompomGhosh,KumarV.S.Totakura,
RadharaniN.NagaVenkata,RamakrishnaNimma,andGopalC.Kundu
PartII TumorGrowth/Progression
7 TG2:PlayerThatDictatestheRulesinCancerProgression. . . . . . 129
KapilMehtaandSantoshKumar
v
vi Contents
8 RoleofSurfactantsinRegulationofCancerGrowth. . . . . . . . . . . 137
AbdelfattahM.Badawi,DinaA.Ismail,SaharAhmed,Ammona
Mohamad,MonaDardir,DaliaE.Mohamed,AshganIbrahem,
NahlaA.Mansour,andAbeerAshmawy
9 HumanAlbuminome:ReflectionsofNeoplasticTransformationand
CancerDetectionThroughAlbumin-AssociatedBiomarkers. . . . . 151
GaganjotSinghKalsey
PartIII CancerinIndiaandApproaches
10 IntegratedCancerScreeningStrategiesinIndia. . . . . . . . . . . . . . . 167
RaviMehrotraandRoopaHariprasad
11 GallBladderCancer:WhatNeedstoBeDoneinIndia?. . . . . . . . 179
VinayK.Kapoor
12 CurrentTreatmentforGallbladderCancer. . . . . . . . . . . . . . . . . . 189
M.A.Ansari,P.Gupta,andV.K.Shukla
13 PrevalenceofGastrointestinalCancersinIndia. . . . . . . . . . . . . . . 217
SatyavatiRana
PartIV TargetsandTherapeutics
14 PersonalizedTherapeuticStrategiesforEpithelialOvarian
Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 235
NeetaSingh,SeemaPatel,andRajarshiKar
15 TumorAngiogenesisandNovelVascularEndothelialReceptor
(VEGFR)-SpecificSmallMoleculeInhibitors. . . . . . . . . . . . . . . . . 245
AppuRathinavelu
16 TargetingMitochondria:APowerhouseApproachtoCancer
Treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263
NavneetAgnihotri,IshaRani,andSandeepKumar
17 DesigningofTumor-TargetedHuRsiRNANanoparticleasa
TherapeuticforLungCancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
RanganayakiMuralidharan,AnishBabu,KantheshBasalingappa,
MeghnaMehta,AnupamaMunshi,andRajagopalRamesh
18 TherapeuticAnticancerApproachesTargetingTelomeraseand
Telomeres. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 295
DeekshaPal,UjjawalSharma,andRajendraPrasad
19 RoleofInositolTriphosphateReceptorinCancerandIts
TargetingThroughAutophagy. . . . . . . . . . . . . . . . . . . . . . . . . . . . 311
AruSingh,MeghaChagtoo,BandanaChakravarti,
andMadanM.Godbole
Contents vii
20 DNATopoisomeraseII:PromisingTargetforAnticancer
Drugs. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 323
ParamjeetKaur,VarinderKaur,andSatwinderjeetKaur
21 ChemopreventiveandAnticancerEfficacyofSilibininAgainst
ColorectalCancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 339
SushilKumar,KomalRaina,andRajeshAgarwal
22 IntegratingTraditionalKoreanMedicineintoModern
CancerCare. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 351
SeongWooYoon
23 SeizingCancerCompletelyThroughSpecificAblatingCancerStem
Cell:TheRoyalRoadtoChemoquiescence. . . . . . . . . . . . . . . . . . . 365
JongMinPark,NapapanKangwan,EunHeeKim,MiKyungChung,
YoungminHan,SungHunKwon,ChangIlKwon,andKiBaikHahm
24 CervicalCancerStemCellsandTheirAssociationwithHuman
Papillomavirus:AreTheyReadyasAnticancerTargets?. . . . . . . . 377
KanchanVishnoi,AbhishekTyagi,SukhMahendraSingh,
BhudevC.Das,andAlokC.Bharti
25 IntegrativeOncology:ScientificResearchinSupportofPatients:
Useful,Possible,Valid. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 401
MassimoBonucci
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Contributors
RajeshAgarwal DepartmentofPharmaceuticalSciences,SkaggsSchoolofPhar-
macyandPharmaceuticalSciences,SanDiego,CA,USA
University of Colorado Cancer Center, University of Colorado Anschutz Medical
Campus,Aurora,CO,USA
Bharat B. Aggarwal Department of Bioimmunotherapy, Section of Cytokine
Research, University of Texas, M.D. Anderson Cancer Center, Houston, Texas
USA
NavneetAgnihotri DepartmentofBiochemistry,PunjabUniversity,Chandigarh,
India
Sahar Ahmed Applied Surfactant Laboratory, Department of Petrochemicals,
EgyptianPetroleumResearchInstitute,Cairo,Egypt
M. A. Ansari Department of General Surgery, Institute of Medical Sciences,
BanarasHinduUniversity,Varanasi,India
Abeer Ashmawy Tumor Biology Department, National Cancer Institute, Cairo,
Egypt
Anish Babu Department of Pathology, University of Oklahoma Health Sciences
Center,OklahomaCity,OK,USA
StephensonCancerCenter,UniversityofOklahomaHealthSciencesCenter,Okla-
homaCity,OK,USA
Abdelfattah M. Badawi Applied Surfactant Laboratory, Department of Petro-
chemicals,EgyptianPetroleumResearchInstitute,NasrCityCairo,Egypt
Kumudha Balakrishnan Departments of Experimental Therapeutics, The Uni-
versityofTexasM.D.AndersonCancerCenter,Houston,TX,USA
Kanthesh Basalingappa Stephenson Cancer Center, University of Oklahoma
HealthSciencesCenter,OklahomaCity,OK,USA
ix