Table Of ContentStudies in Mechanobiology,
Tissue Engineering and Biomaterials 23
Yanhang Zhang Editor
Multi-scale
Extracellular
Matrix
Mechanics and
Mechanobiology
Studies in Mechanobiology, Tissue Engineering
and Biomaterials
Volume 23
Series Editor
Amit Gefen, Department of Biomedical Engineering, Tel Aviv University, Ramat
Aviv, Israel
More information about this series at http://www.springer.com/series/8415
Yanhang Zhang
Editor
Multi-scale Extracellular
Matrix Mechanics
and Mechanobiology
123
Editor
YanhangZhang
Department ofMechanical Engineering,
Department ofBiomedical Engineeringand
DivisionofMaterialsScience&Engineering
BostonUniversity
Boston, MA, USA
ISSN 1868-2006 ISSN 1868-2014 (electronic)
Studies in Mechanobiology,Tissue EngineeringandBiomaterials
ISBN978-3-030-20181-4 ISBN978-3-030-20182-1 (eBook)
https://doi.org/10.1007/978-3-030-20182-1
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Preface
Extracellular matrix (ECM) forms the primary load-bearing component in many
connective tissues. In addition to providing structural support, ECM also plays an
important role in modulating cell function. Reciprocally, cells can modulate the
structure and composition of ECM. Many pathological conditions are associated
withlossoforganizationandfunctionofECM;however,themechanismsbywhich
ECM mechanics influence cell and tissue function remain to be fully elucidated.
Such understandings require multi-scale approaches since the changes associated
with pathological developments span from the tissue to molecular level.
Furthermore, ECM has extremely complex hierarchical three-dimensional struc-
tures and there exists a tremendous interdependence of ECM compositional,
structural, and mechanical properties. This book describes the current state of
knowledge in the field of multi-scale ECM mechanics and mechanobiology with a
focus on experimental and modeling studies in biomechanical characterization,
advancedopticalmicroscopyandimaging,aswellascomputationalmodeling.This
book also discusses the scale dependency of ECM mechanics, translation of
mechanical forces from tissue to cellular level, and advances and challenges in
improving our understanding of cellular mechanotransduction in the context of
living tissues and organisms.
Boston, MA, USA Yanhang Zhang
v
Contents
Biomechanics and Mechanobiology of Extracellular Matrix
Remodeling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Jay D. Humphrey and Marcos Latorre
Multi-scale Modeling of the Heart Valve Interstitial Cell. . . . . . . . . . . . 21
Alex Khang, Daniel P. Howsmon, Emma Lejeune and Michael S. Sacks
Modeling the Structural and Mechanical Properties of the Normal
and Aneurysmatic Aortic Wall. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55
T. Christian Gasser
Cellular and Extracellular Homeostasis in Fluctuating Mechanical
Environments. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83
BélaSuki,HarikrishnanParameswaran,CalebeAlves,AscânioD.Araújo
and Erzsébet Bartolák-Suki
Experimental Characterization of Adventitial Collagen Fiber
KinematicsUsingSecond-HarmonicGenerationImagingMicroscopy:
Similarities and Differences Across Arteries, Species and Testing
Conditions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123
Cristina Cavinato, Pierre Badel, Witold Krasny, Stéphane Avril
and Claire Morin
Intrinsic Optical Imaging of ECM Mechanics . . . . . . . . . . . . . . . . . . . . 165
Raphaël Turcotte and Yanhang Zhang
Collagen Self-assembly: Biophysics and Biosignaling for Advanced
Tissue Generation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203
David O. Sohutskay, Theodore J. Puls and Sherry L. Voytik-Harbin
Roles of Interactions Between Cells and Extracellular Matrices
for Cell Migration and Matrix Remodeling . . . . . . . . . . . . . . . . . . . . . . 247
Jing Li, Wonyeong Jung, Sungmin Nam, Ovijit Chaudhuri
and Taeyoon Kim
vii
viii Contents
Quantification of Cell-Matrix Interaction in 3D Using Optical
Tweezers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 283
Satish Kumar Gupta, Jiawei Sun, Yu Long Han, Chenglin Lyu,
Tianlei He and Ming Guo
Cell-Matrix Interactions in Cardiac Development and Disease. . . . . . . . 311
Matthew C. Watson, Erica M. Cherry-Kemmerling
and Lauren D. Black III
Multi-scale Mechanics of Collagen Networks: Biomechanical
Basis of Matrix Remodeling in Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . 343
J. Ferruzzi, Y. Zhang, D. Roblyer and M. H. Zaman
Author Index.... .... .... .... ..... .... .... .... .... .... ..... .. 389
Subject Index.... .... .... .... ..... .... .... .... .... .... ..... .. 391
Abbreviations/Nomenclature
2D Two-dimensional
3D Three dimensions
AAA Abdominal aortic aneurysm
AC Against curvature
ADAMTS2 ADisinegrinandMetalloproteinase with ThrombospondinMotifs 2
aff Affine prediction
AFG Arbitrary function generator
AFM Atomic force microscopy
AGE Advanced glycation end product
AI Alignment index
AngII Angiotensin II
AOD Acousto-optic deflectors
AT Ascending thoracic part
ATA Ascending thoracic aorta
ATAA Ascending thoracic aortic aneurysm
AV Aortic valve
AVIC Aortic valve interstitial cell
BAV Bicuspid aortic valve
BGN Human gene encoding biglycan
BMP Bone morphogenic protein
BPV Blood pressure variability
CAVD Calcific aortic valve disease
cECM Cardiac extracellular matrix
CF Cardiac fibroblast
CFPG Collagen fibril proteoglycan
circ Circumferential direction
CM Cardiomyocyte
CMP Collagen mimetic peptide
COL3A1 Human gene encoding the alpha 1 chain of collagen III
CPC Cardiac progenitor cell
ix
x Abbreviations/Nomenclature
CRGDS Cysteine–arginine–glycine–aspartic acid–serine (adhesive peptide)
CRM Confocal reflection microscopy
CS Chondroitin sulfate
CT Curvelet transform
CT-A Computed tomography-angiography
DAQ Data acquisition card
DDR Discoidin domain receptor
dECM Decellularized extracellular matrix
DHT Dehydrothermal
DI Dispersion index
diag Diagonal direction
DNA Deoxyribonucleic acid
DOE Diffractive optical element
DS Dermatan sulfate
DT Descending thoracic part
EC Endothelial cell
ECM Extracellular matrix
ECs Endothelial cells
EDC 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride
EFE Endocardial fibroelastosis
ELN Human gene encoding elastin
EMILIN Elastin microfibril interface-located proteins
EMT Epithelial-to-mesenchymal transition
ESC-CM Embryonic-stem-cell-derived cardiomyocyte
ET-1 Endothelin-1
exp Experimentally observed
FA Focal adhesion
F-actins Actin filaments
FAK Focal adhesion kinase
FB Fibroblast
FBLN4 Human gene encoding fibulin-4
FBN1 Human gene encoding fibrillin-1
FDA Food and Drug Administration
FDM Fluctuation-driven mechanotransduction
FE Finite element
FEM Finite element method
FFT Fast Fourier transform
FGF Fibroblast growth factor
FIRE Fiber extraction algorithm
FN Fibronectin
FRET Fluorescence resonance energy transfer
FSM Force spectrum microscopy
G&R Growth and remodeling
GA Glutaraldehyde
GAG Glycosaminoglycan
