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Introductionandmotivation Missingdatamodels Implementations Results Sensitivityanalyses Summaryanddiscussion Much ado about nothing: methods and implementations to estimate incomplete data regression models Nicholas J. Horton Smith College, Northampton, MA, USA and University of Auckland, New Zealand December 6, 2007, Australasian Biometrics Conference [email protected] http://www.math.smith.edu/∼nhorton/muchado.pdf NicholasJ.Horton Muchadoaboutnothing:methodsandimplementationstoestimateincompletedataregressionmodels Introductionandmotivation Missingdatamodels Implementations Results Sensitivityanalyses Summaryanddiscussion Acknowledgements joint work with Ken P. Kleinman, Department of Ambulatory Care Policy, Harvard Medical School partial funding support from NIH MH54693 NicholasJ.Horton Muchadoaboutnothing Introductionandmotivation Missingdatamodels Introductionandmotivation Implementations Whatmethodsareusedinpractice? Results Goal Sensitivityanalyses Healthservicesexample Summaryanddiscussion Introduction and motivation missing data a common problem may be due to design or happenstance ignoring missing data may lead to ineﬃciency ignoring missing data may lead to bias NicholasJ.Horton Muchadoaboutnothing Introductionandmotivation Missingdatamodels Introductionandmotivation Implementations Whatmethodsareusedinpractice? Results Goal Sensitivityanalyses Healthservicesexample Summaryanddiscussion Introduction and motivation 1 many developments in methodology for incomplete data settings 2 software to ﬁt incomplete data regression models is improving (but not yet entirely there!) 3 these methods need to be more widely utilized in practice NicholasJ.Horton Muchadoaboutnothing Introductionandmotivation Missingdatamodels Introductionandmotivation Implementations Whatmethodsareusedinpractice? Results Goal Sensitivityanalyses Healthservicesexample Summaryanddiscussion What missing data methods are used in practice? 1 Burton and Altman (BJC, 2004), review of missing covariates in 100 cancer prognostic papers 2 Horton and Switzer (NEJM, 2005), missing data methods in the Journal NicholasJ.Horton Muchadoaboutnothing Introductionandmotivation Missingdatamodels Introductionandmotivation Implementations Whatmethodsareusedinpractice? Results Goal Sensitivityanalyses Healthservicesexample Summaryanddiscussion Burton and Altman review of 100 papers (BJC, 2004) APPROACH # PAPERS no missing or unclear 6 complete data entry criteria 13 missing data were reported 81 NicholasJ.Horton Muchadoaboutnothing Introductionandmotivation Missingdatamodels Introductionandmotivation Implementations Whatmethodsareusedinpractice? Results Goal Sensitivityanalyses Healthservicesexample Summaryanddiscussion Papers reporting methods (n=32, subset of 81) APPROACH # PAPERS available case 12 complete case 12 omit predictors 6 missing indicator 3 ad-hoc imputation 3 multiple imputation 1 NicholasJ.Horton Muchadoaboutnothing Introductionandmotivation Missingdatamodels Introductionandmotivation Implementations Whatmethodsareusedinpractice? Results Goal Sensitivityanalyses Healthservicesexample Summaryanddiscussion Horton and Switzer (2005) 26 original articles in the NEJM (January 2004–June 2005) reported use of missing data methods APPROACH # PAPERS last value carried forward 12 mean imputation 13 sensitivity analysis 2 multiple imputation 2 NicholasJ.Horton Muchadoaboutnothing Introductionandmotivation Missingdatamodels Introductionandmotivation Implementations Whatmethodsareusedinpractice? Results Goal Sensitivityanalyses Healthservicesexample Summaryanddiscussion Burton and Altman (BJC, 2004) We are concerned that very few authors have considered the impact of missing covariate data; it seems that missing data is generally either not recognised as an issue or considered a nuisance that is best hidden.(p.6) NicholasJ.Horton Muchadoaboutnothing Introductionandmotivation Missingdatamodels Introductionandmotivation Implementations Whatmethodsareusedinpractice? Results Goal Sensitivityanalyses Healthservicesexample Summaryanddiscussion Barriers to use methods not well developed (not so true anymore) little easy to use software (still somewhat true, more later) word count limitations (online methods!) not perceived to be critical to a comprehensive analysis (quite common belief) no CONSORT equivalent (see Burton and Altman) NicholasJ.Horton Muchadoaboutnothing

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Much ado about nothing: methods and implementations to estimate PDF

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Publication Year:	2007
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Language:	English
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