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About MSK Notes
This document summarizes key principles of pharmacokinetics and pharmacology. It discusses: 1) The importance of maintaining appropriate drug concentrations at the site of action over time. Factors like dosage, formulation, and patient characteristics influence absorption and concentrations. 2) Drug metabolism and elimination occurs mainly through the liver and kidneys. Biotransformation makes drugs more soluble for excretion, though some drugs require these transformations to become active. 3) Alcohol is absorbed through the stomach and small intestine and distributed throughout the body. It is mainly metabolized in the liver by alcohol dehydrogenase and acetaldehyde dehydrogenase. Metabolic byproducts can be toxic and cause organ damage with chronic use.
Detailed Information
| Author: | ['Joseph Chan'] |
|---|---|
| Publication Year: | 2014 |
| Pages: | 78 |
| Language: | English |
| Format: | |
| Price: | FREE |
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