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MOUNT SINAI EXPERT GUIDES Obstetrics and Gynecology • Potential pitfalls / common mistakes • Clinical pearls • Management algorithms • Evidence-based guidelines EDITED BY RHODA SPERLING with websit e MOUNT SINAI EXPERT GUIDES Obstetrics and Gynecology MOUNT SINAI EXPERT GUIDES Obstetrics and Gynecology EDITED BY Rhoda Sperling IcahnSchoolofMedicineatMountSinai NewYork,NY,USA Thiseditionfirstpublished2020 ©2020JohnWiley&Sons,Ltd Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,ortransmitted,inanyformorbyanymeans, electronic,mechanical,photocopying,recordingorotherwise,exceptaspermittedbylaw.Adviceonhowtoobtainpermissiontoreusematerial fromthistitleisavailableathttp://www.wiley.com/go/permissions. TherightofRhodaSperlingtobeidentifiedastheauthor(s)oftheeditorialmaterialinthisworkhasbeenassertedinaccordancewithlaw. RegisteredOffice(s) JohnWiley&Sons,Inc.,111RiverStreet,Hoboken,NJ07030,USA JohnWiley&SonsLtd,TheAtrium,SouthernGate,Chichester,WestSussex,PO198SQ,UK EditorialOffice 9600GarsingtonRoad,Oxford,OX42DQ,UK Fordetailsofourglobaleditorialoffices,customerservices,andmoreinformationaboutWileyproductsvisitusatwww.wiley.com. Wileyalsopublishesitsbooksinavarietyofelectronicformatsandbyprint-on-demand.Somecontentthatappearsinstandardprintversionsof thisbookmaynotbeavailableinotherformats. LimitofLiability/DisclaimerofWarranty Thecontentsofthisworkareintendedtofurthergeneralscientificresearch,understanding,anddiscussiononlyandarenotintendedandshould notberelieduponasrecommendingorpromotingscientificmethod,diagnosis,ortreatmentbyphysiciansforanyparticularpatient.Inviewof ongoingresearch,equipmentmodifications,changesingovernmentalregulations,andtheconstantflowofinformationrelatingtotheuseof medicines,equipment,anddevices,thereaderisurgedtoreviewandevaluatetheinformationprovidedinthepackageinsertorinstructionsfor eachmedicine,equipment,ordevicefor,amongotherthings,anychangesintheinstructionsorindicationofusageandforaddedwarningsand precautions.Whilethepublisherandauthorshaveusedtheirbesteffortsinpreparingthiswork,theymakenorepresentationsorwarrantieswith respecttotheaccuracyorcompletenessofthecontentsofthisworkandspecificallydisclaimallwarranties,includingwithoutlimitationanyimplied warrantiesofmerchantabilityorfitnessforaparticularpurpose.Nowarrantymaybecreatedorextendedbysalesrepresentatives,writtensales materialsorpromotionalstatementsforthiswork.Thefactthatanorganization,website,orproductisreferredtointhisworkasacitationand/or potentialsourceoffurtherinformationdoesnotmeanthatthepublisherandauthorsendorsetheinformationorservicestheorganization,website, orproductmayprovideorrecommendationsitmaymake.Thisworkissoldwiththeunderstandingthatthepublisherisnotengagedinrendering professionalservices.Theadviceandstrategiescontainedhereinmaynotbesuitableforyoursituation.Youshouldconsultwithaspecialistwhere appropriate.Further,readersshouldbeawarethatwebsiteslistedinthisworkmayhavechangedordisappearedbetweenwhenthisworkwas writtenandwhenitisread.Neitherthepublishernorauthorsshallbeliableforanylossofprofitoranyothercommercialdamages,includingbut notlimitedtospecial,incidental,consequential,orotherdamages. LibraryofCongressCataloging-in-PublicationData Names:Sperling,Rhoda,editor. Title:Obstetricsandgynecology/editedbyRhodaSperling. Description:Hoboken,NJ:Wiley-Blackwell,2020.|Series:MountSinaiexpertguides|Includesbibliographicalreferencesandindex. Identifiers:LCCN2020010613(print)|LCCN2020010614(ebook)|ISBN9781119450115(librarybinding)|ISBN9781119450108(adobepdf) |ISBN9781119450078(epub) Subjects:LCSH:Obstetrics–Handbooks,manuals,etc.|Gynecology–Handbooks,manuals,etc. Classification:LCCRG531.O272020(print)|LCCRG531(ebook)|DDC618.2–dc23 LCrecordavailableathttps://lccn.loc.gov/2020010613 LCebookrecordavailableathttps://lccn.loc.gov/2020010614 Coverimage:©Raycat/GettyImages CoverdesignbyWiley Setin8.5/12ptFrutigerLTStdbyAptaraInc.,NewDelhi,India PrintedandboundbyCPIGroup(UK)Ltd,Croydon,CR04YY 10 9 8 7 6 5 4 3 2 1 Contents Contributors,viii SeriesForeword,xiv Preface,xv AbouttheCompanionWebsite,xvi Part 1: OBSTETRICS 1 MultipleGestations,3 KatherineA.ConnollyandJoanneL.Stone 2 Preeclampsia/Eclampsia,10 PatriciaRekawekandBrianWagner 3 GestationalDiabetes,21 MartiSoffer,CatherineA.Bigelow,andGarfieldClunie 4 ViralInfectionsandPregnancy,28 CatherineA.BigelowandLaurenFerrara 5 PlacentaPreviaandMorbidlyAdherentPlacenta,36 ElizabethYoselevsky,KatherineA.Connolly,andNoelStrong 6 GastrointestinalDisordersandPregnancy,42 EricP.BerghandMariaTeresaMella 7 UltrasoundinPregnancy,49 EricP.BerghandAngelaBianco 8 CarrierScreeningandAneuploidyScreening,59 LucianaVieiraandKeithEddleman 9 PretermBirth,67 AndreiRebarber 10 AbnormalLabor,80 DyeseTaylor,LoisBrustman,andFrederickFriedmanJr. 11 CesareanDeliveryandOperativeVaginalDelivery,87 FrancescoCallipari,AnnaKremer,FahimehSasan,andJianJennyTang 12 IntrapartumandPostpartumHemorrhage,94 FaithJ.Frieden 13 IntraamnioticInfection,99 AndrewDitchik v vi Contents 14 LiverDiseaseandPregnancy,108 TatyanaKushnerandRhodaSperling 15 ThyroidDiseaseandPregnancy,117 CarolLevy,DanielleBrooks,andKeertiMurari 16 PerinatalMoodandAnxietyDisorders,127 MatthewDominguez,LaudyBurgos,andVeerleBergink Part 2: GYNECOLOGY 17 SurgicalSiteInfections,135 V.OrdSarabanchong 18 Vaginitis,Cervicitis,andPelvicInflammatoryDisease,143 JanineA.DonezaandLisaDabney 19 AbnormalUterineBleeding,152 KarinaHoanandCharlesAscher-Walsh 20 Fibroids,159 KarinaHoanandCharlesAscher-Walsh 21 PelvicOrganProlapse,168 WoojinChongandJohnA.Fantl 22 StressIncontinence,175 NinaS.JacobsonandCharlesAscher-Walsh 23 AdnexalMass,184 JanineA.DonezaandTamaraKolev 24 Endometriosis,193 SuzanneS.Fenske 25 AnogenitalHPV,199 EricM.Ganz,ShannonTomita,andRhodaSperling 26 GenitourinarySyndromeofMenopause,210 KarenF.Brodman 27 MenopausalHotFlashes,218 ElissaGretzFriedman 28 UrinaryTractInfection,228 AnnaceciliaPeacherandAnneHardart 29 EctopicPregnancy,235 AmandaM.SilbermannandPeterG.McGovern 30 Osteoporosis,243 HollyC.Loudon 31 GenitalUlcerDisease,253 OmaraAfzal 32 Vulvodynia,258 SuzanneS.Fenske Contents vii Part 3: REPRODUCTIVE ENDOCRINOLOGY 33 EvaluationoftheInfertileCouple,265 TaranehGharibNazem,DevoraAharon,andAlanB.Copperman 34 OvulationInduction/ART/IVF/ICSI,274 KathrynL.Shaia,AlanB.Copperman,andEricFlisser 35 PolycysticOvarySyndrome,280 RashmiKudesiaandAlanB.Copperman 36 RecurrentPregnancyLoss,291 DanielE.SteinandAlanB.Copperman 37 FertilityPreservation,297 LuckySekhon,NolaS.Herlihy,andAlanB.Copperman Part 4: GYN ONCOLOGY 38 OvarianCancer,307 ElenaPereira,JeannetteGuziel,andAmyTiersten 39 CervicalCancer,322 NavyaNair,AnnMarieBeddoe,andPeterDottino 40 EndometrialCancer,333 JamalRahamanandCarmelJ.Cohen 41 GestationalTrophoblasticDisease,345 MelissaSchwartzandStephanieV.Blank 42 VulvarCancer,351 MelissaSchwartzandStephanieV.Blank Part 5: FAMILY PLANNING 43 UnintendedPregnancy,361 GillianDeanandRachelMasch 44 PregnancyPrevention,372 LauraMacIsaac,GeethaN.Fink,andNehaR.Bhardwaj 45 EarlyPregnancyFailure,381 AdamJacobs,BrittLunde,andSharonGerber Index,387 Contributors OmaraAfzal,DO NehaR.Bhardwaj,MD,MS DepartmentofObstetrics,Gynecologyand DivisionofFamilyPlanning ReproductiveScience DepartmentofObstetrics,Gynecologyand IcahnSchoolofMedicineatMountSinai, ReproductiveScience NewYork,NY IcahnSchoolofMedicineatMountSinai, NewYork,NY DevoraAharon,MD ReproductiveMedicineAssociatesof AngelaBianco,MD NewYork DivisionofMaternal-FetalMedicine DivisionofReproductiveEndocrinologyand DepartmentofObstetrics,Gynecologyand Infertility ReproductiveScience IcahnSchoolofMedicineatMountSinai, IcahnSchoolofMedicineatMountSinai, NewYork,NY NewYork,NY CharlesAscher-Walsh,MD CatherineA.Bigelow,MD DivisionofFemalePelvicMedicineand Maternal-FetalMedicineSubspecialist ReconstructiveSurgery MinnesotaPerinatalPhysicians DepartmentofObstetrics,Gynecologyand AllinaHealth,Minneapolis,MN ReproductiveScience IcahnSchoolofMedicineatMountSinai, StephanieV.Blank,MD NewYork,NY DivisionofGynecologicOncology DepartmentofObstetrics,Gynecologyand AnnMarieBeddoe,MD ReproductiveScience DivisionofGynecologicOncology IcahnSchoolofMedicineatMountSinai, DepartmentofObstetrics,Gynecologyand NewYork,NY ReproductiveScience IcahnSchoolofMedicineatMountSinai, KarenF.Brodman,MD NewYork,NY DepartmentofObstetrics,Gynecologyand ReproductiveScience EricP.Bergh,MD IcahnSchoolofMedicineatMountSinai, Maternal-FetalMedicineSubspecialist NewYork,NY UTHealth–McGovernMedicalSchool DivisionofMaternal-FetalMedicine, DanielleBrooks,MD Houston,TX DepartmentofMedicine DivisionofEndocrinology,Diabetes,and VeerleBergink,MD,PhD Metabolism DepartmentofPsychiatryandDepartmentof IcahnSchoolofMedicineatMountSinai, Obstetrics,GynecologyandReproductive NewYork,NY Science IcahnSchoolofMedicineatMountSinai, NewYork,NY viii Contributors ix LoisBrustman,MD AlanB.Copperman,MD DivisionofMaternal-FetalMedicine ReproductiveMedicineAssociatesofNewYork DepartmentofObstetrics,Gynecologyand DivisionofReproductiveEndocrinologyand ReproductiveScience Infertility IcahnSchoolofMedicineatMountSinai,New IcahnSchoolofMedicineatMountSinai, York,NY NewYork,NY LaudyBurgos,LCSW LisaDabney,MD DepartmentofSocialWorkServices DivisionofFemalePelvicMedicineand MSH,NERA-UndergraduateBehavioralHealth ReconstructiveSurgery FellowshipProgram DepartmentofObstetrics,Gynecologyand IcahnSchoolofMedicineatMountSinai, ReproductiveScience NewYork,NY IcahnSchoolofMedicineatMountSinai,New York,NY FrancescoCallipari,MD DepartmentofObstetrics,Gynecologyand GillianDean,MD,MPH ReproductiveScience PlannedParenthoodFederationofAmerica IcahnSchoolofMedicineatMountSinai, DivisionofFamilyPlanning NewYork,NY DepartmentofObstetrics,Gynecologyand ReproductiveScience WoojinChong,MD IcahnSchoolofMedicineatMountSinai, Urogynecologist,InspiraHealth,Vineland,New NewYork,NY Jersey,NJ DivisionofFemalePelvicMedicineand AndrewDitchik,MD ReconstructiveSurgery DepartmentofObstetricsandGynecology DepartmentofObstetrics,Gynecologyand ElmhurstHospitalCenter,Queens,NY ReproductiveScience DepartmentofObstetrics,Gynecologyand IcahnSchoolofMedicineatMountSinai,New ReproductiveScience York,NY IcahnSchoolofMedicineatMountSinai, NewYork,NY GarfieldClunie,MD Maternal-FetalMedicine MatthewDominguez,MD TheBrooklynHospitalCenter DepartmentofPsychiatry DivisionofMaternal-FetalMedicine IcahnSchoolofMedicineatMountSinai, IcahnSchoolofMedicineatMountSinai, NewYork,NY NewYork,NY JanineA.Doneza,MD CarmelJ.Cohen,MD RoboticandMinimallyInvasiveGynecologic DivisionofGynecologicOncology Surgery DepartmentofObstetrics,Gynecologyand MIGS/UrogynecologyFellowshipProgram ReproductiveScience FibroidCenter IcahnSchoolofMedicineatMountSinai, BronxcareHospital,Bronx,NY, NewYork,NY IcahnSchoolofMedicineatMountSinai, NewYork,NY KatherineA.Connolly,MD DivisionofMaternal-FetalMedicine DepartmentofObstetricsandGynecology UniversityofCalifornia,SanFrancisco,CA x Contributors PeterDottino,MD FaithJ.Frieden,MD DivisionofGynecologicOncology DepartmentofObstetrics,Gynecologyand DepartmentofObstetrics,Gynecologyand ReproductiveScience ReproductiveScience IcahnSchoolofMedicineatMountSinai, IcahnSchoolofMedicineatMountSinai, NewYork,NY NewYork,NY ElissaGretzFriedman,MD KeithEddleman,MD DepartmentofObstetrics,Gynecologyand DivisionofMaternal-FetalMedicine ReproductiveScience DepartmentofObstetrics,Gynecologyand IcahnSchoolofMedicineatMountSinai, ReproductiveScience NewYork,NY IcahnSchoolofMedicineatMountSinai, NewYork,NY FrederickFriedmanJr.,MD DepartmentofObstetrics,Gynecologyand JohnA.Fantl,MD ReproductiveScience DivisionofFemalePelvicMedicineand IcahnSchoolofMedicineatMountSinai, ReconstructiveSurgery NewYork,NY DepartmentofObstetrics,Gynecologyand ReproductiveScience EricM.Ganz,MD IcahnSchoolofMedicineatMountSinai, DepartmentofObstetrics,Gynecologyand NewYork,NY ReproductiveScience IcahnSchoolofMedicineatMountSinai, SuzanneS.Fenske,MD NewYork,NY DepartmentofObstetrics,Gynecologyand ReproductiveScience SharonGerber,MD IcahnSchoolofMedicineatMountSinai, DivisionofFamilyPlanning NewYork,NY DepartmentofObstetrics,Gynecologyand ReproductiveScience LaurenFerrara,MD IcahnSchoolofMedicineatMountSinai, DivisionofMaternal-FetalMedicine NewYork,NY DepartmentofObstetrics,Gynecologyand ReproductiveScience JeannetteGuziel,MD IcahnSchoolofMedicineatMountSinai, Hematology/MedicalOncology NewYork,NY KaiserPermanente SouthernCaliforniaPermanenteMedicalGroup, GeethaN.Fink,MD,MPH WoodlandHills,CA DivisionofFamilyPlanning DepartmentofObstetrics,Gynecologyand AnneHardart,MD ReproductiveScience DivisionofFemalePelvicMedicineand IcahnSchoolofMedicineatMountSinai, ReconstructiveSurgery NewYork,NY DepartmentofObstetrics,Gynecologyand ReproductiveScience EricFlisser,MD IcahnSchoolofMedicineatMountSinai, ReproductiveMedicineAssociatesofNewYork NewYork,NY DivisionofReproductiveEndocrinologyand Infertility NolaS.Herlihy,MD IcahnSchoolofMedicineatMountSinai, ReproductiveEndocrinologyandInfertility NewYork,NY IVIRMA,NewJersey,NJ

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