Morphogenesis and Pathogenicity in Fungi

293 Pages·2012·3.53 MB·English

by  Steven D. Harris (auth.)

Topics in Current Genetics 22
Series Editor: Stefan Hohmann
For furthervolumes:
http://www.springer.com/series/4735
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Jose´ Pe´rez-Mart´ın Antonio Di Pietro
l
Morphogenesis and
Pathogenicity in Fungi
Editors
Jose´Pe´rez-Mart´ın AntonioDiPietro
CentroNacionaldeBiotecnologia UniversityofCordoba
CSIC DepartmentofGenetics
DepartmentofMicrobial CampusRabanales,Edificio
Biotechnology GregorMendel
CampusdeCantoblanco Cordoba
Madrid Spain
Spain [email protected]
[email protected]
ISBN978-3-642-22915-2 e-ISBN978-3-642-22916-9
DOI10.1007/978-3-642-22916-9
SpringerHeidelbergDordrechtLondonNewYork
LibraryofCongressControlNumber:2011941775
#Springer-VerlagBerlinHeidelberg2012
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Preface
Fungal diseases cause human suffering and enormous economic losses. New
approaches for antifungal control are instrumental in meeting the threat imposed
bytheseinfectiousagents.Suchconceptualadvancesareonlypossiblethroughthe
identification of novel biochemical and molecular targets in the fungal cell. The
great diversity that exists among pathogenic fungi in terms of lifestyles, infection
strategies, and disease symptoms represents a major challenge in the search for
common antifungal targets, because it is likely that different attributes will be
important for different fungi to cause disease. However, all pathogens share a
common need for making the appropriate developmental decisions during induc-
tionofthepathogenicprogram.Suchdevelopmentalswitchesareoftenassociated
withdifferentiationprocessesthatrequirearesetofthecellcycleandtheinduction
ofanewmorphogeneticprogram.Theabilityofpathogenicfungitomodulatetheir
cell cycle and morphogenesis is emerging as a key determinant for successful
infection. In the past, experimental approaches to understand regulation of the
pathogenic developmental program have focused on the study of signal transduc-
tion pathways and transcriptional changes. Today, the study of how genetic viru-
lenceprogramscontrolmorphogenesisandcellcycleoffersexcitingopportunities
toexplorethemolecularbasisoffungalpathogenicityundernewangles,whichat
thesametimearecomplementarytopreviousapproachesinthefield.
Inthelastyearstherehasbeenatremendousincreaseintheamountofresearch
and relevant data on the relationships between morphogenesis, cell cycle, and
regulation of virulence programs in pathogenic fungi. This progress has been the
subjectofanumberofexcellentreviewsovertheyears.Sofar,however,thefield
haslackedamonographiccollectionwheremanyoftheseimportantcontributions
andviewsarejoinedtogether.Inthisbookweattemptedtocoverabroadspectrum
oftaxonomicallyandbiologicallydiversefungalpathogens,aswellasanumberof
key topics related to morphogenesis and pathogenesis. The double aim was to
provideintroductorymaterialforthenonspecialistandalsotoofferthemostrecent
andupdatedviewsonthesecrucialcellbiologicalprocesses.
vii
viii Preface
The book is organized in 13 chapters written by qualified researchers on each
topic.Eachchaptercontainsanintroductionfollowedbyanin-depthandup-to-date
analysis of the current state of knowledge on the subject. The chapters were
conceived and written autonomously, so that they can be read independently,
eventhoughthismayhaveresultedinsomerepetitivenessofbasicconcepts.
Finally,wewanttothankeachandeveryauthorforhis/herexcellentcontribu-
tion. We are also indebted to the anonymous reviewers who read and made
important suggestions to improve the chapters. We also thank Stefan Hohmann
forhisconstantencouragementduringtheeditingprocessandthestaffatSpringer
Verlagfortheircontinuoushelpandsupporttomakethisbookpossible.
Madrid/Co´rdoba
Jose´ Pe´rez-Mart´ınandAntonioDiPietro
Contents
1 MolecularBasisofMorphogenesisinFungi ............................ 1
StevenD.Harris
2 TropicOrientationResponsesofPathogenicFungi ................... 21
AlexandraBrandandNeilA.R.Gow
3 HyphalFusion ............................................................ 43
Andre´ Fleißner
4 SignalingofInfectiousGrowthinFusariumoxysporum .............. 61
ElenaPe´rez-NadalesandAntonioDiPietro
5 IntegratingCdkSignalinginCandidaalbicansEnvironmental
SensingNetworks ........................................................ 81
CarlosR.Va´zquezdeAldanaandJaimeCorrea-Bordes
6 CellCycleandMorphogenesisConnectionsDuringtheFormation
oftheInfectiveFilamentinUstilagomaydis ........................... 97
Jose´ Pe´rez-Mart´ın
7 AppressoriumFunctioninColletotrichumorbiculareandProspect
forGenomeBasedAnalysis ............................................ 115
YasuyukiKubo
8 MorphogenesisinCandidaalbicans:HowtoStayFocused ......... 133
MartineBassilanaandPeterFollette
9 MorphogenesisinParacoccidioidesbrasiliensis ....................... 163
IranMalavaziandGustavoHenriqueGoldman
ix
x Contents
10 MorphogenesisofCryptococcusneoformans .......................... 197
ElizabethR.Ballou,J.AndrewAlspaugh,andConnieB.Nichols
11 MorphogenesisandInfectioninBotrytiscinerea ..................... 225
JuliaSchumacherandPaulTudzynski
12 Morphogenesis,Growth,andDevelopmentoftheGrass
SymbiontEpichlo¨efestucae ............................................ 243
BarryScott,YvonneBecker,MatthiasBecker,andGemmaCartwright
13 Cryptococcus–NeutrophilInteraction ................................. 265
AsfiaQureshiandMaurizioDelPoeta
Index .......................................................................... 281