Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Volume II

397 Pages·2011·7.5 MB·English

by  Martien J. Kas

N
euromethods
Series Editor
Wolfgang Walz
University of Saskatchewan
Saskatoon, SK, Canada
For further volumes:
http://www.springer.com/series/7657

Mood and Anxiety Related
Phenotypes in Mice
Characterization Using Behavioral Tests,
Volume II
Edited by
Todd D. Gould
University of Maryland School of Medicine, Department of Psychiatry, Baltimore, USA
Editor
Todd D. Gould
University of Maryland
School of Medicine
Department of Psychiatry
Baltimore, Maryland, USA
[email protected]
ISSN 0893-2336 e -ISSN 1940-6045
ISBN 978-1-61779-312-7 e-ISBN 978-1-61779-313-4
DOI 10.1007/978-1-61779-313-4
Springer New York Dordrecht Heidelberg London
Library of Congress Control Number: 2011935540
© Springer Science+Business Media, LLC 2011
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Preface to the Series
Under the guidance of its founders Alan Boulton and Glen Baker, the Neuromethods series
by Humana Press has been very successful since the first volume appeared in 1985. In about
17 years, 37 volumes have been published. In 2006, Springer Science + Business Media
made a renewed commitment to this series. The new program will focus on methods that
are either unique to the nervous system and excitable cells or which need special consider-
ation to be applied to the neurosciences. The program will strike a balance between recent
and exciting developments like those concerning new animal models of disease, imaging,
in vivo methods, and more established techniques. These include immunocytochemistry
and electrophysiological technologies. New trainees in neurosciences still need a sound
footing in these older methods in order to apply a critical approach to their results. The
careful application of methods is probably the most important step in the process of scien-
tific inquiry. In the past, new methodologies led the way in developing new disciplines in
the biological and medical sciences. For example, Physiology emerged out of Anatomy in
the nineteenth century by harnessing new methods based on the newly discovered phe-
nomenon of electricity. Nowadays, the relationships between disciplines and methods are
more complex. Methods are now widely shared between disciplines and research areas.
New developments in electronic publishing also make it possible for scientists to download
chapters or protocols selectively within a very short time of encountering them. This new
approach has been taken into account in the design of individual volumes and chapters in
this series.
Wolfgang Walz
v

Preface
Preclinical research related to mood and anxiety disorders relies extensively upon mouse
behavioral tests and models. The use of these approaches continues to increase as a greater
number of underlying susceptibility genes are discovered, new targets for medications are
identified, and clinical studies reveal novel neurobiological risk factors.
The rationale for this second volume is straightforward: to include tests that were not
covered in the first volume. This book is meant, therefore, as a complement to Volume I.
Together, the two volumes offer a comprehensive resource for the behavioral approaches
that are valuable for the characterization of mood and anxiety disorder-related behaviors in
mice, and that are utilized in the development of medications that are effective in their
treatment. The contributing authors are world-renowned scientists with broad experiences
in the development and application of mouse behavioral tasks. Each chapter provides a brief
background and review of the test or model as well as a complete and up-to-date protocol
narrative.
The chapters are primarily intended as a resource for scientists actively pursuing or inter-
ested in establishing behavioral protocols in their laboratories and who have prior experience
with studying rodent behavior. However, it will also serve as a reference for those scientists
and practitioners who seek to better understand the behavioral methods used in preclinical
mood and anxiety research. Though the chapters provide an important resource for refer-
ence material and detailed methods, there are a number of subtleties in mouse husbandry,
handling, and testing procedures that cannot be acquired solely from following a book. It is
therefore strongly encouraged that those with limited experience with rodent behavior seek
collaboration with an experienced behavioral neuroscientist to lend a hand in addressing
experimental and analysis issues that will, without a doubt, arise.
Baltimore, USA Todd D. Gould
vii

Contents
Preface............................................................. vii
Contributors......................................................... xi
1 Longitudinal Assessment of Deliberate Mouse Behavior
in the Home Cage and Attached Environments: Relevance
to Anxiety and Mood Disorders ...................................... 1
Martien J. Kas, Ilan Golani, Yoav Benjamini, Ehud Fonio,
and Oliver Stiedl
2 Using Behavioral Patterns Across Species in Mood Disorder Research.......... 21
Jared W. Young and Mark A. Geyer
3 Telemetry in Mice: Applications in Studies of Stress and Anxiety Disorders...... 43
Larry D. Sanford, Linghui Yang, and Laurie L. Wellman
4 Modeling Mouse Anxiety and Sensorimotor Integration:
Neurobehavioral Phenotypes in the Suok Test............................ 61
Elisabeth Dow, Valerie Piet, Adam Stewart, Siddharth Gaikwad,
Jonathan Cachat, Peter Hart, Nadine Wu, Evan Kyzar, Eli Utterback,
Alan Newman, Molly Hook, Kathryn Rhymes,
Dillon Carlos, and Allan V. Kalueff
5 Assessment of Social Approach Behavior in Mice.......................... 83
Orsolya J. Kuti and Damon T. Page
6 The Mouse Defense Test Battery: A Model Measuring
Different Facets of Anxiety-Related Behaviors............................ 97
Guy Griebel and Sandra Beeské
7 Novelty-Suppressed Feeding in the Mouse .............................. 107
Benjamin Adam Samuels and René Hen
8 The Four-Plate Test in Mice......................................... 123
Martine Hascoët and Michel Bourin
9 The Vogel Punished Drinking Task as a Bioassay
of Anxiety-Like Behavior of Mice ..................................... 143
Alicia A. Walf and Cheryl A. Frye
10 A Vogel Conflict Test Using Food Reinforcement in Mice .................. 159
Jeffrey M. Witkin
11 Fear Conditioning and Extinction as a Model of PTSD in Mice .............. 171
Georgette M. Gafford and Kerry J. Ressler
12 The “Cut-Off Behavioral Criteria” Method: Modeling Clinical
Diagnostic Criteria in Animal Studies of PTSD........................... 185
Hagit Cohen, Michael A. Matar, and Joseph Zohar
ix