Molecular Virology and Control of Flaviviruses

369 Pages·2012·5.21 MB·English

by  Pei-Yong Shi

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Molecular Virology and Control of Flaviviruses c
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The editor of this book, Dr Pei-Yong Shi, has assembled an up-to-date and cutting- r
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established investigators who have dedicated their careers to flavivirus research are
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balanced by chapters from those newcomers who have recently made significant a
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contributions to the flavivirus field. The book opens with a brief introduction, then
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divides into two sections: Molecular Virology (Chapters 2–9) and Virus Prevention C
(Chapters 10–15). The first section covers virion structure, virus replication, o
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the NS1 glycoprotein, the NS3 protein, the NS5 protein, innate immunity and t
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flavivirus infection, host responses to flavivirus infection, and flavivirus fitness l

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and transmission. The second section includes vaccines, antibody therapy, small Edited by
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molecule antiviral development, flavivirus diagnostics, vector–virus interactions Fl Pei-Yong Shi
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and vector control. The book represents an important update of flavivirus research v
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and will serve as a reference to flavivirus researchers at the graduate level and v
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ISBN 978-1-904455-92-9
www.caister.com
Caister Academic Press
9 781904 455929
Molecular Virology and
Control of Flaviviruses
Edited by
Pei-Yong Shi
Novartis Institute for Tropical Diseases
Chromos
Singapore
Caister Academic Press
Copyright © 2012
Caister Academic Press
Norfolk, UK
www.caister.com
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library
ISBN: 978-1-904455-92-9 (hardback); 978-1-910190-99-9 (ebook)
Description or mention of instrumentation, software, or other products in this book does
not imply endorsement by the author or publisher. The author and publisher do not assume
responsibility for the validity of any products or procedures mentioned or described in this
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system, or transmitted, in any form or by any means, electronic, mechanical, photocopying,
recording or otherwise, without the prior permission of the publisher. No claim to original
U.S. Government works.
Cover design adapted from Figure 2.1
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Contents
List of Contributors v
Preface ix
1 Flaviviruses: Past, Present and Future 1
Duane J. Gubler
2 Flavivirus Virion Structure 9
Richard J. Kuhn
3 Flavivirus Replication and Assembly 21
Justin A. Roby, Anneke Funk and Alexander A. Khromykh
4 The Many Faces of the Flavivirus Non-structural Glycoprotein NS1 51
David A. Muller and Paul R. Young
5 The Flavivirus NS3 Protein: Structure and Functions 77
Dahai Luo, Siew Pheng Lim and Julien Lescar
6 Structure and Function of the Flavivirus NS5 Protein 101
Julien Lescar, Siew Pheng Lim and Pei-Yong Shi
7 Innate Immunity and Flavivirus Infection 119
Maudry Laurent-Rolle, Juliet Morrison and Adolfo García-Sastre
8 Host Responses During Mild and Severe Dengue 145
Mark Schreiber, F. Joel Leong and Martin L. Hibberd
9 Flavivirus Fitness and Transmission 163
Gregory D. Ebel and Laura D. Kramer
10 Flavivirus Vaccines 185
Scott B. Halstead
11 Antibody Therapeutics Against Flaviviruses 231
Michael S. Diamond, Theodore C. Pierson and John T. Roehrig
12 Flavivirus Antiviral Development 257
Qing-Yin Wang, Yen-Liang Chen, Siew Pheng Lim and Pei-Yong Shi
iv | Contents
13 Flavivirus Diagnostics 271
Elizabeth Hunsperger
14 Flavivirus–Vector Interactions 297
Ken E. Olson and Carol D. Blair
15 Vectors of Flaviviruses and Strategies for Control 335
Lee-Ching Ng and Indra Vythilingam
Index 357
Colour plates A1
Contributors
Carol D. Blair Anneke Funk
Arthropod-borne and Infectious Diseases Laboratory Australian Infectious Disease Research Centre
Department of Microbiology, Immunology and School of Chemistry and Molecular Biosciences
Pathology The University of Queensland
Colorado State University Brisbane, QLD
Fort Collins, CO Australia
USA
[email protected]
[email protected]
Adolfo García-Sastre
Yen-Liang Chen Department of Microbiology
Novartis Institute for Tropical Diseases Mount Sinai School of Medicine
Chromos New York, NY
Singapore USA
[email protected] [email protected]
Michael S. Diamond
Duane J. Gubler
Departments of Medicine, Molecular Microbiology,
Director
Pathology & Immunology and the Midwest Regional
Signature Research Program in Emerging Infectious
Center for Excellence in Biodefense and Emerging
Diseases
Infectious Diseseas Research
Duke – NUS Graduate Medical School
Washington University School of Medicine
Singapore
St. Louis, MO
USA [email protected]
[email protected]
Scott B. Halstead
Supportive Research and Development Program
Gregory D. Ebel
Pediatric Dengue Vaccine Initiative
Department of Pathology
International Vaccine Institute
University of New Mexico School of Medicine
Seoul
Albuquerque, NM
Korea
USA
[email protected]
[email protected]
vi | Contributors
Martin L. Hibberd Maudry Laurent-Rolle
The Genome Institute of Singapore Department of Microbiology
National University of Singapore Mount Sinai School of Medicine
Singapore; New York, NY
Imperial College Medical School USA
London
[email protected]
UK
[email protected] F. Joel Leong
Novartis Institute for Tropical Diseases
Elizabeth Hunsperger Chromos
Serology Diagnostics and Viral Pathogenesis Singapore
Laboratory Dengue Branch
[email protected]
Centers for Disease Control and Prevention
Division of Vector-borne Infectious Diseases
Julien Lescar
San Juan
School of Biological Sciences
Puerto Rico
Nanyang Technological University
[email protected] Singapore;
Architecture et Fonction des Macromolecules
Alexander A. Khromykh Biologiques
Australian Infectious Disease Research Centre CNRS UMR 6098
School of Chemistry and Molecular Biosciences Marseille
The University of Queensland France
Brisbane, QLD
[email protected]
Australia
[email protected] Siew Pheng Lim
Novartis Institute for Tropical Diseases
Laura D. Kramer Chromos
Arbovirus Laboratory Singapore
Wadsworth Center
[email protected]
New York State Department of Health
Albany, NY
Dahai Luo
USA;
School of Biological Sciences
School of Public Health
Nanyang Technological University
State University of New York at Albany
Singapore;
New York, NY
Department of Molecular Biophysics and
USA
Biochemistry
[email protected] Yale University
New Haven, CT
Richard J. Kuhn USA
Department of Biological Sciences
[email protected]
Markey Center for Structural Biology
Purdue University
Juliet Morrison
West Lafayette, IN
Department of Microbiology
USA
Mount Sinai School of Medicine
[email protected] New York, NY
USA
[email protected]
Contributors | vii
David A. Muller John T. Roehrig
Australian Infectious Diseases Research Centre Division of Vector-Borne Infectious Diseases
School of Chemistry and Molecular Biosciences Centers for Disease Control and Prevention
The University of Queensland Public Health Service
Brisbane, QLD U.S. Department of Health and Human Services
Australia Fort Collins, CO
USA
[email protected]
[email protected]
Lee-Ching Ng
Environmental Health Institute Mark Schreiber
The National Environment Agency Novartis Institute for Tropical Diseases
Singapore Chromos
Singapore
[email protected]
[email protected]
Ken E. Olson
Arthropod-borne and Infectious Diseases Laboratory Pei-Yong Shi
Department of Microbiology, Immunology and Novartis Institute for Tropical Diseases
Pathology Chromos
Colorado State University Singapore
Fort Collins, CO
[email protected]
USA
[email protected] Indra Vythilingam
Environmental Health Institute
Theodore C. Pierson The National Environment Agency
Viral Pathogenesis Section Singapore
Laboratory of Viral Diseases
[email protected]
National Institutes of Health
Bethesda, MD
Qing-Yin Wang
USA
Novartis Institute for Tropical Diseases
[email protected] Chromos
Singapore
Justin A. Roby
[email protected]
Australian Infectious Disease Research Centre
School of Chemistry and Molecular Biosciences
Paul R. Young
The University of Queensland
Australian Infectious Diseases Research Centre
Brisbane, QLD
School of Chemistry and Molecular Biosciences
Australia
The University of Queensland
[email protected] Brisbane, QLD
Australia
[email protected]
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Caister Academic Press www.caister.com
Preface
Flaviviruses are pathogens of global importance, major sections: Molecular Virology and Virus
many of which are arthropod-borne and cause Prevention. I hope that this book could serve as
hundreds of millions of human infections each a reference for experienced flavivirus researchers
year. Breakthroughs have recently been made in as well as open the door to new talents who are
the understanding of the molecular details of viral interested in joining the flavivirus research.
replication, transmission, host responses, and As an editor, I am deeply indebted to the col-
pathogenesis. Such progress in basic research has leagues who dedicated their research to flavivirus.
provided new opportunities for development of I am grateful to the authors who contributed and
novel vaccines and antiviral therapy. made this book possible. I also thank Annette
The aim of this book was to assemble an up- Griffin, Acquisition Editor at Caister Academic
to-date anthology from the leading experts in Press, and Emma Needs, Production Editor at
the flavivirus field. The book is divided into two Prepress Projects Ltd.
Pei-Yong Shi
Singapore