Molecular Imaging Probes for Cancer Research

1070 Pages·2012·107.195 MB·English

by  Xiaoyuan Chen, Xiaoyuan Chen

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World Scientific
NEW JERSEY • LONDON • SINGAPORE • BEIJING • SHANGHAI • HONG KONG • TAIPEI • CHENNAI
7605hc.9789814293679-tp.indd 2 20/6/12 2:18 PM
Published by
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601
UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE
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searcOUR MOLECULAR IMAGING PROBES FOR CANCER RESEARCH
er ReASB Copyright © 2012 by World Scientific Publishing Co. Pte. Ltd.
ancTR All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means, electronic
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For photocopying of material in this volume, please pay a copying fee through the Copyright Clearance Center,
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ISBN 978-981-4293-67-9
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Email: [email protected]
Printed in Singapore.
Xiaoling - Molecular Imaging Probes.pmd 1 6/21/2012, 5:21 PM
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b1158 Molecular Imaging Probes for Cancer Research
Contents
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w.wnal Preface xv
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ResearcBOUR Chapter 2 CMroaliegc uSl.a Lr eIvminaging Instrumentation 29
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ancTR Chapter 3 Molecular Imaging Data Analysis 97
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beT Chapter 4 General Principles of Molecular Imaging Probe Design 129
g ProERSI Shuanglong Liu, Jelena Levi and Zhen Cheng
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Lixin Lang and Xiaoyuan Chen
Chapter 6 Multimeric Cyclic RGD Peptides Useful for Development 165
of Integrin α β -Targeted SPECTRadiotracers
v 3
Sudipta Chakraborty and Shuang Liu
Chapter 7 PETand SPECTImaging of Tumor Metabolism 197
Timothy R. DeGrado
Chapter 8 PETand SPECTImaging of Tumor Proliferation 219
Zhanhong Wu and Fouad Kandeel
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Chapter 9 Molecular Imaging of Apoptosis in Cancer 257
Gang Niu and Xiaoyuan Chen
Chapter 10 Non-Invasive Imaging of Hypoxia — Challenges 285
and Opportunities
C.J. Koch and S.M. Evans
Chapter 11 SPECTand PETImaging of Multidrug Resistance 315
Anton G.T. Terwisscha van Scheltinga,
Wouter B. Nagengast, Thijs H. Oude Munnink,
m
o Geke A.P. Hospers, Adrienne H. Brouwers,
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ResearcBOUR Chapter 14 QCh. eSmhaisot,r yY .oMf .O Ypatnigca al nIdm Bag.Gin.g X Pinrogbes 419
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ancTR Chapter 15 Fluorescent Dye Conjugates for Optical Imaging 451
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Seulki Lee and Xiaoyuan Chen

Chapter 18 Raman Imaging Probes for Cancer Research 545
Sangyeop Lee, Sang Wook Son, Chil-Hwan Oh,
Soon Young Shin, Young Han Lee and
Jaebum Choo
Chapter 19 Photoacoustic Imaging Probes for Cancer Research 567
Shai Ashkenazi
Chapter 20 Basic Principles of Magnetic Resonance Imaging 581
Hui Mao
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Contents vii
Chapter 21 T1-Weighted MR Contrast Agents for Cancer Research 611
Claire Corot, Philippe Robert, Sébastien Ballet,
Walter Gonzalez, Jean-Marc Idee, Isabelle Raynal
and Marc Port
Chapter 22 T2 Weighted MR Contrast Agents for Cancer 659
Research
Gabriella Baio and Carlo Emanuele Neumaier
Chapter 23 CESTand PARACESTMRI Contrast Agents for 689
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scionl Chapter 24 MRI Reporter Genes for Cancer Research 715
orlduse Bistra Iordanova and Eric T. Ahrens
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searcOUR Chapter 27 X-ray Computed Tomography Principles and 795
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ancTR Edward E. Graves and Magdalena Bazalova
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ProRSI Chapter 28 Multimodality Instrumentation 831
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cul of Cancer
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Chapter 30 Imaging Cell Trafficking in Cancer Research 905
L. Ottobrini, C. Martelli and G. Lucignani
Session V: Applications of MolecularCancerImaging 949
Probes
Chapter 31 Molecular Imaging in Early Detection of Cancer 951
Xin Lin, Jin Xie and Xiaoyuan Chen
Chapter 32 PETand SPECTin Cancer Theragnostics 979
Silvana Del Vecchio
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viii Contents
Chapter 33 Molecular Imaging in Cancer Drug Development 1015
C. Andrew Boswell, Daniela Bumbaca,
Cinthia V. Pastuskovas, Eduardo E. Mundo,
Ben Q. Shen, Richard A.D. Carano, Jan Marik,
Simon P. Williams, Frank-Peter Theil, Paul J. Fielder,
Nicholas van Bruggen and Leslie A. Khawli
Chapter 34 Clinical Translation of Molecular Imaging Probes 1041
Steve Y. Cho and Martin G. Pomper
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b1158_FM.qxd 6/19/2012 1:42 PM Page ix
b1158 Molecular Imaging Probes for Cancer Research
List of Contributors
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Doon Minnesota, Minneapolis, MN, USA
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searcOUR Gabriella Baio, Department of Diagnostic Imaging, National Cancer Institute,
ReB Genoa, Italy
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CanST Sébastien Ballet, Guerbet Research, BP57400, 95943 Roissy CDG, France
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bes fTY Magdalena Bazalova, Department of Radiation Oncology, Stanford University,
ProRSI Stanford, CA, USA
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Imaging, University of Groningen and University Medical Center Groningen,
Groningen, The Netherlands
Daniela Bumbaca, Pharmacokinetic and Pharmacodynamic Sciences,
Genentech, Inc., South San Francisco, CA, USA
Weibo Cai, Departments of Radiology and Medical Physics, School of Medicine
and Public Health, University of Wisconsin – Madison, Madison, Wisconsin, USA
Richard A.D. Carano, Biomedical Imaging, Genentech, Inc., South San
Francisco, CA, USA
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x Contributors
Sudipta Chakraborty, School of Health Sciences, Purdue University, West
Lafayette, IN, USA
Kai Chen, Laboratory of Molecular Imaging and Nanomedicine, National
Institute of Biomedical Imaging and Bioengineering, National Institutes of Health,
Bethesda, MD, USA
Xiaoyuan Chen, Laboratory of Molecular Imaging and Nanomedicine, National
Institute of Biomedical Imaging and Bioengineering, National Institutes of Health,
Bethesda, MD, USA
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h DoG on University of Southern California, Los Angeles, CA, USA
searcOUR Claire Corot, Guerbet Research, BP57400, 95943 Roissy CDG, France
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ancTR Timothy R. DeGrado, Molecular Imaging Research Program, Mayo Clinic,
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ProbeRSIT Silvana Del Vecchio, Department of Biomorphological and Functional Sciences,
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ular Iby Groningen and University Medical Center Groningen, Groningen, The Netherlands
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Philadelphia, PA, USA
Paul J. Fielder, Pharmacokinetic and Pharmacodynamic Sciences, Genentech,
Inc., South San Francisco, CA, USA
Victor Frenkel, Department of Biomedical Engineering, Catholic University of
America, Washinton, DC, USA
WalterGonzalez, Guerbet Research, BP57400, 95943 Roissy CDG, France
Edward E. Graves, Department of Radiation Oncology, Stanford University,
Stanford, CA, USA