Table Of ContentHabib Zaidi Editor
Molecular
Imaging of
Small Animals
Instrumentation and Applications
Molecular Imaging of Small Animals
Habib Zaidi
Editor
Molecular Imaging
of Small Animals
Instrumentation and Applications
Editor
Habib Zaidi
Department of Radiology & Medical Informatics
Geneva University Hospital
Geneva , Switzerland
ISBN 978-1-4939-0893-6 ISBN 978-1-4939-0894-3 (eBook)
DOI 10.1007/978-1-4939-0894-3
Springer New York Heidelberg Dordrecht London
Library of Congress Control Number: 2014939119
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Contents
1 Scintillation Detectors for Small-Animal Imaging ............................... 1
Tom K. Lewellen and Robert Miyaoka
2 Solid-State Detectors for Small-Animal Imaging ................................. 23
Paolo Russo and Alberto Del Guerra
3 Photon Detectors for Small-Animal Imaging Instrumentation .......... 83
Dieter Renker and Eckart Lorentz
4 Design Considerations of Small-Animal SPECT Cameras ................. 135
Steven R. Meikle, Peter L. Kench, and Jianyu Lin
5 Design Considerations for Small Animal PET Scanners ..................... 163
Virginia Ch. Spanoudaki and Craig S. Levin
6 Design Considerations of Small-Animal CT Systems .......................... 189
Erik L. Ritman
7 Small-Animal MRI Instrumentation..................................................... 211
Andrew M. Blamire
8 Preclinical Optical Molecular Imaging ................................................. 241
Yujie Lu and Ge Wang
9 Advances in Radiotracer Development for Molecular Imaging ......... 275
Yongjian Liu and Michael J. Welch
10 Image Registration for Multimodality Small-Animal Imaging .......... 319
Pat Zanzonico
11 Dual-Modality Preclinical SPECT/PET Instrumentation .................. 337
Alberto Del Guerra and Nicola Belcari
12 Dual-Modality Preclinical SPECT/CT Instrumentation ..................... 351
Youngho Seo and Carina Mari Aparici
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vi Contents
13 Dual-Modality Preclinical PET/CT Instrumentation .......................... 367
Andrew L. Goertzen and Habib Zaidi
14 Dual-Modality Preclinical SPECT/MRI Instrumentation .................. 387
Douglas J. Wagenaar, Dirk Meier, and Bradley E. Patt
15 Dual-Modality Preclinical PET/MRI Instrumentation ....................... 409
David Schlyer and Bosky Ravindranath
16 Dual-Modality Preclinical PET-OI Concepts
and Instrumentation ............................................................................... 447
Jörg Peter
17 Quantifi cation of Small-Animal Imaging Data .................................... 467
Habib Zaidi
18 Animal Handling and Preparation for Imaging ................................... 495
David B. Stout
19 Applications of Small-Animal Imaging in Neurology
and Psychiatry ......................................................................................... 517
Cindy Casteels, Habib Zaidi, and Koen Van Laere
20 Applications of Molecular Small-Animal
Imaging in Cardiology ............................................................................ 547
Ravi Marfatia, Sina Tavakoli, and Mehran M. Sadeghi
21 Applications of Molecular Small-Animal
Imaging in Oncology ............................................................................... 585
Marybeth A. Pysz and Jürgen K. Willmann
22 Applications of Molecular Small-Animal Imaging
in Infl ammation and Infection ............................................................... 637
Alberto Signore, Eri F.J. de Vries, Filippo Galli,
and Gaurav Malviya
23 Applications of Small-Animal Molecular Imaging
of Gene Expression ................................................................................. 685
June-Key Chung, Hyewon Youn, Joo Hyun Kang,
and Keon Wook Kang
24 Applications of Small-Animal Molecular Imaging
in Drug Development .............................................................................. 715
Gang Niu and Xiaoyuan Chen
25 Multimodality Molecular Imaging: A Futuristic Outlook .................. 753
Habib Zaidi and Abass Alavi
About th e Editor
Habib Zaidi, Ph.D., is Chief Physicist and head of the PET Instrumentation &
Neuroimaging Laboratory at Geneva University Hospital and faculty member at the
Medical School of Geneva University. He is also a Professor of Medical Physics at
the University Medical Center of Groningen (The Netherlands) and visiting
Professor at Ecole Nationale Supérieure d’Electronique et de ses Applications
(ENSEA, France). He received a Ph.D. and habilitation (PD) in medical physics
from Geneva University. Dr. Zaidi is actively involved in developing imaging solu-
tions for cutting-edge interdisciplinary biomedical research and clinical diagnosis
in addition to lecturing undergraduate and postgraduate courses on medical physics
and medical imaging. His research centres on modelling nuclear medical imaging
systems using the Monte Carlo method, dosimetry, image correction, reconstruction
and quantifi cation techniques in emission tomography as well as statistical image
analysis in molecular brain imaging, and more recently on novel design of dedi-
cated high-resolution PET and combined PET-MRI scanners. He was guest editor
for seven special issues of peer-reviewed journals and serves as Deputy Editor for
the British Journal of Radiology , Associate editor and member of the editorial board
of many scientifi c journals including M edical Physics, the International Journal of
Biomedical Imaging , N uclear Medicine Communications, Computer Methods and
Programs in Biomedicine, and serves as scientifi c reviewer for leading journals in
medical imaging. He is a senior member of the IEEE and liaison representative of
the International Organization for Medical Physics (IOMP) to the World Health
Organization (WHO) in addition to being affi liated to several International medical
physics and nuclear medicine organisations. He is involved in the evaluation of
research proposals for European and International granting organisations and par-
ticipates in the organisation of International symposia and top conferences as mem-
ber of scientifi c committees. His academic accomplishments in the area of
quantitative PET imaging have been well recognized by his peers and by the medi-
cal imaging community at large since he is a recipient of many awards and distinc-
tions among which the prestigious 2 003 Young Investigator Medical Imaging
Science Award given by the N uclear Medical and Imaging Sciences Technical
Committee of the IEEE , the 2 004 Mark Tetalman Memorial Award given by the
vii
viii About the Editor
Society of Nuclear Medicine , the 2007 Young Scientist Prize in Biological Physics
given by the International Union of Pure and Applied Physics (I UPAP ), the presti-
gious (100,000$) 2 010 kuwait Prize of Applied sciences (known as the M iddle
Eastern Nobel Prize) given by the K uwait Foundation for the Advancement of
Sciences (K FAS ) for “ outstanding accomplishments in Biomedical technology ”, the
2013 J ohn S. Laughlin Young Scientist Award given by the American Association of
Physicists in Medicine (AAPM) and the 2013 V ikram Sarabhai Oration Award
given by the Society of Nuclear Medicine (India). Dr. Zaidi has been an invited
speaker of many keynote lectures at an international level, has authored over 400
publications, including ~180 peer-reviewed journal articles (h-index = 31), confer-
ence proceedings and book chapters and is the editor of three textbooks including
this volume.
E-mail: [email protected]; Web: h ttp://pinlab.hcuge.ch/
Contributors
Abass Alavi Division of Research, Department of Radiology , University of
Pennsylvania , Philadelphia , PA , USA
Carina Mari Aparici Department of Radiology & Biomedical Imaging , San
Francisco and Nuclear Medicine Service, San Francisco Veterans Affairs Medical
Center, University of California , San Francisco , CA , USA
Nicola Belcari Dipartimento di Fisica, Università di Pisa, and INFN Sezione di
Pisa , Pisa , Italy
Andrew M. Blamire N ewcastle Magnetic Resonance Centre, Newcastle
University , Newcastle upon Tyne , UK
Cindy Casteels Nuclear Medicine Department , Leuven University Hospital ,
Leuven , Belgium
Xiaoyuan Chen National Institute of Biomedical Imaging and Bioengineering
(NIBIB), National Institutes of Health (NIH) , Bethesda , MD , USA
June-key Chung Department of Nuclear Medicine , Cancer Research Institute,
Tumor Micro-environment Global Core Research Center, College of Medicine,
Seoul National University , Seoul , South Korea
Eri F.J. de Vries D epartment of Nuclear Medicine and Molecular Imaging,
U niversity of Groningen, U niversity Medical Centre Groningen, Groningen, T he
Netherlands
Alberto Del Guerra D ipartimento di Fisica, Università di Pisa, and INFN
Sezione di Pisa , Pisa , Italy
Filippo Galli N uclear Medicine Unit, II Faculty of Medicine and Surgery,
‘Sapienza’ University of Rome, St. Andrea Hospital , Rome , Italy
Andrew L. Goertzen Department of Radiology , University of Manitoba , Winnipeg ,
MB , Canada
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