Molecular Design and Modeling: Concepts and Applications Part B: Antibodies and Antigens, Nucleic Acids, Polysaccharides, and Drugs

798 Pages·1991·19.16 MB·English

by  John J. Langone (Eds.)

Contributors to Volume 203
elcitrA numbers are in lmmn't.lm~ gniwollof the names of contributors.
snoitailiffA listed are .tnerruc
JEFFREY W. ALMOND (20), Department of NEVETS A. PULLER (16), ADI ,scitsongaiD
Microbiology, University of Reading, Inc., Rexdale, Ontario M9W 4Z7, adanaC
Reading RG1 5AQ, England
TREBOR E. GRmST (9), Department of Bio-
BOCAJ RETSILGNA (10), Department of -yloP chemistry, University of Bath, Bath BA2
mer Research, The Weizmann Institute of A7 ,Y England
,ecneicS Rehovot ,00167 Israel T. M. GUND (32) Department of ,yrtsimehC
TREBOR E. BIRD (4), Molecular ,ygolocnO Chemical ,gnireenignE and Environmen-
Inc., ,grubsrehtiaG Maryland, 20878 tal Science, New Jersey Institute of -hceT
SALOCIN TESSIOB (13), Laboratoire de Bio- ,ygolon Newark, New Jersey 20170
chimie, Facult~ de Pharmacie, ~tisrevinU DETLEF GOSSOW (5), Medical Research
Francois Rabelais, 37042 Tours Cedex, Council Collaborative Centre, London
ecnarF NW7 lAD, England
LEAHCIM B. BOLGER (2), Department of MARIA GUTTINGER (19), Pharma hcraeseR
lacituecamrahP Sciences, School of -rahP ,ygolonhceT .F Hoffmann-La Roche, Ltd.,
macy, University of Southern ,ainrofilaC 2004-HC Basel, Switzerland
Los ,selegnA ainrofilaC 33009
RAGDE HABER (3), Massachusetts General
NAHTANOJ J. MUABRUB (25), Department of Hospital, Harvard Medical School, Bos-
,ygoloiB Massachusetts Institute of -hceT ton, Massachusetts 02114, and The Bris-
,ygolon ,egdirbmaC Massachusetts 93120 tol-Myers Squibb Pharmaceutical Re-
ALAN D. CARDIN (28), tnemtrapeD of search Institute, Princeton, New Jersey
recnaC ,ygoloiB Marion Merrill ,woD Inc., 34580
,itannicniC Ohio 51254 KENNETH W. HILL (18), Departments of
NIALA-ERREIP CARRUPT (31), School of Chemistry and of Molecular ,ygoloiB Re-
Pharmacy, University of Lausanne, CH- hcraes Institute of sppircS ,cinilC La ,alloJ
5001 Lausanne, Switzerland ainrofilaC 73029
TENAJ C. CHEETHAM (6, 9), AMGEN, DLANOD HILVERT (18), Departments of
Thousand Oaks, California 91320 Chemistry and of Molecular ,ygoloiB Re-
DAVID A. DEMETER (28), Department of hcraes Institute of sppircS ,cinilC La ,alloJ
Theoretical Chemistry, Marion Merrill ainrofilaC 92037
Dow, Inc., ,itannicniC Ohio 51254 MERLIN E. HOWDEN (15), Department of
REHPOTSIRHC M. NOSBOD (9), Laboratory lacigoloiB Sciences, Deakin ,ytisrevinU
,gnoleeG 3217 ,airotciV Australia
of Molecular ,scisyhpoiB University of Ox-
ford, Oxford 1XO 3QU, England SEMAJ S. NOTSUH evitaerC,)3( ,seluceloMoiB
DIVAD J. SNAVE (20), Department of -orciM Inc., Hopkinton, Massachusetts 01748
,ygoloib University of Reading, Reading UKKRIS ALOKKAAJ (24), Department of Med-
RGI 5AQ, England ical Biochemistry, University of Turku,
GAIL G. RESEIF (7), Department of -uceloM 20520 Turku, Finland
lar Biology, Research Institute of sppircS RICHARD L. JACKSON (28), Department of
,cinilC La Jolla, ainrofilaC 92037 Research Sciences, Marion Merrill ,woD
DEVAD H. TNOMERF (7), Department of Mo- Inc., ,itannicniC Ohio 51254
lecular Biology, Research Institute of ECNERET C. SNr_KNEJ (22), Cancer hcraeseR
Scripps ,cinilC La Jolla, ainrofilaC 92037 Campaign Biomolecular Structure ,tinU
ix
x CONTRIBUTORS TO VOLUME 203
The Institute of recnaC ,hcraeseR Sutton, try, College of Staten Island, City -revinU
Surrey SM2 5NG, England sity of New York, Staten Island, New York
ECYOJ E. TFOTNEJ (12), Department of -oiB 10301
,yrtsimehc School of Medicine, Case West- NEHPETS NEIDLE (22), Cancer Research
nre Reserve University, Cleveland, Ohio Campaign Biomolecular Structure ,tinU
60144 The Institute of recnaC Research, Sutton,
DYS NOSNHOJ (4), Medlmmune Inc., -htiaG Surrey SM2 5NG, England
,grubsre Maryland 47802 WILMA K. OLSON (21), Department of
NIVLE A. TABAK (1), stnemtrapeD of -orciM Chemistry, Rutgers, The State ytisrevinU
,ygoloib Genetics and ,tnempoleveD and of of New Jersey, New ,kciwsnurB New Jersey
,ygolorueN egelloC of Physicians and Sur- 30980
geons, Columbia University, New York, NNAMREH NNAMREPPO (3), Creative -oiB
New York 23001 ,seluceloM Inc., ,notnikpoH sttesuhcassaM
ECNERWAL KAHAN (14), Department of 8471O
lacigoloisyhP Chemistry, University of NAMRON R. PACE (26), Department of -loiB
Wisconsin--Madison, Madison, Wiscon- ,ygo Indiana ,ytisrevinU ,notgnimoolB In-
sin 60735 diana 50474
SREDNA KARL~N (31), School of ,ycamrahP ODRAUDE A. NALDAP (1), yrotarobaL of Mo-
University of Lausanne, CH-IO05 Lau- ralucel ,ygoloiB National Institute of -aiD
,ennas Switzerland betes and Digestive and Kidney ,sesaesiD
NAEJ N. YMAL (13), Laboratoire de -ihcoiB National Institutes of Health, Bethesda,
mie, Facult~ de Pharmacie, ~tisrevinU Maryland 29802
Francois Rabelais, 37042 Tours Cedex, J. L. REUQELLEP (8), Institut de Biologie
ecnarF erialuc~loM et Cellulaire, CNRS, Stras-
DIVAD J. ENOTSGNIVIL (30), tnemtrapeD of gruob ,00076 France
Medicinal Chemistry, SmithKline Bee- JUHA NENOTLEP (24), Department of Medi-
cham Research, Welwyn, Hertfordshire lac Biochemistry, University of Turku,
AL6 9AR, England 20520 Turku, Finland
DRAWDE L. RELHCEOL (23), Department of EGRES P~REZ (27), Laboratoire de -ocisyhP
,ygoloiB Boston ,ytisrevinU Boston, Mas- chimie des ,seluc6lomorcaM lnstitut Na-
sttesuhcas 51220 tional de al Recherche ,euqimonorgA
WERDNA C. R. MARTIN (6), Department of 62044 Nantes, France
Biochemistry, University of Bath, Bath J. DRAHCIR L. PINK (19), Pharma hcraeseR
BA2 7AY, England ,ygolonhceT .F Hoffmann-La Roche, Ltd.,
ENNOVY CO~OLLY MARTn~ (29), Com- 2004-HC Basel, Switzerland
puter Assisted Molecular Design ,tcejorP LEINAD P. HGIELAR (9), Laboratory of Mo-
lacituecamrahP Products ,noisiviD Abbott ralucel Biophysics, University of ,drofxO
,seirotarobaL Abbott Park, Illinois 46006 Oxford 1XO 3QU, England
JOHN YENTRACCM (3), evitaerC -eloMoiB M. RANCE (ll), Department of raluceloM
,seluc Inc., ,notnikpoH sttesuhcassaM 8471O ,ygoloiB Research Institute of Scripps
HTIDEREM RETNUH-TTEGDUM (3), Massa- ,cinilC La Jolla, ainrofilaC 92037
chusetts General ,latipsoH Harvard Medi- ANITSIRHC DLEIFDER (9), yrotarobaL of Mo-
lac ,loohcS Boston, Massachusetts ,41120 ralucel Biophysics, University of ,drofxO
and The Bristol-Myers Squibb Pharma- Oxford 1XO 3QU, England
lacituec Research Institute, ,notecnirP New YNOHTNA R. SEER (6, 9), Department of -oiB
Jersey 34580 chemistry, University of Bath, Bath BA2
FRED NAIDER (10), Department of -simehC 4,7 ,Y England
CONTRIBUTORS TO VOLUME 203 xi
SEMAJ M. RINI (7), Department of Molecular Inc., Rexdale, Ontario M9W 4Z7,
Biology, Researct~ Institute of Scripps Canada
Clinic, La Jolla, California 92037
LIBAN EL RAYAT (31), School of Pharmacy,
ALOAP ILONGAMOR (19), Immunology Lab- University of Lausanne, CH-1005 Lau-
oratory, National Institute of Allergy and sanne, Switzerland
Infectious Diseases, Bethesda, Maryland DRANREB TESTA (31), School of Pharmacy,
20892 University of Lausanne, CH-1005 Lau-
PAUL LEMMIHCS (25), Department of Biol- sanne, Switzerland
ogy, Massachusetts Institute of Technol-
P. TSANG (11 ), Department of Molecalar Bi-
ogy, Cambridge, Massachusetts 02139
ology, Research Institute of Scripps Clinic,
PETER G. SCHULTZ (17), Department of La Jolla, California 92037
Chemistry, University of California, Berke-
INUOJ UITTO (24), Department of Dermatol-
ley, Berkeley, California 94720
ogy, Jefferson Medical College, Philadel-
DRAHREG NNAMEES (5), Research Laborato- phia, Pennsylvania 19107
ries of Behringwerke AG, D-3550 Mar-
M. H. V. NAV LETROMNEGER (8), Institut
burg, Germany
de Biologie Molbculaire et Cellulaire,
MARK A. NAMREHS (2), Physical Biochemis- CNRS, Strasbourg 67000, France
try Section, Beckman Research Institute of
YELDARB J. HSLAW (15), Centre for Immu-
The City of Hope, Duarte, California nology, St. Vincent's Hospital, Darling-
91010
hurst, 2010 New South Wales, Australia
KEVAN M. SHOKAT (17), Department of KCIREDERF NERRAW (3), Creative BioMole-
Chemistry, University of California, Berke- cules, Inc., Hopkinton, Massachusetts 8471O
ley, Berkeley, California 94720
DIVAD S. WAUGH (26), Department of Biol-
OCSECNARF SImGAGLIA (19), Pharma Re- ogy, Massachusetts Institute of Technol-
search Technology, F. Hoffmann-La
ogy, Cambridge, Massachusetts 02139
Roche, Ltd., CH-4002 Basel, Switzer-
LEHCSREH J. R. BUARTNIEW (28), Depart-
land
ment of Theoretical Chemistry, Marion
C. E. SPIVAK (32), Addiction Research Merrill Dow, Inc., CincinnatL Ohio 45215
Center, National Institute of Drug Abuse,
E. WESTHOF (8), Institut de Biologie
Baltimore, Maryland 21224
Mol~culaire et Cellulaire, CNRS, Stras-
OCIRNE A. STURA (7), Department of Molec-
bourg 67000, France
ular Biology, Research Institute of Scripps
NAI A. NOSLIW (7), Department of Molecu-
Clinic, La Jolla, California 92037
lar Biology, Research Institute of Scripps
WAN-JR UYS (14), Department of Microbiol-
Clinic, La Jolla, California 92037
ogy, National Yang-Ming Medical Col-
TTOCS WINSTON (16), Univax Biologics,
lege, Taipei, 11221 Taiwan, Republic of
Inc., Rockville, Maryland 20852
China
P. E. WRIGHT (11), Department of Molecular
ONEHS-IEM TAI (3), Creative BioMolecules,
Biology, Research Institute of Scripps
Inc., Hopkinton, Massachusetts 8471O
Clinic, La Jolla, California 92037
ALEB SCAKAT (19), Pharma Research Tech-
NESIEP ZHANG (21), Department of Chemis-
nology, F. Hoffmann-La Roche, Ltd., CH-
try, Rutgers, The State University of New
4002 Basel, Switzerland
Jersey, New Brunswick, New Jersey 08903
OKOYIM IHSAHAKAT (16), ADI Diagnostics,
Preface
The construction of molecules based on a rational design that includes
structural features representing binding and/or functional sites has evolved
into a new era as a result of a greater understanding of how acceptors bind
to ligands and the availability of powerful analytical techniques and meth-
ods of synthesis derived mainly from molecular biology. Powerful com-
puter hardware and increasingly friendly software that can be used by
experimentalists as well as by those with a more theoretical background
have fostered an unparalleled level of research interest at a time when
chemical and biological properties that not long ago were essentially the
sole domain of naturally occurring products can now be incorporated into
specifically designed macromolecules and low molecular weight drugs for
use as biochemical reagents, biomedical materials, or in medical devices.
Volumes 202 and 203 of Methods in Enzymology include topics in
which molecular modeling and applications of design principles and tech-
niques are covered from both methodological and didactic approaches.
Computer-based design and modeling, computational approaches, and
instrumental methods for elucidating molecular mechanisms of protein
folding and ligand-acceptor interactions are included as are genetic and
chemical methods for the production of functional molecules, including
antibodies and antigens, enzymes, receptors, nucleic acids and polysaccha-
rides, and drugs.
The aim of these volumes is to present mainstream concepts and
methodology and to give an up-to-date view of the subject matter. This is
with the understanding that new developments appear constantly, and that
it would not be prudent or desirable to attempt to include all available and
often more specialized or limited techniques.
At the end of each of these volumes is a Cross-Index to Prior Volumes
in which related chapters from previously published volumes of Methods
in Enzymology era listed. Each list serves as a reference guide and allows us
to avoid repeated coverage of topics presented in these earlier volumes.
Continued collaboration with John Abelson, Mel Simon, and our col-
leagues at Academic Press is gratefully acknowledged. A special note of
thanks is due Dina Langone for expertly managing the many office tasks
involved in assembling these volumes.
JOHNJ. ENOGNAL
iiix
METHODS IN ENZYMOLOGY
EMULOV I. Preparation and Assay of Enzymes
Editedb y SIDNEY P. KCIWOLOC DNA NATHAN O. KAFLAN
EMULOV II. Preparation and Assay of Enzymes
Edited by SIDNEY P. KCIWOLOC DNA NATHAN O. KAFLAN
VOLUME III. Preparation and Assay of Substrates
Editebdy SIDNEY P. KCIWOLOC DNA NATHAN O. KAPLAN
EMULOV IV. Special Techniques for the Enzymologist
Edited by SIDNEY P. KCIWOLOC DNA NATHAN O. KAPLAN
EMULOV V. Preparation and Assay of Enzymes
Editedb y SIDNEY P. KCIWOLOC DNA NATHAN O. KAPLAN
EMULOV VI. Preparation and Assay of Enzymes (Continued)
Preparation and Assay of Substrates
Special Techniques
Edited by SIDNEY P. KCIWOLOC DNA NATHAN O. KAr'LAN
EMULOV VII. Cumulative Subject Index
Edited by SIDNEY P. KCIWOLOC DNA NATHAN O. KAPLAN
EMULOV VIII. Complex Carbohydrates
Edited by ELIZABETH F. NEUFELD DNA VICTOR GRUBSNIG
VOLUME IX. Carbohydrate Metabolism
Edited by WILLIS A. WOOD
VOLUME X. Oxidation and Phosphorylation
Edited by RONALD W. KOORBATSE DNA DRANYAM E. NAMLLUP
EMULOV XI. Enzyme Structure
Edited by C. H. W. HIRS
EMULOV XII. Nucleic Acids (Parts A and B)
Edited by LAWRENCE NAMSSORG DNA KIVIE EVADLOM
XV
xvi SDOHTEM IN YGOLOMYZNE
EMULOV XIII. Citric Acid Cycle
Edited yb J. M. NIETSNEWOL
EMULOV XlV. Lipids
Edited yb J. M. NIETSNEWOL
EMULOV XV. Steroids and Terpenoids
Edited by RAYMOND B. NOTYALC
EMULOV XVI. Fast Reactions
Edited by KENNETH KUSTIN
EMULOV XVII. Metabolism of Amino Acids and Amines (Parts A and B)
Edited yb HERBERT TABOR DNA CELIA WHITE ROBAT
VOLUME XVIII. Vitamins and Coenzymes (Parts A, B, and C)
Edited yb DONALD B. KCIMROCCM DNA LEMUEL O. WRIGHT
VOLUME XIX. Proteolytic Enzymes
Edited by GERTRUDE E. PERLMANN DNA LASZLO DNAROL
VOLUME XX. Nucleic Acids and Protein Synthesis (Part C)
Edited by KIVIE MOLDAVE DNA LAWRENCE NAMSSORG
EMULOV XXI. Nucleic Acids (Part D)
Edited yb LAWRENCE GROSSMAN DNA KIVIE MOLDAVE
VOLUME XXII. Enzyme Purification and Related Techniques
Edited by WILLIAM B. YBOKAJ
EMULOV XXIII. Photosynthesis (Part A)
Edited by ANTHONY NAS PIETRO
EMULOV XXIV. Photosynthesis and Nitrogen Fixation (Part B)
Edited by ANTHONY NAS ORTEIP
VOLUME XXV. Enzyme Structure (Part B)
Edited yb C. H. W. HIRS DNA SERGE N. FFEHSAMIT
VOLUME XXVI. Enzyme Structure (Part C)
Edited by C. H. W. HIRS DNA SERGE N. FFEHSAMIT
METHODS IN ENZYMOLOGY xvii
EMULOV XXVII. Enzyme Structure (Part D)
Edited by C. H. W. HIRS DNA EGRES N. FFEHSAMIT
EMULOV XXVIII. Complex Carbohydrates (Part B)
Edited by ROTCIV GRUBSNIG
EMULOV XX1X. Nucleic Acids and Protein Synthesis (Part E)
Edited by ECNERWAL NAMSSORG DNA KlVlE EVADLOM
EMULOV XXX. Nucleic Acids and Protein Synthesis (Part F)
Edited by KlVlE EVADLOM DNA ECNERWAL NAMSSORG
EMULOV XXXI. Biomembranes (Part A)
Edited yb YENDIS REHCSIELF DNA RETSEL REKCAP
EMULOV XXXII. Biomembranes (Part B)
Edited by YENDIS REHCSIELF DNA LESTER REKCAP
EMULOV XXXIII. Cumulative Subject Index Volumes I-XXX
Edited by AHTRAM G. DENNIS DNA DRAWDE A. SINNED
EMULOV XXXIV. Affinity Techniques (Enzyme Purification: Part B)
Edited by WILLIAM B. YBOKAJ DNA MEIR KEHCLIW
EMULOV XXXV. Lipids (Part B)
Edited by JOHN M. NIETSNEWOL
EMULOV XXXVI. Hormone Action (Part A: Steroid Hormones)
Edited by BERT W. O'MALLEY DNA JOEL G. NAMDRAH
EMULOV XXXVII. Hormone Action (Part B: Peptide Hormones)
Edited by BERT W. O'MALLEY DNA JOEL G. NAMDRAH
EMULOV XXXVIII. Hormone Action (Part C: Cyclic Nucleotides)
Edited by JOEL G. NAMDRAH DNA BERT W. O'MALLEY
EMULOV XXXIX. Hormone Action (Part D: Isolated Cells, Tissues, and
Organ Systems)
Edited by JOEL G. NAMDRAH DNA BERT W. O'MALLEY
!llVX o°o SDOHTEM IN YGOLOMYZNE
EMULOV XL. Hormone Action (Part E: Nuclear Structure and Function)
Edited by BERT W. O'MALLEY DNA JOEL G. HARDMAN
EMULOV XLI. Carbohydrate Metabolism (Part B)
Edited by W. A. DOOW
EMULOV XLII. Carbohydrate Metabolism (Part C)
Edited by W. A. DOOW
EMULOV XLIII. Antibiotics
Edited by JOHN H. HASH
EMULOV XLIV. Immobilized Enzymes
Edited by SUALK HCABSOM
EMULOV XLV. Proteolytic Enzymes (Part B)
Edited by OLZSAL DNAROL
EMULOV XLVI. Affinity Labeling
Edited by WILLIAM B. JAKOBY AND MEIR WILCHEK
EMULOV XLVII. Enzyme Structure (Part E)
Edited by C. H. W. HIRS DNA EGRES N. EEEHSAMIT
EMULOV XLVIII. Enzyme Structure (Part F)
Edited by C. H. W. HIRS DNA EGRES N. EFEHSAMIT
EMULOV XLIX. Enzyme Structure (Part G)
Edited by C. H. W. HIRS DNA EGRES N. FEEHSAMIT
EMULOV L. Complex Carbohydrates (Part C)
Edited by ROTCIV GRUBSN1G
EMULOV LI. Purine and Pyrimidine Nucleotide Metabolism
Edited by PATRICIA A. HOEFEE DNA MARY ELLEN JONES
EMULOV LII. Biomembranes (Part C: Biological Oxidations)
Edited yb SIDNEY FLEISCHER AND LESTER PACKER
EMULOV LIII. Biomembranes (Part :D Biological Oxidations)
Edited by SIDNEY FLEISCHER DNA LESTER PACKER
METHODS IN ENZYMOLOGY xix
EMULOV LIV. Biomembranes (Part E: Biological Oxidations)
Edited by YENDIS REHCSIELF DNA RETSEL REKCAP
EMULOV LV. Biomembranes (Part F: Bioenergetics)
Edited by YENDIS REHCSIELF DNA LESTER REKCAP
EMULOV LVI. Biomembranes (Part G: Bioenergetics)
Edited by YENDIS REHCSIELF DNA RETSEL REKCAP
EMULOV LVII. Bioluminescence and Chemiluminescence
Edited by ENELRAM A. DELUCA
EMULOV LVIII. Cell Culture
Edited by WILLIAM B. YBOKAJ DNA ARI NATSAP
EMULOV LIX. Nucleic Acids and Protein Synthesis (Part G)
Edited by KIVlE EVADLOM DNA ECNERWAL NAMSSORG
EMULOV LX. Nucleic Acids and Protein Synthesis (Part H)
Edited by KIVlE EVADLOM DNA ECNERWAL NAMSSORG
EMULOV 61. Enzyme Structure (Part H)
Edited by C. H. W. HIRS DNA EGRES N. FFEHSAMIT
EMULOV 62. Vitamins and Coenzymes (Part D)
Edited by DLANOD B. KCIMROCCM DNA LEMUEL D. THGIRW
EMULOV 63. Enzyme Kinetics and Mechanism (Part A: Initial Rate and
Inhibitor Methods)
Edited by DANIEL L. HCIRUP
EMULOV 64. Enzyme Kinetics and Mechanism (Part B: Isotopic Probes
and Complex Enzyme Systems)
Edited by DANIEL L. HCIRUP
EMULOV 65. Nucleic Acids (Part I)
Edited by ECNERWAL NAMSSORG DNA KIVIE EVADLOM
EMULOV 66. Vitamins and Coenzymes (Part E)
Edited by DLANOD B. KCIMROCCM DNA LEMUEL D. THGIRW
XX SDOHTEM IN YGOLOMYZNE
EMULOV 67. Vitamins and Coenzymes (Part F)
Edited by DONALD B. KCIMROCCM DNA LEMUEL D. WRIGHT
VOLUME 68. Recombinant DNA
Edited by YAR Wu
VOLUME 69. Photosynthesis and Nitrogen Fixation (Part C)
Edited by ANTHONY NAS ORTEIP
EMULOV 70. Immunochemical Techniques (Part A)
Edited by HELEN NAV VUNAKIS DNA JOHN J. ENOGNAL
EMULOV 71. Lipids (Part C)
Edited yb JOHN M. NIETSNEWOL
EMULOV 72. Lipids (Part D)
Edited by JOHN M. NIETSNEWOL
VOLUME 73. Immunochemical Techniques (Part B)
Edited by JOHN J. LANGONE DNA HELEN NAV SIKANUV
VOLUME 74. Immunochemical Techniques (Part C)
Edited by JOHN J. LANGONE DNA HELEN NAV SIKANUV
VOLUME 75. Cumulative Subject Index Volumes XXXI, XXXII,
XXXIV-LX
Edited yb EDWARD A. DENNIS DNA MARTHA G. DENNIS
VOLUME 76. Hemoglobins
Edited by ERALDO ANTON1NI, LUIGI ROSSI-BERNARDI, AND EMILIA
CHIANCONE
VOLUME 77. Detoxication and Drug Metabolism
Edited yb WILLIAM B. YBOKAJ
VOLUME 78. Interferons (Part A)
Edited yb SIDNEY AKTSEP
VOLUME 79. Interferons (Part B)
Edited by SIDNEY AKTSEP