Molecular Biology of Acute Lung Injury

328 Pages·2001·19.35 MB·English

by  Thomas P. Shanley

MOLECULAR BIOLOGY OF
ACUTE LUNG INJURY
MOLECULAR AND CELLULAR BIOLOGY
OF CRITICAL CARE MEDICINE
RobertS. B. Clark andJoseph A. Carcillo, Series Editors
1. H. R. Wong and T. P. Shanley (eds.): Molecular Biology ofAcute
Lung Injury. 2001. ISBN: 0-7923-7434-7
MOLECULAR BIOLOGY OF
ACUTE LUNG INJURY
edited by
Hector R. Wong
Division of Critical Care Medicine
Children's Hospital Medical Center and
Children's Hospital Research Foundation
Cincinnati, Ohio
and
Thomas P. Shanley
Division of Critical Care Medicine
Children's Hospital Medical Center and
Children's Hospital Research Foundation
Cincinnati, Ohio
~.
"
Springer Science+ Business Media, LLC
Library of Congress Cataloging-in-Publication Data
Molecular biology of acute lung injury / edited by Hector R. Wong and Thomas P. Shanley.
p. ; cm. --(Molecular & cellular biology of critical care medicine ; MCCM 1)
Includes bibliographical references and index.
ISBN 978-1-4613-5548-9 ISBN 978-1-4615-1427-5 (eBook)
DOI 10.1007/978-1-4615-1427-5
1. Respiratory distress syndrome, Adult--Pathophysiology. 2. Respiratory distress
syndrome, Adult--Molecular aspects. 1. Wong, Hector R., 1963-II. Shanley, Thomas P.,
1963- III. Series.
[DNLM: 1. Respiratory Distress Syndrome, Adult--physiopathology. 2. Molecular
Biology. WF 140 M718 2001]
RC776.R38 M654 2001
616.2'407--dc21
2001038125
Copyright © 2001 bySpringer Science+Business Media New York
Originally published by Kluwer Academic Publishers, New York in 2001
Softcover reprint ofthe hardcover lst edition 2001
AII rights reserved. No part of this publication may be reproduced, stored in a retrieval system
or transmitted in any form or by any means, mechanical, photo-copying, recording, or otherwise,
without the prior written permission of the publisher, Springer Science+Business Media, LLC.
Printed an acid-free pap er.
The Publisher offers discounts on this book for course use and bulk purchases.
For further information, send email tomelissa.ramondettaf.iiJwkap.com
TABLE OFCONTENTS
ListofContributors vii
Preface xi
Acknowledgements xiii
1. Signal TransductionPathways in AcuteLungInjury:
NF-KBand AP-l
Thomas P. Shanleyand HectorR. Wong 1
2. InnateImmuneMechanismsTriggeringLungInjury
Robert M. Strieter, John A. Belperio, David Kelley,
Ammar Sakkour, and Michael P. Keane 17
3. TheRole ofChemokinesin theRecruitmentofLeukocytes
During LungInflammation
RobertM. Strieter, John A. Belperio, David Kelley,
Ammar Sakkour, and Michael P. Keane 35
4. Regulation ofLungImmunity:
Significanceofthe CytokineEnvironment
NicholasW. Lukacs, Theodore Standiford, CoryHogaboam, and
Steven L. KunkeL 53
5. Role ofComplementin Acute LungInjury
Markus S. Huber-Langand PeterA. Ward 71
6. OxidantStress in AcuteLungInjury
Jerry J. Zimmerman 83
7. Endogenous Nitric Oxidein AcuteLungInjury
Neil W. Kooy 101
8. Heme Oxygenase-l in AcuteLungInjury
Jigme M. Sethi and AugustineM. K. Choi. 119
9. Pulmonary Endothelial SurfaceRedox Activity:
Roles in Propagation ofand Protection from Injury
Marilyn P. Merker, Robert D. Bongard,
and ChristopherA. Dawson 133
vi
10. Mechanisms ofLungEpithelial CellInjury by
PseudomonasAeruginosa
Jeanine P. Wiener-Kronish, DaraFrank, and Teiji Sawa 149
11. AlveolarEpithelial Repairin AcuteLungInjury
ThomasK. Geiserand Michael A. Matthay 163
12. MolecularBasis for SurfactantFunction in ARDS
Liqian Zhangand Jeffrey A. Whitsett 177
13. Pulmonary Collectins and Defensins
Ann MarieLeVine 193
14. LungRepair,Remodeling, and Fibrosis
SujataGuharoyand Sem H. Phan 213
l
15. Apoptosisin AcuteLungInjury
Karine Faure, BenoitGuery, and Jean FrancoisPittet 229
16. Corticosteroid Treatmentin Unresolving ARDS
G. UmbertoMeduri 245
17. Anti-inflammatory Cytokines: Role in Regulation
of AcuteLungInjury
ThomasP. Shanley 257
18. TheHeatShockResponseand Heat ShockProtein 70:
Cytoprotection in Acute LungInjury
HectorR. Wong 275
19. Biotrauma: Signal Transduction
and GeneExpression in the Lung
ClaudiaC. dos Santos, Mingyao Liu, and Arthur S. Slutsky 289
Index 327
CONTRIBUTORS
John A. Belperio Thomas K. Geiser
DepartmentofMedicine, Division Division ofPulmonary Medicine
ofPulmonaryandCritical Care UniversityHospital
Medicine, Los Angeles (UCLA) Bern, Switzerland
School ofMedicine
Los Angeles, California BenoitGuery
Laboratoirede Rechercheen
Robert D. Bongard Pathologie Infectieuse
Medical College ofWisconsin UniversityofLille
Milwaukee, Wisconsin Lille, France
AugustineM. K. Choi Sujata Guharoy
Division ofPulmonary, Allergy, DepartmentofPathology
and Critical Care Medicine UniversityofMichigan
University ofPittsburgh Medical Ann Arbor, Michigan
Center
Pittsburgh, Pennsylvania CoryHogaboam
DepartmentofPathology
ChristopherA. Dawson UniversityofMichigan Medical
Medical College ofWisconsin, School
Veterans Affairs Medical Center, Ann Arbor, Michigan
and Marquette University
Milwaukee, Wisconsin Michael P. Keane
DepartmentofMedicine, Division
Claudia C. dos Santos ofPulmonaryand Critical Care
Inter-Departmental Division of Medicine, Los Angeles (UCLA)
Critical Care School ofMedicine
University ofToronto Los Angeles, California
Toronto, Canada
David Kelley
Karine Faure DepartmentofMedicine, Division
DepartmentofAnesthesiaand ofPulmonaryand Critical Care
Surgery, University ofCalifornia Medicine, Los Angeles(UCLA)
at San Francisco School ofMedicine
San Francisco, California Los Angeles, California
Dara Frank Neil W. Kooy
DepartmentofMicrobiologyand Division ofCritical Care
MolecularGenetics, Medical Medicine, Children's Hospital
CollegeofWisconsin Medical Centerand Children's
Milwaukee, Wisconsin Hospital Research Foundation
Cincinnati, Ohio
viii
Jeanine P. Wiener-Kronish G. Umberto Meduri
DepartmentofAnesthesiaand Division ofPulmonaryand
Perioperative Care, Universityof Critical CareMedicine,
Californiaat SanFrancisco UniversityofTennesseeHealth
San Francisco, California Science Center, TheMemphis
LungResearch Program, and
Steven L. Kunkel BaptistMemorial Hospitals
DepartmentofPathology Memphis, Tennessee
UniversityofMichigan Medical
School Marilyn P. Merker
Ann Arbor, Michigan Medical College ofWisconsin
and Veterans Affairs Medical
Markus S. Huber-Lang Center
DepartmentofPathology Milwaukee, Wisconsin
University ofMichigan Medical
School SemH.Phan
Ann Arbor, Michigan DepartmentofPathology
UniversityofMichigan
Ann Marie LeVine Ann Arbor, Michigan
Division ofPulmonary Biology
and Critical CareMedicine Jean FrancoisPittet
Children's Hospital Medical DepartmentofAnesthesiaand
Centerand Children's Hospital Surgery, UniversityofCalifornia
Research Foundation at San Francisco
Cincinnati, Ohio San Francisco, California
Mingyao Liu AmmarSakkour
Thoracic SurgeryResearch DepartmentofMedicine, Division
Laboratory, University Health ofPulmonaryand Critical Care
Network, TorontoGeneral Medicine, Los Angeles(UCLA)
Hospital School ofMedicine
Toronto, Canada Los Angeles, California
Nicholas W. Lukacs Teiji Sawa
DepartmentofPathology DepartmentofAnesthesiaand
University ofMichigan Medical Perioperative Care, Universityof
School Californiaat San Francisco
Ann Arbor, Michigan San Francisco, California
Michael A. Matthay Jigme M. Sethi
CardiovascularResearch Institute Division ofPulmonary, Allergy,
University ofCaliforniaSan and Critical Care Medicine
Francisco University ofPittsburgh Medical
San Francisco, California Center
Pittsburgh, Pennsylvania
ix
ThomasP. Shanley JeffreyWhitsett
Division ofCritical Care Division ofPulmonaryBiology
Medicine, Children's Hospital Children'sHospital Medical
Medical Centerand Children's Centerand Children'sHospital
Hospital Research Foundation Research Foundation
Cincinnati, Ohio Cincinnati, Ohio
Arthur S. Slutsky HectorR. Wong
DepartmentofCritical Care DivisionofCritical Care
Medicine, St. Michael'sHospital Medicine, Children's Hospital
Toronto, Canada Medical Centerand Children's
HospitalResearch Foundation
Theodore Standiford Cincinnati, Ohio
Division ofPulmonaryand
Critical Care Medicine Liqian Zhang
University ofMichiganMedical Division ofPulmonaryBiology
School Children'sHospital Medical
Ann Arbor, Michigan Centerand Children'sHospital
Research Foundation
RobertM. Strieter Cincinnati, Ohio
DepartmentofMedicine, Division
ofPulmonaryand Critical Care JerryJ. Zimmerman
Medicine, Los Angeles(UCLA) Division ofCritical Care
School ofMedicine Medicine, Children's Hospital and
Los Angeles, California Regional Medical Center
Seattle, Washington
PeterA. Ward
DepartmentofPathology
University ofMichigan, School of
Medicine,
Ann Arbor, Michigan
xi
PREFACE
Visit any intensive care unit in the world, whether it be dedicated to
the care ofmedical, surgical, pediatric, orneonatal patients, and the extentto
which acute lung injury (ALI) impacts patient care will become immediately
evident. The impact is measured not only in the number of patients that
suffer from ALI, but also in the costs attributed to care, the number of
clinical and basic researchers dedicated to ALI, and the morbidity and
mortality associated with ALI and itscomplications.
Our collective understanding of the pathophysiology of ALI has
grown immensely over the past decade. Despite this knowledge and the
realization that the outcome of patients with ALI has improved modestly
over the last several years, we contend that the morbidity and mortality of
ALI remain unacceptably high. Thus, clinicians and researchers alike
continue to face the challenge ofdeveloping a greater understanding ofthe
biological basis of ALI. This fundamental understanding will allow us to
move beyond our current supportive therapeutic strategies, toward novel
strategies that specifically target the complex biologic processes involved in
ALI.
This book is not a "how to" book ofALI. Rather, this book attempts
to compile the most current available information regarding the plethora of
molecules and mechanisms thought to be relevant to the pathophysiology
and treatment ofALI. The focus ofthe book reflects our biasthat in orderto
moreeffectivelycarefor patients with ALI, we will needto develop a greater
understanding ofthis processatthe molecular level.
One other point should be addressed. Throughout this book the
reader will note that the terms "ALI" and "ARDS" are used relatively
loosely. Lest the reader be led to believe that we do not comprehend the
formal definitions of"ALI" and its more severe manifestation, "ARDS," rest
assured that thesedefinitions are well understood and recognized. The use of
these two terms in this manner reflects the concept that ALI and ARDS are
not a single disease entity. Rather, they are manifestations ofmultiple insults
to the lung(directlyvia the alveolarcompartment, orrelatively more indirect
viathe vascularcompartment) leadingto a remarkably similarendpoint.
It is our sincere hope that the information provided in this book
serves as a valuable reference to both clinicians and researchers, and more
importantly, that it stimulates the scientific and academic curiosity offuture
clinician/investigators.
HectorR. Wong
ThomasP. Shanley