Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity

671 Pages·2007·7.72 MB·English

by  Gary A. Silverman, David A. Lomas

Molecular and Cellular Aspects
of the Seerpinopathies and
Disorders in Serpin Activity
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Molecular and Cellular Aspects
of the Serpinopathies and
Disorders in Serpin Activity
Editors
Gary A. Silverman
University of Pittshburgh School of Medicine USA
David A. Lomas
University of Cambridge, UK
World Scientific
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British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library.
MOLECULAR AND CELLULAR ASPECTS OF THE SERPINOPATHIES
AND DISORDERS IN SERPIN ACTIVITY
Copyright © 2007 by World Scientific Publishing Co. Pte. Ltd.
All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means,
electronic or mechanical, including photocopying, recording or any information storage and retrieval
system now known or to be invented, without written permission from the Publisher.
For photocopying of material in this volume, please pay a copying fee through the Copyright
Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to
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ISBN-13 978-981-256-963-9
ISBN-10 981-256-963-4
Typeset by Stallion Press
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Jan. 10, 2007 8:57 SPI-B429 Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity fm
Contents
Editors ix
Contributors xi
Serpinopathies Foreword xxv
Serpinopathies Preface xxvii
SECTION I OVERVIEW OF THE SERPIN SUPERFAMILY
Chapter 1 Evolution and Classification of the
Serpin Superfamily 1
James A. Irving, Lisa D. Cabrita, Dion Kaiserman,
Margaret M. Worrall and James C. Whisstock
Chapter 2 Serpin Conformations 35
Mary C. Pearce, Robert N. Pike, Arthur M. Lesk
and Stephen P. Bottomley
Chapter 3 Mechanisms of Serpin Inhibition 67
Peter G. W. Gettins
SECTION II LESSONS FROM MODEL ORGANISMS
Chapter 4 Mouse Serpins and Transgenic Studies 101
David J. Askew, Paul Coughlin and Phillip I. Bird
Chapter 5 Serpins in Prokaryotes 131
Qingwei Zhang, Ruby Law, Ashley M. Buckle,
Lisa Cabrita, Sheena McGowan, James A. Irving,
Noel G. Faux, Arthur M. Lesk,
Stephen P. Bottomley and James C. Whisstock
v
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vi Contents
Chapter 6 New Lessons from Poxvirus Serpins 163
Peter C. Turner, Priscilla F. McAuliffe,
Amy L. MacNeill, and Richard W. Moyer
Chapter 7 The Intracellular Serpins of Caenorhabditis
elegans 195
Stephen C. Pak, Yuko. S. Askew and Cliff J. Luke
Chapter 8 Drosophila Serpins: Regulatory Cascades in
Innate Immunity and Morphogenesis 207
David Gubb, Andrew Robertson, Tim Dafforn,
Laurent Troxler and Jean-Marc Reichhart
Chapter 9 Serpins in a Lepidopteran Insect,
Manduca sexta 229
Michael R. Kanost
Chapter 10 MENT, a Chromatin-Associated Serpin from
Avian Blood Cells: Structure and Function 243
Sergei A. Grigoryev, Yaroslava A. Bulynko,
Robert N. Pike and James C. Whisstock
Chapter 11 Uterine Serpins 261
Peter J. Hansen, Saban Tekin and Maria B. Padua
Chapter 12 Plant Serpins 279
Jørn Hejgaard and Thomas H. Roberts
SECTION III SERPIN PHYSIOLOGY AND
PATHOPHYSIOLOGY
Chapter 13 Serpins, Apoptosis and Other Aspects
of Cell Death 301
Fiona L. Scott
Chapter 14 Serpins in Malignancy: Tumor Cell Invasion,
Motility and Angiogenesis 337
Philip A. Pemberton, Christian Schem,
Nicolai Maass and Ming Zhang
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Contents vii
Chapter 15 Serpins in Malignancy: Prognostic Indicators 363
Hiroshi Kato, Yuko S. Askew, Shugo Nawata, Akihiro
Murakami, Yoshinori Suminami and Gary Clayman
Chapter 16 SERPINB7 (Megsin) Nephropathy 383
Toshio Miyata
Chapter 17 Serpin-Protein and Receptor Interactions 393
Toni M. Antalis and Dudley K. Strickland
Chapter 18 Serpins and the Metabolic Syndrome 411
Jun Wada
Chapter 19 Serpin Interactions with Bacterial Peptidases 425
Jan Potempa, Tomasz Kantyka and Daniel Nelson
SECTION IV CONGENITAL DEFICIENCIES AND
SERPINOPATHIES
Chapter 20 The Serpinopathies and Respiratory Disease 445
David A. Lomas, Didier Belorgey, Elena Miranda,
Meera Mallya, Peter Hägglöf, Lynda K. Sharp,
Russell L. Phillips, Richard Page, Mark J. Davies
and Damian C. Crowther
Chapter 21 Liver Disease in α1-Antitrypsin Deficiency 483
David H. Perlmutter
Chapter 22 Regulation of Hemostasis by Heparin-Binding
Serpins 509
Frank C. Church, Robert N. Pike,
Douglas M. Tollefsen, Ashley M. Buckle,
Angelina V. Ciaccia and Steven T. Olson
Chapter 23 C1 Inhibitor: Structure, Function, Biologic
Activity and Angioedema 555
Philip A. Patston and Alvin E. Davis III
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viii Contents
Chapter 24 Neuroserpin in Neurological Disease 593
Manuel Yepes and Daniel A. Lawrence
Chapter 25 Serpins and Alzheimer’s Disease 619
H. Tonie Wright and Sabina Janciauskiene
Index 635
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EDITORS
Gray A. Silverman
Professor of Pediatrics
University of Pittsburgh School of Medicine
Chief of Neonatology and Development Biology
Chief, UPMC Newborn Medicine Program
Magee-Womens Hospital and Children’s Hospital of Pittsburgh
300 Halket St.
Pittsburgh, PA 15213, USA
David A. Lomas
Department of Medicine
University of Cambridge
Cambridge Institute for Medical Research
Wellcome Trust/MRC Building
Hills Road, Cambridge, CB2 2XY, UK
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