Modeling and simulation in the medical and health sciences

227 Pages·2011·1.779 MB·English

by  John A Sokolowski, Catherine M Banks, Wiley InterScience (Online service)

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MODELING AND SIMULATION
IN THE MEDICAL AND
HEALTH SCIENCES
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MODELING AND SIMULATION
IN THE MEDICAL AND
HEALTH SCIENCES
Editedby
John A. Sokolowski, Ph.D.
Catherine M. Banks, Ph.D.
TheVirginiaModeling,AnalysisandSimulationCenter
OldDominionUniversity
Suffolk,Virginia
AJOHNWILEY&SONS,INC.,PUBLICATION
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Copyright (cid:1)C 2011 by John Wiley & Sons, Inc. All rights reserved.
Published by John Wiley & Sons, Inc., Hoboken, New Jersey.
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LibraryofCongressCataloging-in-PublicationDataIsAvailable
Modelingandsimulationinthemedicalandhealthsciences/editedbyJohnA.Sokolowskiand
CatherineM.Banks
Includesbibliographicalreferencesandindex.
ISBN978-0-470-76947-8
PrintedinSingapore
oBookISBN:9781118003206
ePDFISBN:9781118003183
ePubISBN:9781118003190
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Mywife,Marsha,andmydaughters,AmyandWhitney,
forallyourloveandsupport
—JohnA.Sokolowski
Myhusband,James,theloveofmylife
—CatherineM.Banks
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CONTENTS
CONTRIBUTORS ix
FOREWORD xiii
PREFACE xv
PARTONE FUNDAMENTALSOFMEDICALAND
HEALTHSCIENCESMODELINGAND
SIMULATION 1
1 IntroductiontoModelingandSimulationintheMedical
andHealthSciences 3
CatherineM.Banks
Introduction 3
ModelingandSimulationintheMedicaland
HealthSciences 4
ResearchandDevelopmentofMedicaland
HealthSciencesM&S 8
TheQuestionofEthicsinMedicaland
HealthSciencesM&S 11
Conclusion 19
KeyTerms 20
References 20
2 ThePracticeofModelingandSimulation:
ToolsoftheTrade 23
JohnA.Sokolowski
Introduction 23
ModelingandSimulationTermsandDefinitions 23
ModelingandSimulationParadigms 26
Conclusion 32
KeyTerms 32
References 32
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viii CONTENTS
PARTTWO MODELINGFORTHEMEDICALAND
HEALTHSCIENCES 35
3 MathematicalModelsofTumorGrowthandWound
Healing 37
JohnA.Adam
Introduction 37
OtherBasicModelsofTumorCellPopulationGrowth:
MulticellularSpheroids 40
DiffusionofGrowthInhibitor 41
Time-EvolutionaryDiffusionModels 43
TumorAngiogenesis 46
Conclusion 59
KeyTerms 61
References 61
FurtherReading 63
4 PhysicalModeling 65
StacieI.Ringleb
Introduction 65
TangiblePhysicalModels 66
Cadaver-BasedModels 70
AnimalModels 73
ComputationalPhysicalModels 74
Conclusion 78
KeyTerms 79
References 79
PARTTHREE MODELINGANDSIMULATION
APPLICATIONS 85
5 HumansasModels 87
C.DonaldCombs
Introduction 87
CadaversandWaxModels 88
StandardizedPatients 91
Plastination 100
HumanDataSets 103
Conclusion 105
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CONTENTS ix
KeyTerms 106
References 106
6 ModelingtheHumanSystem 109
MohammedFerdjallahandGyuTaeKim
Introduction 109
OrganModeling 110
ModelingofMuscularElectrophysiology 111
Conclusion 118
KeyTerms 119
References 119
7 Robotics 121
RichardLee
Introduction 121
RoboticsTechnology 122
UsingRobotics:AdvantagesandDisadvantages 123
Conclusion 124
KeyTerms 124
8 Training 125
PaulE.Phrampus
Introduction 125
TypesofTraining 129
CreatingSuccessfulSimulationsinHealthCare 132
Trainingprogramsandstudentlevels 136
Simulation-BasedTraining 139
BarrierstoSimulationTraininginHealthCare 143
KeyTerms 144
References 144
FurtherReading 145
9 PatientCare 147
EugeneSantos,Jr.,JosephM.Rosen,KeumJooKim,
FeiYu,DeqingLi,ElizabethA.Jacob,andLindsayB.Katona
Introduction 147
RelatedWork 149
TeamPerformance 150
SurgicalIntentInferencing 153
EmpiricalStudy 158
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x CONTENTS
Conclusion 170
KeyTerms 171
References 171
10 FutureofModelingandSimulationintheMedicaland
HealthSciences 175
RichardM.Satava
Introduction 175
FutureProcessesforModelingandSimulation 177
FutureTechnologiesandApplications 184
Conclusion 192
KeyTerms 193
References 193
Appendix ModelingHumanBehavior,ModelingHuman
Systems:AddressingtheSkepticism,Responding
totheReservations 195
INDEX 207