Table Of ContentMODEL SYSTEMS OF DEVELOPMENT
AND AGING OF THE NERVOUS SYSTEM
Institute of
Developmental
Neuroscience
~
Aging
MODEL SYSTEMS OF DEVELOPMENT
AND AGING OF THE NERVOUS SYSTEM
EDITED BY:
ANTONIA VERNADAKIS
ALAIN PRIV A T
JEAN M. LAUDER
PAOLA S. TIMIRAS
EZIO GIACOBINI
..
MARTIN US NIJHOFF PUBLISHING
A MEMBER OF THE KLUWER ACADEMIC PUBLISHERS GROUP
BOSTONIDORDRECHT /LANCASTER
© 1987 by Martinus NijhoffPublishing, Boston
Sofkover reprint of the hardcover 1st edition 1987
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system,
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Library of Congress Cata)oging-in-Publication Data
Model systems of development and aging of the nervous system.
1. Developmental neurology. 2. Nervous system
Aging. 3. Biological models. I. Vernadakis, Antonia,
1930- . [DNLM: 1. Aging 2. Models, Neurological.
3. Nervous System-growth & development. 4. Nervous
System-physiology. WL 102 M6885]
QP361.M78 1986 599'.01'88 86-23549
ISBN-\3: 978-1-4612-9212-8 e-ISBN-\3: 978-1-46\3-2037-1
001: 10.1007/978-1-46\3-2037-1
CONTENTS
Contributing Authors IX
Preface xv
I. NEURONS, NEUROGLIA AND NEURONAL-GLIAL INTERACTIONS
1. Cell Culture Systems for Purified Retinal Neurons and Photoreceptors 3
RUBEN ADLER
2. Primary Cultures of GABAergic and Glutamatergic Neurons as Model Systems
to Study Neurotransmitter Functions. 1. Differentiated Cells 19
LEIF HERTZ AND ARNE SCHOUSBOE
3. Primary Cultures ofGABAergic and Glutamatergic Neurons as Model Systems
to Study Neurotransmitter Functions. II. Developmental Aspects 33
ARNE SCHOUSBOE AND LEIF HERTZ
4. Development of Cerebral Cortical GABAergic Neurons In Vitro 43
KINYA KURIYAMA AND SEITARO OHKUMA
5. Morphological Analysis of 5-HT Neurons Transplanted into the Olfactory Bulb
of the Adult Rat 57
ALAIN PRIVAT, HUSSEIN MANSOUR, AND MICHEL GEFFARD
6. An Analysis ofInteractions Between Grafted Serotonin Neurons and an Adult
Host Hippocampus 75
MEN AHEM SEGAL
v
vi Contents
7. Neuronal Modulation by Number and by Volume: A Review and Critical
Analysis 85
GUIDO FILOGAMO
8. Oligodendrocyte Development; Immunological Studies 101
NICHOLAS W. SEEDS, JANET M. COLLINS, SUSAN C. HAFFKE, AND DESSIE FAFOUTIS
9. Intracerebral Transplantation as a Model for Studying the Myelination
Process 115
MADELEINE GUMPEL, FRANyOIS LACHAPELLE, MICHEL BAULAC, ANNICK BARON-VAN
EVERCOOREN, ANNIE GANSMULLER, CLAUDE JACQUE, AND NICOLE BAUMANN
10. In Vitro Effects of Glia Maturation Factor on Bipotential Glial Progenitor
Cells 125
E. PETER BOSCH, JosE G. ASSOULINE AND RAYMON LIM
11. Specialized Junctions of Glial Cells In Situ and In Vitro 139
ENRICO MUGNAINI, PAUL T. MASSA AND SARA SZUCHET
12. Electrophysiological and Ionic Transport Properties of Glial Cells in
Culture 171
H. STEVE WHITE AND DIXON M. WOODBURY
13. In Vitro Regulation of Dopaminergic Maturation 193
ALAIN PROCHIANTZ
14. Do Mouse Cerebellum Astrocytes Playa Role in Neuronal Survival and
Differentiation? 201
BERNARD PESSAC AND FRANyOISE ALLIOT
15. Proliferation and Maturation of Rat Neuroblasts in Culture: Influence of
Meningeal Cells 209
CLAIRE GENSBURGER, GERARD LABOURDETTE AND MONIQUE SENSENBRENNER
II. NEUROMODULATION, SYNAPSE AND RECEPTORS 217
16. Neurotransmitters as Morphogenetic Signals and Trophic Factors 219
JEAN M. LAUDER
17. Multifunctional Roles for Neurotransmitters: The Regulation of Neurite
Outgrowth, Growth-Cone Motility and Synaptogenesis 239
STANLEY B. KATER AND PHILIP G. HAYDON
18. Peptide Modulation of Neuronal Differentiation in Culture 257
DOUGLAS E. BRENNEMAN AND PHILLIP G. NELSON
19. Trophic and Toxic Mechanisms in Neuronal Survival 277
SILVIO VARON, STEPHEN D. SKAPER, AND MARSTON MANTHORPE
20. Factors Influencing the Proliferation and Differentiation of Brain Neurons In
Vitro 297
YAIR AIZENMAN, DORIS K. WU AND JEAN DE VELLIS
21. Role of Steroid Hormones in Neural Growth and Differentiation: In Vivo and In
Vitro Comparisons 321
FUL VIA GREMO AND ANTONIA VERNADAKIS
Contents vii
22. Neural Factor-Induced Formation of Acetylcholine Receptor Aggregates on
Myotubes: An In Vitro Model for Development of the Postsynaptic Cell Surface
Complex 335
MATHEW P. DANIELS, JACQUELINE G. KRIKORIAN, ALICE LING, AND ANTHONY J. OLEK
23. Current Findings on the Morphological Induction of Synaptogenesis in Neuronal
Cells In Vitro 355
POL YXENIE E. SPOERRI
24. Are Age-Related Changes in Receptor Activity an Expression of Altered
Membrane Fluidity? 375
KERN VON HUNGEN AND CLAUDE F. BAXTER
25. Metabolic Regulation in Brain Cells 383
J. TYSON TILDON AND LOIS M. ROEDER
III. AGING AND REGENERATION 403
26. Monoaminergic and Cholinergic Intracerebral Grafts: Use in Model Systems of
Aging 405
FRED H. GAGE
27. The Iris as a Model of Aging 421
EZIO GIACOBINI AND ISABELLA MUSSINI
28. In Vitro Model of Neuronal Aging and Development in the Nervous
System .433
REGINO PEREZ-POLO AND KARIN WERRBACH-PEREZ
29. Gangliosides as a Tool for Studying the Repair of Adult Mammalian Brain After
Injury 443
ADRIANA CONSOLAZIONE, CATERINA ALDINIO, LUCIO CAVICCHIOLI, ALBERTA LEON,.
AND GINO TOFFANO
30. Aging-Related Pathology in Human Neuroblastoma and Teratocarcinoma Cell
Lines 453
GREGORY M. COLE AND PAOLA S. TIMIRAS
31. Comparisons of Glial Cells from Newborn and Aged Mouse in Culture 475
ANTONIA VERNADAKIS, NIKOS SAKELLARIDIS, DIMITRA MANGOURA, AND DAVID DAVIES
32. Tissue Culture in Studies of Aging in the Nervous System: Toxicity of MPTP to
Dopamine Neurons 491
CATHERINE MYTILINEOU
Index 501
CONTRIBUTING AUTHORS
ADLER, Ruben BARON-VAN EVERCOOREN,
Wynn Center, Wilmer Institute, Johns Annick
Hopkins University School of Medicine, INSERM U134, Hoptial de la
600 North Wolfe Street, Baltimore, MD Salpetriere, F-75651 Paris Cedex 13,
21205, USA FRANCE
AIZENMAN, Yair BAULAC, Michel
Departments of Anatomy and Laboratoire Charles Foix, Hopital de la
Psychiatry, University of California Salpetriere, F-75651 Paris Cedex 13,
School of Medicine, Los Angeles, CA
FRANCE
90024, USA
BA UMANN, Nicole
ALDINIO, Caterina
INSERM U134, Hopital de la
Fidia Neurobiological Research
Salpetriere, F-75651 Paris Cedex 13,
Laboratories, Via Ponte della Fabbrica
FRANCE
3/ A, F-35031 Abano Terme, IT AL Y
ALL/OT, Fran<;oise BAXTER, Claude F.
INSERM U178, Batiment INSERM, 16 Department of Psychiatry and
avenue Paul Vaillant Couturier, F-94807 Biobehavioral Sciences, UCLA School of
VillejuifCedex, FRANCE Medicine, Los Angeles, CA 90024, USA
ASSOULINE, Jose G. BOSCH, E. Peter
Division of Neurochemistry and Division of Neurochemistry and
Neurobiology, Department of Neurobiology, Department of
Neurology, University ofIowa College Neurology, University ofIowa College
of Medicine, Iowa City, IA 52242, USA of Medicine, Iowa City, IA 52242, USA
ix
x Contributing Authors
BRENNEMAN, Douglas E. FILOGAMO, Guido
Laboratory of Developmental Department of Anatomy and
Neurobiology, National Institute of Physiology, Corso Massimo D'Azeglio
Child Health and Human Development, 52, 1-10126 Torino, ITALY
National Institutes of Health, Bethesda,
MD 20205, USA GAGE, Fred H.
Department of Neurosciences (M-024),
University of California at San Diego, La
CA VICCHIOLI, Lucio
Jolla, CA 92093, USA
Fidia Neurobiological Research
Laboratories, Via Ponte della Fabbrica
GANSMULLER, Annie
3/ A, 1-35031 Abano Terme, ITA L Y
INSERM U134, H6pital de la
Sal petri ere, F-75651 Paris Cedex 13,
COLE, Gregory M.
FRANCE
Department of Physiology-Anatomy,
University of California, Berkeley, CA GEFFARD, Michel
94720, USA IBCN-CNRS, Rue Camille Saint-Saens,
F-33077 Bordeaux Cedex, FRANCE
COLLINS, Janet M.
Department of Biochemistry /Biophysics/ GENSBURGER, Claire
Genetics, University of Colorado Centre de Neurochimie du CNRS and
Medical School, 4200 East 9th A venue INSERM U44, 5 rue Blaise Pascal,
B-121, Denver, CO 80262, USA F-67084 Strasbourg Cedex, FRANCE
CONSOLAZIONE, Adriana GIACOBINI, Ezio
Fidia Neurobiological Research Department of Pharmacology, Southern
Laboratories, Via Ponte della Fabbrica Illinois University School of Medicine,
3/ A, 1-35031 Abano Terme, ITA L Y PO Box 3926, Springfield, IL 62708,
USA
DANIELS, Mathew P.
GREMO, Fulvia
Laboratory of Biochemical Genetics,
Institute of Human Anatomy, School of
National Heart, Lung and Blood
Medicine, Cagliari, ITA L Y
Institute, National Institutes of Health,
Bethesda, MD 20892, USA
GUMPEL, Madeleine
INSERM U134, H6pital de la
DA VIES, David
Salpetriere, F-75651 Paris Cedex 13,
Department of Anatomy no. 510,
FRANCE
University of Arkansas for Medical
Sciences, 4301 West Markham Street,
HAFFKE, Susan C.
Little Rock, AR 72205-7199, USA
Department of Biochemistry /Biophysics/
Genetics, University of Colorado
DE VELLIS, Jean Medical School, 4200 East 9th A venue
68-177 Mental Retardation Research B-121, Denver, CO 80262, USA
Center, Center for Health Sciences,
University of California, 760 Westwood HAYDON, Philip G.
Plaza, Los Angeles, CA 90024, USA Department of Zoology, Iowa State
University, Ames, IA 50010, USA
FAFOUTIS, Dessie
Department of Biochemistry Biophysics HERTZ, Leif
Genetics, University of Colorado Department of Pharmacology,
Medical School, 4200 East 9th A venue University of Saskatchewan, Saskatoon,
B-121, Denver, CO 80262, USA Saskatchewan S7N OWO, CANADA
Contributing Authors xi
JACQUE, Claude MANGOURA, Dimitra
INSERM U134, H6pital de la Departments of Psychiatry and
Salpetriere, F-75651 Paris Cedex 13, Pharmacology, University of Colorado
FRANCE School of Medicine, 4200 East 9th
Avenue, Denver, CO 80262, USA
KA TER, Stanley B.
Program in Neuronal Growth and MANSOUR, Hussein
Development, Colorado State Neurobiologie du Developpement,
University, Fort Collins, CO 80521, INSERM U249, F-34060 Montpellier
USA Cedex, FRANCE
KRIKORIAN, Jacqueline G. MANTHORPE, Marston
Laboratory of Biochemical Genetics, Department of Biology M-001, School
National Heart, Lung and Blood of Medicine, University of California at
Institute, National Institutes of Health, San Diego, La Jolla, CA 92093, USA
Bethesda, MD 20892, USA
MASSA, Paul T.
KURIYA MA, Kinya Laboratory of N euromorphology,
Department of Pharmacology, Kyoto University of Connecticut, Box U-154,
Storrs, CT 06268, USA
Prefectural University of Medicine,
Kawaramachi-Hirokoji, Kamikyo-ku,
MUGNAINI, Enrico
Kyoto 602, JAPAN
La bora tory of N euromorphology,
University of Connecticut, Box U-154,
LABOURDETTE, Gerard
Storrs, CT 06268, USA
Centre de Neurochimie du CNRS and
INSERM U44, 5 rue Blaise Pascal, MUSSINI, Isabella
F-67084 Strasbourg C. S. Biologia e Fisiopatologia
Muscolare, clo Istituto di Patologia
LaCHAPELLE, Franc;ois Generale, Via Loredan 16, 1-35100
INSERM U134, H6pital de la Padova, ITA L Y
Salpetriere, F-75651 Paris Cedex 13,
FRANCE MYTILINEO U, Catherine
Department of Neurology, Mount Sinai
LAUDER, Jean M. School of Medicine, New York, NY
Department of Anatomy, University of 10029, USA
North Carolina School of Medicine,
Chapel Hill, NC 27514, USA NELSON, Phillip G.
Laboratory of Developmental
LEON, Alberta Neurobiology, National Institute of
Fidia Neurobiological Research Child Health and Human Development,
Laboratories, Via Ponte della Fabbrica 3/ National Institutes of Health, Bethesda,
A, 1-35031 Abano Terme, IT AL Y MD 20205, USA
LIM, Raymon OHKUMA, Seitaro
Department of Neurology, University of Department of Pharmacology, Kyoto
Iowa Hospitals and Clinics, Iowa City, Prefectural University of Medicine,
IA 52242, USA Kawaramachi-Hirokoji, Kamikyo-ku,
Kyoto 602, JAPAN
LING, Alice
Laboratory of Biochemical Genetics, OLEK, Anthony J.
National Heart, Lung and Blood Department of Zoology, University of
Institute, National Institutes of Health, Maryland, College Park, MD 20742,
Bethesda, MD 20892, USA USA
